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Volumn 50, Issue 1, 2011, Pages 39-48

T cell recognition of weak ligands: Roles of signaling, receptor number, and affinity

Author keywords

Altered peptide ligands; Autoimmunity; Intracellular signaling; T cell; Viral escape

Indexed keywords

EPITOPE; GAMMA INTERFERON; INTERLEUKIN 10; MEMBRANE RECEPTOR; T LYMPHOCYTE RECEPTOR;

EID: 79955636189     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-011-8204-3     Document Type: Review
Times cited : (28)

References (98)
  • 1
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold BD, Allen PM. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science. 1991;252:1308-10. (Pubitemid 21917045)
    • (1991) Science , vol.252 , Issue.5010 , pp. 1308-1310
    • Evavold, B.D.1    Allen, P.M.2
  • 3
    • 0027298445 scopus 로고
    • Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
    • DOI 10.1038/363156a0
    • Sloan-Lancaster J, Evavold BD, Allen PM. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature. 1993;363:156-9. (Pubitemid 23147012)
    • (1993) Nature , vol.363 , Issue.6425 , pp. 156-159
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 4
    • 0027967385 scopus 로고
    • Partial T cell signaling: Altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy
    • DOI 10.1016/0092-8674(94)90080-9
    • Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM. Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy. Cell. 1994;79:913-22. (Pubitemid 24371981)
    • (1994) Cell , vol.79 , Issue.5 , pp. 913-922
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.M.4
  • 5
    • 0028902752 scopus 로고
    • Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science. 1995;267:515-8.
    • (1995) Science , vol.267 , pp. 515-518
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3    Isakov, N.4    Samelson, L.E.5    Germain, R.N.6
  • 7
    • 77950809538 scopus 로고    scopus 로고
    • The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
    • Huang J, Zarnitsyna VI, Liu B, Edwards LJ, Jiang N, Evavold BD, Zhu C. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature. 2010;464:932-6.
    • (2010) Nature , vol.464 , pp. 932-936
    • Huang, J.1    Zarnitsyna, V.I.2    Liu, B.3    Edwards, L.J.4    Jiang, N.5    Evavold, B.D.6    Zhu, C.7
  • 9
    • 0028360076 scopus 로고
    • Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
    • DOI 10.1038/369407a0
    • Bertoletti A, Sette A, Chisari FV, Penna A, Levrero M, De Carli M, Fiaccadori F, Ferrari C. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature. 1994;369:407-10. (Pubitemid 24184055)
    • (1994) Nature , vol.369 , Issue.6479 , pp. 407-410
    • Bertoletti, A.1    Sette, A.2    Chisari, F.V.3    Penna, A.4    Levrero, M.5    De Carli, M.6    Fiaccadori, F.7    Ferrari, C.8
  • 11
    • 76249116437 scopus 로고    scopus 로고
    • Naturally occurring altered peptide ligands control Salmonella-specific CD4+ T cell proliferation, IFN-gamma production, and protective potency
    • Johanns TM, Ertelt JM, Lai JC, Rowe JH, Avant RA, Way SS. Naturally occurring altered peptide ligands control Salmonella-specific CD4+ T cell proliferation, IFN-gamma production, and protective potency. J Immunol. 2010;184:869-76.
    • (2010) J Immunol , vol.184 , pp. 869-876
    • Johanns, T.M.1    Ertelt, J.M.2    Lai, J.C.3    Rowe, J.H.4    Avant, R.A.5    Way, S.S.6
  • 13
    • 0030747157 scopus 로고    scopus 로고
    • RNA virus mutations and fitness for survival
    • DOI 10.1146/annurev.micro.51.1.151
    • Domingo E, Holland JJ. RNA virus mutations and fitness for survival. Annu Rev Microbiol. 1997;51:151-78. (Pubitemid 27433046)
    • (1997) Annual Review of Microbiology , vol.51 , pp. 151-178
    • Domingo, E.1    Holland, J.J.2
  • 14
    • 0034657177 scopus 로고    scopus 로고
    • An altered peptide ligand antagonizes antigen-specific T cells of patients with human T lymphotropic virus type I-associated neurological disease
    • Kubota R, Soldan SS, Martin R, Jacobson S. An altered peptide ligand antagonizes antigen-specific T cells of patients with human T lymphotropic virus type I-associated neurological disease. J Immunol. 2000;164:5192-8. (Pubitemid 30305195)
    • (2000) Journal of Immunology , vol.164 , Issue.10 , pp. 5192-5198
    • Kubota, R.1    Soldan, S.S.2    Martin, R.3    Jacobson, S.4
  • 18
    • 33646547656 scopus 로고    scopus 로고
    • Dimorphic Plasmodium falciparum merozoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming
    • Lee EA, Flanagan KL, Minigo G, Reece WH, Bailey R, Pinder M, Hill AV, Plebanski M. Dimorphic Plasmodium falciparum merozoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming. Eur J Immunol. 2006;36:1168-78.
    • (2006) Eur J Immunol , vol.36 , pp. 1168-1178
    • Lee, E.A.1    Flanagan, K.L.2    Minigo, G.3    Reece, W.H.4    Bailey, R.5    Pinder, M.6    Hill, A.V.7    Plebanski, M.8
  • 19
    • 0030869489 scopus 로고    scopus 로고
    • Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides
    • DOI 10.1002/eji.1830270929
    • Sewell AK, Harcourt GC, Goulder PJ, Price DA, Phillips RE. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. Eur J Immunol. 1997;27:2323-9. (Pubitemid 27404317)
    • (1997) European Journal of Immunology , vol.27 , Issue.9 , pp. 2323-2329
    • Sewell, A.K.1    Harcourt, G.C.2    Goulder, P.J.R.3    Price, D.A.4    Phillips, R.E.5
  • 21
    • 0035031798 scopus 로고    scopus 로고
    • In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb
    • Puglielli MT, Zajac AJ, van der Most RG, Dzuris JL, Sette A, Altman JD, Ahmed R. In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb. J Virol. 2001;75:5099-107.
    • (2001) J Virol , vol.75 , pp. 5099-5107
    • Puglielli, M.T.1    Zajac, A.J.2    Van Der Most, R.G.3    Dzuris, J.L.4    Sette, A.5    Altman, J.D.6    Ahmed, R.7
  • 23
    • 0032948455 scopus 로고    scopus 로고
    • Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming
    • DOI 10.1038/8444
    • Plebanski M, Lee EA, Hannan CM, Flanagan KL, Gilbert SC, Gravenor MB, Hill AV. Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming. Nat Med. 1999;5:565-71. (Pubitemid 29220217)
    • (1999) Nature Medicine , vol.5 , Issue.5 , pp. 565-571
    • Plebanski, M.1    Lee, L.A.M.2    Hannan, C.M.3    Flanagan, K.L.4    Gilbert, S.C.5    Gravenor, M.B.6    Hill, A.V.S.7
  • 26
    • 0033960578 scopus 로고    scopus 로고
    • + cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide
    • DOI 10.1128/JVI.74.5.2121-2130.2000
    • Bouhdoud L, Villain P, Merzouki A, Arella M, Couture C. T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide. J Virol. 2000;74:2121-30. (Pubitemid 30091465)
    • (2000) Journal of Virology , vol.74 , Issue.5 , pp. 2121-2130
    • Bouhdoud, L.1    Villain, P.2    Merzouki, A.3    Arella, M.4    Couture, C.5
  • 27
    • 77951929316 scopus 로고    scopus 로고
    • Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosis
    • Ream RM, Sun J, Braciale TJ. Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosis. J Immunol. 2010;184:2401-9.
    • (2010) J Immunol , vol.184 , pp. 2401-2409
    • Ream, R.M.1    Sun, J.2    Braciale, T.J.3
  • 28
    • 61449195722 scopus 로고    scopus 로고
    • CD8+ T cell responses to a viral escape mutant epitope: Active suppression via altered SHP-1 activity
    • Schnell FJ, Alberts-Grill N, Evavold BD. CD8+ T cell responses to a viral escape mutant epitope: active suppression via altered SHP-1 activity. J Immunol. 2009;182:1829-35.
    • (2009) J Immunol , vol.182 , pp. 1829-1835
    • Schnell, F.J.1    Alberts-Grill, N.2    Evavold, B.D.3
  • 30
    • 0034903068 scopus 로고    scopus 로고
    • The Impact of duration versus extent of TCR occupancy on T cell activation: A revision of the kinetic proofreading model
    • DOI 10.1016/S1074-7613(01)00173-X
    • Rosette C, Werlen G, Daniels MA, Holman PO, Alam SM, Travers PJ, Gascoigne NR, Palmer E, Jameson SC. The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity. 2001;15:59-70. (Pubitemid 32728320)
    • (2001) Immunity , vol.15 , Issue.1 , pp. 59-70
    • Rosette, C.1    Werlen, G.2    Daniels, M.A.3    Holman, P.O.4    Alam S.Munir5    Travers, P.J.6    Gascoigne, N.R.J.7    Palmer, E.8    Jameson, S.C.9
  • 31
    • 0031682733 scopus 로고    scopus 로고
    • Measuring two-dimensional receptor-ligand binding kinetics by micropipette
    • Chesla SE, Selvaraj P, Zhu C. Measuring two-dimensional receptor-ligand binding kinetics by micropipette. Biophys J. 1998;75:1553-72. (Pubitemid 28397625)
    • (1998) Biophysical Journal , vol.75 , Issue.3 , pp. 1553-1572
    • Chesla, S.E.1    Selvaraj, P.2    Zhu, C.3
  • 32
    • 38349108802 scopus 로고    scopus 로고
    • Kinetics of MHCCD8 interaction at the T cell membrane
    • Huang J, Edwards LJ, Evavold BD, Zhu C. Kinetics of MHCCD8 interaction at the T cell membrane. J Immunol. 2007;179:7653-62.
    • (2007) J Immunol , vol.179 , pp. 7653-7662
    • Huang, J.1    Edwards, L.J.2    Evavold, B.D.3    Zhu, C.4
  • 33
    • 78651490414 scopus 로고    scopus 로고
    • High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responses
    • Sabatino JJ, Huang J, Zhu C, Evavold BD. High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responses. J Exp Med. 2011;208:81-90.
    • (2011) J Exp Med , vol.208 , pp. 81-90
    • Sabatino, J.J.1    Huang, J.2    Zhu, C.3    Evavold, B.D.4
  • 34
    • 78751696945 scopus 로고    scopus 로고
    • Two-stage cooperative T cell receptorpeptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination
    • Jiang N, Huang J, Edwards LJ, Liu B, Zhang Y, Beal CD, Evavold BD, Zhu C. Two-stage cooperative T cell receptorpeptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination. Immunity. 2011;34:13-23.
    • (2011) Immunity , vol.34 , pp. 13-23
    • Jiang, N.1    Huang, J.2    Edwards, L.J.3    Liu, B.4    Zhang, Y.5    Beal, C.D.6    Evavold, B.D.7    Zhu, C.8
  • 36
    • 0036909439 scopus 로고    scopus 로고
    • Inefficient clustering of tyrosine-phosphorylated proteins at the immunological synapse in response to an antagonist peptide
    • DOI 10.1002/1521-4141(2002012)32:12<3386::AID-IMMU3386>3.0.CO;2-E
    • Smyth LA, Ardouin L, Williams O, Norton T, Tybulewicz V, Kioussis D. Inefficient clustering of tyrosine-phosphorylated proteins at the immunological synapse in response to an antagonist peptide. Eur J Immunol. 2002;32:3386-94. (Pubitemid 36024376)
    • (2002) European Journal of Immunology , vol.32 , Issue.12 , pp. 3386-3394
    • Smyth, L.A.1    Ardouin, L.2    Williams, O.3    Norton, T.4    Tybulewicz, V.5    Kioussis, D.6
  • 38
    • 4143146469 scopus 로고    scopus 로고
    • T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation
    • DOI 10.1083/jcb.200404059
    • Sumen C. T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation. J Cell Biol. 2004;166:579-90. (Pubitemid 39097177)
    • (2004) Journal of Cell Biology , vol.166 , Issue.4 , pp. 579-590
    • Sumen, C.1    Dustin, M.L.2    Davis, M.M.3
  • 39
    • 0036906497 scopus 로고    scopus 로고
    • Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation
    • DOI 10.1016/S1074-7613(02)00481-8
    • Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 2002;17:809-22. (Pubitemid 35477799)
    • (2002) Immunity , vol.17 , Issue.6 , pp. 809-822
    • Ehrlich, L.I.R.1    Ebert, P.J.R.2    Krummel, M.F.3    Weiss, A.4    Davis, M.M.5
  • 40
    • 0033987234 scopus 로고    scopus 로고
    • TCR antagonist peptides induce formation of APC-T cell conjugates and activate a Rac signaling pathway
    • DOI 10.1002/1521-4141(200001)30:1<50::AID-IMMU50>3.0.CO;2-I
    • Huang J, Sugie K, La Face DM, Altman A, Grey HM. TCR antagonist peptides induce formation of APC-T cell conjugates and activate a Rac signaling pathway. Eur J Immunol. 2000;30:50-8. (Pubitemid 30011765)
    • (2000) European Journal of Immunology , vol.30 , Issue.1 , pp. 50-58
    • Huang, J.1    Sugie, K.2    La, F.D.M.3    Altman, A.4    Grey, H.M.5
  • 41
    • 0034718608 scopus 로고    scopus 로고
    • T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase
    • Huang J, Tilly D, Altman A, Sugie K, Grey HM. T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. Proc Natl Acad Sci USA. 2000;97:10923-9.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10923-10929
    • Huang, J.1    Tilly, D.2    Altman, A.3    Sugie, K.4    Grey, H.M.5
  • 42
    • 73649085433 scopus 로고    scopus 로고
    • A unique unresponsive CD4+ T cell phenotype post TCR antagonism
    • Edwards LJ, Evavold BD. A unique unresponsive CD4+ T cell phenotype post TCR antagonism. Cell Immunol. 2010;261:64-8.
    • (2010) Cell Immunol , vol.261 , pp. 64-68
    • Edwards, L.J.1    Evavold, B.D.2
  • 43
    • 0033199986 scopus 로고    scopus 로고
    • Cross-antagonism of a T cell clone expressing two distinct T cell receptors
    • DOI 10.1016/S1074-7613(00)80104-1
    • Dittel BN, Stefanova I, Germain RN, Janeway CA Jr. Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity. 1999;11:289-98. (Pubitemid 29463237)
    • (1999) Immunity , vol.11 , Issue.3 , pp. 289-298
    • Dittel, B.N.1    Stefanova, I.2    Germain, R.N.3    Janeway Jr., C.A.4
  • 44
    • 0038665319 scopus 로고    scopus 로고
    • Cutting edge: Dependence of TCR antagonism on Src homology 2 domain-containing protein tyrosine phosphatase activity
    • Kilgore NE, Carter JD, Lorenz U, Evavold BD. Cutting edge: dependence of TCR antagonism on Src homology 2 domain-containing protein tyrosine phosphatase activity. J Immunol. 2003;170:4891-5. (Pubitemid 36554717)
    • (2003) Journal of Immunology , vol.170 , Issue.10 , pp. 4891-4895
    • Kilgore, N.E.1    Carter, J.D.2    Lorenz, U.3    Evavold, B.D.4
  • 46
    • 0037338890 scopus 로고    scopus 로고
    • TCR ligand discrimination is enforced by competing ERK positive and SHP-I negative feedback pathways
    • DOI 10.1038/ni895
    • Stefanova I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol. 2003;4:248-54. (Pubitemid 36322134)
    • (2003) Nature Immunology , vol.4 , Issue.3 , pp. 248-254
    • Stefanova, I.1    Hemmer, B.2    Vergelli, M.3    Martin, R.4    Biddison, W.E.5    Germain, R.N.6
  • 48
    • 0032767536 scopus 로고    scopus 로고
    • Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1
    • DOI 10.1002/(SICI)1521-4141(199908)29:08<2539::AID-IMMU2539>3.0. CO;2-M
    • Brockdorff J, Williams S, Couture C, Mustelin T. Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1. Eur J Immunol. 1999;29:2539-50. (Pubitemid 29378125)
    • (1999) European Journal of Immunology , vol.29 , Issue.8 , pp. 2539-2550
    • Brockdorff, J.1    Williams, S.2    Couture, C.3    Mustelin, T.4
  • 49
    • 0029973560 scopus 로고    scopus 로고
    • Direct association with and dephosphorylation of Jak2 kinase by the SH2- domain-containing protein tyrosine phosphatase SHP-1
    • Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol. 1996;16:6985-92. (Pubitemid 26389758)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.12 , pp. 6985-6992
    • Jiao, H.1    Berrada, K.2    Yang, W.3    Tabrizi, M.4    Platanias, L.C.5    Yi, T.6
  • 50
    • 0028956353 scopus 로고
    • Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    • Klingmuller U, Lorenz U, Cantley LC, Neel BG, Lodish HF. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 1995;80:729-38.
    • (1995) Cell , vol.80 , pp. 729-738
    • Klingmuller, U.1    Lorenz, U.2    Cantley, L.C.3    Neel, B.G.4    Lodish, H.F.5
  • 51
    • 0033600848 scopus 로고    scopus 로고
    • SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
    • Cuevas B, Lu Y, Watt S, Kumar R, Zhang J, Siminovitch KA, Mills GB. SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J Biol Chem. 1999;274:27583-9.
    • (1999) J Biol Chem , vol.274 , pp. 27583-27589
    • Cuevas, B.1    Lu, Y.2    Watt, S.3    Kumar, R.4    Zhang, J.5    Siminovitch, K.A.6    Mills, G.B.7
  • 52
    • 40849136040 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase inhibition induces antitumor activity: Evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells
    • Caron D, Savard PE, Doillon CJ, Olivier M, Shink E, Lussier JG, Faure RL. Protein tyrosine phosphatase inhibition induces antitumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Lett. 2008;262:265-75.
    • (2008) Cancer Lett , vol.262 , pp. 265-275
    • Caron, D.1    Savard, P.E.2    Doillon, C.J.3    Olivier, M.4    Shink, E.5    Lussier, J.G.6    Faure, R.L.7
  • 53
    • 54449092916 scopus 로고    scopus 로고
    • Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells
    • Simoneau M, Boulanger J, Coulombe G, Renaud MA, Duchesne C, Rivard N. Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells. J Biol Chem. 2008;283:25544-56.
    • (2008) J Biol Chem , vol.283 , pp. 25544-25556
    • Simoneau, M.1    Boulanger, J.2    Coulombe, G.3    Renaud, M.A.4    Duchesne, C.5    Rivard, N.6
  • 55
    • 0037737741 scopus 로고    scopus 로고
    • The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation
    • DOI 10.1074/jbc.M210028200
    • Zhang Z, Shen K, Lu W, Cole PA. The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. J Biol Chem. 2003;278:4668-74. (Pubitemid 36800966)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.7 , pp. 4668-4674
    • Zhang, Z.1    Shen, K.2    Lu, W.3    Cole, P.A.4
  • 56
    • 34548461710 scopus 로고    scopus 로고
    • Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity
    • DOI 10.1189/jlb.1206736
    • Liu Y, Kruhlak MJ, Hao JJ, Shaw S. Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity. J Leukoc Biol. 2007;82:742-51. (Pubitemid 47367166)
    • (2007) Journal of Leukocyte Biology , vol.82 , Issue.3 , pp. 742-751
    • Liu, Y.1    Kruhlak, M.J.2    Hao, J.-J.3    Shaw, S.4
  • 57
    • 58149198194 scopus 로고    scopus 로고
    • MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1
    • Wasserman HA, Beal CD, Zhang Y, Jiang N, Zhu C, Evavold BD. MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1. J Immunol. 2008;181:6843-9.
    • (2008) J Immunol , vol.181 , pp. 6843-6849
    • Wasserman, H.A.1    Beal, C.D.2    Zhang, Y.3    Jiang, N.4    Zhu, C.5    Evavold, B.D.6
  • 59
    • 0033120578 scopus 로고    scopus 로고
    • Cutting edge: A test of the dominant negative signal model for TCR antagonism
    • Daniels MA, Schober SL, Hogquist KA, Jameson SC. Cutting edge: a test of the dominant negative signal model for TCR antagonism. J Immunol. 1999;162:3761-4. (Pubitemid 29314750)
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 3761-3764
    • Daniels, M.A.1    Schober, S.L.2    Hogquist, K.A.3    Jameson, S.C.4
  • 60
    • 0037406912 scopus 로고    scopus 로고
    • Study of the mechanism of TCR antagonism using dual-TCR-expressing T cells
    • Yang W, Grey HM. Study of the mechanism of TCR antagonism using dual-TCR-expressing T Cells. J Immunol. 2003;170:4532-8. (Pubitemid 36519958)
    • (2003) Journal of Immunology , vol.170 , Issue.9 , pp. 4532-4538
    • Yang, W.1    Grey, H.M.2
  • 61
    • 0033566824 scopus 로고    scopus 로고
    • + T cells with dual antigen specificities
    • Robertson JM, Evavold BD. Cutting edge: dueling TCRs: peptide antagonism of CD4+ T cells with dual antigen specificities. J Immunol. 1999;163:1750-4. (Pubitemid 29382171)
    • (1999) Journal of Immunology , vol.163 , Issue.4 , pp. 1750-1754
    • Robertson, J.M.1    Evavold, B.D.2
  • 62
    • 0037310591 scopus 로고    scopus 로고
    • TCR reserve: A novel principle of CD4 T cell activation by weak ligands
    • McNeil LK, Evavold BD. TCR reserve: a novel principle of CD4 T cell activation by weak ligands. J Immunol. 2003;170:1224-30. (Pubitemid 36139487)
    • (2003) Journal of Immunology , vol.170 , Issue.3 , pp. 1224-1230
    • McNeil, L.K.1    Evavold, B.D.2
  • 64
    • 47249146866 scopus 로고    scopus 로고
    • Induction of anergy by antibody blockade of TCR in myelin oligodendrocyte glycoprotein-specific cells
    • Wasserman HA, Evavold BD. Induction of anergy by antibody blockade of TCR in myelin oligodendrocyte glycoprotein-specific cells. J Immunol. 2008;180:7259-64.
    • (2008) J Immunol , vol.180 , pp. 7259-7264
    • Wasserman, H.A.1    Evavold, B.D.2
  • 66
    • 0025286210 scopus 로고
    • Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
    • Harding CV, Unanue ER. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature. 1990;346:574-6.
    • (1990) Nature , vol.346 , pp. 574-576
    • Harding, C.V.1    Unanue, E.R.2
  • 67
    • 0025182003 scopus 로고
    • The minimal number of class II MHC-antigen complexes needed for T cell activation
    • Demotz S, Grey HM, Sette A. The minimal number of class II MHC-antigen complexes needed for T cell activation. Science. 1990;249:1028-30.
    • (1990) Science , vol.249 , pp. 1028-1030
    • Demotz, S.1    Grey, H.M.2    Sette, A.3
  • 68
    • 0031458442 scopus 로고    scopus 로고
    • The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells
    • DOI 10.1002/eji.1830271230
    • Kimachi K, Croft M, Grey HM. The minimal number of antigenmajor histocompatibility complex class II complexes required for activation of naive and primed T cells. Eur J Immunol. 1997;27:3310-7. (Pubitemid 28018028)
    • (1997) European Journal of Immunology , vol.27 , Issue.12 , pp. 3310-3317
    • Kimachi, K.1    Croft, M.2    Grey, H.M.3
  • 69
  • 70
    • 0034507693 scopus 로고    scopus 로고
    • Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion
    • DOI 10.1016/S1074-7613(00)00080-7
    • Bouneaud C, Kourilsky P, Bousso P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity. 2000;13:829-40. (Pubitemid 32041805)
    • (2000) Immunity , vol.13 , Issue.6 , pp. 829-840
    • Bouneaud, C.1    Kourilsky, P.2    Bousso, P.3
  • 71
    • 33747092627 scopus 로고    scopus 로고
    • T Cells with Low Avidity for a Tissue-Restricted Antigen Routinely Evade Central and Peripheral Tolerance and Cause Autoimmunity
    • DOI 10.1016/j.immuni.2006.06.009, PII S1074761306003426
    • Zehn D, Bevan MJ. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity. 2006;25:261-70. (Pubitemid 44224142)
    • (2006) Immunity , vol.25 , Issue.2 , pp. 261-270
    • Zehn, D.1    Bevan, M.J.2
  • 72
    • 0030873556 scopus 로고    scopus 로고
    • Differential requirements for survival and proliferation of CD8 naive or memory T cells
    • DOI 10.1126/science.276.5321.2057
    • Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science. 1997;276:2057-62. (Pubitemid 27443614)
    • (1997) Science , vol.276 , Issue.5321 , pp. 2057-2062
    • Tanchot, C.1    Lemonnier, F.A.2    Perarnau, B.3    Freitas, A.A.4    Rocha, B.5
  • 73
    • 0033180491 scopus 로고    scopus 로고
    • The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
    • DOI 10.1016/S1074-7613(00)80092-8
    • Ernst B, Lee DS, Chang JM, Sprent J, Surh CD. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity. 1999;11:173-81. (Pubitemid 29428810)
    • (1999) Immunity , vol.11 , Issue.2 , pp. 173-181
    • Ernst, B.1    Lee, D.-S.2    Chang, J.M.3    Sprent, J.4    Surh, C.D.5
  • 74
    • 77953758560 scopus 로고    scopus 로고
    • Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs
    • Ji Q, Perchellet A, Goverman JM. Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs. Nat Immunol. 2010;11:628-34.
    • (2010) Nat Immunol , vol.11 , pp. 628-634
    • Ji, Q.1    Perchellet, A.2    Goverman, J.M.3
  • 75
    • 0028148199 scopus 로고
    • Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production
    • Karin N, Mitchell DJ, Brocke S, Ling N, Steinman L. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production. J Exp Med. 1994;180:2227-37.
    • (1994) J Exp Med , vol.180 , pp. 2227-2237
    • Karin, N.1    Mitchell, D.J.2    Brocke, S.3    Ling, N.4    Steinman, L.5
  • 76
    • 0028866978 scopus 로고
    • An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
    • Nicholson L, Nicholson B, Greer JM, Sobel RA, Lees MB, Kuchroo VK. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity. 1995;3:397-405.
    • (1995) Immunity , vol.3 , pp. 397-405
    • Nicholson, L.1    Nicholson, B.2    Greer, J.M.3    Sobel, R.A.4    Lees, M.B.5    Kuchroo, V.K.6
  • 78
    • 0029843291 scopus 로고    scopus 로고
    • Altered peptide ligands of a myasthenogenic epitope as modulators of specific T-cell responses
    • Kirshner SL, Zisman E, Fridkin M, Sela M, Mozes E. Altered peptide ligands of a myasthenogenic epitope as modulators of specific T-cell responses. Scand J Immunol. 1996;44:512-21. (Pubitemid 26382335)
    • (1996) Scandinavian Journal of Immunology , vol.44 , Issue.5 , pp. 512-521
    • Kirshner, S.L.1    Zisman, E.2    Fridkin, M.3    Sela, M.4    Mozes, E.5
  • 80
    • 0030023918 scopus 로고    scopus 로고
    • Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T cell responses and T cell receptor antagonism
    • DOI 10.1016/S0091-6749(96)70283-X
    • Ikagawa S, Matsushita S, Chen YZ, Ishikawa T, Nishimura Y. Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T cell responses and T cell receptor antagonism. J Allergy Clin Immunol. 1996;97:53-64. (Pubitemid 26045969)
    • (1996) Journal of Allergy and Clinical Immunology , vol.97 , Issue.1 I , pp. 53-64
    • Ikagawa, S.1    Matsushita, S.2    Chen, Y.-Z.3    Ishikawa, T.4    Nishimura, Y.5
  • 82
    • 0031754261 scopus 로고    scopus 로고
    • Altered peptide ligands of islet autoantigen imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes
    • DOI 10.1006/jaut.1998.0207
    • Geluk A, van Meijgaarden KE, Roep BO, Ottenhoff TH. Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes. J Autoimmun. 1998;11:353-61. (Pubitemid 28428258)
    • (1998) Journal of Autoimmunity , vol.11 , Issue.4 , pp. 353-361
    • Geluk, A.1    Van Meijgaarden, K.E.2    Roep, B.O.3    Ottenhoff, T.H.M.4
  • 83
    • 0036046080 scopus 로고    scopus 로고
    • Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand
    • DOI 10.1006/clim.2002.5258
    • Kim HJ, Antel JP, Duquette P, Alleva DG, Conlon PJ, Bar-Or A. Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand. Clin Immunol. 2002;104:105-14. (Pubitemid 35026220)
    • (2002) Clinical Immunology , vol.104 , Issue.2 , pp. 105-114
    • Kim, H.J.1    Antel, J.P.2    Duquette, P.3    Alleva, D.G.4    Conlon, P.J.5    Bar-Or, A.6
  • 84
    • 0036065042 scopus 로고    scopus 로고
    • Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope
    • DOI 10.1002/art.10366
    • Prakken BJ, Roord S, van Kooten PJ, Wagenaar JP, van Eden W, Albani S, Wauben MH. Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope. Arthritis Rheum. 2002;46:1937-46. (Pubitemid 34774527)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.7 , pp. 1937-1946
    • Prakken, B.J.1    Roord, S.2    Van Kooten, P.J.S.3    Wagenaar, J.P.A.4    Van Eden, W.5    Albani, S.6    Wauben, M.H.M.7
  • 87
    • 33646252723 scopus 로고    scopus 로고
    • SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling
    • Yu Z, Maoui M, Zhao ZJ, Li Y, Shen SH. SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling. Febs J. 2006;273:2195-205.
    • (2006) Febs J , vol.273 , pp. 2195-2205
    • Yu, Z.1    Maoui, M.2    Zhao, Z.J.3    Li, Y.4    Shen, S.H.5
  • 88
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, Gran B, Eaton J, Antel J, Frank JA, McFarland HF, Martin R. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med. 2000;6:1167-75.
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10    McFarland, H.F.11    Martin, R.12
  • 89
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helpercell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
    • The altered peptide ligand in relapsing MS study group
    • Kappos L, Comi G, Panitch H, Oger J, Antel J, Conlon P, Steinman L. Induction of a non-encephalitogenic type 2 T helpercell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The altered peptide ligand in relapsing MS study group. Nat Med. 2000;6:1176-82.
    • (2000) Nat Med , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3    Oger, J.4    Antel, J.5    Conlon, P.6    Steinman, L.7
  • 90
    • 70449412682 scopus 로고    scopus 로고
    • No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes
    • Walter M, Philotheou A, Bonnici F, Ziegler AG, Jimenez R. No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes. Diabetes Care. 2009;32:2036-40.
    • (2009) Diabetes Care , vol.32 , pp. 2036-2040
    • Walter, M.1    Philotheou, A.2    Bonnici, F.3    Ziegler, A.G.4    Jimenez, R.5
  • 91
    • 0033762708 scopus 로고    scopus 로고
    • NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients
    • Crowe PD, Qin Y, Conlon PJ, Antel JP. NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. Ann Neurol. 2000;48:758-65.
    • (2000) Ann Neurol , vol.48 , pp. 758-765
    • Crowe, P.D.1    Qin, Y.2    Conlon, P.J.3    Antel, J.P.4
  • 92
    • 0036046080 scopus 로고    scopus 로고
    • Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand
    • DOI 10.1006/clim.2002.5258
    • Kim HJ, Antel JP, Duquette P, Alleva DG, Conlon PJ, Bar-Or A. Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand. Clin Immunol. 2002;104:105-14. (Pubitemid 35026220)
    • (2002) Clinical Immunology , vol.104 , Issue.2 , pp. 105-114
    • Kim, H.J.1    Antel, J.P.2    Duquette, P.3    Alleva, D.G.4    Conlon, P.J.5    Bar-Or, A.6
  • 95
    • 0036790542 scopus 로고    scopus 로고
    • Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23
    • Liu E, Moriyama H, Abiru N, Miao D, Yu L, Taylor RM, Finkelman FD, Eisenbarth GS. Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23. J Clin Invest. 2002;110:1021-7.
    • (2002) J Clin Invest , vol.110 , pp. 1021-1027
    • Liu, E.1    Moriyama, H.2    Abiru, N.3    Miao, D.4    Yu, L.5    Taylor, R.M.6    Finkelman, F.D.7    Eisenbarth, G.S.8
  • 96
    • 14844346786 scopus 로고    scopus 로고
    • Amelioration of established experimental autoimmune encephalomyelitis by an MHC anchor-substituted variant of proteolipid protein 139-151
    • Margot CD, Ford ML, Evavold BD. Amelioration of established experimental autoimmune encephalomyelitis by an MHC anchor-substituted variant of proteolipid protein 139-151. J Immunol. 2005;174:3352-8. (Pubitemid 40354039)
    • (2005) Journal of Immunology , vol.174 , Issue.6 , pp. 3352-3358
    • Margot, C.D.1    Ford, M.L.2    Evavold, B.D.3
  • 97
    • 37549045964 scopus 로고    scopus 로고
    • Peptide-based immunotherapy of experimental autoimmune encephalomyelitis without anaphylaxis
    • Leech MD, Chung CY, Culshaw A, Anderton SM. Peptide-based immunotherapy of experimental autoimmune encephalomyelitis without anaphylaxis. Eur J Immunol. 2007;37:3576-81.
    • (2007) Eur J Immunol , vol.37 , pp. 3576-3581
    • Leech, M.D.1    Chung, C.Y.2    Culshaw, A.3    Anderton, S.M.4
  • 98
    • 0042847235 scopus 로고    scopus 로고
    • Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of myelin oligodendrocyte glycoprotein 35-55
    • Ford ML, Evavold BD. Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of myelin oligodendrocyte glycoprotein 35-55. J Immunol. 2003;171:1247-54. (Pubitemid 36900054)
    • (2003) Journal of Immunology , vol.171 , Issue.3 , pp. 1247-1254
    • Ford, M.L.1    Evavold, B.D.2


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