메뉴 건너뛰기




Volumn 200, Issue 11, 2004, Pages 1371-1382

Functional reprogramming of the primary immune response by T cell receptor antagonism

Author keywords

Clonal deletion; Immune tolerance; Immunization; Lymphocyte activation; T lymphocyte effector

Indexed keywords

T LYMPHOCYTE RECEPTOR;

EID: 10644281093     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20041226     Document Type: Article
Times cited : (10)

References (55)
  • 1
    • 0034613152 scopus 로고    scopus 로고
    • Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells
    • Lanzavecchia, A., and F. Sallusto. 2000. Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science. 290:92-97.
    • (2000) Science , vol.290 , pp. 92-97
    • Lanzavecchia, A.1    Sallusto, F.2
  • 4
    • 0035348175 scopus 로고    scopus 로고
    • Memory CD8+ T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
    • Kaech, S.M., and R. Ahmed. 2001. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2:415-422.
    • (2001) Nat. Immunol. , vol.2 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 5
    • 0036550559 scopus 로고    scopus 로고
    • Effector and memory T-cell differentiation: Implications for vaccine development
    • Kaech, S.M., E.J. Wherry, and R. Ahmed. 2002. Effector and memory T-cell differentiation: implications for vaccine development. Nat. Rev. Immunol. 2:251-262.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 251-262
    • Kaech, S.M.1    Wherry, E.J.2    Ahmed, R.3
  • 6
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigenic stimulation determines the fate of naive and effector T cells
    • Iezzi, G., K. Karjalainen, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity. 8:89-95.
    • (1998) Immunity , vol.8 , pp. 89-95
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3
  • 8
    • 1542321204 scopus 로고    scopus 로고
    • The role of programming in memory T-cell development
    • Masopust, D., S.M. Kaech, and R. Ahmed. 2004. The role of programming in memory T-cell development. Curr. Opin. Immunol. 16:217-225.
    • (2004) Curr. Opin. Immunol. , vol.16 , pp. 217-225
    • Masopust, D.1    Kaech, S.M.2    Ahmed, R.3
  • 9
    • 0035282433 scopus 로고    scopus 로고
    • Visualizing the generation of memory CD4 T cells in the whole body
    • Reinhardt, R.L., A. Khoruts, R. Merica, T. Zell, and M.K. Jenkins. 2001. Visualizing the generation of memory CD4 T cells in the whole body. Nature. 410:101-105.
    • (2001) Nature , vol.410 , pp. 101-105
    • Reinhardt, R.L.1    Khoruts, A.2    Merica, R.3    Zell, T.4    Jenkins, M.K.5
  • 11
    • 0032438551 scopus 로고    scopus 로고
    • High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling
    • Kersh, G.J., E.N. Kersh, D.H. Fremont, and P.M. Allen. 1998. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity. 9:817-826.
    • (1998) Immunity , vol.9 , pp. 817-826
    • Kersh, G.J.1    Kersh, E.N.2    Fremont, D.H.3    Allen, P.M.4
  • 17
    • 0042696999 scopus 로고    scopus 로고
    • Antigen presentation to naive CD4 T cells in the lymph node
    • Itano, A.A., and M.K. Jenkins. 2003. Antigen presentation to naive CD4 T cells in the lymph node. Nat. Immunol. 4:733-739.
    • (2003) Nat. Immunol. , vol.4 , pp. 733-739
    • Itano, A.A.1    Jenkins, M.K.2
  • 18
    • 0036144764 scopus 로고    scopus 로고
    • T cells down-modulate peptide-MHC complexes on APCs in vivo
    • Kedl, R.M., B.C. Schaefer, J.W. Kappler, and P. Marrack. 2002. T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat. Immunol. 3:27-32.
    • (2002) Nat. Immunol. , vol.3 , pp. 27-32
    • Kedl, R.M.1    Schaefer, B.C.2    Kappler, J.W.3    Marrack, P.4
  • 20
    • 0041695164 scopus 로고    scopus 로고
    • Continuous T cell receptor signaling required for synapse maintenance and full effector potential
    • Huppa, J.B., M. Gleimer, C. Sumen, and M.M. Davis. 2003. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4:749-755.
    • (2003) Nat. Immunol. , vol.4 , pp. 749-755
    • Huppa, J.B.1    Gleimer, M.2    Sumen, C.3    Davis, M.M.4
  • 22
  • 23
    • 0031135533 scopus 로고    scopus 로고
    • Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR
    • Dittel, B.N., D.B. Sant'Angelo, and C.A. Janeway Jr. 1997. Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR. J. Immunol. 158: 4065-4073.
    • (1997) J. Immunol. , vol.158 , pp. 4065-4073
    • Dittel, B.N.1    Sant'Angelo, D.B.2    Janeway Jr., C.A.3
  • 25
    • 0036224370 scopus 로고    scopus 로고
    • Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse
    • Zal, T., M.A. Zal, and N.R. Gascoigne. 2002. Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity. 16:521-534.
    • (2002) Immunity , vol.16 , pp. 521-534
    • Zal, T.1    Zal, M.A.2    Gascoigne, N.R.3
  • 26
    • 0032948455 scopus 로고    scopus 로고
    • Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming
    • Plebanski, M., E.A. Lee, C.M. Hannan, K.L. Flanagan, S.C. Gilbert, M.B. Gravenor, and A.V. Hill. 1999. Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming. Nat. Med. 5:565-571.
    • (1999) Nat. Med. , vol.5 , pp. 565-571
    • Plebanski, M.1    Lee, E.A.2    Hannan, C.M.3    Flanagan, K.L.4    Gilbert, S.C.5    Gravenor, M.B.6    Hill, A.V.7
  • 27
    • 0038345165 scopus 로고    scopus 로고
    • Modulation of the peripheral T-cell response by CD4 mutants of hepatitis C virus: Transition from a Th1 to a Th2 response
    • Wang, J.H., T.J. Layden, and D.D. Eckels. 2003. Modulation of the peripheral T-cell response by CD4 mutants of hepatitis C virus: transition from a Th1 to a Th2 response. Hum. Immunol. 64:662-673.
    • (2003) Hum. Immunol. , vol.64 , pp. 662-673
    • Wang, J.H.1    Layden, T.J.2    Eckels, D.D.3
  • 28
    • 0035411217 scopus 로고    scopus 로고
    • Mechanisms of T cell receptor antagonism: Implications in the treatment of disease
    • Dittel, B.N. 2001. Mechanisms of T cell receptor antagonism: implications in the treatment of disease. Curr. Mol. Med. 1:339-355.
    • (2001) Curr. Mol. Med. , vol.1 , pp. 339-355
    • Dittel, B.N.1
  • 29
    • 0033404953 scopus 로고    scopus 로고
    • Partially phosphorylated T cell receptor ζ molecules can inhibit T cell activation
    • Kersh, E.N., G.J. Kersh, and P.M. Allen. 1999. Partially phosphorylated T cell receptor ζ molecules can inhibit T cell activation. J. Exp. Med. 190:1627-1636.
    • (1999) J. Exp. Med. , vol.190 , pp. 1627-1636
    • Kersh, E.N.1    Kersh, G.J.2    Allen, P.M.3
  • 30
    • 0038665319 scopus 로고    scopus 로고
    • Cutting edge: Dependence of TCR antagonism on Src homology 2 domain-containing protein tyrosine phosphatase activity
    • Kilgore, N.E., J.D. Carter, U. Lorenz, and B.D. Evavold. 2003. Cutting edge: dependence of TCR antagonism on Src homology 2 domain-containing protein tyrosine phosphatase activity. J. Immunol. 170:4891-4895.
    • (2003) J. Immunol. , vol.170 , pp. 4891-4895
    • Kilgore, N.E.1    Carter, J.D.2    Lorenz, U.3    Evavold, B.D.4
  • 31
    • 0037338890 scopus 로고    scopus 로고
    • TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
    • Stefanova, I., B. Hemmer, M. Vergelli, R. Martin, W.E. Biddison, and R.N. Germain. 2003. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat. Immunol. 4:248-254.
    • (2003) Nat. Immunol. , vol.4 , pp. 248-254
    • Stefanova, I.1    Hemmer, B.2    Vergelli, M.3    Martin, R.4    Biddison, W.E.5    Germain, R.N.6
  • 32
    • 0032564340 scopus 로고    scopus 로고
    • In vivo antagonism of a T cell response by an endogenously expressed ligand
    • Basu, D., C.B. Williams, and P.M. Allen. 1998. In vivo antagonism of a T cell response by an endogenously expressed ligand. Proc. Natl. Acad. Sci. USA. 95:14332-14336.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14332-14336
    • Basu, D.1    Williams, C.B.2    Allen, P.M.3
  • 33
    • 0037191792 scopus 로고    scopus 로고
    • Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
    • Stefanova, I., J.R. Dorfman, and R.N. Germain. 2002. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature. 420:429-434.
    • (2002) Nature , vol.420 , pp. 429-434
    • Stefanova, I.1    Dorfman, J.R.2    Germain, R.N.3
  • 34
    • 0033199986 scopus 로고    scopus 로고
    • Cross-antagonism of a T cell clone expressing two distinct T cell receptors
    • Dittel, B.N., I. Stefanova, R.N. Germain, and C.A. Janeway Jr. 1999. Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity. 11:289-298.
    • (1999) Immunity , vol.11 , pp. 289-298
    • Dittel, B.N.1    Stefanova, I.2    Germain, R.N.3    Janeway Jr., C.A.4
  • 35
    • 0033566824 scopus 로고    scopus 로고
    • Cutting edge: Dueling TCRs: Peptide antagonism of CD4+ T cells with dual antigen specificities
    • Robertson, J.M., and B.D. Evavold. 1999. Cutting edge: dueling TCRs: peptide antagonism of CD4+ T cells with dual antigen specificities. J. Immunol. 163:1750-1754.
    • (1999) J. Immunol. , vol.163 , pp. 1750-1754
    • Robertson, J.M.1    Evavold, B.D.2
  • 36
    • 0032528486 scopus 로고    scopus 로고
    • TCR transgenic mice in which usage of transgenic α- and β-chains is highly dependent on the level of selecting ligand
    • Kersh, G.J., D.L. Donermeyer, K.E. Frederick, J.M. White, B.L. Hsu, and P.M. Allen. 1998. TCR transgenic mice in which usage of transgenic α- and β-chains is highly dependent on the level of selecting ligand. J. Immunol. 161:585-593.
    • (1998) J. Immunol. , vol.161 , pp. 585-593
    • Kersh, G.J.1    Donermeyer, D.L.2    Frederick, K.E.3    White, J.M.4    Hsu, B.L.5    Allen, P.M.6
  • 37
    • 0033577859 scopus 로고    scopus 로고
    • A kinetic threshold between positive and negative selection based on the longevity of the T cell receptor-ligand complex
    • Williams, C.B., D.L. Engle, G.J. Kersh, J.M. White, and P.M. Allen. 1999. A kinetic threshold between positive and negative selection based on the longevity of the T cell receptor-ligand complex. J. Exp. Med. 189:1531-1544.
    • (1999) J. Exp. Med. , vol.189 , pp. 1531-1544
    • Williams, C.B.1    Engle, D.L.2    Kersh, G.J.3    White, J.M.4    Allen, P.M.5
  • 38
    • 0029961893 scopus 로고    scopus 로고
    • Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large continuum of related ligands
    • Kersh, G.J., and P.M. Allen. 1996. Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184:1259-1268.
    • (1996) J. Exp. Med. , vol.184 , pp. 1259-1268
    • Kersh, G.J.1    Allen, P.M.2
  • 39
    • 0031831379 scopus 로고    scopus 로고
    • In vivo expression of a T cell receptor antagonist: T cells escape central tolerance but are antagonized in the periphery
    • Williams, C.B., K. Vidal, D.L. Donermeyer, D.A. Peterson, J.M. White, and P.M. Allen. 1998. In vivo expression of a T cell receptor antagonist: T cells escape central tolerance but are antagonized in the periphery. J. Immunol. 161:128-137.
    • (1998) J. Immunol. , vol.161 , pp. 128-137
    • Williams, C.B.1    Vidal, K.2    Donermeyer, D.L.3    Peterson, D.A.4    White, J.M.5    Allen, P.M.6
  • 40
    • 0029966057 scopus 로고    scopus 로고
    • Essential flexibility in the T cell recognition of antigen
    • Kersh, G.J., and P.M. Allen. 1996. Essential flexibility in the T cell recognition of antigen. Nature. 222:495-498.
    • (1996) Nature , vol.222 , pp. 495-498
    • Kersh, G.J.1    Allen, P.M.2
  • 42
    • 0348047600 scopus 로고    scopus 로고
    • Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
    • Krogsgaard, M., N. Prado, E.J. Adams, X.L. He, D.C. Chow, D.B. Wilson, K.C. Garcia, and M.M. Davis. 2003. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol. Cell. 12:1367-1378.
    • (2003) Mol. Cell , vol.12 , pp. 1367-1378
    • Krogsgaard, M.1    Prado, N.2    Adams, E.J.3    He, X.L.4    Chow, D.C.5    Wilson, D.B.6    Garcia, K.C.7    Davis, M.M.8
  • 43
    • 0037037543 scopus 로고    scopus 로고
    • Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
    • Davey, G.M., C. Kurts, J.F. Miller, P. Bouillet, A. Strasser, A.G. Brooks, F.R. Carbone, and W.R. Heath. 2002. Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J. Exp. Med. 196:947-955.
    • (2002) J. Exp. Med. , vol.196 , pp. 947-955
    • Davey, G.M.1    Kurts, C.2    Miller, J.F.3    Bouillet, P.4    Strasser, A.5    Brooks, A.G.6    Carbone, F.R.7    Heath, W.R.8
  • 45
    • 0027967385 scopus 로고
    • Partial T cell signaling: Altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy
    • Sloan-Lancaster, J., A.S. Shaw, J.B. Rothbard, and P.M. Allen. 1994. Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy. Cell. 79:913-922.
    • (1994) Cell , vol.79 , pp. 913-922
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.M.4
  • 46
    • 0028902752 scopus 로고
    • Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Madrenas, J., R.L. Wange, J.L. Wang, N. Isakov, L.E. Samelson, and R.N. Germain. 1995. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science. 267:515-518.
    • (1995) Science , vol.267 , pp. 515-518
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3    Isakov, N.4    Samelson, L.E.5    Germain, R.N.6
  • 47
    • 0032563231 scopus 로고    scopus 로고
    • Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation
    • Kersh, E.N., A.S. Shaw, and P.M. Allen. 1998. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science. 281:572-575.
    • (1998) Science , vol.281 , pp. 572-575
    • Kersh, E.N.1    Shaw, A.S.2    Allen, P.M.3
  • 48
    • 0033565718 scopus 로고    scopus 로고
    • Differential CD3 zeta phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands
    • Liu, H., and D.A. Vignali. 1999. Differential CD3 zeta phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands. J. Immunol. 163:599-602.
    • (1999) J. Immunol. , vol.163 , pp. 599-602
    • Liu, H.1    Vignali, D.A.2
  • 49
    • 0037769031 scopus 로고    scopus 로고
    • T cell antagonism is functionally uncoupled from the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits
    • Pitcher, L.A., P.S. Ohashi, and N.S. van Oers. 2003. T cell antagonism is functionally uncoupled from the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits. J. Immunol. 171:845-852.
    • (2003) J. Immunol. , vol.171 , pp. 845-852
    • Pitcher, L.A.1    Ohashi, P.S.2    Van Oers, N.S.3
  • 50
    • 0028294682 scopus 로고
    • Positive and negative thymocyte selection induced by different concentrations of a single peptide
    • Sebzda, E., V.A. Wallace, J. Mayer, R.S.M. Yeung, T.W. Mak, and P.S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science. 263:1615-1618.
    • (1994) Science , vol.263 , pp. 1615-1618
    • Sebzda, E.1    Wallace, V.A.2    Mayer, J.3    Yeung, R.S.M.4    Mak, T.W.5    Ohashi, P.S.6
  • 51
    • 0032584069 scopus 로고    scopus 로고
    • The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells
    • Wang, R., A. Nelson, K. Kimachi, H.M. Grey, and A.G. Farr. 1998. The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells. Proc. Natl. Acad. Sci. USA. 95:3804-3809.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3804-3809
    • Wang, R.1    Nelson, A.2    Kimachi, K.3    Grey, H.M.4    Farr, A.G.5
  • 53
    • 2942640089 scopus 로고    scopus 로고
    • Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells
    • Yamagata, T., D. Mathis, and C. Benoist. 2004. Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells. Nat. Immunol. 5:597-605.
    • (2004) Nat. Immunol. , vol.5 , pp. 597-605
    • Yamagata, T.1    Mathis, D.2    Benoist, C.3
  • 54
    • 0037306466 scopus 로고    scopus 로고
    • On the role of self-recognition in T cell responses to foreign antigen
    • Stefanova, I., J.R. Dorfman, M. Tsukamoto, and R.N. Germain. 2003. On the role of self-recognition in T cell responses to foreign antigen. Immunol. Rev. 191:97-106.
    • (2003) Immunol. Rev. , vol.191 , pp. 97-106
    • Stefanova, I.1    Dorfman, J.R.2    Tsukamoto, M.3    Germain, R.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.