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Volumn 16, Issue 16, 2010, Pages 1953-1969

Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity

Author keywords

Anergy; Cytotoxic; Epitopes; Human; T cells; Viral

Indexed keywords

HLA A2 ANTIGEN; NONSTRUCTURAL PROTEIN 3; NUCLEOTIDE;

EID: 77951959327     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i16.1953     Document Type: Article
Times cited : (7)

References (100)
  • 1
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001; 345: 41-52.
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 2
    • 0029794026 scopus 로고    scopus 로고
    • Hepatitis C virus: Models of immunopathogenesis and prophylaxis
    • Eckels DD, Flomenberg P, Gill JC. Hepatitis C virus: models of immunopathogenesis and prophylaxis. Transfusion 1996; 36: 836-844.
    • (1996) Transfusion , vol.36 , pp. 836-844
    • Eckels, D.D.1    Flomenberg, P.2    Gill, J.C.3
  • 5
    • 0033054459 scopus 로고    scopus 로고
    • Stealth, sabotage and exploitation
    • Brodsky FM. Stealth, sabotage and exploitation. Immunol Rev 1999; 168: 5-11.
    • (1999) Immunol Rev , vol.168 , pp. 5-11
    • Brodsky, F.M.1
  • 7
    • 0028945033 scopus 로고
    • Genetic heterogeneity of hepatitis C virus: Quasispecies and genotypes
    • Bukh J, Miller RH, Purcell RH. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin Liver Dis 1995; 15: 41-63.
    • (1995) Semin Liver Dis , vol.15 , pp. 41-63
    • Bukh, J.1    Miller, R.H.2    Purcell, R.H.3
  • 11
    • 0032904882 scopus 로고    scopus 로고
    • In vitro human Th-cell responses to a recombinant hepatitis C virus antigen: Failure in IL-2 production despite proliferation
    • Eckels DD, Tabatabail N, Bian TH, Wang H, Muheisen SS, Rice CM, Yoshizawa K, Gill J. In vitro human Th-cell responses to a recombinant hepatitis C virus antigen: failure in IL-2 production despite proliferation. Hum Immunol 1999; 60: 187-199.
    • (1999) Hum Immunol , vol.60 , pp. 187-199
    • Eckels, D.D.1    Tabatabail, N.2    Bian, T.H.3    Wang, H.4    Muheisen, S.S.5    Rice, C.M.6    Yoshizawa, K.7    Gill, J.8
  • 12
    • 0032911169 scopus 로고    scopus 로고
    • Functionally distinct T-cell epitopes within the hepatitis C virus non-structural 3 protein
    • Tabatabai NM, Bian TH, Rice CM, Yoshizawa, Gill J, Eckels DD. Functionally distinct T-cell epitopes within the hepatitis C virus non-structural 3 protein. Hum Immunol 1999; 60: 105-115.
    • (1999) Hum Immunol , vol.60 , pp. 105-115
    • Tabatabai, N.M.1    Bian, T.H.2    Rice, C.M.3    Yoshizawa, G.J.4    Eckels, D.D.5
  • 13
    • 0036213763 scopus 로고    scopus 로고
    • Sequence variation in the gene encoding the nonstructural 3 protein of hepatitis C virus: Evidence for immune selection
    • Wang H, Bian T, Merrill SJ, Eckels DD. Sequence variation in the gene encoding the nonstructural 3 protein of hepatitis C virus: evidence for immune selection. J Mol Evol 2002; 54: 465-473.
    • (2002) J Mol Evol , vol.54 , pp. 465-473
    • Wang, H.1    Bian, T.2    Merrill, S.J.3    Eckels, D.D.4
  • 14
    • 0033120555 scopus 로고    scopus 로고
    • Mutations in immunodominant T cell epitopes derived from the nonstructural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition
    • Wang H, Eckels DD. Mutations in immunodominant T cell epitopes derived from the nonstructural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition. J Immunol 1999; 162: 4177-4183.
    • (1999) J Immunol , vol.162 , pp. 4177-4183
    • Wang, H.1    Eckels, D.D.2
  • 16
    • 0030671121 scopus 로고    scopus 로고
    • Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
    • Chang KM, Rehermann B, McHutchison JG, Pasquinelli C, Southwood S, Sette A, Chisari FV. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J Clin Invest 1997; 100: 2376-2385.
    • (1997) J Clin Invest , vol.100 , pp. 2376-2385
    • Chang, K.M.1    Rehermann, B.2    McHutchison, J.G.3    Pasquinelli, C.4    Southwood, S.5    Sette, A.6    Chisari, F.V.7
  • 17
    • 0030761598 scopus 로고    scopus 로고
    • Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope
    • Kaneko T, Moriyama T, Udaka K, Hiroishi K, Kita H, Okamoto H, Yagita H, Okumura K, Imawari M. Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope. Eur J Immunol 1997; 27: 1782-1787.
    • (1997) Eur J Immunol , vol.27 , pp. 1782-1787
    • Kaneko, T.1    Moriyama, T.2    Udaka, K.3    Hiroishi, K.4    Kita, H.5    Okamoto, H.6    Yagita, H.7    Okumura, K.8    Imawari, M.9
  • 22
    • 22344447485 scopus 로고    scopus 로고
    • Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
    • Ray SC, Fanning L, Wang XH, Netski DM, Kenny-Walsh E, Thomas DL. Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. J Exp Med 2005; 201: 1753-1759.
    • (2005) J Exp Med , vol.201 , pp. 1753-1759
    • Ray, S.C.1    Fanning, L.2    Wang, X.H.3    Netski, D.M.4    Kenny-Walsh, E.5    Thomas, D.L.6
  • 24
    • 0023187442 scopus 로고
    • The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
    • Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 1987; 329: 512-518.
    • (1987) Nature , vol.329 , pp. 512-518
    • Bjorkman, P.J.1    Saper, M.A.2    Samraoui, B.3    Bennett, W.S.4    Strominger, J.L.5    Wiley, D.C.6
  • 26
    • 0022483534 scopus 로고
    • The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
    • Townsend AR, Rothbard J, Gotch FM, Bahadur G, Wraith D, McMichael AJ. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 1986; 44: 959-968.
    • (1986) Cell , vol.44 , pp. 959-968
    • Townsend, A.R.1    Rothbard, J.2    Gotch, F.M.3    Bahadur, G.4    Wraith, D.5    McMichael, A.J.6
  • 27
    • 0025166228 scopus 로고
    • Isolation of an endogenously processed immunodominant viral peptide from the class I H-2Kb molecule
    • Van Bleek GM, Nathenson SG. Isolation of an endogenously processed immunodominant viral peptide from the class I H-2Kb molecule. Nature 1990; 348: 213-216.
    • (1990) Nature , vol.348 , pp. 213-216
    • van Bleek, G.M.1    Nathenson, S.G.2
  • 29
    • 0033960578 scopus 로고    scopus 로고
    • T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide
    • Bouhdoud L, Villain P, Merzouki A, Arella M, Couture C. T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide. J Virol 2000; 74: 2121-2130.
    • (2000) J Virol , vol.74 , pp. 2121-2130
    • Bouhdoud, L.1    Villain, P.2    Merzouki, A.3    Arella, M.4    Couture, C.5
  • 32
    • 0031746017 scopus 로고    scopus 로고
    • Substitutions in a major histocompatibility complex class II-restricted human immunodeficiency virus type 1 gp120 epitope can affect CD4+ T-helper-cell function
    • Lekutis C, Letvin NL. Substitutions in a major histocompatibility complex class II-restricted human immunodeficiency virus type 1 gp120 epitope can affect CD4+ T-helper-cell function. J Virol 1998; 72: 5840-5844.
    • (1998) J Virol , vol.72 , pp. 5840-5844
    • Lekutis, C.1    Letvin, N.L.2
  • 33
    • 0029120420 scopus 로고
    • Viral mutations T.C.R antagonism and escape from the immune response
    • Franco A, Ferrari C, Sette A, Chisari FV. Viral mutations, TCR antagonism and escape from the immune response. Curr Opin Immunol 1995; 7: 524-531.
    • (1995) Curr Opin Immunol , vol.7 , pp. 524-531
    • Franco, A.1    Ferrari, C.2    Sette, A.3    Chisari, F.V.4
  • 34
    • 0028832184 scopus 로고
    • HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release
    • Koziel MJ, Dudley D, Afdhal N, Grakoui A, Rice CM, Choo QL, Houghton M, Walker BD. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest 1995; 96: 2311-2321.
    • (1995) J Clin Invest , vol.96 , pp. 2311-2321
    • Koziel, M.J.1    Dudley, D.2    Afdhal, N.3    Grakoui, A.4    Rice, C.M.5    Choo, Q.L.6    Houghton, M.7    Walker, B.D.8
  • 35
    • 0024973417 scopus 로고
    • Avoiding false positives with PCR
    • Kwok S, Higuchi R. Avoiding false positives with PCR. Nature 1989; 339: 237-238.
    • (1989) Nature , vol.339 , pp. 237-238
    • Kwok, S.1    Higuchi, R.2
  • 36
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui A, Wychowski C, Lin C, Feinstone SM, Rice CM. Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol 1993; 67: 1385-1395.
    • (1993) J Virol , vol.67 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 37
    • 0030878535 scopus 로고    scopus 로고
    • Virus quasispecies: Making a mountain out of a molehill?
    • Smith DB, McAllister J, Casino C, Simmonds P. Virus quasispecies: making a mountain out of a molehill? J Gen Virol 1997; 78 (Pt 7): 1511-1519.
    • (1997) J Gen Virol , vol.78 , Issue.7 , pp. 1511-1519
    • Smith, D.B.1    McAllister, J.2    Casino, C.3    Simmonds, P.4
  • 39
    • 24944541417 scopus 로고    scopus 로고
    • Development and validation of a fluorescence polarization-based competitive peptidebinding assay for HLA-A*0201--a new tool for epitope discovery
    • Buchli R, VanGundy RS, Hickman-Miller HD, Giberson CF, Bardet W, Hildebrand WH. Development and validation of a fluorescence polarization-based competitive peptidebinding assay for HLA-A*0201--a new tool for epitope discovery. Biochemistry 2005; 44: 12491-12507.
    • (2005) Biochemistry , vol.44 , pp. 12491-12507
    • Buchli, R.1    Vangundy, R.S.2    Hickman-Miller, H.D.3    Giberson, C.F.4    Bardet, W.5    Hildebrand, W.H.6
  • 40
    • 0036727208 scopus 로고    scopus 로고
    • Functionally distinct helper T-cell epitopes of HCV and their role in modulation of NS3-specific, CD8+/ tetramer positive CTL
    • Zhu F, Eckels DD. Functionally distinct helper T-cell epitopes of HCV and their role in modulation of NS3-specific, CD8+/ tetramer positive CTL. Hum Immunol 2002; 63: 710-718.
    • (2002) Hum Immunol , vol.63 , pp. 710-718
    • Zhu, F.1    Eckels, D.D.2
  • 41
    • 0027205194 scopus 로고
    • Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells
    • Jameson SC, Carbone FR, Bevan MJ. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J Exp Med 1993; 177: 1541-1550.
    • (1993) J Exp Med , vol.177 , pp. 1541-1550
    • Jameson, S.C.1    Carbone, F.R.2    Bevan, M.J.3
  • 42
    • 0023764283 scopus 로고
    • Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
    • Hughes AL, Nei M. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature 1988; 335: 167-170.
    • (1988) Nature , vol.335 , pp. 167-170
    • Hughes, A.L.1    Nei, M.2
  • 43
    • 0022507362 scopus 로고
    • Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions
    • Nei M, Gojobori T. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 1986; 3: 418-426.
    • (1986) Mol Biol Evol , vol.3 , pp. 418-426
    • Nei, M.1    Gojobori, T.2
  • 44
    • 0025788241 scopus 로고
    • High-fidelity amplification using a thermostable DNA polymerase isolated from Pyrococcus furiosus
    • Lundberg KS, Shoemaker DD, Adams MW, Short JM, Sorge JA, Mathur EJ. High-fidelity amplification using a thermostable DNA polymerase isolated from Pyrococcus furiosus. Gene 1991; 108: 1-6.
    • (1991) Gene , vol.108 , pp. 1-6
    • Lundberg, K.S.1    Shoemaker, D.D.2    Adams, M.W.3    Short, J.M.4    Sorge, J.A.5    Mathur, E.J.6
  • 45
    • 0037407859 scopus 로고    scopus 로고
    • From RNA to quasispecies: A DNA polymerase with proofreading activity is highly recommended for accurate assessment of viral diversity
    • Malet I, Belnard M, Agut H, Cahour A. From RNA to quasispecies: a DNA polymerase with proofreading activity is highly recommended for accurate assessment of viral diversity. J Virol Methods 2003; 109: 161-170.
    • (2003) J Virol Methods , vol.109 , pp. 161-170
    • Malet, I.1    Belnard, M.2    Agut, H.3    Cahour, A.4
  • 46
    • 0028295047 scopus 로고
    • Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins
    • Kast WM, Brandt RM, Sidney J, Drijfhout JW, Kubo RT, Grey HM, Melief CJ, Sette A. Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins. J Immunol 1994; 152: 3904-3912.
    • (1994) J Immunol , vol.152 , pp. 3904-3912
    • Kast, W.M.1    Brandt, R.M.2    Sidney, J.3    Drijfhout, J.W.4    Kubo, R.T.5    Grey, H.M.6    Melief, C.J.7    Sette, A.8
  • 48
    • 0027304399 scopus 로고
    • Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules
    • Ruppert J, Sidney J, Celis E, Kubo RT, Grey HM, Sette A. Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules. Cell 1993; 74: 929-937.
    • (1993) Cell , vol.74 , pp. 929-937
    • Ruppert, J.1    Sidney, J.2    Celis, E.3    Kubo, R.T.4    Grey, H.M.5    Sette, A.6
  • 49
    • 0028876917 scopus 로고
    • Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans
    • Vitiello A, Ishioka G, Grey HM, Rose R, Farness P, LaFond R, Yuan L, Chisari FV, Furze J, Bartholomeuz R. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans. J Clin Invest 1995; 95: 341-349.
    • (1995) J Clin Invest , vol.95 , pp. 341-349
    • Vitiello, A.1    Ishioka, G.2    Grey, H.M.3    Rose, R.4    Farness, P.5    Lafond, R.6    Yuan, L.7    Chisari, F.V.8    Furze, J.9    Bartholomeuz, R.10
  • 50
    • 0030898038 scopus 로고    scopus 로고
    • Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation
    • Goulder PJ, Sewell AK, Lalloo DG, Price DA, Whelan JA, Evans J, Taylor GP, Luzzi G, Giangrande P, Phillips RE, McMichael AJ. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J Exp Med 1997; 185: 1423-1433.
    • (1997) J Exp Med , vol.185 , pp. 1423-1433
    • Goulder, P.J.1    Sewell, A.K.2    Lalloo, D.G.3    Price, D.A.4    Whelan, J.A.5    Evans, J.6    Taylor, G.P.7    Luzzi, G.8    Giangrande, P.9    Phillips, R.E.10    McMichael, A.J.11
  • 55
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001; 194: 1395-1406.
    • (2001) J Exp Med , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5    Chisari, F.V.6
  • 58
    • 0034030136 scopus 로고    scopus 로고
    • Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
    • Takaki A, Wiese M, Maertens G, Depla E, Seifert U, Liebetrau A, Miller JL, Manns MP, Rehermann B. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 2000; 6: 578-582.
    • (2000) Nat Med , vol.6 , pp. 578-582
    • Takaki, A.1    Wiese, M.2    Maertens, G.3    Depla, E.4    Seifert, U.5    Liebetrau, A.6    Miller, J.L.7    Manns, M.P.8    Rehermann, B.9
  • 59
    • 0027507602 scopus 로고
    • Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C
    • Erickson AL, Houghton M, Choo QL, Weiner AJ, Ralston R, Muchmore E, Walker CM. Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C. J Immunol 1993; 151: 4189-4199.
    • (1993) J Immunol , vol.151 , pp. 4189-4199
    • Erickson, A.L.1    Houghton, M.2    Choo, Q.L.3    Weiner, A.J.4    Ralston, R.5    Muchmore, E.6    Walker, C.M.7
  • 69
    • 0037270978 scopus 로고    scopus 로고
    • Hepatic T cells and liver tolerance
    • Crispe IN. Hepatic T cells and liver tolerance. Nat Rev Immunol 2003; 3: 51-62.
    • (2003) Nat Rev Immunol , vol.3 , pp. 51-62
    • Crispe, I.N.1
  • 70
    • 0027015655 scopus 로고
    • Hepatitis C viral RNA in serum of patients with chronic non-A, non-B hepatitis: Detection by the polymerase chain reaction using multiple primer sets
    • Cristiano K, Di Bisceglie AM, Hoofnagle JH, Feinstone SM. Hepatitis C viral RNA in serum of patients with chronic non-A, non-B hepatitis: detection by the polymerase chain reaction using multiple primer sets. Arch Virol Suppl 1992; 4: 172-178.
    • (1992) Arch Virol Suppl , vol.4 , pp. 172-178
    • Cristiano, K.1    di Bisceglie, A.M.2    Hoofnagle, J.H.3    Feinstone, S.M.4
  • 74
    • 0028086591 scopus 로고
    • Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope
    • Bertoletti A, Costanzo A, Chisari FV, Levrero M, Artini M, Sette A, Penna A, Giuberti T, Fiaccadori F, Ferrari C. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. J Exp Med 1994; 180: 933-943.
    • (1994) J Exp Med , vol.180 , pp. 933-943
    • Bertoletti, A.1    Costanzo, A.2    Chisari, F.V.3    Levrero, M.4    Artini, M.5    Sette, A.6    Penna, A.7    Giuberti, T.8    Fiaccadori, F.9    Ferrari, C.10
  • 75
    • 0030869489 scopus 로고    scopus 로고
    • Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides
    • Sewell AK, Harcourt GC, Goulder PJ, Price DA, Phillips RE. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. Eur J Immunol 1997; 27: 2323-2329.
    • (1997) Eur J Immunol , vol.27 , pp. 2323-2329
    • Sewell, A.K.1    Harcourt, G.C.2    Goulder, P.J.3    Price, D.A.4    Phillips, R.E.5
  • 79
    • 0032934341 scopus 로고    scopus 로고
    • Identification of antigenic escape variants in an immunodominant epitope of hepatitis C virus
    • Eckels DD, Zhou H, Bian TH, Wang H. Identification of antigenic escape variants in an immunodominant epitope of hepatitis C virus. Int Immunol 1999; 11: 577-583.
    • (1999) Int Immunol , vol.11 , pp. 577-583
    • Eckels, D.D.1    Zhou, H.2    Bian, T.H.3    Wang, H.4
  • 83
    • 0029778817 scopus 로고    scopus 로고
    • Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
    • Rehermann B, Chang KM, McHutchison JG, Kokka R, Houghton M, Chisari FV. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J Clin Invest 1996; 98: 1432-1440.
    • (1996) J Clin Invest , vol.98 , pp. 1432-1440
    • Rehermann, B.1    Chang, K.M.2    McHutchison, J.G.3    Kokka, R.4    Houghton, M.5    Chisari, F.V.6
  • 84
    • 0026504248 scopus 로고
    • Genetic diversity and evolution of retroviruses
    • Coffin JM. Genetic diversity and evolution of retroviruses. Curr Top Microbiol Immunol 1992; 176: 143-164.
    • (1992) Curr Top Microbiol Immunol , vol.176 , pp. 143-164
    • Coffin, J.M.1
  • 85
    • 0024438889 scopus 로고
    • Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase
    • Bebenek K, Abbotts J, Roberts JD, Wilson SH, Kunkel TA. Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. J Biol Chem 1989; 264: 16948-16956.
    • (1989) J Biol Chem , vol.264 , pp. 16948-16956
    • Bebenek, K.1    Abbotts, J.2    Roberts, J.D.3    Wilson, S.H.4    Kunkel, T.A.5
  • 86
    • 0024273119 scopus 로고
    • The accuracy of reverse transcriptase from HIV-1
    • Roberts JD, Bebenek K, Kunkel TA. The accuracy of reverse transcriptase from HIV-1. Science 1988; 242: 1171-1173.
    • (1988) Science , vol.242 , pp. 1171-1173
    • Roberts, J.D.1    Bebenek, K.2    Kunkel, T.A.3
  • 88
    • 0031831625 scopus 로고    scopus 로고
    • Virtues of being faithful: Can we limit the genetic variation in human immunodeficiency virus?
    • Drosopoulos WC, Rezende LF, Wainberg MA, Prasad VR. Virtues of being faithful: can we limit the genetic variation in human immunodeficiency virus? J Mol Med 1998; 76: 604-612.
    • (1998) J Mol Med , vol.76 , pp. 604-612
    • Drosopoulos, W.C.1    Rezende, L.F.2    Wainberg, M.A.3    Prasad, V.R.4
  • 90
    • 0034846053 scopus 로고    scopus 로고
    • Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations
    • Cao K, Hollenbach J, Shi X, Shi W, Chopek M, Fernández-Viña MA. Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations. Hum Immunol 2001; 62: 1009-1030.
    • (2001) Hum Immunol , vol.62 , pp. 1009-1030
    • Cao, K.1    Hollenbach, J.2    Shi, X.3    Shi, W.4    Chopek, M.5    Fernández-Viña, M.A.6
  • 91
    • 0033559908 scopus 로고    scopus 로고
    • Molecular and functional analysis of a conserved CTL epitope in HIV-1 p24 recognized from a long-term nonprogressor: Constraints on immune escape associated with targeting a sequence essential for viral replication
    • Wagner R, Leschonsky B, Harrer E, Paulus C, Weber C, Walker BD, Buchbinder S, Wolf H, Kalden JR, Harrer T. Molecular and functional analysis of a conserved CTL epitope in HIV-1 p24 recognized from a long-term nonprogressor: constraints on immune escape associated with targeting a sequence essential for viral replication. J Immunol 1999; 162: 3727-3734.
    • (1999) J Immunol , vol.162 , pp. 3727-3734
    • Wagner, R.1    Leschonsky, B.2    Harrer, E.3    Paulus, C.4    Weber, C.5    Walker, B.D.6    Buchbinder, S.7    Wolf, H.8    Kalden, J.R.9    Harrer, T.10
  • 94
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligandinduced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster J, Allen PM. Altered peptide ligandinduced partial T cell activation: molecular mechanisms and role in T cell biology. Annu Rev Immunol 1996; 14: 1-27.
    • (1996) Annu Rev Immunol , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 95
    • 0025741031 scopus 로고
    • Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis
    • Christinck ER, Luscher MA, Barber BH, Williams DB. Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis. Nature 1991; 352: 67-70.
    • (1991) Nature , vol.352 , pp. 67-70
    • Christinck, E.R.1    Luscher, M.A.2    Barber, B.H.3    Williams, D.B.4
  • 96
    • 0031567905 scopus 로고    scopus 로고
    • Antagonism of vaccine-induced HIV-1-specific CD4+ T cells by primary HIV-1 infection: Potential mechanism of vaccine failure
    • Kent SJ, Greenberg PD, Hoffman MC, Akridge RE, McElrath MJ. Antagonism of vaccine-induced HIV-1-specific CD4+ T cells by primary HIV-1 infection: potential mechanism of vaccine failure. J Immunol 1997; 158: 807-815.
    • (1997) J Immunol , vol.158 , pp. 807-815
    • Kent, S.J.1    Greenberg, P.D.2    Hoffman, M.C.3    Akridge, R.E.4    McElrath, M.J.5
  • 98
    • 0028988331 scopus 로고
    • T cell receptor antagonists and partial agonists
    • Jameson SC, Bevan MJ. T cell receptor antagonists and partial agonists. Immunity 1995; 2: 1-11.
    • (1995) Immunity , vol.2 , pp. 1-11
    • Jameson, S.C.1    Bevan, M.J.2
  • 99
    • 0032752883 scopus 로고    scopus 로고
    • Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules
    • Livingston BD, Crimi C, Fikes J, Chesnut RW, Sidney J, Sette A. Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules. Hum Immunol 1999; 60: 1013-1017.
    • (1999) Hum Immunol , vol.60 , pp. 1013-1017
    • Livingston, B.D.1    Crimi, C.2    Fikes, J.3    Chesnut, R.W.4    Sidney, J.5    Sette, A.6
  • 100
    • 0029974607 scopus 로고    scopus 로고
    • Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability
    • van der Burg SH, Visseren MJ, Brandt RM, Kast WM, Melief CJ. Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability. J Immunol 1996; 156: 3308-3314
    • (1996) J Immunol , vol.156 , pp. 3308-3314
    • van der Burg, S.H.1    Visseren, M.J.2    Brandt, R.M.3    Kast, W.M.4    Melief, C.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.