-
1
-
-
20344405468
-
The GI-GPx gene is a target for Nrf2
-
Banning, A., S. Deubel, D. Kluth, Z. Zhou, and R. Brigelius-Flohe. 2005. The GI-GPx gene is a target for Nrf2. Mol Cell Biol 25:4914-4923.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4914-4923
-
-
Banning, A.1
Deubel, S.2
Kluth, D.3
Zhou, Z.4
Brigelius-Flohe, R.5
-
2
-
-
0024208540
-
Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation
-
Bast, A. and G.R. Haenen. 1988. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochim Biophys Acta 963:558-561.
-
(1988)
Biochim Biophys Acta
, vol.963
, pp. 558-561
-
-
Bast, A.1
Haenen, G.R.2
-
3
-
-
0242666198
-
Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
-
Bloom, D.A. and A.K. Jaiswal. 2003. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. JBiol Chem 278:44675-44682.
-
(2003)
JBiol Chem
, vol.278
, pp. 44675-44682
-
-
Bloom, D.A.1
Jaiswal, A.K.2
-
4
-
-
0344959510
-
Dose-proportionality of oral thioctic acid-coincidence of assessments via pooled plasma and individual data
-
Breithaupt-Grogler, K., G. Niebch, E. Schneider, K. Erb, R. Hermann, H.H. Blume, B.S. Schug, and G.G. Belz. 1999. Dose-proportionality of oral thioctic acid-coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci 8:57-65.
-
(1999)
Eur J Pharm Sci
, vol.8
, pp. 57-65
-
-
Breithaupt-Grogler, K.1
Niebch, G.2
Schneider, E.3
Erb, K.4
Hermann, R.5
Blume, H.H.6
Schug, B.S.7
Belz, G.G.8
-
5
-
-
0026736464
-
Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo
-
Busse, E., G. Zimmer, B. Schopohl, and B. Kornhuber. 1992. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittelforschung 42:829-831.
-
(1992)
Arzneimittelforschung
, vol.42
, pp. 829-831
-
-
Busse, E.1
Zimmer, G.2
Schopohl, B.3
Kornhuber, B.4
-
6
-
-
0032054899
-
Alpha-lipoic acid in liver metabolism and disease
-
Bustamante, J., J.K. Lodge, L. Marcocci, H.J. Tritschler, L. Packer, and B.H. Rihn. 1998. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med 24:1023-1039.
-
(1998)
Free Radic Biol Med
, vol.24
, pp. 1023-1039
-
-
Bustamante, J.1
Lodge, J.K.2
Marcocci, L.3
Tritschler, H.J.4
Packer, L.5
Rihn, B.H.6
-
7
-
-
0035836698
-
An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
-
Chan, K., X.D. Han, and Y.W. Kan. 2001. An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen. Proc Natl Acad Sci USA 98:4611-1616.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4611-1616
-
-
Chan, K.1
Han, X.D.2
Kan, Y.W.3
-
8
-
-
0037101768
-
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
-
Chanas, S.A., Q. Jiang, M. McMahon, G.K. McWalter, L.I. McLellan, C.R. Elcombe, C.J. Henderson, C.R. Wolf, G.J. Moffat, K. Itoh, M. Yamamoto, and J.D. Hayes. 2002. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem J 365:405-116.
-
(2002)
Biochem J
, vol.365
, pp. 405-116
-
-
Chanas, S.A.1
Jiang, Q.2
McMahon, M.3
McWalter, G.K.4
McLellan, L.I.5
Elcombe, C.R.6
Henderson, C.J.7
Wolf, C.R.8
Moffat, G.J.9
Itoh, K.10
Yamamoto, M.11
Hayes, J.D.12
-
9
-
-
29644437160
-
4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
-
Chen, Z.H., Y. Saito, Y. Yoshida, A. Sekine, N. Noguchi, and E. Niki. 2005. 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2. J Biol Chem 280:41921-11927.
-
(2005)
J Biol Chem
, vol.280
, pp. 41921-11927
-
-
Chen, Z.H.1
Saito, Y.2
Yoshida, Y.3
Sekine, A.4
Noguchi, N.5
Niki, E.6
-
10
-
-
0041976916
-
Alpha-lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes
-
Cho, K.J., H. Moini, H.K. Shon, A.S. Chung, and L. Packer. 2003. Alpha-lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes. Biochem Pharmacol 66:849-858.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 849-858
-
-
Cho, K.J.1
Moini, H.2
Shon, H.K.3
Chung, A.S.4
Packer, L.5
-
11
-
-
33750607920
-
Long-term safety of alpha-lipoic acid (ALA) consumption: A 2-year study
-
Cremer, D.R., R. Rabeler, A. Roberts, and B. Lynch. 2006. Long-term safety of alpha-lipoic acid (ALA) consumption: A 2-year study. Regul Toxicol Pharmacol 46:193-201.
-
(2006)
Regul Toxicol Pharmacol
, vol.46
, pp. 193-201
-
-
Cremer, D.R.1
Rabeler, R.2
Roberts, A.3
Lynch, B.4
-
12
-
-
4544294365
-
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
-
Cullinan, S.B., J.D. Gordan, J. Jin, J.W. Harper, and J.A. Diehl. 2004. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 24:8477-8486.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8477-8486
-
-
Cullinan, S.B.1
Gordan, J.D.2
Jin, J.3
Harper, J.W.4
Diehl, J.A.5
-
13
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
Cullinan, S.B., D. Zhang, M. Hannink, E. Arvisais, R.J. Kaufman, and J.A. Diehl. 2003. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23:7198-7209.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
14
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova, A.T., W.D. Holtzclaw, R.N. Cole, K. Itoh, N. Wakabayashi, Y. Katoh, M. Yamamoto, and P. Talalay. 2002. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99:11908-11913.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
Itoh, K.4
Wakabayashi, N.5
Katoh, Y.6
Yamamoto, M.7
Talalay, P.8
-
15
-
-
22544464124
-
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
-
Eggler, A.L., G. Liu, J.M. Pezzuto, R.B. van Breemen, and A.D. Mesecar. 2005. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci USA 102:10070-10075.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10070-10075
-
-
Eggler, A.L.1
Liu, G.2
Pezzuto, J.M.3
van Breemen, R.B.4
Mesecar, A.D.5
-
16
-
-
0035153227
-
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
-
Enomoto, A., K. Itoh, E. Nagayoshi, J. Haruta, T. Kimura, T. O'Connor, T. Harada, and M. Yamamoto. 2001. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 59:169-177.
-
(2001)
Toxicol Sci
, vol.59
, pp. 169-177
-
-
Enomoto, A.1
Itoh, K.2
Nagayoshi, E.3
Haruta, J.4
Kimura, T.5
O'Connor, T.6
Harada, T.7
Yamamoto, M.8
-
17
-
-
0036161589
-
Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid
-
Evans, J.L., C.J. Heymann, I.D. Goldfine, and L.A. Gavin. 2002. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid. Endocr Pract 8:29-35.
-
(2002)
Endocr Pract
, vol.8
, pp. 29-35
-
-
Evans, J.L.1
Heymann, C.J.2
Goldfine, I.D.3
Gavin, L.A.4
-
18
-
-
0025806510
-
Transcriptional regulation of the rat NAD(P)H: Quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants
-
Favreau, L.V. and C.B. Pickett. 1991. Transcriptional regulation of the rat NAD(P)H: quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants. J Biol Chem 266:4556-4561.
-
(1991)
J Biol Chem
, vol.266
, pp. 4556-4561
-
-
Favreau, L.V.1
Pickett, C.B.2
-
19
-
-
0033743950
-
(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo
-
Hagen, T.M., V. Vinarsky, C.M. Wehr, and B.N. Ames. 2000. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal 2:473-483.
-
(2000)
Antioxid Redox Signal
, vol.2
, pp. 473-483
-
-
Hagen, T.M.1
Vinarsky, V.2
Wehr, C.M.3
Ames, B.N.4
-
20
-
-
0030696877
-
Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization
-
Han, D., G. Handelman, L. Marcocci, C.K. Sen, S. Roy, H. Kobuchi, H.J. Tritschler, L. Flohe, and L. Packer. 1997. Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors 6:321-338.
-
(1997)
Biofactors
, vol.6
, pp. 321-338
-
-
Han, D.1
Handelman, G.2
Marcocci, L.3
Sen, C.K.4
Roy, S.5
Kobuchi, H.6
Tritschler, H.J.7
Flohe, L.8
Packer, L.9
-
21
-
-
0015986669
-
The metabolism of dl-(1,6-14C)lipoic acid in the rat
-
Harrison, E.H. and D.B. McCormick. 1974. The metabolism of dl-(1,6-14C)lipoic acid in the rat. Arch Biochem Biophys 160:514-522.
-
(1974)
Arch Biochem Biophys
, vol.160
, pp. 514-522
-
-
Harrison, E.H.1
McCormick, D.B.2
-
22
-
-
33747643517
-
Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 X Keap1 X Cul3 complex and recruiting Nrf2 X Maf to the antioxidant response element enhancer
-
He, X., M.G. Chen, G.X. Lin, and Q. Ma. 2006. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 X Keap1 X Cul3 complex and recruiting Nrf2 X Maf to the antioxidant response element enhancer. J Biol Chem 281:23620-23631.
-
(2006)
J Biol Chem
, vol.281
, pp. 23620-23631
-
-
He, X.1
Chen, M.G.2
Lin, G.X.3
Ma, Q.4
-
23
-
-
0037044791
-
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
-
Huang, H.C., T. Nguyen, and C.B. Pickett. 2002. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 277:42769-42774.
-
(2002)
J Biol Chem
, vol.277
, pp. 42769-42774
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
24
-
-
0033731182
-
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
-
Huang, H.C., T. Nguyen, and C.B. Pickett. 2000. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci USA 97:12475-12480.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12475-12480
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
25
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh, K., T. Chiba, S. Takahashi, T. Ishii, K. Igarashi, Y. Katoh, T. Oyake, N. Hayashi, K. Satoh, I. Hatayama, M. Yamamoto, and Y. Nabeshima. 1997. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-322.
-
(1997)
Biochem Biophys Res Commun
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.12
-
26
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh, K., N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, and M. Yamamoto. 1999. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13:76-86.
-
(1999)
Genes Dev
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
27
-
-
12444257799
-
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
-
Itoh, K., N. Wakabayashi, Y. Katoh, T. Ishii, T. O'Connor, and M. Yamamoto. 2003. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8:379-391.
-
(2003)
Genes Cells
, vol.8
, pp. 379-391
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
O'Connor, T.5
Yamamoto, M.6
-
28
-
-
33744953050
-
Phosphorylation of tyrosine 568 controls nuclear export of Nrf2
-
Jain, A.K. and A.K. Jaiswal. 2006. Phosphorylation of tyrosine 568 controls nuclear export of Nrf2. J Biol Chem 281:12132-12142.
-
(2006)
J Biol Chem
, vol.281
, pp. 12132-12142
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
29
-
-
1242274394
-
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
-
Kang, M.I., A. Kobayashi, N. Wakabayashi, S.G. Kim, and M. Yamamoto. 2004. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci U S A 101:2046-2051.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 2046-2051
-
-
Kang, M.I.1
Kobayashi, A.2
Wakabayashi, N.3
Kim, S.G.4
Yamamoto, M.5
-
30
-
-
19944430116
-
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: Implications for expression of oxidative stress-protecting genes
-
Karapetian, R.N., A.G. Evstafieva, I.S. Abaeva, N.V. Chichkova, G.S. Filonov, Y.P. Rubtsov, E.A. Sukhacheva, S.V. Melnikov, U. Schneider, E.E. Wanker, and A.B. Vartapetian. 2005. Nuclear oncoprotein prothymosin alpha is a partner of Keap1: Implications for expression of oxidative stress-protecting genes. Mol Cell Biol 25:1089-1099.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1089-1099
-
-
Karapetian, R.N.1
Evstafieva, A.G.2
Abaeva, I.S.3
Chichkova, N.V.4
Filonov, G.S.5
Rubtsov, Y.P.6
Sukhacheva, E.A.7
Melnikov, S.V.8
Schneider, U.9
Wanker, E.E.10
Vartapetian, A.B.11
-
31
-
-
0037468933
-
Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response
-
Kim, Y.C., Y. Yamaguchi, N. Kondo, H. Masutani, and J. Yodoi. 2003. Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response. Oncogene 22:1860-1865.
-
(2003)
Oncogene
, vol.22
, pp. 1860-1865
-
-
Kim, Y.C.1
Yamaguchi, Y.2
Kondo, N.3
Masutani, H.4
Yodoi, J.5
-
32
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi, A., M.I. Kang, H. Okawa, M. Ohtsuji, Y. Zenke, T. Chiba, K. Igarashi, and M. Yamamoto. 2004. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24:7130-7139.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
Igarashi, K.7
Yamamoto, M.8
-
33
-
-
33344469643
-
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
-
Kobayashi, A., M.I. Kang, Y. Watai, K.I. Tong, T. Shibata, K. Uchida, and M. Yamamoto. 2006. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 26:221-229.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 221-229
-
-
Kobayashi, A.1
Kang, M.I.2
Watai, Y.3
Tong, K.I.4
Shibata, T.5
Uchida, K.6
Yamamoto, M.7
-
34
-
-
0036668466
-
Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system
-
Kobayashi, M., K. Itoh, T. Suzuki, H. Osanai, K. Nishikawa, Y. Katoh, Y. Takagi, and M. Yamamoto. 2002. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells 7:807-820.
-
(2002)
Genes Cells
, vol.7
, pp. 807-820
-
-
Kobayashi, M.1
Itoh, K.2
Suzuki, T.3
Osanai, H.4
Nishikawa, K.5
Katoh, Y.6
Takagi, Y.7
Yamamoto, M.8
-
35
-
-
0038578527
-
Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: Effect of the polyamine metabolite acrolein
-
Kwak, M.K., T.W. Kensler, and R.A. Casero, Jr. 2003. Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: Effect of the polyamine metabolite acrolein. Biochem Biophys Res Commun 305:662-670.
-
(2003)
Biochem Biophys Res Commun
, vol.305
, pp. 662-670
-
-
Kwak, M.K.1
Kensler, T.W.2
Casero, R.A.3
-
36
-
-
0242721624
-
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway
-
Kwak, M.K., N. Wakabayashi, J.L. Greenlaw, M. Yamamoto, and T.W. Kensler. 2003. Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol 23:8786-8794.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8786-8794
-
-
Kwak, M.K.1
Wakabayashi, N.2
Greenlaw, J.L.3
Yamamoto, M.4
Kensler, T.W.5
-
37
-
-
0037424262
-
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
-
Kwak, M.K., N. Wakabayashi, K. Itoh, H. Motohashi, M. Yamamoto, and T.W. Kensler. 2003. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. JBiol Chem 278:8135-8145.
-
(2003)
JBiol Chem
, vol.278
, pp. 8135-8145
-
-
Kwak, M.K.1
Wakabayashi, N.2
Itoh, K.3
Motohashi, H.4
Yamamoto, M.5
Kensler, T.W.6
-
38
-
-
25144440916
-
Cloning and characterization of the human glutathione synthetase 5'-flanking region
-
Lee, T.D., H. Yang, J. Whang, and S.C. Lu. 2005. Cloning and characterization of the human glutathione synthetase 5'-flanking region. Biochem J 390:521-528.
-
(2005)
Biochem J
, vol.390
, pp. 521-528
-
-
Lee, T.D.1
Yang, H.2
Whang, J.3
Lu, S.C.4
-
39
-
-
0026755187
-
Regulation of human NAD(P)H:quinone oxidore-ductase gene. Role of AP1 binding site contained within human antioxidant response element
-
Li, Y. and A.K. Jaiswal. 1992. Regulation of human NAD(P)H:quinone oxidore-ductase gene. Role of AP1 binding site contained within human antioxidant response element. J Biol Chem 267:15097-15104.
-
(1992)
J Biol Chem
, vol.267
, pp. 15097-15104
-
-
Li, Y.1
Jaiswal, A.K.2
-
40
-
-
33646344983
-
Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats
-
Louhelainen, M., S. Merasto, P. Finckenberg, R. Lapatto, Z.J. Cheng, and E.M. Mervaala. 2006. Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats. J Hypertens 24:947-956.
-
(2006)
J Hypertens
, vol.24
, pp. 947-956
-
-
Louhelainen, M.1
Merasto, S.2
Finckenberg, P.3
Lapatto, R.4
Cheng, Z.J.5
Mervaala, E.M.6
-
41
-
-
0029867723
-
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats
-
Maitra, I., E. Serbinova, H.J. Tritschler, and L. Packer. 1996. Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. Biochem Biophys Res Commun 221:422-429.
-
(1996)
Biochem Biophys Res Commun
, vol.221
, pp. 422-429
-
-
Maitra, I.1
Serbinova, E.2
Tritschler, H.J.3
Packer, L.4
-
42
-
-
1542335553
-
Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
-
Martin, D., A.I. Rojo, M. Salinas, R. Diaz, G. Gallardo, J. Alam, C.M. De Galarreta, and A. Cuadrado. 2004. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 279:8919-8929.
-
(2004)
J Biol Chem
, vol.279
, pp. 8919-8929
-
-
Martin, D.1
Rojo, A.I.2
Salinas, M.3
Diaz, R.4
Gallardo, G.5
Alam, J.6
De Galarreta, C.M.7
Cuadrado, A.8
-
43
-
-
0035870298
-
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
-
McMahon, M., K. Itoh, M. Yamamoto, S.A. Chanas, C.J. Henderson, L.I. McLellan, C.R. Wolf, C. Cavin, and J.D. Hayes. 2001. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res 61:3299-3307.
-
(2001)
Cancer Res
, vol.61
, pp. 3299-3307
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Chanas, S.A.4
Henderson, C.J.5
McLellan, L.I.6
Wolf, C.R.7
Cavin, C.8
Hayes, J.D.9
-
44
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon, M., K. Itoh, M. Yamamoto, and J.D. Hayes. 2003. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278:21592-21600.
-
(2003)
J Biol Chem
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
45
-
-
2642671110
-
An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site
-
Moinova, H.R. and R.T. Mulcahy. 1998. An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site. J Biol Chem 273:14683-14689.
-
(1998)
J Biol Chem
, vol.273
, pp. 14683-14689
-
-
Moinova, H.R.1
Mulcahy, R.T.2
-
46
-
-
0033546686
-
Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element
-
Moinova, H.R. and R.T. Mulcahy. 1999. Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element. Biochem Biophys Res Commun 261:661-668.
-
(1999)
Biochem Biophys Res Commun
, vol.261
, pp. 661-668
-
-
Moinova, H.R.1
Mulcahy, R.T.2
-
47
-
-
0028914295
-
Identification of a putative antioxidant response element in the 5'-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene
-
Mulcahy, R.T. and J.J. Gipp. 1995. Identification of a putative antioxidant response element in the 5'-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene. Biochem Biophys Res Commun 209:227-233.
-
(1995)
Biochem Biophys Res Commun
, vol.209
, pp. 227-233
-
-
Mulcahy, R.T.1
Gipp, J.J.2
-
48
-
-
0141590207
-
Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway
-
Muller, C., F. Dunschede, E. Koch, A.M. Vollmar, and A.K. Kiemer. 2003. Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway. Am J Physiol Gastrointest Liver Physiol 285:G769-G778.
-
(2003)
Am J Physiol Gastrointest Liver Physiol
, vol.285
, pp. G769-G778
-
-
Muller, C.1
Dunschede, F.2
Koch, E.3
Vollmar, A.M.4
Kiemer, A.K.5
-
49
-
-
0013282861
-
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome
-
Nguyen, T., P.J. Sherratt, H.C. Huang, C.S. Yang, and C.B. Pickett. 2003. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J Biol Chem 278:4536-4541.
-
(2003)
J Biol Chem
, vol.278
, pp. 4536-4541
-
-
Nguyen, T.1
Sherratt, P.J.2
Huang, H.C.3
Yang, C.S.4
Pickett, C.B.5
-
50
-
-
25444449520
-
Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1
-
Nguyen, T., P.J. Sherratt, P. Nioi, C.S. Yang, and C.B. Pickett. 2005. Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1. J Biol Chem 280: 32485-32492.
-
(2005)
J Biol Chem
, vol.280
, pp. 32485-32492
-
-
Nguyen, T.1
Sherratt, P.J.2
Nioi, P.3
Yang, C.S.4
Pickett, C.B.5
-
51
-
-
0042330074
-
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P) H:quinone oxidoreductase 1 gene: Reassessment of the ARE consensus sequence
-
Nioi, P., M. McMahon, K. Itoh, M. Yamamoto, and J.D. Hayes. 2003. Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P) H:quinone oxidoreductase 1 gene: Reassessment of the ARE consensus sequence. Biochem J 374:337-348.
-
(2003)
Biochem J
, vol.374
, pp. 337-348
-
-
Nioi, P.1
McMahon, M.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
52
-
-
14644397287
-
Transcription factor Nrf2 regulates promoter activity of mouse aldose reductase (AKR1B3) gene
-
Nishinaka, T. and C. Yabe-Nishimura. 2005. Transcription factor Nrf2 regulates promoter activity of mouse aldose reductase (AKR1B3) gene. J Pharmacol Sci 97:43-51.
-
(2005)
J Pharmacol Sci
, vol.97
, pp. 43-51
-
-
Nishinaka, T.1
Yabe-Nishimura, C.2
-
53
-
-
26244450392
-
Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
-
Ogborne, R.M., S.A. Rushworth, and M.A. O'Connell. 2005. Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arterioscler Thromb Vasc Biol 25:2100-2105.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 2100-2105
-
-
Ogborne, R.M.1
Rushworth, S.A.2
O'Connell, M.A.3
-
54
-
-
28144445947
-
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
-
Okawa, H., H. Motohashi, A. Kobayashi, H. Aburatani, T.W. Kensler, and M. Yamamoto. 2006. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun 339:79-88.
-
(2006)
Biochem Biophys Res Commun
, vol.339
, pp. 79-88
-
-
Okawa, H.1
Motohashi, H.2
Kobayashi, A.3
Aburatani, H.4
Kensler, T.W.5
Yamamoto, M.6
-
55
-
-
0029411321
-
Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electro-philes and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE)
-
Prestera, T., P. Talalay, J. Alam, Y.I. Ahn, P.J. Lee, and A.M. Choi. 1995. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electro-philes and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE). Mol Med 1:827-837.
-
(1995)
Mol Med
, vol.1
, pp. 827-837
-
-
Prestera, T.1
Talalay, P.2
Alam, J.3
Ahn, Y.I.4
Lee, P.J.5
Choi, A.M.6
-
56
-
-
0029830816
-
Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones
-
Primiano, T., T.W. Kensler, P. Kuppusamy, J.L. Zweier, and T.R. Sutter. 1996. Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones. Carcinogenesis 17:2291-2296.
-
(1996)
Carcinogenesis
, vol.17
, pp. 2291-2296
-
-
Primiano, T.1
Kensler, T.W.2
Kuppusamy, P.3
Zweier, J.L.4
Sutter, T.R.5
-
57
-
-
0031950013
-
Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: Implications for chemoprevention
-
Primiano, T., Y. Li, T.W. Kensler, M.A. Trush, and T.R. Sutter. 1998. Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: Implications for chemoprevention. Carcinogenesis 19:999-1005.
-
(1998)
Carcinogenesis
, vol.19
, pp. 999-1005
-
-
Primiano, T.1
Li, Y.2
Kensler, T.W.3
Trush, M.A.4
Sutter, T.R.5
-
58
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in Nrf2 transcription factor-deficient mice
-
Ramos-Gomez, M., M.K. Kwak, P.M. Dolan, K. Itoh, M. Yamamoto, P. Talalay, and T.W. Kensler. 2001. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in Nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98:3410-3415.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
Kwak, M.K.2
Dolan, P.M.3
Itoh, K.4
Yamamoto, M.5
Talalay, P.6
Kensler, T.W.7
-
59
-
-
0032881613
-
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). alpha lipoic acid in diabetic neuropathy
-
Reljanovic, M., G. Reichel, K. Rett, M. Lobisch, K. Schuette, W. Moller, H.J. Tritschler, and H. Mehnert. 1999. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). alpha lipoic acid in diabetic neuropathy. Free Radic Res 31:171-179.
-
(1999)
Free Radic Res
, vol.31
, pp. 171-179
-
-
Reljanovic, M.1
Reichel, G.2
Rett, K.3
Lobisch, M.4
Schuette, K.5
Moller, W.6
Tritschler, H.J.7
Mehnert, H.8
-
60
-
-
0004570568
-
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy
-
Ruhnau, K.J., H.P. Meissner, J.R. Finn, M. Reljanovic, M. Lobisch, K. Schutte, D. Nehrdich, H.J. Tritschler, H. Mehnert, and D. Ziegler. 1999. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med 16:1040-1043.
-
(1999)
Diabet Med
, vol.16
, pp. 1040-1043
-
-
Ruhnau, K.J.1
Meissner, H.P.2
Finn, J.R.3
Reljanovic, M.4
Lobisch, M.5
Schutte, K.6
Nehrdich, D.7
Tritschler, H.J.8
Mehnert, H.9
Ziegler, D.10
-
61
-
-
0025368036
-
Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds
-
Rushmore, T.H., R.G. King, K.E. Paulson, and C.B. Pickett. 1990. Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc Natl Acad Sci U S A 87:3826-3830.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 3826-3830
-
-
Rushmore, T.H.1
King, R.G.2
Paulson, K.E.3
Pickett, C.B.4
-
62
-
-
32344432720
-
Role of protein kinase C delta in curcumin-induced antioxidant response elementmediated gene expression in human monocytes
-
Rushworth, S.A., R.M. Ogborne, C.A. Charalambos, and M.A. O'Connell. 2006. Role of protein kinase C delta in curcumin-induced antioxidant response elementmediated gene expression in human monocytes. Biochem Biophys Res Commun 341:1007-1016.
-
(2006)
Biochem Biophys Res Commun
, vol.341
, pp. 1007-1016
-
-
Rushworth, S.A.1
Ogborne, R.M.2
Charalambos, C.A.3
O'Connell, M.A.4
-
63
-
-
18244386712
-
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF-E2-related factor-2
-
Sakurai, A., M. Nishimoto, S. Himeno, N. Imura, M. Tsujimoto, M. Kunimoto, and S. Hara. 2005. Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF-E2-related factor-2. J Cell Physiol 203:529-537.
-
(2005)
J Cell Physiol
, vol.203
, pp. 529-537
-
-
Sakurai, A.1
Nishimoto, M.2
Himeno, S.3
Imura, N.4
Tsujimoto, M.5
Kunimoto, M.6
Hara, S.7
-
64
-
-
33744950387
-
Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
-
Salazar, M., A.I. Rojo, D. Velasco, R.M. de Sagarra, and A. Cuadrado. 2006. Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. J Biol Chem 281:14841-14851.
-
(2006)
J Biol Chem
, vol.281
, pp. 14841-14851
-
-
Salazar, M.1
Rojo, A.I.2
Velasco, D.3
de Sagarra, R.M.4
Cuadrado, A.5
-
65
-
-
33748916602
-
Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways
-
Shelby, M.K. and C.D. Klaassen. 2006. Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways. Drug Metab Dispos 34:1772-1778.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1772-1778
-
-
Shelby, M.K.1
Klaassen, C.D.2
-
66
-
-
33645821903
-
Trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors
-
Slitt, A.L., N.J. Cherrington, M.Z. Dieter, L.M. Aleksunes, G.L. Scheffer, W. Huang, D.D. Moore, and C.D. Klaassen. 2006. trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors. Mol Pharmacol 69:1554-1563.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1554-1563
-
-
Slitt, A.L.1
Cherrington, N.J.2
Dieter, M.Z.3
Aleksunes, L.M.4
Scheffer, G.L.5
Huang, W.6
Moore, D.D.7
Klaassen, C.D.8
-
67
-
-
1542723493
-
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
-
Suh, J.H., S.V. Shenvi, B.M. Dixon, H. Liu, A.K. Jaiswal, R.M. Liu, and T.M. Hagen. 2004. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A 101:3381-3386.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3381-3386
-
-
Suh, J.H.1
Shenvi, S.V.2
Dixon, B.M.3
Liu, H.4
Jaiswal, A.K.5
Liu, R.M.6
Hagen, T.M.7
-
68
-
-
1042290476
-
(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: Evidence for increased cysteine requirement for GSH synthesis
-
Suh, J.H., H. Wang, R.M. Liu, J. Liu, and T.M. Hagen. 2004. (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: Evidence for increased cysteine requirement for GSH synthesis. Arch Biochem Biophys 423:126-135.
-
(2004)
Arch Biochem Biophys
, vol.423
, pp. 126-135
-
-
Suh, J.H.1
Wang, H.2
Liu, R.M.3
Liu, J.4
Hagen, T.M.5
-
69
-
-
16244378900
-
Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice
-
Tanito, M., H. Masutani, Y.C. Kim, M. Nishikawa, A. Ohira, and J. Yodoi. 2005. Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice. Invest Ophthalmol Vis Sci 46:979-987.
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 979-987
-
-
Tanito, M.1
Masutani, H.2
Kim, Y.C.3
Nishikawa, M.4
Ohira, A.5
Yodoi, J.6
-
70
-
-
0031743135
-
Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers
-
Teichert, J., J. Kern, H.J. Tritschler, H. Ulrich, and R. Preiss. 1998. Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int J Clin Pharmacol Ther 36:625-628.
-
(1998)
Int J Clin Pharmacol Ther
, vol.36
, pp. 625-628
-
-
Teichert, J.1
Kern, J.2
Tritschler, H.J.3
Ulrich, H.4
Preiss, R.5
-
71
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa, R.K., K.H. Mai, S. Srisuma, T.W. Kensler, M. Yamamoto, and S. Biswal. 2002. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62:5196-5203.
-
(2002)
Cancer Res
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
Kensler, T.W.4
Yamamoto, M.5
Biswal, S.6
-
72
-
-
18944373186
-
Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism
-
Velichkova, M. and T. Hasson. 2005. Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism. Mol Cell Biol 25:4501-4513.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4501-4513
-
-
Velichkova, M.1
Hasson, T.2
-
73
-
-
1242296811
-
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
-
Wakabayashi, N., A.T. Dinkova-Kostova, W.D. Holtzclaw, M.I. Kang, A. Kobayashi, M. Yamamoto, T.W. Kensler, and P. Talalay. 2004. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci USA 101:2040-2045.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2040-2045
-
-
Wakabayashi, N.1
Dinkova-Kostova, A.T.2
Holtzclaw, W.D.3
Kang, M.I.4
Kobayashi, A.5
Yamamoto, M.6
Kensler, T.W.7
Talalay, P.8
-
74
-
-
0242329881
-
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
-
Wakabayashi, N., K. Itoh, J. Wakabayashi, H. Motohashi, S. Noda, S. Takahashi, S. Imakado, T. Kotsuji, F. Otsuka, D.R. Roop, T. Harada, J.D. Engel, and M. Yamamoto. 2003. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35:238-245.
-
(2003)
Nat Genet
, vol.35
, pp. 238-245
-
-
Wakabayashi, N.1
Itoh, K.2
Wakabayashi, J.3
Motohashi, H.4
Noda, S.5
Takahashi, S.6
Imakado, S.7
Kotsuji, T.8
Otsuka, F.9
Roop, D.R.10
Harada, T.11
Engel, J.D.12
Yamamoto, M.13
-
75
-
-
0031000208
-
Functional antioxidant responsive elements
-
Wasserman, W.W. and W.E. Fahl. 1997. Functional antioxidant responsive elements. Proc Natl Acad Sci USA 94:5361-5366.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5361-5366
-
-
Wasserman, W.W.1
Fahl, W.E.2
-
76
-
-
0032104212
-
Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene
-
Wild, A.C., J.J. Gipp, and T. Mulcahy. 1998. Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene. Biochem J 332 (Pt 2):373-381.
-
(1998)
Biochem J
, vol.332
, pp. 373-381
-
-
Wild, A.C.1
Gipp, J.J.2
Mulcahy, T.3
-
77
-
-
0033584867
-
Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2
-
Wild, A.C., H.R. Moinova, and R.T. Mulcahy. 1999. Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. J Biol Chem 274:33627-33636.
-
(1999)
J Biol Chem
, vol.274
, pp. 33627-33636
-
-
Wild, A.C.1
Moinova, H.R.2
Mulcahy, R.T.3
-
78
-
-
33748358379
-
Mechanism of action of isothiocyanates: The induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphory-lation and nuclear translocation of Nrf2
-
Xu, C., X. Yuan, Z. Pan, G. Shen, J.H. Kim, S. Yu, T.O. Khor, W. Li, J. Ma, and A.N. Kong. 2006. Mechanism of action of isothiocyanates: The induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphory-lation and nuclear translocation of Nrf2. Mol Cancer Ther 5:1918-1926.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1918-1926
-
-
Xu, C.1
Yuan, X.2
Pan, Z.3
Shen, G.4
Kim, J.H.5
Yu, S.6
Khor, T.O.7
Li, W.8
Ma, J.9
Kong, A.N.10
-
79
-
-
0034064348
-
Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes
-
Yaworsky, K., R. Somwar, T. Ramlal, H.J. Tritschler, and A. Klip. 2000. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia 43:294-303.
-
(2000)
Diabetologia
, vol.43
, pp. 294-303
-
-
Yaworsky, K.1
Somwar, R.2
Ramlal, T.3
Tritschler, H.J.4
Klip, A.5
-
80
-
-
10044228504
-
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
-
Zhang, D.D., S.C. Lo, J.V. Cross, D.J. Templeton, and M. Hannink. 2004. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24:10941-10953.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10941-10953
-
-
Zhang, D.D.1
Lo, S.C.2
Cross, J.V.3
Templeton, D.J.4
Hannink, M.5
-
81
-
-
33744970045
-
Gamma-glutamyl transpeptidase is induced by 4-hydroxynonenal viaEpRE/Nrf2signalinginratepithelialtypeIIcells
-
Zhang, H., H. Liu, D.A. Dickinson, R.M. Liu, E.M. Postlethwait, Y. Laperche, and H.J. Forman. 2006. Gamma-glutamyl transpeptidase is induced by 4-hydroxynonenal viaEpRE/Nrf2signalinginratepithelialtypeIIcells. FreeRadicBiolMed40:1281-1292.
-
(2006)
FreeRadicBiolMed
, vol.40
, pp. 1281-1292
-
-
Zhang, H.1
Liu, H.2
Dickinson, D.A.3
Liu, R.M.4
Postlethwait, E.M.5
Laperche, Y.6
Forman, H.J.7
-
82
-
-
32044466295
-
4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/ nuclear factor erythroid 2-related factor 2 signaling
-
Zhang, H., H. Liu, K.E. Iles, R.M. Liu, E.M. Postlethwait, Y. Laperche, and H.J. Forman. 2006. 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/ nuclear factor erythroid 2-related factor 2 signaling. Am J Respir Cell Mol Biol 34:174-181.
-
(2006)
Am J Respir Cell Mol Biol
, vol.34
, pp. 174-181
-
-
Zhang, H.1
Liu, H.2
Iles, K.E.3
Liu, R.M.4
Postlethwait, E.M.5
Laperche, Y.6
Forman, H.J.7
-
83
-
-
0035955513
-
Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signaling pathway
-
Zhang, L., G.Q. Xing, J.L. Barker, Y. Chang, D. Maric, W. Ma, B.S. Li, and D.R. Rubinow. 2001. Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signaling pathway. Neurosci Lett 312:125-128.
-
(2001)
Neurosci Lett
, vol.312
, pp. 125-128
-
-
Zhang, L.1
Xing, G.Q.2
Barker, J.L.3
Chang, Y.4
Maric, D.5
Ma, W.6
Li, B.S.7
Rubinow, D.R.8
-
84
-
-
2642548826
-
Thioctic acid for patients with symptomatic diabetic polyneuropathy: A critical review
-
Ziegler, D. 2004. Thioctic acid for patients with symptomatic diabetic polyneuropathy: A critical review. Treat Endocrinol 3:173-189.
-
(2004)
Treat Endocrinol
, vol.3
, pp. 173-189
-
-
Ziegler, D.1
-
85
-
-
0032788081
-
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-lipoic acid in diabetic neuropathy
-
Ziegler, D., M. Hanefeld, K.J. Ruhnau, H. Hasche, M. Lobisch, K. Schutte, G. Kerum, and R. Malessa. 1999. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-lipoic acid in diabetic neuropathy. Diabetes Care 22:1296-1301.
-
(1999)
Diabetes Care
, vol.22
, pp. 1296-1301
-
-
Ziegler, D.1
Hanefeld, M.2
Ruhnau, K.J.3
Hasche, H.4
Lobisch, M.5
Schutte, K.6
Kerum, G.7
Malessa, R.8
-
86
-
-
0028845524
-
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study)
-
Ziegler, D., M. Hanefeld, K.J. Ruhnau, H.P. Meissner, M. Lobisch, K. Schutte, and F.A. Gries. 1995. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia 38:1425-1433.
-
(1995)
Diabetologia
, vol.38
, pp. 1425-1433
-
-
Ziegler, D.1
Hanefeld, M.2
Ruhnau, K.J.3
Meissner, H.P.4
Lobisch, M.5
Schutte, K.6
Gries, F.A.7
-
87
-
-
0037183998
-
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
-
Zipper, L.M. and R.T. Mulcahy. 2002. The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm. J Biol Chem 277:36544-36552.
-
(2002)
J Biol Chem
, vol.277
, pp. 36544-36552
-
-
Zipper, L.M.1
Mulcahy, R.T.2
|