메뉴 건너뛰기




Volumn 7, Issue 4, 2011, Pages

A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELLS;

EID: 79955562832     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1001121     Document Type: Review
Times cited : (236)

References (110)
  • 1
    • 0033605718 scopus 로고    scopus 로고
    • The role of phosphoinositide 3-kinase lipid products in cell function
    • Rameh L, Cantley L, (1999) The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 274: 8347-8350.
    • (1999) J Biol Chem , vol.274 , pp. 8347-8350
    • Rameh, L.1    Cantley, L.2
  • 2
    • 35549001736 scopus 로고    scopus 로고
    • The PAR proteins: Fundamental players in animal cell polarization
    • Goldstein B, Macara I, (2007) The PAR proteins: Fundamental players in animal cell polarization. Dev Cell 13: 609-622.
    • (2007) Dev Cell , vol.13 , pp. 609-622
    • Goldstein, B.1    Macara, I.2
  • 3
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • Raftopoulou M, Hall A, (2004) Cell migration: Rho GTPases lead the way. Dev Biol 265: 23-32.
    • (2004) Dev Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 4
    • 0024635815 scopus 로고
    • Quantitative analysis of cell motility and chemotaxis in dictyostelium discoideum by using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients
    • Fisher P, Merkl R, Gerisch G, (1989) Quantitative analysis of cell motility and chemotaxis in dictyostelium discoideum by using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients. J Cell Biol 108: 973-984.
    • (1989) J Cell Biol , vol.108 , pp. 973-984
    • Fisher, P.1    Merkl, R.2    Gerisch, G.3
  • 5
    • 0032911044 scopus 로고    scopus 로고
    • Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
    • Servant G, Weiner O, Neptune E, Sedat J, Bourne H, (1999) Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10: 1163-1178.
    • (1999) Mol Biol Cell , vol.10 , pp. 1163-1178
    • Servant, G.1    Weiner, O.2    Neptune, E.3    Sedat, J.4    Bourne, H.5
  • 6
    • 33747621801 scopus 로고    scopus 로고
    • Dictyostelium discoideum chemotaxis: threshold for directed motion
    • Song L, Nadkarni S, Bödeker H, Beta C, Bae A, et al. (2006) Dictyostelium discoideum chemotaxis: threshold for directed motion. Eur J Cell Biol 85: 981-989.
    • (2006) Eur J Cell Biol , vol.85 , pp. 981-989
    • Song, L.1    Nadkarni, S.2    Bödeker, H.3    Beta, C.4    Bae, A.5
  • 8
    • 0037376655 scopus 로고    scopus 로고
    • Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell
    • Tyson J, Chen K, Novak B, (2003) Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol 15: 221-231.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 221-231
    • Tyson, J.1    Chen, K.2    Novak, B.3
  • 9
    • 54249137797 scopus 로고    scopus 로고
    • Feedback loops shape cellular signals in space and time
    • Brandman O, Meyer T, (2008) Feedback loops shape cellular signals in space and time. Science 322: 390-395.
    • (2008) Science , vol.322 , pp. 390-395
    • Brandman, O.1    Meyer, T.2
  • 10
    • 77953802995 scopus 로고    scopus 로고
    • Symmetry breaking in the life cycle of the budding yeast
    • Slaughter B, Smith S, Li R, (2009) Symmetry breaking in the life cycle of the budding yeast. Cold Spring Harb Perspect Biol 1: a003384.
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , pp. 003384
    • Slaughter, B.1    Smith, S.2    Li, R.3
  • 11
    • 33947398366 scopus 로고    scopus 로고
    • Central roles of small GTPases in the development of cell polarity in yeast and beyond
    • Park HO, Bi E, (2007) Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev 71: 48-96.
    • (2007) Microbiol Mol Biol Rev , vol.71 , pp. 48-96
    • Park, H.O.1    Bi, E.2
  • 12
    • 0037385661 scopus 로고    scopus 로고
    • Spontaneous cell polarization: undermining determinism
    • Wedlich-Soldner R, Li R, (2003) Spontaneous cell polarization: undermining determinism. Nat Cell Biol 5: 267-270.
    • (2003) Nat Cell Biol , vol.5 , pp. 267-270
    • Wedlich-Soldner, R.1    Li, R.2
  • 13
    • 0344394312 scopus 로고    scopus 로고
    • Scaffold-mediated symmetry breaking by cdc42p
    • Irazoqui J, Gladfelter A, Lew D, (2003) Scaffold-mediated symmetry breaking by cdc42p. Nature Cell Biol 5: 1062-1070.
    • (2003) Nature Cell Biol , vol.5 , pp. 1062-1070
    • Irazoqui, J.1    Gladfelter, A.2    Lew, D.3
  • 14
    • 4544295912 scopus 로고    scopus 로고
    • Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling
    • Wedlich-Soldner R, Wai S, Schmidt T, Li R, (2004) Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol 166: 889-900.
    • (2004) J Cell Biol , vol.166 , pp. 889-900
    • Wedlich-Soldner, R.1    Wai, S.2    Schmidt, T.3    Li, R.4
  • 15
    • 26444469935 scopus 로고    scopus 로고
    • A system of counteracting feedback loops regulates cdc42p activity during spontaneous cell polarization
    • Ozbudak EM, Becskei A, van Oudenaarden A, (2005) A system of counteracting feedback loops regulates cdc42p activity during spontaneous cell polarization. Dev Cell 9: 565-571.
    • (2005) Dev Cell , vol.9 , pp. 565-571
    • Ozbudak, E.M.1    Becskei, A.2    van Oudenaarden, A.3
  • 16
    • 47749105334 scopus 로고    scopus 로고
    • Persistent cell motion in the absence of external signals: A search strategy for eukaryotic cells
    • Li L, Nørrelykke SF, Cox EC, (2008) Persistent cell motion in the absence of external signals: A search strategy for eukaryotic cells. PLoS ONE 3: e2093.
    • (2008) PLoS ONE , vol.3 , pp. 2093
    • Li, L.1    Nørrelykke, S.F.2    Cox, E.C.3
  • 17
    • 77952955309 scopus 로고    scopus 로고
    • Understanding eukaryotic chemotaxis: a pseudopod-centred view
    • Insall R, (2010) Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nat Rev Mol Cell Biol 11: 453-458.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 453-458
    • Insall, R.1
  • 18
    • 0027772188 scopus 로고
    • The locomotion, shape and pseudopodial dynamics of unstimulated dictyostelium cells are not random
    • Killich T, Plath P, Wei X, Bultmann H, Rensing L, et al. (1993) The locomotion, shape and pseudopodial dynamics of unstimulated dictyostelium cells are not random. J Cell Sci 106: 1005-1013.
    • (1993) J Cell Sci , vol.106 , pp. 1005-1013
    • Killich, T.1    Plath, P.2    Wei, X.3    Bultmann, H.4    Rensing, L.5
  • 19
    • 56649112739 scopus 로고    scopus 로고
    • Ordered patterns of cell shape and orientational correlation during spontaneous cell migration
    • doi:10.1371/journal.pone.0003734
    • Maeda Y, Inose J, Matsuo M, Iwaya S, Sano M, (2008) Ordered patterns of cell shape and orientational correlation during spontaneous cell migration. PLoS ONE 3: e3734 doi:10.1371/journal.pone.0003734.
    • (2008) PLoS ONE , vol.3 , pp. 3734
    • Maeda, Y.1    Inose, J.2    Matsuo, M.3    Iwaya, S.4    Sano, M.5
  • 20
    • 33947206045 scopus 로고    scopus 로고
    • Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
    • Andrew N, Insall R, (2007) Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat Cell Biol 9: 193-200.
    • (2007) Nat Cell Biol , vol.9 , pp. 193-200
    • Andrew, N.1    Insall, R.2
  • 21
    • 67649197971 scopus 로고    scopus 로고
    • The ordered extension of pseudopodia by amoeboid cells in the absence of external cues
    • doi:10.1371/journal.pone.0005253
    • Bosgraaf L, Van Haastert P, (2009) The ordered extension of pseudopodia by amoeboid cells in the absence of external cues. PLoS ONE 4: e5253 doi:10.1371/journal.pone.0005253.
    • (2009) PLoS ONE , vol.4 , pp. 5253
    • Bosgraaf, L.1    Van Haastert, P.2
  • 22
    • 2942687012 scopus 로고    scopus 로고
    • Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
    • Janetopoulos C, Ma L, Devreotes PN, Iglesias PA, (2004) Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A 101: 8951-8956.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8951-8956
    • Janetopoulos, C.1    Ma, L.2    Devreotes, P.N.3    Iglesias, P.A.4
  • 23
    • 0344012465 scopus 로고    scopus 로고
    • Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia
    • Postma M, Roelofs J, Goedhart J, Gadella T, Visser A, et al. (2003) Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia. Mol Biol Cell 14: 5019-5027.
    • (2003) Mol Biol Cell , vol.14 , pp. 5019-5027
    • Postma, M.1    Roelofs, J.2    Goedhart, J.3    Gadella, T.4    Visser, A.5
  • 24
    • 38549134374 scopus 로고    scopus 로고
    • Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation
    • Dalous J, Burghardt E, Müller-Taubenberger A, Bruckert F, Gerisch G, et al. (2008) Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation. Biophys J 94: 1063-1074.
    • (2008) Biophys J , vol.94 , pp. 1063-1074
    • Dalous, J.1    Burghardt, E.2    Müller-Taubenberger, A.3    Bruckert, F.4    Gerisch, G.5
  • 25
    • 0033617576 scopus 로고    scopus 로고
    • A cell's sense of direction
    • Parent C, Devreotes P, (1999) A cell's sense of direction. Science 284: 765-770.
    • (1999) Science , vol.284 , pp. 765-770
    • Parent, C.1    Devreotes, P.2
  • 26
    • 0037743735 scopus 로고    scopus 로고
    • Eukaryotic chemotaxis: Distinctions between directional sensing and polarization
    • Devreotes P, Janetopoulos C, (2003) Eukaryotic chemotaxis: Distinctions between directional sensing and polarization. J Biol Chem 278: 20445-20448.
    • (2003) J Biol Chem , vol.278 , pp. 20445-20448
    • Devreotes, P.1    Janetopoulos, C.2
  • 27
    • 33748269657 scopus 로고    scopus 로고
    • Signaling pathways mediating chemotaxis in the social amoeba, dictyostelium discoideum
    • Willard S, Devreotes P, (2006) Signaling pathways mediating chemotaxis in the social amoeba, dictyostelium discoideum. Eur J Cell Biol 85: 897-904.
    • (2006) Eur J Cell Biol , vol.85 , pp. 897-904
    • Willard, S.1    Devreotes, P.2
  • 28
    • 0035282887 scopus 로고    scopus 로고
    • The Dictyostelium discoideum family of Rho-related proteins
    • Rivero F, Dislich H, Glockner G, Noegel A, (2001) The Dictyostelium discoideum family of Rho-related proteins. Nucleic Acids Res 29: 1068-1079.
    • (2001) Nucleic Acids Res , vol.29 , pp. 1068-1079
    • Rivero, F.1    Dislich, H.2    Glockner, G.3    Noegel, A.4
  • 29
    • 33947718091 scopus 로고    scopus 로고
    • Rap1 controls cell adhesion and cell motility through the regulation of myosin II
    • Jeon T, Lee DJ, Merlot S, Weeks G, Firtel R, (2007) Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J Cell Biol 176: 1021-1033.
    • (2007) J Cell Biol , vol.176 , pp. 1021-1033
    • Jeon, T.1    Lee, D.J.2    Merlot, S.3    Weeks, G.4    Firtel, R.5
  • 30
    • 0033143333 scopus 로고    scopus 로고
    • Spatial control of actin polymerization during neutrophil chemotaxis
    • Weiner O, Servant G, Welch M, Mitchison T, Sedat J, et al. (1999) Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol 1: 75-81.
    • (1999) Nat Cell Biol , vol.1 , pp. 75-81
    • Weiner, O.1    Servant, G.2    Welch, M.3    Mitchison, T.4    Sedat, J.5
  • 31
    • 0042354714 scopus 로고    scopus 로고
    • Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
    • Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, et al. (2003) Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114: 201-214.
    • (2003) Cell , vol.114 , pp. 201-214
    • Xu, J.1    Wang, F.2    Van Keymeulen, A.3    Herzmark, P.4    Straight, A.5
  • 32
    • 28644445999 scopus 로고    scopus 로고
    • Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration
    • Bodin S, Welch M, (2005) Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration. Mol Biol Cell 16: 5773-5783.
    • (2005) Mol Biol Cell , vol.16 , pp. 5773-5783
    • Bodin, S.1    Welch, M.2
  • 33
    • 33644865751 scopus 로고    scopus 로고
    • Neutrophil polarization: Spatiotemporal dynamics of RhoA activity support a self-organizing mechanism
    • Wong K, Pertz O, Hahn K, Bourne H, (2006) Neutrophil polarization: Spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc Natl Acad Sci USA 103: 3639-3644.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3639-3644
    • Wong, K.1    Pertz, O.2    Hahn, K.3    Bourne, H.4
  • 34
    • 33746648129 scopus 로고    scopus 로고
    • To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
    • Van Keymeulen A, Wong K, Knight Z, Govaerts C, Hahn K, et al. (2006) To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol 174: 437-445.
    • (2006) J Cell Biol , vol.174 , pp. 437-445
    • Van Keymeulen, A.1    Wong, K.2    Knight, Z.3    Govaerts, C.4    Hahn, K.5
  • 35
    • 1642328487 scopus 로고    scopus 로고
    • Making all the right moves: chemotaxis in neutrophils and Dictyostelium
    • Parent C, (2004) Making all the right moves: chemotaxis in neutrophils and Dictyostelium. Curr Opin Cell Biol 16: 4-13.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 4-13
    • Parent, C.1
  • 36
    • 28544448768 scopus 로고    scopus 로고
    • Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
    • Schneider I, Haugh J, (2005) Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts. J Cell Biol 171: 883-892.
    • (2005) J Cell Biol , vol.171 , pp. 883-892
    • Schneider, I.1    Haugh, J.2
  • 37
    • 65249089072 scopus 로고    scopus 로고
    • Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts
    • Weiger M, Wang CC, Krajcovic M, Melvin A, Rhoden J, et al. (2009) Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts. J Cell Sci 122: 313-323.
    • (2009) J Cell Sci , vol.122 , pp. 313-323
    • Weiger, M.1    Wang, C.C.2    Krajcovic, M.3    Melvin, A.4    Rhoden, J.5
  • 38
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A, (1998) Rho GTPases and the actin cytoskeleton. Science 279: 509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 39
    • 0036308972 scopus 로고    scopus 로고
    • A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
    • Weiner O, Neilsen P, Prestwich G, Kirschner M, Cantley L, et al. (2002) A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4: 509-512.
    • (2002) Nat Cell Biol , vol.4 , pp. 509-512
    • Weiner, O.1    Neilsen, P.2    Prestwich, G.3    Kirschner, M.4    Cantley, L.5
  • 41
    • 34548103595 scopus 로고    scopus 로고
    • Mechanisms of gradient detection: A comparison of axon pathfinding with eukaryotic cell migration
    • San Diego, Academic Press
    • von Philipsborn A, Bastmeyer M, (2007) Mechanisms of gradient detection: A comparison of axon pathfinding with eukaryotic cell migration. A survey of cell biology. Volume 263 San Diego Academic Press pp. 1-62.
    • (2007) A Survey of Cell Biology , vol.263 , pp. 1-62
    • von Philipsborn, A.1    Bastmeyer, M.2
  • 42
    • 68249083818 scopus 로고    scopus 로고
    • Migration of cortical interneurons relies on branched leading process dynamics
    • Valiente M, Martini F, (2009) Migration of cortical interneurons relies on branched leading process dynamics. Cell Adh Migr 3: 278-280.
    • (2009) Cell Adh Migr , vol.3 , pp. 278-280
    • Valiente, M.1    Martini, F.2
  • 43
    • 0032901710 scopus 로고    scopus 로고
    • Self-polarization and directional motility of cytoplasm
    • Verkhovsky AB, Svitkina TM, Borisy GG, (1999) Self-polarization and directional motility of cytoplasm. Curr Biol 9: 11-20.
    • (1999) Curr Biol , vol.9 , pp. 11-20
    • Verkhovsky, A.B.1    Svitkina, T.M.2    Borisy, G.G.3
  • 44
    • 34748878938 scopus 로고    scopus 로고
    • Actin myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility
    • Yam P, Wilson C, Ji L, Hebert B, Barnhart E, et al. (2007) Actin myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility. J Cell Biol 178: 1207-1221.
    • (2007) J Cell Biol , vol.178 , pp. 1207-1221
    • Yam, P.1    Wilson, C.2    Ji, L.3    Hebert, B.4    Barnhart, E.5
  • 45
    • 39149118309 scopus 로고    scopus 로고
    • Navigating through models of chemotaxis
    • Iglesias P, Devreotes P, (2008) Navigating through models of chemotaxis. Curr Opin Cell Biol 20: 35-40.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 35-40
    • Iglesias, P.1    Devreotes, P.2
  • 46
    • 79955566080 scopus 로고    scopus 로고
    • Signaling pathways that control cell migration: models and analysis
    • Welf ES, Haugh JM, (2011) Signaling pathways that control cell migration: models and analysis. Wiley Interdiscip Rev Syst Biol Med 3: 231-240.
    • (2011) Wiley Interdiscip Rev Syst Biol Med , vol.3 , pp. 231-240
    • Welf, E.S.1    Haugh, J.M.2
  • 48
    • 0015454185 scopus 로고
    • A theory of biological pattern formation
    • Gierer A, Meinhardt H, (1972) A theory of biological pattern formation. Kybernetik 12: 30-39.
    • (1972) Kybernetik , vol.12 , pp. 30-39
    • Gierer, A.1    Meinhardt, H.2
  • 49
    • 0016209638 scopus 로고
    • Application of a theory of biological pattern formation based on lateral inhibition
    • Meinhardt H, Gierer A, (1974) Application of a theory of biological pattern formation based on lateral inhibition. J Cell Sci 15: 321-346.
    • (1974) J Cell Sci , vol.15 , pp. 321-346
    • Meinhardt, H.1    Gierer, A.2
  • 50
    • 0032823984 scopus 로고    scopus 로고
    • Orientation of chemotactic cells and growth cones: models and mechanisms
    • Meinhardt H, (1999) Orientation of chemotactic cells and growth cones: models and mechanisms. J Cell Sci 112: 2867-2874.
    • (1999) J Cell Sci , vol.112 , pp. 2867-2874
    • Meinhardt, H.1
  • 51
    • 4444271530 scopus 로고    scopus 로고
    • A mechanistic model for eukaryotic gradient sensing: Spontaneous and induced phosphoinositide polarization
    • Subramanian K, Narang A, (2004) A mechanistic model for eukaryotic gradient sensing: Spontaneous and induced phosphoinositide polarization. J Theor Biol 231: 49-67.
    • (2004) J Theor Biol , vol.231 , pp. 49-67
    • Subramanian, K.1    Narang, A.2
  • 52
    • 33646764616 scopus 로고    scopus 로고
    • Spontaneous polarization in eukaryotic gradient sensing: A mathematical model based on mutual inhibition of frontness and backness pathways
    • Narang A, (2006) Spontaneous polarization in eukaryotic gradient sensing: A mathematical model based on mutual inhibition of frontness and backness pathways. J Theor Biol 240: 538-553.
    • (2006) J Theor Biol , vol.240 , pp. 538-553
    • Narang, A.1
  • 53
    • 34347352254 scopus 로고    scopus 로고
    • A mass conserved reaction-diffusion system captures properties of cell polarity
    • doi:10.1371/journal.pcbi.0030108
    • Otsuji M, Ishihara S, Co C, Kaibuchi K, Mochizuki A, et al. (2007) A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol 3: e108 doi:10.1371/journal.pcbi.0030108.
    • (2007) PLoS Comput Biol , vol.3 , pp. 108
    • Otsuji, M.1    Ishihara, S.2    Co, C.3    Kaibuchi, K.4    Mochizuki, A.5
  • 54
    • 42049115235 scopus 로고    scopus 로고
    • Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity
    • Goryachev A, Pokhilko A, (2008) Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Lett 582: 1437-1443.
    • (2008) FEBS Lett , vol.582 , pp. 1437-1443
    • Goryachev, A.1    Pokhilko, A.2
  • 55
    • 60749120831 scopus 로고    scopus 로고
    • Calling heads from tails: the role of mathematical modeling in understanding cell polarization
    • Onsum M, Rao CV, (2009) Calling heads from tails: the role of mathematical modeling in understanding cell polarization. Curr Opin Cell Biol 21: 74-81.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 74-81
    • Onsum, M.1    Rao, C.V.2
  • 56
    • 34147175165 scopus 로고    scopus 로고
    • Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity
    • Marco E, Wedlich-Soldner R, Li R, Altschuler S, Wu L, (2007) Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell 129: 411-422.
    • (2007) Cell , vol.129 , pp. 411-422
    • Marco, E.1    Wedlich-Soldner, R.2    Li, R.3    Altschuler, S.4    Wu, L.5
  • 57
    • 0036532226 scopus 로고    scopus 로고
    • Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability
    • Ferrell J Jr, (2002) Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 14: 140-148.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 140-148
    • Ferrell Jr., J.1
  • 58
    • 0034741649 scopus 로고    scopus 로고
    • A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics
    • Narang A, Subramanian K, Lauffenburger D, (2001) A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics. Ann Biomed Eng 29: 677-691.
    • (2001) Ann Biomed Eng , vol.29 , pp. 677-691
    • Narang, A.1    Subramanian, K.2    Lauffenburger, D.3
  • 59
    • 70350784148 scopus 로고    scopus 로고
    • Singularity in polarization: Rewiring yeast cells to make two buds
    • Howell A, Savage N, Johnson S, Bose I, Wagner A, et al. (2009) Singularity in polarization: Rewiring yeast cells to make two buds. Cell 139: 731-743.
    • (2009) Cell , vol.139 , pp. 731-743
    • Howell, A.1    Savage, N.2    Johnson, S.3    Bose, I.4    Wagner, A.5
  • 60
    • 0037015118 scopus 로고    scopus 로고
    • Modeling the cell's guidance system
    • Iglesias P, Levchenko A, (2002) Modeling the cell's guidance system. Sci STKE 2002: RE12.
    • (2002) Sci STKE , vol.2002 , pp. 12
    • Iglesias, P.1    Levchenko, A.2
  • 61
    • 0036219106 scopus 로고    scopus 로고
    • Models of eukaryotic gradient sensing: Application to chemotaxis of amoebae and neutrophils
    • Levchenko A, Iglesias P, (2002) Models of eukaryotic gradient sensing: Application to chemotaxis of amoebae and neutrophils. Biophys J 82: 50-63.
    • (2002) Biophys J , vol.82 , pp. 50-63
    • Levchenko, A.1    Iglesias, P.2
  • 62
    • 10044250005 scopus 로고    scopus 로고
    • Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P-3 response in Dictyostelium cells
    • Ma L, Janetopoulos C, Yang L, Devreotes P, Iglesias P, (2004) Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P-3 response in Dictyostelium cells. Biophys J 87: 3764-3774.
    • (2004) Biophys J , vol.87 , pp. 3764-3774
    • Ma, L.1    Janetopoulos, C.2    Yang, L.3    Devreotes, P.4    Iglesias, P.5
  • 63
    • 33745594814 scopus 로고    scopus 로고
    • Directional sensing in eukaryotic chemotaxis: A balanced inactivation model
    • Levine H, Kessler DA, Rappel WJ, (2006) Directional sensing in eukaryotic chemotaxis: A balanced inactivation model. Proc Natl Acad Sci USA 103: 9761-9766.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9761-9766
    • Levine, H.1    Kessler, D.A.2    Rappel, W.J.3
  • 64
    • 33846815127 scopus 로고    scopus 로고
    • Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells
    • Krishnan J, Iglesias P, (2007) Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Biophys J 92: 816-830.
    • (2007) Biophys J , vol.92 , pp. 816-830
    • Krishnan, J.1    Iglesias, P.2
  • 65
    • 44449172361 scopus 로고    scopus 로고
    • Directional sensing during chemotaxis
    • Janetopoulos C, Firtel RA, (2008) Directional sensing during chemotaxis. FEBS Lett 582: 2075-2085.
    • (2008) FEBS Lett , vol.582 , pp. 2075-2085
    • Janetopoulos, C.1    Firtel, R.A.2
  • 66
    • 34247361650 scopus 로고    scopus 로고
    • Chemotaxis in the absence of PIP3 gradients
    • Hoeller O, Kay R, (2007) Chemotaxis in the absence of PIP3 gradients. Curr Biol 17: 813-817.
    • (2007) Curr Biol , vol.17 , pp. 813-817
    • Hoeller, O.1    Kay, R.2
  • 67
  • 68
    • 34548703094 scopus 로고    scopus 로고
    • An actin-based wave generator organizes cell motility
    • doi:10.1371/journal.pbio.0050221
    • Weiner O, Marganski W, Wu L, Altschuler S, Kirschner M, (2007) An actin-based wave generator organizes cell motility. PLoS Biol 5: e221 doi:10.1371/journal.pbio.0050221.
    • (2007) PLoS Biol , vol.5 , pp. 221
    • Weiner, O.1    Marganski, W.2    Wu, L.3    Altschuler, S.4    Kirschner, M.5
  • 69
    • 34447504022 scopus 로고    scopus 로고
    • G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility
    • Sasaki A, Janetopoulos C, Lee S, Charest P, Takeda K, et al. (2007) G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol 178: 185-191.
    • (2007) J Cell Biol , vol.178 , pp. 185-191
    • Sasaki, A.1    Janetopoulos, C.2    Lee, S.3    Charest, P.4    Takeda, K.5
  • 70
    • 77950829850 scopus 로고    scopus 로고
    • Transient localized patterns in noise-driven reaction-diffusion systems
    • Hecht I, Kessler D, Levine H, (2010) Transient localized patterns in noise-driven reaction-diffusion systems. Phys Rev Lett 104: 158301-158305.
    • (2010) Phys Rev Lett , vol.104 , pp. 158301-158305
    • Hecht, I.1    Kessler, D.2    Levine, H.3
  • 71
    • 78049265815 scopus 로고    scopus 로고
    • Cells navigate with a local-excitation, global-inhibition-biased excitable network
    • Xiong Y, Huang CH, Iglesias P, Devreotes P, (2010) Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc Natl Acad Sci U S A 107: 17079-17086.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17079-17086
    • Xiong, Y.1    Huang, C.H.2    Iglesias, P.3    Devreotes, P.4
  • 72
    • 77955445443 scopus 로고    scopus 로고
    • Self-organization of the phosphatidylinositol lipids signaling system for random cell migration
    • Arai Y, Shibata T, Matsuoka S, Sato MJ, Yanagida T, et al. (2010) Self-organization of the phosphatidylinositol lipids signaling system for random cell migration. Proc Natl Acad Sci U S A 107: 12399-12404.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12399-12404
    • Arai, Y.1    Shibata, T.2    Matsuoka, S.3    Sato, M.J.4    Yanagida, T.5
  • 74
    • 34547699211 scopus 로고    scopus 로고
    • Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk
    • Jilkine A, Marée AFM, Edelstein-Keshet L, (2007) Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk. Bull Math Biol 69: 1943-1978.
    • (2007) Bull Math Biol , vol.69 , pp. 1943-1978
    • Jilkine, A.1    Marée, A.F.M.2    Edelstein-Keshet, L.3
  • 75
    • 58849123106 scopus 로고    scopus 로고
    • Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a 1D model of a motile cell
    • Dawes A, Edelstein-Keshet L, (2007) Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a 1D model of a motile cell. Biophys J 92: 1-25.
    • (2007) Biophys J , vol.92 , pp. 1-25
    • Dawes, A.1    Edelstein-Keshet, L.2
  • 76
    • 43649095122 scopus 로고    scopus 로고
    • Wave-pinning and cell polarity from a bistable reaction-diffusion system
    • Mori Y, Jilkine A, Edelstein-Keshet L, (2008) Wave-pinning and cell polarity from a bistable reaction-diffusion system. Biophys J 94: 3684-3697.
    • (2008) Biophys J , vol.94 , pp. 3684-3697
    • Mori, Y.1    Jilkine, A.2    Edelstein-Keshet, L.3
  • 77
    • 33846042014 scopus 로고    scopus 로고
    • Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades
    • Markevich N, Tsyganov M, Hoek J, Kholodenko B, (2006) Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades. Mol Syst Biol 2: 61-69.
    • (2006) Mol Syst Biol , vol.2 , pp. 61-69
    • Markevich, N.1    Tsyganov, M.2    Hoek, J.3    Kholodenko, B.4
  • 78
    • 50249178222 scopus 로고    scopus 로고
    • A bistable mechanism for directional sensing
    • Beta C, Amselem G, Bodenschatz E, (2008) A bistable mechanism for directional sensing. New J Phys 10: 083015.
    • (2008) New J Phys , vol.10 , pp. 083015
    • Beta, C.1    Amselem, G.2    Bodenschatz, E.3
  • 79
    • 49649089500 scopus 로고    scopus 로고
    • On the spontaneous emergence of cell polarity
    • Altschuler S, Angenent S, Wang Y, Wu L, (2008) On the spontaneous emergence of cell polarity. Nature 454: 886-9.
    • (2008) Nature , vol.454 , pp. 886-889
    • Altschuler, S.1    Angenent, S.2    Wang, Y.3    Wu, L.4
  • 80
    • 79955563217 scopus 로고    scopus 로고
    • [Master's Thesis] Zurich, ETH Zurich; and Vancouver: IAM, University of British Columbia
    • Walther G, (2010) Stochastic simulation of cell polarization [master's thesis] Zurich ETH Zurich; and Vancouver: IAM, University of British Columbia.
    • (2010) Stochastic Simulation of Cell Polarization
    • Walther, G.1
  • 82
    • 35148873540 scopus 로고    scopus 로고
    • Patch coalescence as a mechanism for eukaryotic directional sensing
    • Gamba A, Kolokolov I, Lebedev V, Orentzi G, (2007) Patch coalescence as a mechanism for eukaryotic directional sensing. Phys Rev Lett 99: 158101-1-158101-4.
    • (2007) Phys Rev Lett , vol.99 , pp. 1-4
    • Gamba, A.1    Kolokolov, I.2    Lebedev, V.3    Orentzi, G.4
  • 83
    • 13344269588 scopus 로고    scopus 로고
    • A local coupling model and compass parameter for eukaryotic chemotaxis
    • Arrieumerlou C, Meyer T, (2005) A local coupling model and compass parameter for eukaryotic chemotaxis. Dev Cell 8: 215-227.
    • (2005) Dev Cell , vol.8 , pp. 215-227
    • Arrieumerlou, C.1    Meyer, T.2
  • 84
    • 78649283328 scopus 로고    scopus 로고
    • A stochastic model for chemotaxis based on the ordered extension of pseudopods
    • Van Haastert P, (2010) A stochastic model for chemotaxis based on the ordered extension of pseudopods. Biophys J 99: 3345-3354.
    • (2010) Biophys J , vol.99 , pp. 3345-3354
    • Van Haastert, P.1
  • 85
    • 70149103973 scopus 로고    scopus 로고
    • Autocatalytic loop, amplification and diffusion: A mathematical and computational model of cell polarization in neural chemotaxis
    • doi:10.1371/journal.pcbi.1000479
    • Causin P, Facchetti G, (2009) Autocatalytic loop, amplification and diffusion: A mathematical and computational model of cell polarization in neural chemotaxis. PLoS Comput Biol 5: e1000479 doi:10.1371/journal.pcbi.1000479.
    • (2009) PLoS Comput Biol , vol.5 , pp. 1000479
    • Causin, P.1    Facchetti, G.2
  • 86
    • 34047218649 scopus 로고    scopus 로고
    • A mathematical model for neutrophil gradient sensing and polarization
    • doi:10.1371/journal.pcbi.0030036
    • Onsum M, Rao CV, (2007) A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput Biol 3: e36 doi:10.1371/journal.pcbi.0030036.
    • (2007) PLoS Comput Biol , vol.3 , pp. 36
    • Onsum, M.1    Rao, C.V.2
  • 87
    • 34347378672 scopus 로고    scopus 로고
    • Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing
    • Xu X, Meier-Schellersheim M, Jian T, (2007) Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing. J Cell Biol 178: 141-153.
    • (2007) J Cell Biol , vol.178 , pp. 141-153
    • Xu, X.1    Meier-Schellersheim, M.2    Jian, T.3
  • 88
    • 71649099053 scopus 로고    scopus 로고
    • Dual modes of Cdc42 recycling fine-tune polarized morphogenesis
    • Slaughter BD, Das A, Schwartz JW, Rubinstein B, Li R, (2009) Dual modes of Cdc42 recycling fine-tune polarized morphogenesis. Dev Cell 17: 823-835.
    • (2009) Dev Cell , vol.17 , pp. 823-835
    • Slaughter, B.D.1    Das, A.2    Schwartz, J.W.3    Rubinstein, B.4    Li, R.5
  • 89
    • 27144517984 scopus 로고    scopus 로고
    • Interlinked fast and slow positive feedback loops drive reliable cell decisions
    • Brandman O, Ferrell JJ, Li R, Meyer T, (2005) Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310: 496-498.
    • (2005) Science , vol.310 , pp. 496-498
    • Brandman, O.1    Ferrell, J.J.2    Li, R.3    Meyer, T.4
  • 90
    • 68049142313 scopus 로고    scopus 로고
    • Adaptive-control model for neutrophil orientation in the direction of chemical gradients
    • Irimia D, Balázsi G, Agrawal N, Toner M, (2009) Adaptive-control model for neutrophil orientation in the direction of chemical gradients. Biophys J 96: 3897-3916.
    • (2009) Biophys J , vol.96 , pp. 3897-3916
    • Irimia, D.1    Balázsi, G.2    Agrawal, N.3    Toner, M.4
  • 91
    • 33750619877 scopus 로고    scopus 로고
    • Potential for control of signaling pathways via cell size and shape
    • Meyers J, Craig J, Odde D, (2006) Potential for control of signaling pathways via cell size and shape. Curr Biol 16: 1685-1693.
    • (2006) Curr Biol , vol.16 , pp. 1685-1693
    • Meyers, J.1    Craig, J.2    Odde, D.3
  • 93
    • 70350070364 scopus 로고    scopus 로고
    • Spatiotemporal control of cell signaling using a light-switchable protein interaction
    • Levskaya A, Weiner O, Lim W, Voigt C, (2009) Spatiotemporal control of cell signaling using a light-switchable protein interaction. Nature 461: 997-1001.
    • (2009) Nature , vol.461 , pp. 997-1001
    • Levskaya, A.1    Weiner, O.2    Lim, W.3    Voigt, C.4
  • 94
    • 69949104482 scopus 로고    scopus 로고
    • Genetically-encoded photoactivatable Rac reveals spatiotemporal coordination of Rac and Rho during cell motility
    • Wu Y, Frey D, Lungu O, Jaehrig A, Schlichting I, et al. (2009) Genetically-encoded photoactivatable Rac reveals spatiotemporal coordination of Rac and Rho during cell motility. Nature 461: 104-110.
    • (2009) Nature , vol.461 , pp. 104-110
    • Wu, Y.1    Frey, D.2    Lungu, O.3    Jaehrig, A.4    Schlichting, I.5
  • 95
    • 76249109093 scopus 로고    scopus 로고
    • Differential regulation of protrusion and polarity by PI(3)K during neutrophil motility in live zebrafish
    • Yoo S, Deng Q, Cavnar P, Wu Y, Hahn K, et al. (2010) Differential regulation of protrusion and polarity by PI(3)K during neutrophil motility in live zebrafish. Dev Cell 18: 226-236.
    • (2010) Dev Cell , vol.18 , pp. 226-236
    • Yoo, S.1    Deng, Q.2    Cavnar, P.3    Wu, Y.4    Hahn, K.5
  • 96
    • 34447263536 scopus 로고    scopus 로고
    • Stochastic signal processing and transduction in chemotactic response of eukaryotic cells
    • Ueda M, Shibata T, (2007) Stochastic signal processing and transduction in chemotactic response of eukaryotic cells. Biophys Journal 93: 11-20.
    • (2007) Biophys Journal , vol.93 , pp. 11-20
    • Ueda, M.1    Shibata, T.2
  • 97
    • 58049221114 scopus 로고    scopus 로고
    • Receptor noise limitations on chemotactic sensing
    • Rappel W, Levine H, (2008) Receptor noise limitations on chemotactic sensing. Proc Natl Acad Sci U S A 105: 19270-19275.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19270-19275
    • Rappel, W.1    Levine, H.2
  • 98
    • 71549171886 scopus 로고    scopus 로고
    • Accuracy of direct gradient sensing by cell-surface receptors
    • Endres R, Wingreen N, (2009) Accuracy of direct gradient sensing by cell-surface receptors. Prog Biophys Mol Biol 100: 33-39.
    • (2009) Prog Biophys Mol Biol , vol.100 , pp. 33-39
    • Endres, R.1    Wingreen, N.2
  • 99
    • 38749131207 scopus 로고    scopus 로고
    • Spatial controls for growth zone formation during the fission yeast cell cycle
    • Csikasz-Nagy A, Gyrffy B, Alt W, Tyson J, Novak B, (2008) Spatial controls for growth zone formation during the fission yeast cell cycle. Yeast 25: 59-69.
    • (2008) Yeast , vol.25 , pp. 59-69
    • Csikasz-Nagy, A.1    Gyrffy, B.2    Alt, W.3    Tyson, J.4    Novak, B.5
  • 100
    • 0347319164 scopus 로고    scopus 로고
    • Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: I. uniform stimulation model and bounds on dimensionless groups
    • Haugh J, Schneider I, (2004) Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: I. uniform stimulation model and bounds on dimensionless groups. Biophys J 86: 589-598.
    • (2004) Biophys J , vol.86 , pp. 589-598
    • Haugh, J.1    Schneider, I.2
  • 101
    • 0347319166 scopus 로고    scopus 로고
    • Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: II: parameter estimates for individual cells from experiments
    • Schneider I, Haugh J, (2004) Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: II: parameter estimates for individual cells from experiments. Biophys J 86: 599-608.
    • (2004) Biophys J , vol.86 , pp. 599-608
    • Schneider, I.1    Haugh, J.2
  • 102
    • 23244462276 scopus 로고    scopus 로고
    • Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological polarity
    • Schneider I, Parrish E, Haugh J, (2005) Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological polarity. Biophys J 89: 1420-1430.
    • (2005) Biophys J , vol.89 , pp. 1420-1430
    • Schneider, I.1    Parrish, E.2    Haugh, J.3
  • 103
    • 0037266984 scopus 로고    scopus 로고
    • Analysis of the signal transduction properties of a module of spatial sensing in eukaryotic chemotaxis
    • Krishnan J, Iglesias P, (2003) Analysis of the signal transduction properties of a module of spatial sensing in eukaryotic chemotaxis. Bull Math Biol 65: 95-128.
    • (2003) Bull Math Biol , vol.65 , pp. 95-128
    • Krishnan, J.1    Iglesias, P.2
  • 104
    • 2642574089 scopus 로고    scopus 로고
    • A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cells
    • Krishnan J, Iglesias P, (2004) A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cells. J Theor Biol 229: 85-99.
    • (2004) J Theor Biol , vol.229 , pp. 85-99
    • Krishnan, J.1    Iglesias, P.2
  • 105
    • 0346688723 scopus 로고    scopus 로고
    • Self-organization of polarized cell signaling via autocrine circuits: Computational model analysis
    • Maly I, Wiley H, Lauffenburger D, (2004) Self-organization of polarized cell signaling via autocrine circuits: Computational model analysis. Biophys J 86: 10-22.
    • (2004) Biophys J , vol.86 , pp. 10-22
    • Maly, I.1    Wiley, H.2    Lauffenburger, D.3
  • 106
    • 33746595848 scopus 로고    scopus 로고
    • Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method
    • doi:10.1371/journal.pcbi.0020082
    • Meier-Schellersheim M, Xu X, Angermann B, Kunkel EJ, Jin T, et al. (2006) Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. PLoS Comput Biol 2: e82 doi:10.1371/journal.pcbi.0020082.
    • (2006) PLoS Comput Biol , vol.2 , pp. 82
    • Meier-Schellersheim, M.1    Xu, X.2    Angermann, B.3    Kunkel, E.J.4    Jin, T.5
  • 107
    • 0037458909 scopus 로고    scopus 로고
    • Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase
    • Wedlich-Soldner R, Altschuter S, Wu L, Li R, (2003) Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science 299: 1231-1235.
    • (2003) Science , vol.299 , pp. 1231-1235
    • Wedlich-Soldner, R.1    Altschuter, S.2    Wu, L.3    Li, R.4
  • 108
    • 0034866573 scopus 로고    scopus 로고
    • A diffusion-translocation model for gradient sensing by chemotactic cells
    • Postma M, Van Haastert P, (2001) A diffusion-translocation model for gradient sensing by chemotactic cells. Biophys J 81: 1314-1323.
    • (2001) Biophys J , vol.81 , pp. 1314-1323
    • Postma, M.1    Van Haastert, P.2
  • 109
    • 23244442051 scopus 로고    scopus 로고
    • A molecular model for axon guidance based on cross talk between Rho GTPases
    • Sakumura Y, Tsukada Y, Yamamoto N, Ishii S, (2005) A molecular model for axon guidance based on cross talk between Rho GTPases. Biophys J 89: 812-822.
    • (2005) Biophys J , vol.89 , pp. 812-822
    • Sakumura, Y.1    Tsukada, Y.2    Yamamoto, N.3    Ishii, S.4
  • 110
    • 21844452715 scopus 로고    scopus 로고
    • Distinguishing modes of eukaryotic gradient sensing
    • Skupsky R, Losert W, Nossal R, (2005) Distinguishing modes of eukaryotic gradient sensing. Biophys J 89: 2806-2823.
    • (2005) Biophys J , vol.89 , pp. 2806-2823
    • Skupsky, R.1    Losert, W.2    Nossal, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.