Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation

Immunity

Volumn 17, Issue 6, 2002, Pages 809-822

  Ehrlich, Lauren I Richie ^a   Ebert, Peter J R ^a   Krummel, Matthew F ^a   Weiss, Arthur ^b   Davis, Mark M ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; GREEN FLUORESCENT PROTEIN; LIGAND; P56LCK PROTEIN; PEPTIDE; PROTEIN P56; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELLULAR IMMUNITY; CONJUGATION; CONTROLLED STUDY; ENDOSOME; IMMUNOSTIMULATION; MICROSCOPY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTOGENESIS; T LYMPHOCYTE;

EID: 0036906497     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00481-8     Document Type: Article

References (50)

1. Abraham N., Miceli M.C., Parnes J.R., Veillette A. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature. 350:1991;62-66.
2. Anderson P., Blue M.L., Morimoto C., Schlossman S.F. Cross-linking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes. J. Immunol. 139:1987;678-682.
3. Appleby M.W., Gross J.A., Cooke M.P., Levin S.D., Qian X., Perlmutter R.M. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell. 70:1992;751-763.
4. Bromley S.K., Iaboni A., Davis S.J., Whitty A., Green J.M., Shaw A.S., Weiss A., Dustin M.L. The immunological synapse and CD28-CD80 interactions. Nat. Immunol. 2:2001;1159-1166.
5. Cary L.A., Klinghoffer R.A., Sachsenmaier C., Cooper J.A. SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading. Mol. Cell. Biol. 22:2002;2427-2440.
6. Cornall R.J., Cyster J.G., Hibbs M.L., Dunn A.R., Otipoby K.L., Clark E.A., Goodnow C.C. Polygenic autoimmune traits. Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection Immunity. 8:1998;497-508.
7. Davis S.J., van der Merwe P.A. The immunological synapse. required for T cell receptor signalling or directing T cell effector function? Curr. Biol. 11:2001;R289-R291.
8. Dittel B.N., Sant'Angelo D.B., Janeway C.A. Jr. Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR. J. Immunol. 158:1997;4065-4073.
9. Dustin M.L., Cooper J.A. The immunological synapse and the actin cytoskeleton. molecular hardware for T cell signaling Nat. Immunol. 1:2000;23-29.
10. Dustin M.L., Olszowy M.W., Holdorf A.D., Li J., Bromley S., Desai N., Widder P., Rosenberger F., van der Merwe P.A., Allen P.M.et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell. 94:1998;667-677.
11. Egen J.G., Allison J.P. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity. 16:2002;23-35.
12. Enns C.A., Shindelman J.E., Tonik S.E., Sussman H.H. Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody. Proc. Natl. Acad. Sci. USA. 78:1981;4222-4225.
13. Fazekas de St. Groth B., Patten P.A., Ho W.Y., Rock E.P., Davis M.M. An analysis of T cell receptor-ligand interaction using a transgenic antigen model for T cell tolerance and T cell receptor mutagenesis. Alt F.W., Vogel H.J. Molecular Mechanisms of Immunological Self-Recognition. 1993;Academic Press, San Diego. 123-127.pp.
14. Glaichenhaus N., Shastri N., Littman D.R., Turner J.M. Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells. Cell. 64:1991;511-520.
15. Grakoui A., Bromley S.K., Sumen C., Davis M.M., Shaw A.S., Allen P.M., Dustin M.L. The immunological synapse. a molecular machine controlling T cell activation Science. 285:1999;221-227.
16. Hanke J.H., Gardner J.P., Dow R.L., Changelian P.S., Brissette W.H., Weringer E.J., Pollok B.A., Connelly P.A. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. J. Biol. Chem. 271:1996;695-701.
17. Holdorf A.D., Green J.M., Levin S.D., Denny M.F., Straus D.B., Link V., Changelian P.S., Allen P.M., Shaw A.S. Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation. J. Exp. Med. 190:1999;375-384.
18. Holdorf A.D., Lee K.H., Burack W.R., Allen P.M., Shaw A.S. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nat. Immunol. 3:2002;259-264.
19. Huang J., Sugie K., La Face D.M., Altman A., Grey H.M. TCR antagonist peptides induce formation of APC-T cell conjugates and activate a Rac signaling pathway. Eur. J. Immunol. 30:2000;50-58.
20. Iwashima M., Irving B.A., van Oers N.S., Chan A.C., Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 263:1994;1136-1139.
21. Johnson K.G., Bromley S.K., Dustin M.L., Thomas M.L. A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. Proc. Natl. Acad. Sci. USA. 97:2000;10138-10143.
22. Kane L.P., Lin J., Weiss A. Signal transduction by the TCR for antigen. Curr. Opin. Immunol. 12:2000;242-249.
23. Karttunen J., Shastri N. Measurement of ligand-induced activation in single viable T cells using the lacZ reporter gene. Proc. Natl. Acad. Sci. USA. 88:1991;3972-3976.
24. Kaye J., Porcelli S., Tite J., Jones B., Janeway C.A. Jr. Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J. Exp. Med. 158:1983;836-856.
25. Kersh E.N., Shaw A.S., Allen P.M. Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation. Science. 281:1998;572-575.
26. Krummel M.F., Sjaastad M.D., Wulfing C., Davis M.M. Differential clustering of CD4 and CD3zeta during T cell recognition. Science. 289:2000;1349-1352.
27. Kuhn J.R., Poenie M. Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. Immunity. 16:2002;111-121.
28. Kupfer A., Swain S.L., Singer S.J. The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells. J. Exp. Med. 165:1987;1565-1580.
29. Lee K.H., Holdorf A.D., Dustin M.L., Chan A.C., Allen P.M., Shaw A.S. T cell receptor signaling precedes immunological synapse formation. Science. 295:2002;1539-1542.
30. Lewis L.A., Chung C.D., Chen J., Parnes J.R., Moran M., Patel V.P., Miceli M.C. The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production. J. Immunol. 159:1997;2292-2300.
31. Ley S.C., Marsh M., Bebbington C.R., Proudfoot K., Jordan P. Distinct intracellular localization of Lck and Fyn protein tyrosin kinases in human T lymphocytes. J. Cell Biol. 125:1994;639-649.
32. Lowin-Kropf B., Shapiro V.S., Weiss A. Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J. Cell Biol. 140:1998;861-871.
33. Luo K.X., Sefton B.M. Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol. Cell. Biol. 10:1990;5305-5313.
34. Luton F., Legendre V., Gorvel J.P., Schmitt-Verhulst A.M., Boyer C. Tyrosine and serine protein kinase activities associated with ligand-induced internalized TCR/CD3 complexes. J. Immunol. 158:1997;3140-3147.
35. McKeithan T.W. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA. 92:1995;5042-5046.
36. Molina T.J., Kishihara K., Siderovski D.P., van Ewijk W., Narendran A., Timms E., Wakeham A., Paige C.J., Harmann K.-U., Veillette A.et al. Profound block in thymocyte development in mice lacking p56lck. Nature. 357:1992;161-164.
37. Monks C.R., Freiberg B.A., Kupfer H., Sciaky N., Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature. 395:1998;82-86.
38. Morgan M.M., Labno C.M., Van Seventer G.A., Denny M.F., Straus D.B., Burkhardt J.K. Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70. J. Immunol. 167:2001;5708-5718.
39. Rabinowitz J.D., Beeson C., Lyons D.S., Davis M.M., McConnell H.M. Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA. 93:1996;1401-1405. a.
40. Rabinowitz J.D., Beeson C., Wulfing C., Tate K., Allen P.M., Davis M.M., McConnell H.M. Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity. 5:1996;125-135. b.
41. Richie L.I., Ebert P.J.R., Wu L.C., Krummel M.F., Owen J.J.T., Davis M.M. Imaging synapse formation during thymocyte selection. inability of CD3zeta to form a stable central accumulation during negative selection Immunity. 16:2002;595-606.
42. Rudd C.E., Barber E.K., Burgess K.E., Hahn J.Y., Odysseos A.D., Sy M.S., Schlossman S.F. Molecular analysis of the interaction of p56lck with the CD4 and CD8 antigens. Adv. Exp. Med. Biol. 292:1991;85-96.
43. Stein P.L., Lee H.M., Rich S., Soriano P. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell. 70:1992;741-750.
44. Straus D.B., Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 70:1992;585-593.
45. Straus D.B., Chan A.C., Patai B., Weiss A. SH2 domain function is essential for the role of the lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 271:1996;9976-9981.
46. Trowbridge I.S., Thomas M.L. CD45. an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development Annu. Rev. Immunol. 12:1994;85-116.
47. Turner J.M., Brodsky M.H., Irving B.A., Levin S.D., Perlmutter R.M., Littman D.R. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell. 60:1990;755-765.
48. Wange R.L., Samelson L.E. Complex complexes. signaling at the TCR Immunity. 5:1996;197-205.
49. Wulfing C., Rabinowitz J.D., Beeson C., Sjaastad M.D., McConnell H.M., Davis M.M. Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med. 185:1997;1815-1825.
50. Zal T., Zal M.A., Gascoigne N.R. Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of T-hybridoma immunological synapse. Immunity. 16:2002;521-534.