Selective expansion of cross-reactive CD8+ memory T cells by viral variants

Journal of Experimental Medicine

Volumn 190, Issue 9, 1999, Pages 1319-1328

  Haanen, John B A G ^a   Wolkers, Monika C ^a   Kruisbeek, Ada M ^a   Schumacher, Ton N M ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

In vivo; Influenza virus; Major histocompatibility complex tetramers; Peptides C57BL mice

Indexed keywords

EPITOPE; VIRUS NUCLEOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ANTIGENIC VARIATION; ARTICLE; CONTROLLED STUDY; CROSS REACTION; CYTOTOXIC T LYMPHOCYTE; IMMUNE RESPONSE; INFLUENZA; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CROSS REACTIONS; CYTOTOXICITY TESTS, IMMUNOLOGIC; EPITOPES; FLOW CYTOMETRY; IMMUNIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; NUCLEOPROTEINS; PEPTIDES; RNA-BINDING PROTEINS; VIRAL CORE PROTEINS;

EID: 0033230907     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.9.1319     Document Type: Article

References (51)

1. Garboczi, D.N., P. Ghosh, U. Utz, Q.R. Fan, W.E. Biddison, and D.C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature. 384:134-141.
2. Lorenz, R.G., A.N. Tyler, and P.M. Allen. 1989. Reconstruction of the immunogenic peptide RNase(43-56) by identification and transfer of the critical residues into an unrelated peptide backbone. J. Exp. Med. 170:203-215.
3. Wucherpfennig, K.W., and J.L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
4. Evavold, B.D., L.J. Sloan, K.J. Wilson, J.B. Rothbard, and P.M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity. 2:655-663.
5. Kersh, G.J., and P.M. Allen. 1996. Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184:1259-1268.
6. Sloan-Lancaster, J., and P.M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1-27.
7. De Magistris, M.T., J. Alexander, M. Coggeshall, A. Altman, F.C. Gaeta, H.M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell. 68:625-634.
8. Sloan-Lancaster, J., B.D. Evavold, and P.M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature. 363:156-159.
9. Evavold, B.D., J. Sloan-Lancaster, B.L. Hsu, and P.M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131-3140.
10. Klenerman, P., S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, et al. 1994. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature. 369:403-407.
11. Bertoletti, A., A. Sette, F.V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature. 369:407-410.
12. Klenerman, P., and R.M. Zinkernagel. 1998. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature. 394:482-485.
13. Basu, D., C.B. Williams, and P.M. Allen. 1998. In vivo antagonism of a T cell response by an endogenously expressed ligand. Proc. Natl. Acad. Sci. USA. 95:14332-14336.
14. Plebanski, M., E.A. Lee, C.M. Hannan, K.L. Flanagan, S.C. Gilbert, M.B. Gravenor, and A.V. Hill. 1999. Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming. Nat. Med. 5:565-571.
15. + T cells in primary and secondary influenza pneumonia. Immunity. 8:683-691.
16. Dunbar, P.R., G.S. Ogg, J. Chen, N. Rust, P. van der Bruggen, and V. Cerundolo. 1998. Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood. Curr. Biol. 8:413-416.
17. Haanen, J.B.A.G., M. Toebes, G.A. Cordaro, M. Wolkers, A.M. Kruisbeek, and T.N.M. Schumacher. 1999. Systemic T cell expansion during localized viral infection. Eur. J. Immunol. 29:1168-1174.
18. Townsend, A.R., and J.J. Skehel. 1984. The influenza A virus nucleoprotein gene controls the induction of both subtype-specific and cross-reactive cytotoxic T cells. J. Exp. Med. 160:552-563.
19. Altman, J.D., P.A.H. Moss, P.J.R. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:94-96.
20. Murali, K.K., J.D. Altman, M. Suresh, D.J. Sourdive, A.J. Zajac, J.D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 8:177-187.
21. Diehl, L., A.T. den Boer, S.P. Schoenberger, E.I.H. van der Voort, T.N.M. Schumacher, C.J.M. Melief, R. Offringa, and R. Toes. 1999. Peptide-induced peripheral CTL tolerance can be overcome by in vivo CD40 activation. Nat. Med. 5:774-779.
22. b at 2.4 Å resolution: implications for antigen-determinant selection. Cell. 76:39-50.
23. Padovan, E., G. Casorati, P. Dellabona, S. Meyer, M. Brockhaus, and A. Lanzavecchia. 1993. Expression of two T cell receptor alpha chains: dual receptor T cells. Science. 262: 422-424.
24. Heath, W.R., F.R. Carbone, P. Bertolino, J. Kelly, S. Cose, and J.F. Miller. 1995. Expression of two T cell receptor alpha chains on the surface of normal murine T cells. Eur. J. Immunol. 25:1617-1623.
25. Matsui, K., J.J. Boniface, P. Steffner, P.A. Reay, and M.M. Davis. 1994. Kinetics of T-cell receptor binding to peptide/ 1-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA. 91:12862-12866.
26. Alam, S.M., P.J. Travers, J.L. Wung, W. Nasholds, S. Redpath, S.C. Jameson, and N.R. Gascoigne. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature. 381:616-620.
27. Lyons, D.S., S.A. Lieberman, J. Hampl, J.J. Boniface, Y. Chien, L.J. Berg, and M.M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity. 5:53-61.
28. Kersh, G.J., E.N. Kersh, D.H. Fremont, and P.M. Allen. 1998. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity. 9:817-826.
29. Savage, P.A., J.J. Boniface, and M.M. Davis. 1999. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity. 10:485-492.
30. McHeyzer-Williams, M.G., and M.M. Davis. 1995. Antigen-specific development of primary and memory T cells in vivo. Science. 268:106-111.
31. Bachmann, M.F., D.E. Speiser, and P.S. Ohashi. 1997. Functional maturation of an antiviral cytotoxic T-cell response. J. Virol. 71:5764-5768.
32. Busch, D.H., I. Pilip, and E.G. Pamer. 1998. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J. Exp. Med. 188:61-70.
33. Busch, D.H., and E.G. Pamer. 1999. T cell affinity maturation by selective expansion during infection. J. Exp. Med. 189:701-710.
34. Deckhut, A.M., W. Allan, A. McMickle, M. Eichelberger, M.A. Blackman, P.C. Doherty, and D.L. Woodland. 1993. Prominent usage of V beta 8.3 T cells in the H-2Db-restricted response to an influenza A virus nucleoprotein epitope. J. Immunol. 151:2658-2666.
35. Tough, D.F., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127-1135.
36. Sprent, J., and D.F. Tough. 1994. Lymphocyte life-span and memory. Science. 265:1395-1400.
37. Tough, D.F., P. Borrow, and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science. 272:1947-1950.
38. + T cells are hyperreactive to antigenic challenge in vitro. J. Exp. Med. 184:2141-2151.
39. Ehl, S., J. Hombach, P. Aichele, H. Hengartner, and R.M. Zinkernagel. 1997. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J. Exp. Med. 185:1241-1251.
40. Zarozinski, C.C., and R.M. Welsh. 1997. Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response. J. Exp. Med. 185:1629-1639.
41. Butz, E.A., and M.J. Bevan. 1998. Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity. 8:167-175.
42. Bennett, S.R., F.R. Carbone, F. Karamalis, R.A. Flavell, J.F. Miller, and W.R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 393:478-480.
43. Ridge, J.P., R.F. Di, and P. Matzinger. 1998. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature. 393:474-478.
44. Schoenberger, S.P., R.E. Toes, E. van der Voort, R. Offringa, and C.J. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 393: 480-483.
45. Oldstone, M.B. 1997. How viruses escape from cytotoxic T lymphocytes: molecular parameters and players. Virology. 234:179-185.
46. Borrow, P., and G.M. Shaw. 1998. Cytotoxic T-lymphocyte escape viral variants: how important are they in viral evasion of immune clearance in vivo? Immunol. Rev. 164:37-51.
47. + T cells in chronic HIV infection are antigen specific. J. Exp. Med. 188:785-790.
48. Croft, M., L.M. Bradley, and S.L. Swain. 1994. Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J. Immunol. 152:2675-2685.
49. Iezzi, G., K. Karjalainen, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity. 8:89-95.
50. Dutton, R.W., L.M. Bradley, and S.L. Swain. 1998. T cell memory. Annu. Rev. Immunol. 16:201-223.
51. Selin, L.K., S.M. Varga, I.C. Wong, and R.M. Welsh. 1998. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J. Exp. Med. 188:1705-1715.