An altered peptide ligand antagonizes antigen-specific T cells of patients with human T lymphotropic virus type I-associated neurological disease

Journal of Immunology

Volumn 164, Issue 10, 2000, Pages 5192-5198

  Kubota, Ryuji ^a,b   Soldan, Samantha S ^a   Martin, Roland ^a   Jacobson, Steven ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A2 ANTIGEN; LIGAND; PEPTIDE; TAX PROTEIN;

ANTIGEN RECOGNITION; ARTICLE; CASE REPORT; CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOTHERAPY; PRIORITY JOURNAL; PROTEIN MODIFICATION; SPASTIC PARESIS; SPINAL CORD DISEASE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

EID: 0034657177     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.10.5192     Document Type: Article

References (52)

1. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
2. De Magistris, M. T., J. Alexander, M. Coggeshall, A. Altman, F. C. Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompalibility complexes act as antagonists of the T cell receptor. Cell 68:625.
3. Evavold, B. D., J. Sloan-Lancaster, K. J. Wilson, J. B. Rothbard, and P. M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2:655.
4. Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 380:495.
5. Vergelli, M., B. Hemmer, M. Kalbus, A. B. Vogt, N. Ling, P. Conlon, J. E. Coligan, H. McFarland, and R. Martin. 1997. Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells. J. Immunol. 158:3746.
6. Hemmer, B., M. Vergelli, L. Tranquill, P. Conlon, N. Ling, H. F. McFarland, and R. Martin. 1997. Human T cell response to myelin basic protein peptide (83-99): extensive heterogeneity in antigen recognition, function, and phenotype. Neurology 49:1116.
7. Racioppi, L., F. Ronchese, L. A. Matis, and R. N. Germain. 1993. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med. 177:1047.
8. Sloan-Lancaster, J., B .D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell receptor ligand on live antigen-presenting cells. Nature 363:156.
9. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1994. Th2 cell clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195.
10. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79:913.
11. Jameson, S. C., F. R. Carbone, and M. J. Bevan. 1993. Clone-specific T cell receptor antagonists of major histocompatihility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177:1541.
12. Ashton-Rickardt, P. G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15:362.
13. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369:407.
14. Klenerman, P., S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, et al. 1994. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature 369:403.
15. Plebanski, M., E. A. Lee, C. M. Hannan, K. L. Flanagan, S. C. Gilbert, M. B. Gravenor, and A. V. Hill. 1999. Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming. Nat. Med. 5:565.
16. Kuchroo, V. K., J. M. Greer, D. Kaul, G. Ishioka, A. Franco, A. Sette, R. A. Sobel, and M. B. Lees. 1994. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J. Immunol. 153:3326.
17. Nicholson, L. B., J. M. Greer, R. A. Sobel, M. B. Lees, and V. K. Kuchroo. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3:397.
18. Brocke, S., K. Gijbels, M. Allegretta, I. Ferber, C. Piercy, T. Blankenstein, R. Martin, U. Utz, N. Karin, D. Mitchell, et al. 1996. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379: 343.
19. Windhagen, A., C. Scholz, P. Hollsberg, H. Fukaura, A. Sette, and D. A. Hafler. 1995. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 2:373.
20. Vergelli, M., B. Hemmer, U. Utz, A. Vogt, M. Kalbus, L. Tranquill, P. Conlon, N. Ling, L. Steinman, H. F. McFarland, and R. Martin. 1996. Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99). Eur. J. Immunol. 26:2624.
21. Uchiyama, T., J. Yodoi, K. Sagawa, K. Takatsuki, and H. Uchino. 1977. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 50:481.
22. Gessain, A., F. Barin, J. C. Vernant, O. Gout, L. Maurs, A. Calender, and G. de The. 1985. Antibodies to human T-lymphotropic virus type-1 in patients with tropical spastic paraparesis. Lancet 2:407.
23. Osame, M., K. Usuku, S. Izumo, N. Ijichi, H. Amitani, A. Igata, M. Matsumoto, and M. Tara. 1986. HTLV-1 associated myelopathy, a new clinical entity. Lancet 1:1031.
24. Akizuki, S., O. Nakazato, Y. Higuchi, K. Tanabe, M. Setoguchi, S. Yoshida, Y. Miyazaki, S. Yamamoto, S. Sudou, K. Sannomiya, and T. Okajima. 1987. Necropsy findings in HTLV-I associated myelopathy. Lancet 1:156.
25. Umehara, F., S. Izumo, M. Nakagawa, A.T. Ronquillo, K. Takahashi, K. Matsumuro, E. Sato, and M. Osame. 1993. Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy. J. Neuropathol. Exp. Neurol. 52:424.
26. Moore, G. R. W., U. Traugott, L. C. Scheinberg, and C. S. Raine. 1989. Tropical spastic paraparesis: a model of virus-induced T-cell mediated demyelination? Ann. Neurol 26:523.
27. Lehky, T. J., C. H. Fox, S. Koenig, M. C. Levin, N. Flerlage, S. Izumo, E. Sato, C. S. Raine, M. Osame, and S. Jacobson. 1995. Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization. Ann. Neurol. 37:167.
28. + T lymphocytes. Ann. Neurol. 40:84.
29. Levin, M. C., T. J. Lehky, A. N. Flerlage, D. Katz, D. W. Kingma, E. S. Jaffe, J. D. Heiss, N. Patronas, H .F. McFarland, and S. Jacobson. 1997. Immunologic analysis of a spinal cord-biopsy specimen from a patient with human T-cell lymphotropic virus type I-associated neurologic disease. N. Engl. J. Med. 336: 839.
30. + cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature 348:245.
31. Koenig, S., R. M. Woods, Y. A. Brewah, A. J. Newell, G. M. Jones, E. Boone, J. W. Adelsberger, M. W. Baseler, S. M. Robinson, and S. Jacobson. 1993. Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease. J. Immunol. 151:3874.
32. Elovaara, I., S. Koenig, A. Y. Brewah, R. M. Woods, T. Lehky, and S. Jacobson. 1993. High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease. J. Exp. Med. 177:1567.
33. Jacobson, S. 1996. Cellular immune responses to HTLV-I: immunopathogenic role in HTLV-I-associated neurologic disease. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 13(Suppl. 1): S100.
34. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
35. Ding, Y. H., K. J. Smith, D. N. Garboczi, U. Utz, W. E. Biddison, and D. C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8:403.
36. Osame, M., M. Matsumoto, K. Usuku, S. Izumo, N. Ijichi, H. Amitani, M. Tara, and A. Igata. 1987. Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type 1 and adult T-cell leukemialike cells. Ann. Neurol. 21:117.
37. Madden, D. R., D. N. Garboczi, and D. C. Wiley. 1993. The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 75:693.
38. Parker, K. C., M. A. Bednarek, L. K. Hull, B. Cunningham, H. J. Zweerink, W. E. Biddison, and J. E. Coligan. 1992. Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2. J. Immunol. 149:3580.
39. Utz, U., S. Koenig, J. E. Coligan, and W. E. Biddison. 1992. Presentation of three different viral peptides, HTLV-1 Tax, HCMV gB, and influenza virus Ml, is determined by common structural features of the HLA-A2.1 molecule. J. Immunol. 149:214.
40. Blomberg, K., R. Hautala, J. Lovgren, V. M. Mukkala, C. Lindqvist, and K. Akerman. 1996. Time-resolved fluorometric assay for natural killer activity using target cells labeled with a fluorescence enhancing ligand. J. Immunol. Methods 191:199.
41. Storkus, W. J., D. N. Howell, R. D. Salter, J. R. Dawson, and P. Cresswell. 1987. NK susceptibility varies inversely with target cell class I HLA antigen expression. J. Immunol. 138:1657.
42. + T cells with dual antigen specificities. J. Immunol. 163:1750.
43. Dittel, B. N., I. Stefanova, R. N. Germain, and C. A. Janeway, Jr. 1999. Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity 11:2892.
44. Stotz, S. H., L. Bolliger, F. R. Carbone, and E. Palmer. 1999. T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs. J. Exp. Med. 189:253.
45. + T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients. Proc: Natl. Acad. Sci. USA 95:7568.
46. + cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion. J. Virol. 70:843.
47. Klenerman, P., U. C. Meier, R. E. Phillips, and A. J. McMichael. 1995. The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus. Eur. J. Immunol. 25:1927.
48. Niewiesk, S., S. Daenke, C. E. Parker, G. Taylor, J. Weber, S. Nightingale, and C. R. Bangham. 1995. Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax. J. Virol. 69:2649.
49. Acha-Orbea, H., D. J. Mitchell, L. Timmermann, D. C. Wraith, G. S. Tausch, M. K. Waldor, S. S. Zamvil, H. O. McDevitt, and L. Steinman. 1988. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263.
50. Urban, J. L., V. Kumar, D. H. Kono, C. Gomes, S. J. Horvath, J. Clayton, D. G. Ando, E. E. Sercarz, and L. Hood. 1988. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577.
51. Utz, U., J. A. Brooks, H. F. McFarland, R. Martin, and W. E. Biddison. 1994. Heterogeneity of T-cell receptor α-chain complementarity-determining region 3 in myelin basic protein-specific T cells increases with seventy of multiple sclerosis. Proc. Natl. Acad. Sci. USA 91:5567.
52. Höger, T. A., S. Jacobson, T. Kawanishi, T. Kato, K. Nishioka, and K. Yamamoto. 1997. Accumulation of human T lymphotropic virus (HTLV)-I-specific T cell clones in HTLV-I-associated myelopathy/tropical spastic paraparesis patients. J. Immunol. 159:2042.