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Volumn 16, Issue 1, 2004, Pages 4-13

Making all the right moves: Chemotaxis in neutrophils and Dictyostelium

Author keywords

cGMP binding protein; CRAC; Cytosolic regulator of adenylyl cyclase; Gbp; GEF; Guanine nucleotide exchange factor; P Rex; p21 activated kinases; PAK; PAK interacting exchange factor; PH; PH domain containing protein A; PhdA; PIX ; Pleckstrin homology

Indexed keywords

CHEMOATTRACTANT; ENZYME INHIBITOR; F ACTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; MYOSIN II; RAC PROTEIN;

EID: 1642328487     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2003.11.008     Document Type: Review
Times cited : (169)

References (67)
  • 1
    • 0033617576 scopus 로고    scopus 로고
    • A cell's sense of direction
    • Parent C.A., Devreotes P.N. A cell's sense of direction. Science. 284:1999;765-770.
    • (1999) Science , vol.284 , pp. 765-770
    • Parent, C.A.1    Devreotes, P.N.2
  • 2
    • 0036532115 scopus 로고    scopus 로고
    • Regulation of cell polarity during eukaryotic chemotaxis: The chemotactic compass
    • Weiner O.D. Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr. Opin. Cell Biol. 14:2002;196-202.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 196-202
    • Weiner, O.D.1
  • 3
    • 0037567299 scopus 로고    scopus 로고
    • The signal to move: D. discoideum go orienteering
    • This review accompanies the D. discoideum cAMP signaling pathway described in Science's online STKE site. On this site, the D. discoideum chemoattractant-mediated pathways are described in great detail, with specific comments and a complete set of references for every entry. A must if you need a more in-depth analysis.
    • Kimmel A.R., Parent C.A. The signal to move: D. discoideum go orienteering. Science. 300:2003;1525-1527 This review accompanies the D. discoideum cAMP signaling pathway described in Science's online STKE site. On this site, the D. discoideum chemoattractant-mediated pathways are described in great detail, with specific comments and a complete set of references for every entry. A must if you need a more in-depth analysis.
    • (2003) Science , vol.300 , pp. 1525-1527
    • Kimmel, A.R.1    Parent, C.A.2
  • 6
    • 0032911044 scopus 로고    scopus 로고
    • Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
    • Servant G., Weiner O.D., Neptune E.R., Sedat J.W., Bourne H.R. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol. Biol. Cell. 10:1999;1163-1178.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1163-1178
    • Servant, G.1    Weiner, O.D.2    Neptune, E.R.3    Sedat, J.W.4    Bourne, H.R.5
  • 7
    • 0030729285 scopus 로고    scopus 로고
    • Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation
    • Xiao Z., Zhang N., Murphy D.B., Devreotes P.N. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J. Cell Biol. 139:1997;365-374.
    • (1997) J. Cell Biol. , vol.139 , pp. 365-374
    • Xiao, Z.1    Zhang, N.2    Murphy, D.B.3    Devreotes, P.N.4
  • 8
    • 0034635567 scopus 로고    scopus 로고
    • Localization of the G protein βγ complex in living cells during chemotaxis
    • Jin T., Zhang N., Long Y., Parent C.A., Devreotes P.N. Localization of the G protein βγ complex in living cells during chemotaxis. Science. 287:2000;1034-1036.
    • (2000) Science , vol.287 , pp. 1034-1036
    • Jin, T.1    Zhang, N.2    Long, Y.3    Parent, C.A.4    Devreotes, P.N.5
  • 9
    • 0035937571 scopus 로고    scopus 로고
    • Receptor-mediated activation of heterotrimeric G-proteins in living cells
    • Janetopoulos C., Jin T., Devreotes P.N. Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science. 291:2001;2408-2411.
    • (2001) Science , vol.291 , pp. 2408-2411
    • Janetopoulos, C.1    Jin, T.2    Devreotes, P.N.3
  • 10
    • 0032475863 scopus 로고    scopus 로고
    • G protein signaling events are activated at the leading edge of chemotactic cells
    • Parent C.A., Blacklock B.J., Froehlich W.M., Murphy D.B., Devreotes P.N. G protein signaling events are activated at the leading edge of chemotactic cells. Cell. 95:1998;81-91.
    • (1998) Cell , vol.95 , pp. 81-91
    • Parent, C.A.1    Blacklock, B.J.2    Froehlich, W.M.3    Murphy, D.B.4    Devreotes, P.N.5
  • 11
    • 0033560747 scopus 로고    scopus 로고
    • Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
    • Meili R., Ellsworth C., Lee S., Reddy T.B., Firtel R.A. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18:1999;2092-2105.
    • (1999) EMBO J. , vol.18 , pp. 2092-2105
    • Meili, R.1    Ellsworth, C.2    Lee, S.3    Reddy, T.B.4    Firtel, R.A.5
  • 12
    • 0034635513 scopus 로고    scopus 로고
    • Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
    • Servant G., Weiner O.D., Herzmark P., Balla T., Sedat J.W., Bourne H.R. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science. 287:2000;1037-1040.
    • (2000) Science , vol.287 , pp. 1037-1040
    • Servant, G.1    Weiner, O.D.2    Herzmark, P.3    Balla, T.4    Sedat, J.W.5    Bourne, H.R.6
  • 13
    • 0035858886 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
    • Funamoto S., Milan K., Meili R., Firtel R.A. Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J. Cell Biol. 153:2001;795-810.
    • (2001) J. Cell Biol. , vol.153 , pp. 795-810
    • Funamoto, S.1    Milan, K.2    Meili, R.3    Firtel, R.A.4
  • 14
    • 0036773899 scopus 로고    scopus 로고
    • Temporal and spatial regulation of chemotaxis
    • Iijima M., Huang Y.E., Devreotes P. Temporal and spatial regulation of chemotaxis. Dev. Cell. 3:2002;469-478.
    • (2002) Dev. Cell , vol.3 , pp. 469-478
    • Iijima, M.1    Huang, Y.E.2    Devreotes, P.3
  • 15
    • 0036532121 scopus 로고    scopus 로고
    • Roles of PI3Ks in leukocyte chemotaxis and phagocytosis
    • Stephens L., Ellson C., Hawkins P. Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Curr. Opin. Cell Biol. 14:2002;203-213.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 203-213
    • Stephens, L.1    Ellson, C.2    Hawkins, P.3
  • 16
    • 0035449609 scopus 로고    scopus 로고
    • Signaling pathways controlling cell polarity and chemotaxis
    • Chung C.Y., Funamoto S., Firtel R.A. Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem. Sci. 26:2001;557-566.
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 557-566
    • Chung, C.Y.1    Funamoto, S.2    Firtel, R.A.3
  • 18
    • 0034635221 scopus 로고    scopus 로고
    • Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant- mediated signal transduction
    • Li Z., Jiang H., Xie W., Zhang Z., Smrcka A.V., Wu D. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science. 287:2000;1046-1049.
    • (2000) Science , vol.287 , pp. 1046-1049
    • Li, Z.1    Jiang, H.2    Xie, W.3    Zhang, Z.4    Smrcka, A.V.5    Wu, D.6
  • 20
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase δ in neutrophil directional movement
    • These authors have developed an isoform-specific PI3Kδ inhibitor that inhibits neutrophil chemotaxis, but not chemokinesis, to fMLP. In addition, fMLP-mediated actin polymerization remains unchanged in the presence of the inhibitor.
    • Sadhu C., Masinovsky B., Dick K., Sowell C.G., Staunton D.E. Essential role of phosphoinositide 3-kinase δ in neutrophil directional movement. J. Immunol. 170:2003;2647-2654 These authors have developed an isoform-specific PI3Kδ inhibitor that inhibits neutrophil chemotaxis, but not chemokinesis, to fMLP. In addition, fMLP-mediated actin polymerization remains unchanged in the presence of the inhibitor.
    • (2003) J. Immunol. , vol.170 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 21
    • 0029148780 scopus 로고
    • G-protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase/Shc adapter protein signaling complexes
    • Ptasznik A., Traynor-Kaplan A., Bokoch G.M. G-protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase/Shc adapter protein signaling complexes. J. Biol. Chem. 270:1995;19969-19973.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19969-19973
    • Ptasznik, A.1    Traynor-Kaplan, A.2    Bokoch, G.M.3
  • 22
    • 0027285860 scopus 로고
    • Receptor-stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein-mediated pathways in human myeloid-derived cells
    • Stephens L., Eguinoa A., Corey S., Jackson T., Hawkins P.T. Receptor-stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein-mediated pathways in human myeloid-derived cells. EMBO J. 12:1993;2265-2273.
    • (1993) EMBO J. , vol.12 , pp. 2265-2273
    • Stephens, L.1    Eguinoa, A.2    Corey, S.3    Jackson, T.4    Hawkins, P.T.5
  • 23
    • 0034268796 scopus 로고    scopus 로고
    • Src tyrosine kinase is a novel direct effector of G proteins
    • Ma Y.C., Huang J., Ali S., Lowry W., Huang X.Y. Src tyrosine kinase is a novel direct effector of G proteins. Cell. 102:2000;635-646.
    • (2000) Cell , vol.102 , pp. 635-646
    • Ma, Y.C.1    Huang, J.2    Ali, S.3    Lowry, W.4    Huang, X.Y.5
  • 25
    • 0142011466 scopus 로고    scopus 로고
    • PTEN: From pathology to biology
    • Sulis M.L., Parsons R. PTEN: from pathology to biology. Trends Cell Biol. 13:2003;478-483.
    • (2003) Trends Cell Biol. , vol.13 , pp. 478-483
    • Sulis, M.L.1    Parsons, R.2
  • 26
    • 0037205230 scopus 로고    scopus 로고
    • Tumor suppressor PTEN mediates sensing of chemoattractant gradients
    • ••].
    • ••].
    • (2002) Cell , vol.109 , pp. 599-610
    • Iijima, M.1    Devreotes, P.2
  • 28
    • 0025731596 scopus 로고
    • Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
    • Stephens L.R., Hughes K.T., Irvine R.F. Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature. 351:1991;33-39.
    • (1991) Nature , vol.351 , pp. 33-39
    • Stephens, L.R.1    Hughes, K.T.2    Irvine, R.F.3
  • 30
    • 0037205265 scopus 로고    scopus 로고
    • Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
    • ••] are two outstanding papers that extensively characterize the role and cellular distribution of PI3K and PTEN in D. discoideum cells undergoing chemotaxis.
    • ••] are two outstanding papers that extensively characterize the role and cellular distribution of PI3K and PTEN in D. discoideum cells undergoing chemotaxis.
    • (2002) Cell , vol.109 , pp. 611-623
    • Funamoto, S.1    Meili, R.2    Lee, S.3    Parry, L.4    Firtel, R.A.5
  • 31
    • 0041352963 scopus 로고    scopus 로고
    • Directional sensing requires G βγ-mediated PAK1 and PIXα-dependent activation of Cdc42
    • This remarkable paper describes the existence of a complex between Gnβγ/PIXα/Cdc42/PAK1 that is important for the proper polarized localization of F-actin and PTEN and for chemotaxis in neutrophils.
    • Li Z., Hannigan M., Mo Z., Liu B., Lu W., Wu Y., Smrcka A.V., Wu G., Li L., Liu M.et al. Directional sensing requires G βγ-mediated PAK1 and PIXα-dependent activation of Cdc42. Cell. 114:2003;215-227 This remarkable paper describes the existence of a complex between Gnβγ/PIXα/Cdc42/PAK1 that is important for the proper polarized localization of F-actin and PTEN and for chemotaxis in neutrophils.
    • (2003) Cell , vol.114 , pp. 215-227
    • Li, Z.1    Hannigan, M.2    Mo, Z.3    Liu, B.4    Lu, W.5    Wu, Y.6    Smrcka, A.V.7    Wu, G.8    Li, L.9    Liu, M.10
  • 32
    • 0141817911 scopus 로고    scopus 로고
    • Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate
    • 2 to PTEN induces a conformational change that leads to the activation of PTEN.
    • 2 to PTEN induces a conformational change that leads to the activation of PTEN.
    • (2003) J. Biol. Chem. , vol.278 , pp. 33617-33620
    • Campbell, R.B.1    Liu, F.2    Ross, A.H.3
  • 33
    • 0037046799 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase γ by Ras
    • This paper shows that Ras can potently activate mammalian PI3Kγ. This occurs in the absence of any detectable PI3Kγ translocation to membranes.
    • Suire S., Hawkins P., Stephens L. Activation of phosphoinositide 3-kinase γ by Ras. Curr. Biol. 12:2002;1068-1075 This paper shows that Ras can potently activate mammalian PI3Kγ. This occurs in the absence of any detectable PI3Kγ translocation to membranes.
    • (2002) Curr. Biol. , vol.12 , pp. 1068-1075
    • Suire, S.1    Hawkins, P.2    Stephens, L.3
  • 34
    • 0037421204 scopus 로고    scopus 로고
    • Roles of G βγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ
    • HEK cells expressing various combinations of the regulatory (p101) and catalytic (p110γ) subunits of PI3Kγ provide evidence that Gβγ subunits activate PI3Kγ by two mechanisms: via membrane recruitment mediated by p101 and by direct stimulation of p110γ. The requirement for p101 may not be essential for PI3Kγ function as monomeric p110γ could also be active in vivo.
    • Brock C., Schaefer M., Reusch H.P., Czupalla C., Michalke M., Spicher K., Schultz G., Nurnberg B. Roles of G βγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ J. Cell Biol. 160:2003;89-99 HEK cells expressing various combinations of the regulatory (p101) and catalytic (p110γ) subunits of PI3Kγ provide evidence that Gβγ subunits activate PI3Kγ by two mechanisms: via membrane recruitment mediated by p101 and by direct stimulation of p110γ. The requirement for p101 may not be essential for PI3Kγ function as monomeric p110γ could also be active in vivo.
    • (2003) J. Cell Biol. , vol.160 , pp. 89-99
    • Brock, C.1    Schaefer, M.2    Reusch, H.P.3    Czupalla, C.4    Michalke, M.5    Spicher, K.6    Schultz, G.7    Nurnberg, B.8
  • 35
    • 0037086679 scopus 로고    scopus 로고
    • Mechanism of the regulation of type IB phosphoinositide 3OH-kinase by G-protein βγ subunits
    • Purified mammalian PI3Kγ regulatory and catalytic subunits can associate with lipid vesicles in the absence or presence of Gβγ. Moreover, membrane-targeted PI3Kγ catalytic subunit can be super-activated by Gβγ subunits.
    • Krugmann S., Cooper M.A., Williams D.H., Hawkins P.T., Stephens L.R. Mechanism of the regulation of type IB phosphoinositide 3OH-kinase by G-protein βγ subunits. Biochem. J. 362:2002;725-731 Purified mammalian PI3Kγ regulatory and catalytic subunits can associate with lipid vesicles in the absence or presence of Gβγ. Moreover, membrane-targeted PI3Kγ catalytic subunit can be super-activated by Gβγ subunits.
    • (2002) Biochem. J. , vol.362 , pp. 725-731
    • Krugmann, S.1    Cooper, M.A.2    Williams, D.H.3    Hawkins, P.T.4    Stephens, L.R.5
  • 36
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature. 420:2002;629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 37
    • 0037459075 scopus 로고    scopus 로고
    • Cellular motility driven by assembly and disassembly of actin filaments
    • Pollard T.D., Borisy G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell. 112:2003;453-465.
    • (2003) Cell , vol.112 , pp. 453-465
    • Pollard, T.D.1    Borisy, G.G.2
  • 38
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch G.M. Biology of the p21-activated kinases. Annu. Rev. Biochem. 72:2003;743-781.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 39
    • 0033531955 scopus 로고    scopus 로고
    • Characterization of Rac and Cdc42 activation in chemoattractant- stimulated human neutrophils using a novel assay for active GTPases
    • Benard V., Bohl B.P., Bokoch G.M. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J. Biol. Chem. 274:1999;13198-13204.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13198-13204
    • Benard, V.1    Bohl, B.P.2    Bokoch, G.M.3
  • 40
    • 0037415640 scopus 로고    scopus 로고
    • 3 and polarity during neutrophil chemotaxis
    • By expressing constitutively active and dominant-negative versions of Rac and Cdc42 in a neutrophil cell line, the authors propose that Rac represents a key regulator in the formation of the leading edge. Conversely, Cdc42 would be involved in locally directing and stabilizing the leading edge.
    • 3 and polarity during neutrophil chemotaxis. J. Cell Biol. 160:2003;375-385 By expressing constitutively active and dominant-negative versions of Rac and Cdc42 in a neutrophil cell line, the authors propose that Rac represents a key regulator in the formation of the leading edge. Conversely, Cdc42 would be involved in locally directing and stabilizing the leading edge.
    • (2003) J. Cell Biol. , vol.160 , pp. 375-385
    • Srinivasan, S.1    Wang, F.2    Glavas, S.3    Ott, A.4    Hofmann, F.5    Aktories, K.6    Kalman, D.7    Bourne, H.R.8
  • 43
    • 0034685772 scopus 로고    scopus 로고
    • Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding
    • Das B., Shu X., Day G.J., Han J., Krishna U.M., Falck J.R., Broek D. Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J. Biol. Chem. 275:2000;15074-15081.
    • (2000) J. Biol. Chem. , vol.275 , pp. 15074-15081
    • Das, B.1    Shu, X.2    Day, G.J.3    Han, J.4    Krishna, U.M.5    Falck, J.R.6    Broek, D.7
  • 44
    • 0141889083 scopus 로고    scopus 로고
    • The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions
    • Using neutrophils derived from mice lacking Vav1, the authors show that this exchange factor is specifically involved in controlling fMLP-mediated superoxide production and F-actin generation. They also report weak defects in chemotaxis to fMLP.
    • Kim C., Marchal C.C., Penninger J., Dinauer M.C. The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl- phenylalanine-activated neutrophil functions. J. Immunol. 171:2003;4425-4430 Using neutrophils derived from mice lacking Vav1, the authors show that this exchange factor is specifically involved in controlling fMLP-mediated superoxide production and F-actin generation. They also report weak defects in chemotaxis to fMLP.
    • (2003) J. Immunol. , vol.171 , pp. 4425-4430
    • Kim, C.1    Marchal, C.C.2    Penninger, J.3    Dinauer, M.C.4
  • 46
    • 0035061264 scopus 로고    scopus 로고
    • Small GTPases in Dictyostelium: Lessons from a social amoeba
    • Wilkins A., Insall R.H. Small GTPases in Dictyostelium: lessons from a social amoeba. Trends Genet. 17:2001;41-48.
    • (2001) Trends Genet. , vol.17 , pp. 41-48
    • Wilkins, A.1    Insall, R.H.2
  • 47
    • 0037147305 scopus 로고    scopus 로고
    • Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in Dictyostelium
    • The authors characterize the function of VASP in D. discoideum cells and find that cells lacking VASP have chemotaxis defects that are probably due to their defects in adhesion to the substratum.
    • Han Y.H., Chung C.Y., Wessels D., Stephens S., Titus M.A., Soll D.R., Firtel R.A. Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in Dictyostelium. J. Biol. Chem. 277:2002;49877-49887 The authors characterize the function of VASP in D. discoideum cells and find that cells lacking VASP have chemotaxis defects that are probably due to their defects in adhesion to the substratum.
    • (2002) J. Biol. Chem. , vol.277 , pp. 49877-49887
    • Han, Y.H.1    Chung, C.Y.2    Wessels, D.3    Stephens, S.4    Titus, M.A.5    Soll, D.R.6    Firtel, R.A.7
  • 48
    • 0032494137 scopus 로고    scopus 로고
    • SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development
    • Bear J.E., Rawls J.F., Saxe C.L. III SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. J. Cell Biol. 142:1998;1325-1335.
    • (1998) J. Cell Biol. , vol.142 , pp. 1325-1335
    • Bear, J.E.1    Rawls, J.F.2    Saxe III, C.L.3
  • 49
    • 0037102301 scopus 로고    scopus 로고
    • Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
    • The authors have purified a SCAR/WAVE-containing complex from bovine brain composed of PIR121, Nap125, WAVE1 and HSPC300. They show that Rac-GTP or the adaptor Nck can activate WAVE1 activity. Interestingly, they find that while recombinant WAVE1 is active, the WAVE1 complex is inactive. They propose that Rac-GTP or Nck activates WAVE1 by complex dissociation.
    • Eden S., Rohatgi R., Podtelejnikov A.V., Mann M., Kirschner M.W. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 418:2002;790-793 The authors have purified a SCAR/WAVE-containing complex from bovine brain composed of PIR121, Nap125, WAVE1 and HSPC300. They show that Rac-GTP or the adaptor Nck can activate WAVE1 activity. Interestingly, they find that while recombinant WAVE1 is active, the WAVE1 complex is inactive. They propose that Rac-GTP or Nck activates WAVE1 by complex dissociation.
    • (2002) Nature , vol.418 , pp. 790-793
    • Eden, S.1    Rohatgi, R.2    Podtelejnikov, A.V.3    Mann, M.4    Kirschner, M.W.5
  • 50
    • 0042921214 scopus 로고    scopus 로고
    • PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium
    • •] in D. discoideum and generate cells lacking PIR121. These cells show excessive levels of polymerized actin and display severe motility and chemotaxis defects. Genetic analyses show that PIR121 is acting downstream of SCAR.
    • •] in D. discoideum and generate cells lacking PIR121. These cells show excessive levels of polymerized actin and display severe motility and chemotaxis defects. Genetic analyses show that PIR121 is acting downstream of SCAR.
    • (2003) Curr. Biol. , vol.13 , pp. 1480-1487
    • Blagg, S.L.1    Stewart, M.2    Sambles, C.3    Insall, R.H.4
  • 51
    • 0035157971 scopus 로고    scopus 로고
    • Activation of RhoA and ROCK are essential for detachment of migrating leukocytes
    • Alblas J., Ulfman L., Hordijk P., Koenderman L. Activation of RhoA and ROCK are essential for detachment of migrating leukocytes. Mol. Biol. Cell. 12:2001;2137-2145.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2137-2145
    • Alblas, J.1    Ulfman, L.2    Hordijk, P.3    Koenderman, L.4
  • 52
    • 0035833247 scopus 로고    scopus 로고
    • RhoA is required for monocyte tail retraction during transendothelial migration
    • Worthylake R.A., Lemoine S., Watson J.M., Burridge K. RhoA is required for monocyte tail retraction during transendothelial migration. J. Cell Biol. 154:2001;147-160.
    • (2001) J. Cell Biol. , vol.154 , pp. 147-160
    • Worthylake, R.A.1    Lemoine, S.2    Watson, J.M.3    Burridge, K.4
  • 53
    • 0042354714 scopus 로고    scopus 로고
    • Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
    • Using inhibitors as well as expression of constitutively active and dominant-negative versions of various G proteins and GTPases in a neutrophil cell line, the authors present data suggesting that chemoattractants segregate signals by triggering Gαi/Rac-dependent events at the front of cells and Gα12-13/RhoA-dependent events at the back.
    • Xu J., Wang F., Van Keymeulen A., Herzmark P., Straight A., Kelly K., Takuwa Y., Sugimoto N., Mitchison T., Bourne H.R. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell. 114:2003;201-214 Using inhibitors as well as expression of constitutively active and dominant-negative versions of various G proteins and GTPases in a neutrophil cell line, the authors present data suggesting that chemoattractants segregate signals by triggering Gαi/Rac-dependent events at the front of cells and Gα12-13/RhoA-dependent events at the back.
    • (2003) Cell , vol.114 , pp. 201-214
    • Xu, J.1    Wang, F.2    Van Keymeulen, A.3    Herzmark, P.4    Straight, A.5    Kelly, K.6    Takuwa, Y.7    Sugimoto, N.8    Mitchison, T.9    Bourne, H.R.10
  • 54
    • 0035947085 scopus 로고    scopus 로고
    • Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
    • Chung C.Y., Potikyan G., Firtel R.A. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell. 7:2001;937-947.
    • (2001) Mol. Cell , vol.7 , pp. 937-947
    • Chung, C.Y.1    Potikyan, G.2    Firtel, R.A.3
  • 55
  • 56
    • 0026895972 scopus 로고
    • Streamer F mutants and chemotaxis of Dictyostelium
    • Newell P.C., Liu G. Streamer F mutants and chemotaxis of Dictyostelium. Bioessays. 14:1992;473-479.
    • (1992) Bioessays , vol.14 , pp. 473-479
    • Newell, P.C.1    Liu, G.2
  • 57
    • 0037370584 scopus 로고    scopus 로고
    • CGMP signalling: Different ways to create a pathway
    • Roelofs J., Smith J.L., Van Haastert P.J. cGMP signalling: different ways to create a pathway. Trends Genet. 19:2003;132-134.
    • (2003) Trends Genet. , vol.19 , pp. 132-134
    • Roelofs, J.1    Smith, J.L.2    Van Haastert, P.J.3
  • 58
    • 0042019962 scopus 로고    scopus 로고
    • A model for cGMP signal transduction in Dictyostelium in perspective of 25 years of cGMP research
    • Bosgraaf L., Van Haastert P.J. A model for cGMP signal transduction in Dictyostelium in perspective of 25 years of cGMP research. J. Muscle Res. Cell Motil. 23:2002;781-791.
    • (2002) J. Muscle Res. Cell Motil. , vol.23 , pp. 781-791
    • Bosgraaf, L.1    Van Haastert, P.J.2
  • 59
    • 0034192402 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP
    • Pham N., Cheglakov I., Koch C.A., de Hoog C.L., Moran M.F., Rotin D. The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP. Curr. Biol. 10:2000;555-558.
    • (2000) Curr. Biol. , vol.10 , pp. 555-558
    • Pham, N.1    Cheglakov, I.2    Koch, C.A.3    De Hoog, C.L.4    Moran, M.F.5    Rotin, D.6
  • 60
    • 0035430553 scopus 로고    scopus 로고
    • Nitric oxide synthase activity in neutrophils from patients with localized aggressive periodontitis
    • Shibata K., Warbington M.L., Gordon B.J., Kurihara H., Van Dyke T.E. Nitric oxide synthase activity in neutrophils from patients with localized aggressive periodontitis. J. Periodontol. 72:2001;1052-1058.
    • (2001) J. Periodontol. , vol.72 , pp. 1052-1058
    • Shibata, K.1    Warbington, M.L.2    Gordon, B.J.3    Kurihara, H.4    Van Dyke, T.E.5
  • 62
    • 0033230933 scopus 로고    scopus 로고
    • PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis
    • Chung C.Y., Firtel R.A. PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. J. Cell Biol. 147:1999;559-576.
    • (1999) J. Cell Biol. , vol.147 , pp. 559-576
    • Chung, C.Y.1    Firtel, R.A.2
  • 63
    • 0034640350 scopus 로고    scopus 로고
    • A membrane-permeant ester of phosphatidylinositol 3,4,5-trisphosphate (PIP[3]) is an activator of human neutrophil migration
    • Niggli V. A membrane-permeant ester of phosphatidylinositol 3,4,5-trisphosphate (PIP[3]) is an activator of human neutrophil migration. FEBS Lett. 473:2000;217-221.
    • (2000) FEBS Lett. , vol.473 , pp. 217-221
    • Niggli, V.1
  • 65
    • 0028093610 scopus 로고
    • CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G-protein-mediated activation of adenylyl cyclase in Dictyostelium
    • Insall R., Kuspa A., Lilly P.J., Shaulsky G., Levin L.R., Loomis W.F., Devreotes P.N. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G-protein-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 126:1994;1537-1545.
    • (1994) J. Cell Biol. , vol.126 , pp. 1537-1545
    • Insall, R.1    Kuspa, A.2    Lilly, P.J.3    Shaulsky, G.4    Levin, L.R.5    Loomis, W.F.6    Devreotes, P.N.7
  • 66
    • 0037459060 scopus 로고    scopus 로고
    • Adenylyl cyclase localization regulates streaming during chemotaxis
    • This paper provides a molecular mechanism to explain how D. discoideum cells align in a head-to-tail fashion to form streams when they undergo chemotaxis. The authors find that the adenylyl cyclase ACA is highly enriched at the back of cells undergoing chemotaxis and propose that this provides a compartment from which the chemoattractant cAMP is secreted to locally attract surrounding cells.
    • Kriebel P.W., Barr V.A., Parent C.A. Adenylyl cyclase localization regulates streaming during chemotaxis. Cell. 112:2003;549-560 This paper provides a molecular mechanism to explain how D. discoideum cells align in a head-to-tail fashion to form streams when they undergo chemotaxis. The authors find that the adenylyl cyclase ACA is highly enriched at the back of cells undergoing chemotaxis and propose that this provides a compartment from which the chemoattractant cAMP is secreted to locally attract surrounding cells.
    • (2003) Cell , vol.112 , pp. 549-560
    • Kriebel, P.W.1    Barr, V.A.2    Parent, C.A.3
  • 67
    • 0037743735 scopus 로고    scopus 로고
    • Eukaryotic chemotaxis: Distinctions between directional sensing and polarization
    • Devreotes P., Janetopoulos C. Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J. Biol. Chem. 278:2003;20445-20448.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20445-20448
    • Devreotes, P.1    Janetopoulos, C.2


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