-
1
-
-
0033605718
-
The role of phosphoinositide 3-kinase lipid products in cell function
-
Rameh L, Cantley L, (1999) The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 274: 8347-8350.
-
(1999)
J Biol Chem
, vol.274
, pp. 8347-8350
-
-
Rameh, L.1
Cantley, L.2
-
2
-
-
35549001736
-
The PAR proteins: Fundamental players in animal cell polarization
-
Goldstein B, Macara I, (2007) The PAR proteins: Fundamental players in animal cell polarization. Dev Cell 13: 609-622.
-
(2007)
Dev Cell
, vol.13
, pp. 609-622
-
-
Goldstein, B.1
Macara, I.2
-
3
-
-
0345731237
-
Cell migration: Rho GTPases lead the way
-
Raftopoulou M, Hall A, (2004) Cell migration: Rho GTPases lead the way. Dev Biol 265: 23-32.
-
(2004)
Dev Biol
, vol.265
, pp. 23-32
-
-
Raftopoulou, M.1
Hall, A.2
-
4
-
-
0024635815
-
Quantitative analysis of cell motility and chemotaxis in dictyostelium discoideum by using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients
-
Fisher P, Merkl R, Gerisch G, (1989) Quantitative analysis of cell motility and chemotaxis in dictyostelium discoideum by using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients. J Cell Biol 108: 973-984.
-
(1989)
J Cell Biol
, vol.108
, pp. 973-984
-
-
Fisher, P.1
Merkl, R.2
Gerisch, G.3
-
5
-
-
0032911044
-
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
-
Servant G, Weiner O, Neptune E, Sedat J, Bourne H, (1999) Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10: 1163-1178.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 1163-1178
-
-
Servant, G.1
Weiner, O.2
Neptune, E.3
Sedat, J.4
Bourne, H.5
-
6
-
-
33747621801
-
Dictyostelium discoideum chemotaxis: threshold for directed motion
-
Song L, Nadkarni S, Bödeker H, Beta C, Bae A, et al. (2006) Dictyostelium discoideum chemotaxis: threshold for directed motion. Eur J Cell Biol 85: 981-989.
-
(2006)
Eur J Cell Biol
, vol.85
, pp. 981-989
-
-
Song, L.1
Nadkarni, S.2
Bödeker, H.3
Beta, C.4
Bae, A.5
-
7
-
-
77953099980
-
External and internal constraints on eukaryotic chemotaxis
-
Fuller D, Chen W, Adler M, Groisman A, Levine H, et al. (2010) External and internal constraints on eukaryotic chemotaxis. Proc Natl Acad Sci U S A 107: 9656-9659.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 9656-9659
-
-
Fuller, D.1
Chen, W.2
Adler, M.3
Groisman, A.4
Levine, H.5
-
8
-
-
0037376655
-
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell
-
Tyson J, Chen K, Novak B, (2003) Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol 15: 221-231.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 221-231
-
-
Tyson, J.1
Chen, K.2
Novak, B.3
-
9
-
-
54249137797
-
Feedback loops shape cellular signals in space and time
-
Brandman O, Meyer T, (2008) Feedback loops shape cellular signals in space and time. Science 322: 390-395.
-
(2008)
Science
, vol.322
, pp. 390-395
-
-
Brandman, O.1
Meyer, T.2
-
11
-
-
33947398366
-
Central roles of small GTPases in the development of cell polarity in yeast and beyond
-
Park HO, Bi E, (2007) Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev 71: 48-96.
-
(2007)
Microbiol Mol Biol Rev
, vol.71
, pp. 48-96
-
-
Park, H.O.1
Bi, E.2
-
12
-
-
0037385661
-
Spontaneous cell polarization: undermining determinism
-
Wedlich-Soldner R, Li R, (2003) Spontaneous cell polarization: undermining determinism. Nat Cell Biol 5: 267-270.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 267-270
-
-
Wedlich-Soldner, R.1
Li, R.2
-
13
-
-
0344394312
-
Scaffold-mediated symmetry breaking by cdc42p
-
Irazoqui J, Gladfelter A, Lew D, (2003) Scaffold-mediated symmetry breaking by cdc42p. Nature Cell Biol 5: 1062-1070.
-
(2003)
Nature Cell Biol
, vol.5
, pp. 1062-1070
-
-
Irazoqui, J.1
Gladfelter, A.2
Lew, D.3
-
14
-
-
4544295912
-
Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling
-
Wedlich-Soldner R, Wai S, Schmidt T, Li R, (2004) Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol 166: 889-900.
-
(2004)
J Cell Biol
, vol.166
, pp. 889-900
-
-
Wedlich-Soldner, R.1
Wai, S.2
Schmidt, T.3
Li, R.4
-
15
-
-
26444469935
-
A system of counteracting feedback loops regulates cdc42p activity during spontaneous cell polarization
-
Ozbudak EM, Becskei A, van Oudenaarden A, (2005) A system of counteracting feedback loops regulates cdc42p activity during spontaneous cell polarization. Dev Cell 9: 565-571.
-
(2005)
Dev Cell
, vol.9
, pp. 565-571
-
-
Ozbudak, E.M.1
Becskei, A.2
van Oudenaarden, A.3
-
16
-
-
47749105334
-
Persistent cell motion in the absence of external signals: A search strategy for eukaryotic cells
-
Li L, Nørrelykke SF, Cox EC, (2008) Persistent cell motion in the absence of external signals: A search strategy for eukaryotic cells. PLoS ONE 3: e2093.
-
(2008)
PLoS ONE
, vol.3
, pp. 2093
-
-
Li, L.1
Nørrelykke, S.F.2
Cox, E.C.3
-
17
-
-
77952955309
-
Understanding eukaryotic chemotaxis: a pseudopod-centred view
-
Insall R, (2010) Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nat Rev Mol Cell Biol 11: 453-458.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 453-458
-
-
Insall, R.1
-
18
-
-
0027772188
-
The locomotion, shape and pseudopodial dynamics of unstimulated dictyostelium cells are not random
-
Killich T, Plath P, Wei X, Bultmann H, Rensing L, et al. (1993) The locomotion, shape and pseudopodial dynamics of unstimulated dictyostelium cells are not random. J Cell Sci 106: 1005-1013.
-
(1993)
J Cell Sci
, vol.106
, pp. 1005-1013
-
-
Killich, T.1
Plath, P.2
Wei, X.3
Bultmann, H.4
Rensing, L.5
-
19
-
-
56649112739
-
Ordered patterns of cell shape and orientational correlation during spontaneous cell migration
-
doi:10.1371/journal.pone.0003734
-
Maeda Y, Inose J, Matsuo M, Iwaya S, Sano M, (2008) Ordered patterns of cell shape and orientational correlation during spontaneous cell migration. PLoS ONE 3: e3734 doi:10.1371/journal.pone.0003734.
-
(2008)
PLoS ONE
, vol.3
, pp. 3734
-
-
Maeda, Y.1
Inose, J.2
Matsuo, M.3
Iwaya, S.4
Sano, M.5
-
20
-
-
33947206045
-
Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
-
Andrew N, Insall R, (2007) Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat Cell Biol 9: 193-200.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 193-200
-
-
Andrew, N.1
Insall, R.2
-
21
-
-
67649197971
-
The ordered extension of pseudopodia by amoeboid cells in the absence of external cues
-
doi:10.1371/journal.pone.0005253
-
Bosgraaf L, Van Haastert P, (2009) The ordered extension of pseudopodia by amoeboid cells in the absence of external cues. PLoS ONE 4: e5253 doi:10.1371/journal.pone.0005253.
-
(2009)
PLoS ONE
, vol.4
, pp. 5253
-
-
Bosgraaf, L.1
Van Haastert, P.2
-
22
-
-
2942687012
-
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
-
Janetopoulos C, Ma L, Devreotes PN, Iglesias PA, (2004) Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A 101: 8951-8956.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8951-8956
-
-
Janetopoulos, C.1
Ma, L.2
Devreotes, P.N.3
Iglesias, P.A.4
-
23
-
-
0344012465
-
Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia
-
Postma M, Roelofs J, Goedhart J, Gadella T, Visser A, et al. (2003) Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia. Mol Biol Cell 14: 5019-5027.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 5019-5027
-
-
Postma, M.1
Roelofs, J.2
Goedhart, J.3
Gadella, T.4
Visser, A.5
-
24
-
-
38549134374
-
Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation
-
Dalous J, Burghardt E, Müller-Taubenberger A, Bruckert F, Gerisch G, et al. (2008) Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation. Biophys J 94: 1063-1074.
-
(2008)
Biophys J
, vol.94
, pp. 1063-1074
-
-
Dalous, J.1
Burghardt, E.2
Müller-Taubenberger, A.3
Bruckert, F.4
Gerisch, G.5
-
25
-
-
0033617576
-
A cell's sense of direction
-
Parent C, Devreotes P, (1999) A cell's sense of direction. Science 284: 765-770.
-
(1999)
Science
, vol.284
, pp. 765-770
-
-
Parent, C.1
Devreotes, P.2
-
26
-
-
0037743735
-
Eukaryotic chemotaxis: Distinctions between directional sensing and polarization
-
Devreotes P, Janetopoulos C, (2003) Eukaryotic chemotaxis: Distinctions between directional sensing and polarization. J Biol Chem 278: 20445-20448.
-
(2003)
J Biol Chem
, vol.278
, pp. 20445-20448
-
-
Devreotes, P.1
Janetopoulos, C.2
-
27
-
-
33748269657
-
Signaling pathways mediating chemotaxis in the social amoeba, dictyostelium discoideum
-
Willard S, Devreotes P, (2006) Signaling pathways mediating chemotaxis in the social amoeba, dictyostelium discoideum. Eur J Cell Biol 85: 897-904.
-
(2006)
Eur J Cell Biol
, vol.85
, pp. 897-904
-
-
Willard, S.1
Devreotes, P.2
-
28
-
-
0035282887
-
The Dictyostelium discoideum family of Rho-related proteins
-
Rivero F, Dislich H, Glockner G, Noegel A, (2001) The Dictyostelium discoideum family of Rho-related proteins. Nucleic Acids Res 29: 1068-1079.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 1068-1079
-
-
Rivero, F.1
Dislich, H.2
Glockner, G.3
Noegel, A.4
-
29
-
-
33947718091
-
Rap1 controls cell adhesion and cell motility through the regulation of myosin II
-
Jeon T, Lee DJ, Merlot S, Weeks G, Firtel R, (2007) Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J Cell Biol 176: 1021-1033.
-
(2007)
J Cell Biol
, vol.176
, pp. 1021-1033
-
-
Jeon, T.1
Lee, D.J.2
Merlot, S.3
Weeks, G.4
Firtel, R.5
-
30
-
-
0033143333
-
Spatial control of actin polymerization during neutrophil chemotaxis
-
Weiner O, Servant G, Welch M, Mitchison T, Sedat J, et al. (1999) Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol 1: 75-81.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 75-81
-
-
Weiner, O.1
Servant, G.2
Welch, M.3
Mitchison, T.4
Sedat, J.5
-
31
-
-
0042354714
-
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
-
Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, et al. (2003) Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114: 201-214.
-
(2003)
Cell
, vol.114
, pp. 201-214
-
-
Xu, J.1
Wang, F.2
Van Keymeulen, A.3
Herzmark, P.4
Straight, A.5
-
32
-
-
28644445999
-
Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration
-
Bodin S, Welch M, (2005) Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration. Mol Biol Cell 16: 5773-5783.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 5773-5783
-
-
Bodin, S.1
Welch, M.2
-
33
-
-
33644865751
-
Neutrophil polarization: Spatiotemporal dynamics of RhoA activity support a self-organizing mechanism
-
Wong K, Pertz O, Hahn K, Bourne H, (2006) Neutrophil polarization: Spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc Natl Acad Sci USA 103: 3639-3644.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3639-3644
-
-
Wong, K.1
Pertz, O.2
Hahn, K.3
Bourne, H.4
-
34
-
-
33746648129
-
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
-
Van Keymeulen A, Wong K, Knight Z, Govaerts C, Hahn K, et al. (2006) To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol 174: 437-445.
-
(2006)
J Cell Biol
, vol.174
, pp. 437-445
-
-
Van Keymeulen, A.1
Wong, K.2
Knight, Z.3
Govaerts, C.4
Hahn, K.5
-
35
-
-
1642328487
-
Making all the right moves: chemotaxis in neutrophils and Dictyostelium
-
Parent C, (2004) Making all the right moves: chemotaxis in neutrophils and Dictyostelium. Curr Opin Cell Biol 16: 4-13.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 4-13
-
-
Parent, C.1
-
36
-
-
28544448768
-
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
-
Schneider I, Haugh J, (2005) Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts. J Cell Biol 171: 883-892.
-
(2005)
J Cell Biol
, vol.171
, pp. 883-892
-
-
Schneider, I.1
Haugh, J.2
-
37
-
-
65249089072
-
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts
-
Weiger M, Wang CC, Krajcovic M, Melvin A, Rhoden J, et al. (2009) Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts. J Cell Sci 122: 313-323.
-
(2009)
J Cell Sci
, vol.122
, pp. 313-323
-
-
Weiger, M.1
Wang, C.C.2
Krajcovic, M.3
Melvin, A.4
Rhoden, J.5
-
38
-
-
0032559362
-
Rho GTPases and the actin cytoskeleton
-
Hall A, (1998) Rho GTPases and the actin cytoskeleton. Science 279: 509-514.
-
(1998)
Science
, vol.279
, pp. 509-514
-
-
Hall, A.1
-
39
-
-
0036308972
-
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
-
Weiner O, Neilsen P, Prestwich G, Kirschner M, Cantley L, et al. (2002) A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4: 509-512.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 509-512
-
-
Weiner, O.1
Neilsen, P.2
Prestwich, G.3
Kirschner, M.4
Cantley, L.5
-
41
-
-
34548103595
-
Mechanisms of gradient detection: A comparison of axon pathfinding with eukaryotic cell migration
-
San Diego, Academic Press
-
von Philipsborn A, Bastmeyer M, (2007) Mechanisms of gradient detection: A comparison of axon pathfinding with eukaryotic cell migration. A survey of cell biology. Volume 263 San Diego Academic Press pp. 1-62.
-
(2007)
A Survey of Cell Biology
, vol.263
, pp. 1-62
-
-
von Philipsborn, A.1
Bastmeyer, M.2
-
42
-
-
68249083818
-
Migration of cortical interneurons relies on branched leading process dynamics
-
Valiente M, Martini F, (2009) Migration of cortical interneurons relies on branched leading process dynamics. Cell Adh Migr 3: 278-280.
-
(2009)
Cell Adh Migr
, vol.3
, pp. 278-280
-
-
Valiente, M.1
Martini, F.2
-
43
-
-
0032901710
-
Self-polarization and directional motility of cytoplasm
-
Verkhovsky AB, Svitkina TM, Borisy GG, (1999) Self-polarization and directional motility of cytoplasm. Curr Biol 9: 11-20.
-
(1999)
Curr Biol
, vol.9
, pp. 11-20
-
-
Verkhovsky, A.B.1
Svitkina, T.M.2
Borisy, G.G.3
-
44
-
-
34748878938
-
Actin myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility
-
Yam P, Wilson C, Ji L, Hebert B, Barnhart E, et al. (2007) Actin myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility. J Cell Biol 178: 1207-1221.
-
(2007)
J Cell Biol
, vol.178
, pp. 1207-1221
-
-
Yam, P.1
Wilson, C.2
Ji, L.3
Hebert, B.4
Barnhart, E.5
-
45
-
-
39149118309
-
Navigating through models of chemotaxis
-
Iglesias P, Devreotes P, (2008) Navigating through models of chemotaxis. Curr Opin Cell Biol 20: 35-40.
-
(2008)
Curr Opin Cell Biol
, vol.20
, pp. 35-40
-
-
Iglesias, P.1
Devreotes, P.2
-
46
-
-
79955566080
-
Signaling pathways that control cell migration: models and analysis
-
Welf ES, Haugh JM, (2011) Signaling pathways that control cell migration: models and analysis. Wiley Interdiscip Rev Syst Biol Med 3: 231-240.
-
(2011)
Wiley Interdiscip Rev Syst Biol Med
, vol.3
, pp. 231-240
-
-
Welf, E.S.1
Haugh, J.M.2
-
48
-
-
0015454185
-
A theory of biological pattern formation
-
Gierer A, Meinhardt H, (1972) A theory of biological pattern formation. Kybernetik 12: 30-39.
-
(1972)
Kybernetik
, vol.12
, pp. 30-39
-
-
Gierer, A.1
Meinhardt, H.2
-
49
-
-
0016209638
-
Application of a theory of biological pattern formation based on lateral inhibition
-
Meinhardt H, Gierer A, (1974) Application of a theory of biological pattern formation based on lateral inhibition. J Cell Sci 15: 321-346.
-
(1974)
J Cell Sci
, vol.15
, pp. 321-346
-
-
Meinhardt, H.1
Gierer, A.2
-
50
-
-
0032823984
-
Orientation of chemotactic cells and growth cones: models and mechanisms
-
Meinhardt H, (1999) Orientation of chemotactic cells and growth cones: models and mechanisms. J Cell Sci 112: 2867-2874.
-
(1999)
J Cell Sci
, vol.112
, pp. 2867-2874
-
-
Meinhardt, H.1
-
51
-
-
4444271530
-
A mechanistic model for eukaryotic gradient sensing: Spontaneous and induced phosphoinositide polarization
-
Subramanian K, Narang A, (2004) A mechanistic model for eukaryotic gradient sensing: Spontaneous and induced phosphoinositide polarization. J Theor Biol 231: 49-67.
-
(2004)
J Theor Biol
, vol.231
, pp. 49-67
-
-
Subramanian, K.1
Narang, A.2
-
52
-
-
33646764616
-
Spontaneous polarization in eukaryotic gradient sensing: A mathematical model based on mutual inhibition of frontness and backness pathways
-
Narang A, (2006) Spontaneous polarization in eukaryotic gradient sensing: A mathematical model based on mutual inhibition of frontness and backness pathways. J Theor Biol 240: 538-553.
-
(2006)
J Theor Biol
, vol.240
, pp. 538-553
-
-
Narang, A.1
-
53
-
-
34347352254
-
A mass conserved reaction-diffusion system captures properties of cell polarity
-
doi:10.1371/journal.pcbi.0030108
-
Otsuji M, Ishihara S, Co C, Kaibuchi K, Mochizuki A, et al. (2007) A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol 3: e108 doi:10.1371/journal.pcbi.0030108.
-
(2007)
PLoS Comput Biol
, vol.3
, pp. 108
-
-
Otsuji, M.1
Ishihara, S.2
Co, C.3
Kaibuchi, K.4
Mochizuki, A.5
-
54
-
-
42049115235
-
Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity
-
Goryachev A, Pokhilko A, (2008) Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Lett 582: 1437-1443.
-
(2008)
FEBS Lett
, vol.582
, pp. 1437-1443
-
-
Goryachev, A.1
Pokhilko, A.2
-
55
-
-
60749120831
-
Calling heads from tails: the role of mathematical modeling in understanding cell polarization
-
Onsum M, Rao CV, (2009) Calling heads from tails: the role of mathematical modeling in understanding cell polarization. Curr Opin Cell Biol 21: 74-81.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 74-81
-
-
Onsum, M.1
Rao, C.V.2
-
56
-
-
34147175165
-
Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity
-
Marco E, Wedlich-Soldner R, Li R, Altschuler S, Wu L, (2007) Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell 129: 411-422.
-
(2007)
Cell
, vol.129
, pp. 411-422
-
-
Marco, E.1
Wedlich-Soldner, R.2
Li, R.3
Altschuler, S.4
Wu, L.5
-
57
-
-
0036532226
-
Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability
-
Ferrell J Jr, (2002) Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 14: 140-148.
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 140-148
-
-
Ferrell Jr., J.1
-
58
-
-
0034741649
-
A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics
-
Narang A, Subramanian K, Lauffenburger D, (2001) A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics. Ann Biomed Eng 29: 677-691.
-
(2001)
Ann Biomed Eng
, vol.29
, pp. 677-691
-
-
Narang, A.1
Subramanian, K.2
Lauffenburger, D.3
-
59
-
-
70350784148
-
Singularity in polarization: Rewiring yeast cells to make two buds
-
Howell A, Savage N, Johnson S, Bose I, Wagner A, et al. (2009) Singularity in polarization: Rewiring yeast cells to make two buds. Cell 139: 731-743.
-
(2009)
Cell
, vol.139
, pp. 731-743
-
-
Howell, A.1
Savage, N.2
Johnson, S.3
Bose, I.4
Wagner, A.5
-
60
-
-
0037015118
-
Modeling the cell's guidance system
-
Iglesias P, Levchenko A, (2002) Modeling the cell's guidance system. Sci STKE 2002: RE12.
-
(2002)
Sci STKE
, vol.2002
, pp. 12
-
-
Iglesias, P.1
Levchenko, A.2
-
61
-
-
0036219106
-
Models of eukaryotic gradient sensing: Application to chemotaxis of amoebae and neutrophils
-
Levchenko A, Iglesias P, (2002) Models of eukaryotic gradient sensing: Application to chemotaxis of amoebae and neutrophils. Biophys J 82: 50-63.
-
(2002)
Biophys J
, vol.82
, pp. 50-63
-
-
Levchenko, A.1
Iglesias, P.2
-
62
-
-
10044250005
-
Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P-3 response in Dictyostelium cells
-
Ma L, Janetopoulos C, Yang L, Devreotes P, Iglesias P, (2004) Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P-3 response in Dictyostelium cells. Biophys J 87: 3764-3774.
-
(2004)
Biophys J
, vol.87
, pp. 3764-3774
-
-
Ma, L.1
Janetopoulos, C.2
Yang, L.3
Devreotes, P.4
Iglesias, P.5
-
63
-
-
33745594814
-
Directional sensing in eukaryotic chemotaxis: A balanced inactivation model
-
Levine H, Kessler DA, Rappel WJ, (2006) Directional sensing in eukaryotic chemotaxis: A balanced inactivation model. Proc Natl Acad Sci USA 103: 9761-9766.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9761-9766
-
-
Levine, H.1
Kessler, D.A.2
Rappel, W.J.3
-
64
-
-
33846815127
-
Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells
-
Krishnan J, Iglesias P, (2007) Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells. Biophys J 92: 816-830.
-
(2007)
Biophys J
, vol.92
, pp. 816-830
-
-
Krishnan, J.1
Iglesias, P.2
-
65
-
-
44449172361
-
Directional sensing during chemotaxis
-
Janetopoulos C, Firtel RA, (2008) Directional sensing during chemotaxis. FEBS Lett 582: 2075-2085.
-
(2008)
FEBS Lett
, vol.582
, pp. 2075-2085
-
-
Janetopoulos, C.1
Firtel, R.A.2
-
66
-
-
34247361650
-
Chemotaxis in the absence of PIP3 gradients
-
Hoeller O, Kay R, (2007) Chemotaxis in the absence of PIP3 gradients. Curr Biol 17: 813-817.
-
(2007)
Curr Biol
, vol.17
, pp. 813-817
-
-
Hoeller, O.1
Kay, R.2
-
67
-
-
67649305121
-
The three-dimensional dynamics of actin waves, a model of cytoskeletal self-organization
-
Bretschneider T, Anderson K, Ecke M, Müller-Taubenberger A, Schroth-Diez B, et al. (2009) The three-dimensional dynamics of actin waves, a model of cytoskeletal self-organization. Biophys J 96: 2888-2900.
-
(2009)
Biophys J
, vol.96
, pp. 2888-2900
-
-
Bretschneider, T.1
Anderson, K.2
Ecke, M.3
Müller-Taubenberger, A.4
Schroth-Diez, B.5
-
68
-
-
34548703094
-
An actin-based wave generator organizes cell motility
-
doi:10.1371/journal.pbio.0050221
-
Weiner O, Marganski W, Wu L, Altschuler S, Kirschner M, (2007) An actin-based wave generator organizes cell motility. PLoS Biol 5: e221 doi:10.1371/journal.pbio.0050221.
-
(2007)
PLoS Biol
, vol.5
, pp. 221
-
-
Weiner, O.1
Marganski, W.2
Wu, L.3
Altschuler, S.4
Kirschner, M.5
-
69
-
-
34447504022
-
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility
-
Sasaki A, Janetopoulos C, Lee S, Charest P, Takeda K, et al. (2007) G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol 178: 185-191.
-
(2007)
J Cell Biol
, vol.178
, pp. 185-191
-
-
Sasaki, A.1
Janetopoulos, C.2
Lee, S.3
Charest, P.4
Takeda, K.5
-
70
-
-
77950829850
-
Transient localized patterns in noise-driven reaction-diffusion systems
-
Hecht I, Kessler D, Levine H, (2010) Transient localized patterns in noise-driven reaction-diffusion systems. Phys Rev Lett 104: 158301-158305.
-
(2010)
Phys Rev Lett
, vol.104
, pp. 158301-158305
-
-
Hecht, I.1
Kessler, D.2
Levine, H.3
-
71
-
-
78049265815
-
Cells navigate with a local-excitation, global-inhibition-biased excitable network
-
Xiong Y, Huang CH, Iglesias P, Devreotes P, (2010) Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc Natl Acad Sci U S A 107: 17079-17086.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 17079-17086
-
-
Xiong, Y.1
Huang, C.H.2
Iglesias, P.3
Devreotes, P.4
-
72
-
-
77955445443
-
Self-organization of the phosphatidylinositol lipids signaling system for random cell migration
-
Arai Y, Shibata T, Matsuoka S, Sato MJ, Yanagida T, et al. (2010) Self-organization of the phosphatidylinositol lipids signaling system for random cell migration. Proc Natl Acad Sci U S A 107: 12399-12404.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 12399-12404
-
-
Arai, Y.1
Shibata, T.2
Matsuoka, S.3
Sato, M.J.4
Yanagida, T.5
-
73
-
-
33745608331
-
Polarisation and movement of keratocytes: a multiscale modelling approach
-
Marée A, Jilkine A, Dawes A, Grieneisen V, Edelstein-Keshet L, (2006) Polarisation and movement of keratocytes: a multiscale modelling approach. Bull Math Biol 68: 1169-1211.
-
(2006)
Bull Math Biol
, vol.68
, pp. 1169-1211
-
-
Marée, A.1
Jilkine, A.2
Dawes, A.3
Grieneisen, V.4
Edelstein-Keshet, L.5
-
74
-
-
34547699211
-
Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk
-
Jilkine A, Marée AFM, Edelstein-Keshet L, (2007) Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk. Bull Math Biol 69: 1943-1978.
-
(2007)
Bull Math Biol
, vol.69
, pp. 1943-1978
-
-
Jilkine, A.1
Marée, A.F.M.2
Edelstein-Keshet, L.3
-
75
-
-
58849123106
-
Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a 1D model of a motile cell
-
Dawes A, Edelstein-Keshet L, (2007) Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a 1D model of a motile cell. Biophys J 92: 1-25.
-
(2007)
Biophys J
, vol.92
, pp. 1-25
-
-
Dawes, A.1
Edelstein-Keshet, L.2
-
76
-
-
43649095122
-
Wave-pinning and cell polarity from a bistable reaction-diffusion system
-
Mori Y, Jilkine A, Edelstein-Keshet L, (2008) Wave-pinning and cell polarity from a bistable reaction-diffusion system. Biophys J 94: 3684-3697.
-
(2008)
Biophys J
, vol.94
, pp. 3684-3697
-
-
Mori, Y.1
Jilkine, A.2
Edelstein-Keshet, L.3
-
77
-
-
33846042014
-
Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades
-
Markevich N, Tsyganov M, Hoek J, Kholodenko B, (2006) Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades. Mol Syst Biol 2: 61-69.
-
(2006)
Mol Syst Biol
, vol.2
, pp. 61-69
-
-
Markevich, N.1
Tsyganov, M.2
Hoek, J.3
Kholodenko, B.4
-
78
-
-
50249178222
-
A bistable mechanism for directional sensing
-
Beta C, Amselem G, Bodenschatz E, (2008) A bistable mechanism for directional sensing. New J Phys 10: 083015.
-
(2008)
New J Phys
, vol.10
, pp. 083015
-
-
Beta, C.1
Amselem, G.2
Bodenschatz, E.3
-
79
-
-
49649089500
-
On the spontaneous emergence of cell polarity
-
Altschuler S, Angenent S, Wang Y, Wu L, (2008) On the spontaneous emergence of cell polarity. Nature 454: 886-9.
-
(2008)
Nature
, vol.454
, pp. 886-889
-
-
Altschuler, S.1
Angenent, S.2
Wang, Y.3
Wu, L.4
-
80
-
-
79955563217
-
-
[Master's Thesis] Zurich, ETH Zurich; and Vancouver: IAM, University of British Columbia
-
Walther G, (2010) Stochastic simulation of cell polarization [master's thesis] Zurich ETH Zurich; and Vancouver: IAM, University of British Columbia.
-
(2010)
Stochastic Simulation of Cell Polarization
-
-
Walther, G.1
-
81
-
-
28044473385
-
Diffusion-limited phase separation in eukaryotic chemotaxis
-
Gamba A, de Candia A, Di Talia S, Coniglio A, Bussolino F, et al. (2005) Diffusion-limited phase separation in eukaryotic chemotaxis. Proc Natl Acad Sci U S A 102: 16927-16932.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 16927-16932
-
-
Gamba, A.1
de Candia, A.2
Di Talia, S.3
Coniglio, A.4
Bussolino, F.5
-
82
-
-
35148873540
-
Patch coalescence as a mechanism for eukaryotic directional sensing
-
Gamba A, Kolokolov I, Lebedev V, Orentzi G, (2007) Patch coalescence as a mechanism for eukaryotic directional sensing. Phys Rev Lett 99: 158101-1-158101-4.
-
(2007)
Phys Rev Lett
, vol.99
, pp. 1-4
-
-
Gamba, A.1
Kolokolov, I.2
Lebedev, V.3
Orentzi, G.4
-
83
-
-
13344269588
-
A local coupling model and compass parameter for eukaryotic chemotaxis
-
Arrieumerlou C, Meyer T, (2005) A local coupling model and compass parameter for eukaryotic chemotaxis. Dev Cell 8: 215-227.
-
(2005)
Dev Cell
, vol.8
, pp. 215-227
-
-
Arrieumerlou, C.1
Meyer, T.2
-
84
-
-
78649283328
-
A stochastic model for chemotaxis based on the ordered extension of pseudopods
-
Van Haastert P, (2010) A stochastic model for chemotaxis based on the ordered extension of pseudopods. Biophys J 99: 3345-3354.
-
(2010)
Biophys J
, vol.99
, pp. 3345-3354
-
-
Van Haastert, P.1
-
85
-
-
70149103973
-
Autocatalytic loop, amplification and diffusion: A mathematical and computational model of cell polarization in neural chemotaxis
-
doi:10.1371/journal.pcbi.1000479
-
Causin P, Facchetti G, (2009) Autocatalytic loop, amplification and diffusion: A mathematical and computational model of cell polarization in neural chemotaxis. PLoS Comput Biol 5: e1000479 doi:10.1371/journal.pcbi.1000479.
-
(2009)
PLoS Comput Biol
, vol.5
, pp. 1000479
-
-
Causin, P.1
Facchetti, G.2
-
86
-
-
34047218649
-
A mathematical model for neutrophil gradient sensing and polarization
-
doi:10.1371/journal.pcbi.0030036
-
Onsum M, Rao CV, (2007) A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput Biol 3: e36 doi:10.1371/journal.pcbi.0030036.
-
(2007)
PLoS Comput Biol
, vol.3
, pp. 36
-
-
Onsum, M.1
Rao, C.V.2
-
87
-
-
34347378672
-
Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing
-
Xu X, Meier-Schellersheim M, Jian T, (2007) Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing. J Cell Biol 178: 141-153.
-
(2007)
J Cell Biol
, vol.178
, pp. 141-153
-
-
Xu, X.1
Meier-Schellersheim, M.2
Jian, T.3
-
88
-
-
71649099053
-
Dual modes of Cdc42 recycling fine-tune polarized morphogenesis
-
Slaughter BD, Das A, Schwartz JW, Rubinstein B, Li R, (2009) Dual modes of Cdc42 recycling fine-tune polarized morphogenesis. Dev Cell 17: 823-835.
-
(2009)
Dev Cell
, vol.17
, pp. 823-835
-
-
Slaughter, B.D.1
Das, A.2
Schwartz, J.W.3
Rubinstein, B.4
Li, R.5
-
89
-
-
27144517984
-
Interlinked fast and slow positive feedback loops drive reliable cell decisions
-
Brandman O, Ferrell JJ, Li R, Meyer T, (2005) Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310: 496-498.
-
(2005)
Science
, vol.310
, pp. 496-498
-
-
Brandman, O.1
Ferrell, J.J.2
Li, R.3
Meyer, T.4
-
90
-
-
68049142313
-
Adaptive-control model for neutrophil orientation in the direction of chemical gradients
-
Irimia D, Balázsi G, Agrawal N, Toner M, (2009) Adaptive-control model for neutrophil orientation in the direction of chemical gradients. Biophys J 96: 3897-3916.
-
(2009)
Biophys J
, vol.96
, pp. 3897-3916
-
-
Irimia, D.1
Balázsi, G.2
Agrawal, N.3
Toner, M.4
-
91
-
-
33750619877
-
Potential for control of signaling pathways via cell size and shape
-
Meyers J, Craig J, Odde D, (2006) Potential for control of signaling pathways via cell size and shape. Curr Biol 16: 1685-1693.
-
(2006)
Curr Biol
, vol.16
, pp. 1685-1693
-
-
Meyers, J.1
Craig, J.2
Odde, D.3
-
92
-
-
0037043341
-
Effects of cell tension on the small GTPase Rac
-
Katsumi A, Kiosses MilaniniWJ, del Pozo M, Kaunas R, Chien S, et al. (2002) Effects of cell tension on the small GTPase Rac. J Cell Biol 158: 153-164.
-
(2002)
J Cell Biol
, vol.158
, pp. 153-164
-
-
Katsumi, A.1
Kiosses Milanini, W.J.2
del Pozo, M.3
Kaunas, R.4
Chien, S.5
-
93
-
-
70350070364
-
Spatiotemporal control of cell signaling using a light-switchable protein interaction
-
Levskaya A, Weiner O, Lim W, Voigt C, (2009) Spatiotemporal control of cell signaling using a light-switchable protein interaction. Nature 461: 997-1001.
-
(2009)
Nature
, vol.461
, pp. 997-1001
-
-
Levskaya, A.1
Weiner, O.2
Lim, W.3
Voigt, C.4
-
94
-
-
69949104482
-
Genetically-encoded photoactivatable Rac reveals spatiotemporal coordination of Rac and Rho during cell motility
-
Wu Y, Frey D, Lungu O, Jaehrig A, Schlichting I, et al. (2009) Genetically-encoded photoactivatable Rac reveals spatiotemporal coordination of Rac and Rho during cell motility. Nature 461: 104-110.
-
(2009)
Nature
, vol.461
, pp. 104-110
-
-
Wu, Y.1
Frey, D.2
Lungu, O.3
Jaehrig, A.4
Schlichting, I.5
-
95
-
-
76249109093
-
Differential regulation of protrusion and polarity by PI(3)K during neutrophil motility in live zebrafish
-
Yoo S, Deng Q, Cavnar P, Wu Y, Hahn K, et al. (2010) Differential regulation of protrusion and polarity by PI(3)K during neutrophil motility in live zebrafish. Dev Cell 18: 226-236.
-
(2010)
Dev Cell
, vol.18
, pp. 226-236
-
-
Yoo, S.1
Deng, Q.2
Cavnar, P.3
Wu, Y.4
Hahn, K.5
-
96
-
-
34447263536
-
Stochastic signal processing and transduction in chemotactic response of eukaryotic cells
-
Ueda M, Shibata T, (2007) Stochastic signal processing and transduction in chemotactic response of eukaryotic cells. Biophys Journal 93: 11-20.
-
(2007)
Biophys Journal
, vol.93
, pp. 11-20
-
-
Ueda, M.1
Shibata, T.2
-
97
-
-
58049221114
-
Receptor noise limitations on chemotactic sensing
-
Rappel W, Levine H, (2008) Receptor noise limitations on chemotactic sensing. Proc Natl Acad Sci U S A 105: 19270-19275.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 19270-19275
-
-
Rappel, W.1
Levine, H.2
-
98
-
-
71549171886
-
Accuracy of direct gradient sensing by cell-surface receptors
-
Endres R, Wingreen N, (2009) Accuracy of direct gradient sensing by cell-surface receptors. Prog Biophys Mol Biol 100: 33-39.
-
(2009)
Prog Biophys Mol Biol
, vol.100
, pp. 33-39
-
-
Endres, R.1
Wingreen, N.2
-
99
-
-
38749131207
-
Spatial controls for growth zone formation during the fission yeast cell cycle
-
Csikasz-Nagy A, Gyrffy B, Alt W, Tyson J, Novak B, (2008) Spatial controls for growth zone formation during the fission yeast cell cycle. Yeast 25: 59-69.
-
(2008)
Yeast
, vol.25
, pp. 59-69
-
-
Csikasz-Nagy, A.1
Gyrffy, B.2
Alt, W.3
Tyson, J.4
Novak, B.5
-
100
-
-
0347319164
-
Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: I. uniform stimulation model and bounds on dimensionless groups
-
Haugh J, Schneider I, (2004) Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: I. uniform stimulation model and bounds on dimensionless groups. Biophys J 86: 589-598.
-
(2004)
Biophys J
, vol.86
, pp. 589-598
-
-
Haugh, J.1
Schneider, I.2
-
101
-
-
0347319166
-
Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: II: parameter estimates for individual cells from experiments
-
Schneider I, Haugh J, (2004) Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: II: parameter estimates for individual cells from experiments. Biophys J 86: 599-608.
-
(2004)
Biophys J
, vol.86
, pp. 599-608
-
-
Schneider, I.1
Haugh, J.2
-
102
-
-
23244462276
-
Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological polarity
-
Schneider I, Parrish E, Haugh J, (2005) Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological polarity. Biophys J 89: 1420-1430.
-
(2005)
Biophys J
, vol.89
, pp. 1420-1430
-
-
Schneider, I.1
Parrish, E.2
Haugh, J.3
-
103
-
-
0037266984
-
Analysis of the signal transduction properties of a module of spatial sensing in eukaryotic chemotaxis
-
Krishnan J, Iglesias P, (2003) Analysis of the signal transduction properties of a module of spatial sensing in eukaryotic chemotaxis. Bull Math Biol 65: 95-128.
-
(2003)
Bull Math Biol
, vol.65
, pp. 95-128
-
-
Krishnan, J.1
Iglesias, P.2
-
104
-
-
2642574089
-
A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cells
-
Krishnan J, Iglesias P, (2004) A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cells. J Theor Biol 229: 85-99.
-
(2004)
J Theor Biol
, vol.229
, pp. 85-99
-
-
Krishnan, J.1
Iglesias, P.2
-
105
-
-
0346688723
-
Self-organization of polarized cell signaling via autocrine circuits: Computational model analysis
-
Maly I, Wiley H, Lauffenburger D, (2004) Self-organization of polarized cell signaling via autocrine circuits: Computational model analysis. Biophys J 86: 10-22.
-
(2004)
Biophys J
, vol.86
, pp. 10-22
-
-
Maly, I.1
Wiley, H.2
Lauffenburger, D.3
-
106
-
-
33746595848
-
Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method
-
doi:10.1371/journal.pcbi.0020082
-
Meier-Schellersheim M, Xu X, Angermann B, Kunkel EJ, Jin T, et al. (2006) Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. PLoS Comput Biol 2: e82 doi:10.1371/journal.pcbi.0020082.
-
(2006)
PLoS Comput Biol
, vol.2
, pp. 82
-
-
Meier-Schellersheim, M.1
Xu, X.2
Angermann, B.3
Kunkel, E.J.4
Jin, T.5
-
107
-
-
0037458909
-
Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase
-
Wedlich-Soldner R, Altschuter S, Wu L, Li R, (2003) Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science 299: 1231-1235.
-
(2003)
Science
, vol.299
, pp. 1231-1235
-
-
Wedlich-Soldner, R.1
Altschuter, S.2
Wu, L.3
Li, R.4
-
108
-
-
0034866573
-
A diffusion-translocation model for gradient sensing by chemotactic cells
-
Postma M, Van Haastert P, (2001) A diffusion-translocation model for gradient sensing by chemotactic cells. Biophys J 81: 1314-1323.
-
(2001)
Biophys J
, vol.81
, pp. 1314-1323
-
-
Postma, M.1
Van Haastert, P.2
-
109
-
-
23244442051
-
A molecular model for axon guidance based on cross talk between Rho GTPases
-
Sakumura Y, Tsukada Y, Yamamoto N, Ishii S, (2005) A molecular model for axon guidance based on cross talk between Rho GTPases. Biophys J 89: 812-822.
-
(2005)
Biophys J
, vol.89
, pp. 812-822
-
-
Sakumura, Y.1
Tsukada, Y.2
Yamamoto, N.3
Ishii, S.4
-
110
-
-
21844452715
-
Distinguishing modes of eukaryotic gradient sensing
-
Skupsky R, Losert W, Nossal R, (2005) Distinguishing modes of eukaryotic gradient sensing. Biophys J 89: 2806-2823.
-
(2005)
Biophys J
, vol.89
, pp. 2806-2823
-
-
Skupsky, R.1
Losert, W.2
Nossal, R.3
|