-
1
-
-
0037452071
-
Adaptation of core mechanisms to generate cell polarity
-
Nelson W.J. Adaptation of core mechanisms to generate cell polarity. Nature 422 (2003) 766-774
-
(2003)
Nature
, vol.422
, pp. 766-774
-
-
Nelson, W.J.1
-
2
-
-
0037032795
-
Anterior-posterior polarity in C. elegans and Drosophila-parallels and differences
-
Pellettieri J., and Seydoux G. Anterior-posterior polarity in C. elegans and Drosophila-parallels and differences. Science 298 (2002) 1946-1950
-
(2002)
Science
, vol.298
, pp. 1946-1950
-
-
Pellettieri, J.1
Seydoux, G.2
-
3
-
-
0002011401
-
The chemical basis of morphogenesis
-
Turing A.M. The chemical basis of morphogenesis. Phil Trans Roy Soc B 237 (1952) 37-72
-
(1952)
Phil Trans Roy Soc B
, vol.237
, pp. 37-72
-
-
Turing, A.M.1
-
4
-
-
0015454185
-
A theory of biological pattern formation
-
Gierer A., and Meinhardt H. A theory of biological pattern formation. Kybernetik 12 (1972) 30-39
-
(1972)
Kybernetik
, vol.12
, pp. 30-39
-
-
Gierer, A.1
Meinhardt, H.2
-
5
-
-
0032823984
-
Orientation of chemotactic cells and growth cones: models and mechanisms
-
Meinhardt H. Orientation of chemotactic cells and growth cones: models and mechanisms. J Cell Sci 112 Pt 17 (1999) 2867-2874
-
(1999)
J Cell Sci
, vol.112
, Issue.PART 17
, pp. 2867-2874
-
-
Meinhardt, H.1
-
6
-
-
0016209638
-
Applications of a theory of biological pattern formation based on lateral inhibition
-
Meinhardt H., and Gierer A. Applications of a theory of biological pattern formation based on lateral inhibition. J Cell Sci 15 (1974) 321-346
-
(1974)
J Cell Sci
, vol.15
, pp. 321-346
-
-
Meinhardt, H.1
Gierer, A.2
-
7
-
-
49649089500
-
On the spontaneous emergence of cell polarity
-
This study employs a combination of experimental analysis and mathematical modeling to study a simplified mechanism for cell polarization. In the process, they are able to relate how the degree of polarization depends on the supply of the Cdc42 substrate.
-
Altschuler S.J., Angenent S.B., Wang Y., and Wu L.F. On the spontaneous emergence of cell polarity. Nature 454 (2008) 886-889. This study employs a combination of experimental analysis and mathematical modeling to study a simplified mechanism for cell polarization. In the process, they are able to relate how the degree of polarization depends on the supply of the Cdc42 substrate.
-
(2008)
Nature
, vol.454
, pp. 886-889
-
-
Altschuler, S.J.1
Angenent, S.B.2
Wang, Y.3
Wu, L.F.4
-
8
-
-
43649095122
-
Wave-pinning and cell polarity from a bistable reaction-diffusion system
-
This paper develops the theory behind polarization involving substrate limitation. It also demonstrates that this mechanism is not mathematically equivalent to a Turing-like instability.
-
Mori Y., Jilkine A., and Edelstein-Keshet L. Wave-pinning and cell polarity from a bistable reaction-diffusion system. Biophys J 94 (2008) 3684-3697. This paper develops the theory behind polarization involving substrate limitation. It also demonstrates that this mechanism is not mathematically equivalent to a Turing-like instability.
-
(2008)
Biophys J
, vol.94
, pp. 3684-3697
-
-
Mori, Y.1
Jilkine, A.2
Edelstein-Keshet, L.3
-
9
-
-
0036220079
-
Bud-site selection and cell polarity in budding yeast
-
Casamayor A., and Snyder M. Bud-site selection and cell polarity in budding yeast. Curr Opin Microbiol 5 (2002) 179-186
-
(2002)
Curr Opin Microbiol
, vol.5
, pp. 179-186
-
-
Casamayor, A.1
Snyder, M.2
-
10
-
-
33947398366
-
Central roles of small GTPases in the development of cell polarity in yeast and beyond
-
Park H.O., and Bi E. Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev 71 (2007) 48-96
-
(2007)
Microbiol Mol Biol Rev
, vol.71
, pp. 48-96
-
-
Park, H.O.1
Bi, E.2
-
11
-
-
0037458909
-
Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase
-
Wedlich-Soldner R., Altschuler S., Wu L., and Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science 299 (2003) 1231-1235
-
(2003)
Science
, vol.299
, pp. 1231-1235
-
-
Wedlich-Soldner, R.1
Altschuler, S.2
Wu, L.3
Li, R.4
-
12
-
-
0034056057
-
Polarization of cell growth in yeast
-
Pruyne D., and Bretscher A. Polarization of cell growth in yeast. J Cell Sci 113 Pt 4 (2000) 571-585
-
(2000)
J Cell Sci
, vol.113
, Issue.PART 4
, pp. 571-585
-
-
Pruyne, D.1
Bretscher, A.2
-
14
-
-
4544295912
-
Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling
-
Wedlich-Soldner R., Wai S.C., Schmidt T., and Li R. Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol 166 (2004) 889-900
-
(2004)
J Cell Biol
, vol.166
, pp. 889-900
-
-
Wedlich-Soldner, R.1
Wai, S.C.2
Schmidt, T.3
Li, R.4
-
15
-
-
34147175165
-
Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity
-
Using a combination of experimental analysis and mathematical modeling, the authors explore the role of endocytosis in establishing polarity in budding yeast expressing activated Cdc42. The authors conclude from their analysis that endocytosis rates are optimized in order to maximize both the height and sharpness of the polarized cap.
-
Marco E., Wedlich-Soldner R., Li R., Altschuler S.J., and Wu L.F. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell 129 (2007) 411-422. Using a combination of experimental analysis and mathematical modeling, the authors explore the role of endocytosis in establishing polarity in budding yeast expressing activated Cdc42. The authors conclude from their analysis that endocytosis rates are optimized in order to maximize both the height and sharpness of the polarized cap.
-
(2007)
Cell
, vol.129
, pp. 411-422
-
-
Marco, E.1
Wedlich-Soldner, R.2
Li, R.3
Altschuler, S.J.4
Wu, L.F.5
-
16
-
-
0035831555
-
Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p
-
Bose I., Irazoqui J.E., Moskow J.J., Bardes E.S., Zyla T.R., and Lew D.J. Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. J Biol Chem 276 (2001) 7176-7186
-
(2001)
J Biol Chem
, vol.276
, pp. 7176-7186
-
-
Bose, I.1
Irazoqui, J.E.2
Moskow, J.J.3
Bardes, E.S.4
Zyla, T.R.5
Lew, D.J.6
-
17
-
-
0037007225
-
A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization
-
Butty A.C., Perrinjaquet N., Petit A., Jaquenoud M., Segall J.E., Hofmann K., Zwahlen C., and Peter M. A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization. EMBO J 21 (2002) 1565-1576
-
(2002)
EMBO J
, vol.21
, pp. 1565-1576
-
-
Butty, A.C.1
Perrinjaquet, N.2
Petit, A.3
Jaquenoud, M.4
Segall, J.E.5
Hofmann, K.6
Zwahlen, C.7
Peter, M.8
-
18
-
-
26444469935
-
A system of counteracting feedback loops regulates Cdc42p activity during spontaneous cell polarization
-
Ozbudak E.M., Becskei A., and van Oudenaarden A. A system of counteracting feedback loops regulates Cdc42p activity during spontaneous cell polarization. Dev Cell 9 (2005) 565-571
-
(2005)
Dev Cell
, vol.9
, pp. 565-571
-
-
Ozbudak, E.M.1
Becskei, A.2
van Oudenaarden, A.3
-
19
-
-
0033279824
-
Cell polarity in yeast
-
Chant J. Cell polarity in yeast. Annu Rev Cell Dev Biol 15 (1999) 365-391
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 365-391
-
-
Chant, J.1
-
20
-
-
42049115235
-
Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity
-
This paper develops a mathematical model of yeast polarization using a bottom-up approach. It also provides an elegant example of how a detailed mechanistic model can be used to derive a simplified, top-down model.
-
Goryachev A.B., and Pokhilko A.V. Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Lett 582 (2008) 1437-1443. This paper develops a mathematical model of yeast polarization using a bottom-up approach. It also provides an elegant example of how a detailed mechanistic model can be used to derive a simplified, top-down model.
-
(2008)
FEBS Lett
, vol.582
, pp. 1437-1443
-
-
Goryachev, A.B.1
Pokhilko, A.V.2
-
22
-
-
44349180298
-
Moving towards a better understanding of chemotaxis
-
Stephens L., Milne L., and Hawkins P. Moving towards a better understanding of chemotaxis. Curr Biol 18 (2008) R485-494
-
(2008)
Curr Biol
, vol.18
-
-
Stephens, L.1
Milne, L.2
Hawkins, P.3
-
24
-
-
0037026480
-
A chemical compass
-
Bourne H.R., and Weiner O. A chemical compass. Nature 419 (2002) 21
-
(2002)
Nature
, vol.419
, pp. 21
-
-
Bourne, H.R.1
Weiner, O.2
-
25
-
-
0034332904
-
Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products
-
Rickert P., Weiner O.D., Wang F., Bourne H.R., and Servant G. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol 10 (2000) 466-473
-
(2000)
Trends Cell Biol
, vol.10
, pp. 466-473
-
-
Rickert, P.1
Weiner, O.D.2
Wang, F.3
Bourne, H.R.4
Servant, G.5
-
26
-
-
39149118309
-
Navigating through models of chemotaxis
-
This paper provides an insightful review of many of the key issues and questions involved in modeling eukaryotic chemotaxis.
-
Iglesias P.A., and Devreotes P.N. Navigating through models of chemotaxis. Curr Opin Cell Biol 20 (2008) 35-40. This paper provides an insightful review of many of the key issues and questions involved in modeling eukaryotic chemotaxis.
-
(2008)
Curr Opin Cell Biol
, vol.20
, pp. 35-40
-
-
Iglesias, P.A.1
Devreotes, P.N.2
-
28
-
-
0032911044
-
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
-
Servant G., Weiner O.D., Neptune E.R., Sedat J.W., and Bourne H.R. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10 (1999) 1163-1178
-
(1999)
Mol Biol Cell
, vol.10
, pp. 1163-1178
-
-
Servant, G.1
Weiner, O.D.2
Neptune, E.R.3
Sedat, J.W.4
Bourne, H.R.5
-
29
-
-
34548086764
-
Bound attractant at the leading vs. the trailing edge determines chemotactic prowess
-
Herzmark P., Campbell K., Wang F., Wong K., El-Samad H., Groisman A., and Bourne H.R. Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proc Natl Acad Sci U S A 104 (2007) 13349-13354
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 13349-13354
-
-
Herzmark, P.1
Campbell, K.2
Wang, F.3
Wong, K.4
El-Samad, H.5
Groisman, A.6
Bourne, H.R.7
-
30
-
-
0036219106
-
Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils
-
Levchenko A., and Iglesias P.A. Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils. Biophys J 82 (2002) 50-63
-
(2002)
Biophys J
, vol.82
, pp. 50-63
-
-
Levchenko, A.1
Iglesias, P.A.2
-
31
-
-
0033617576
-
A cell's sense of direction
-
Parent C.A., and Devreotes P.N. A cell's sense of direction. Science 284 (1999) 765-770
-
(1999)
Science
, vol.284
, pp. 765-770
-
-
Parent, C.A.1
Devreotes, P.N.2
-
32
-
-
0024147085
-
Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium
-
Devreotes P.N., and Zigmond S.H. Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. Annu Rev Cell Biol 4 (1988) 649-686
-
(1988)
Annu Rev Cell Biol
, vol.4
, pp. 649-686
-
-
Devreotes, P.N.1
Zigmond, S.H.2
-
33
-
-
33646764616
-
Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways
-
Narang A. Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways. J Theor Biol 240 (2006) 538-553
-
(2006)
J Theor Biol
, vol.240
, pp. 538-553
-
-
Narang, A.1
-
34
-
-
33746595848
-
Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method
-
Meier-Schellersheim M., Xu X., Angermann B., Kunkel E.J., Jin T., and Germain R.N. Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. PLoS Comput Biol 2 (2006) e82
-
(2006)
PLoS Comput Biol
, vol.2
-
-
Meier-Schellersheim, M.1
Xu, X.2
Angermann, B.3
Kunkel, E.J.4
Jin, T.5
Germain, R.N.6
-
35
-
-
34347352254
-
A mass conserved reaction-diffusion system captures properties of cell polarity
-
Otsuji M., Ishihara S., Co C., Kaibuchi K., Mochizuki A., and Kuroda S. A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol 3 (2007) e108
-
(2007)
PLoS Comput Biol
, vol.3
-
-
Otsuji, M.1
Ishihara, S.2
Co, C.3
Kaibuchi, K.4
Mochizuki, A.5
Kuroda, S.6
-
36
-
-
21844452715
-
Distinguishing modes of eukaryotic gradient sensing
-
Skupsky R., Losert W., and Nossal R.J. Distinguishing modes of eukaryotic gradient sensing. Biophys J 89 (2005) 2806-2823
-
(2005)
Biophys J
, vol.89
, pp. 2806-2823
-
-
Skupsky, R.1
Losert, W.2
Nossal, R.J.3
-
37
-
-
34047218649
-
A mathematical model for neutrophil gradient sensing and polarization
-
Onsum M., and Rao C.V. A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput Biol 3 (2007) e36
-
(2007)
PLoS Comput Biol
, vol.3
-
-
Onsum, M.1
Rao, C.V.2
-
38
-
-
0042354714
-
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
-
Xu J., Wang F., Van Keymeulen A., Herzmark P., Straight A., Kelly K., Takuwa Y., Sugimoto N., Mitchison T., and Bourne H.R. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114 (2003) 201-214
-
(2003)
Cell
, vol.114
, pp. 201-214
-
-
Xu, J.1
Wang, F.2
Van Keymeulen, A.3
Herzmark, P.4
Straight, A.5
Kelly, K.6
Takuwa, Y.7
Sugimoto, N.8
Mitchison, T.9
Bourne, H.R.10
-
39
-
-
33750523841
-
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils
-
Suire S., Condliffe A.M., Ferguson G.J., Ellson C.D., Guillou H., Davidson K., Welch H., Coadwell J., Turner M., Chilvers E.R., et al. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol 8 (2006) 1303-1309
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1303-1309
-
-
Suire, S.1
Condliffe, A.M.2
Ferguson, G.J.3
Ellson, C.D.4
Guillou, H.5
Davidson, K.6
Welch, H.7
Coadwell, J.8
Turner, M.9
Chilvers, E.R.10
-
40
-
-
33846781374
-
Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell
-
Dawes A.T., and Edelstein-Keshet L. Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J 92 (2007) 744-768
-
(2007)
Biophys J
, vol.92
, pp. 744-768
-
-
Dawes, A.T.1
Edelstein-Keshet, L.2
-
41
-
-
0017660115
-
Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors
-
Zigmond S.H. Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. J Cell Biol 75 (1977) 606-616
-
(1977)
J Cell Biol
, vol.75
, pp. 606-616
-
-
Zigmond, S.H.1
-
42
-
-
2942687012
-
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
-
Janetopoulos C., Ma L., Devreotes P.N., and Iglesias P.A. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A 101 (2004) 8951-8956
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8951-8956
-
-
Janetopoulos, C.1
Ma, L.2
Devreotes, P.N.3
Iglesias, P.A.4
-
43
-
-
34047134459
-
PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis
-
Chen L., Iijima M., Tang M., Landree M.A., Huang Y.E., Xiong Y., Iglesias P.A., and Devreotes P.N. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell 12 (2007) 603-614
-
(2007)
Dev Cell
, vol.12
, pp. 603-614
-
-
Chen, L.1
Iijima, M.2
Tang, M.3
Landree, M.A.4
Huang, Y.E.5
Xiong, Y.6
Iglesias, P.A.7
Devreotes, P.N.8
-
44
-
-
47049110588
-
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis
-
Kamimura Y., Xiong Y., Iglesias P.A., Hoeller O., Bolourani P., and Devreotes P.N. PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol 18 (2008) 1034-1043
-
(2008)
Curr Biol
, vol.18
, pp. 1034-1043
-
-
Kamimura, Y.1
Xiong, Y.2
Iglesias, P.A.3
Hoeller, O.4
Bolourani, P.5
Devreotes, P.N.6
-
45
-
-
33947206045
-
Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
-
Andrew N., and Insall R.H. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat Cell Biol 9 (2007) 193-200
-
(2007)
Nat Cell Biol
, vol.9
, pp. 193-200
-
-
Andrew, N.1
Insall, R.H.2
-
46
-
-
34247361650
-
Chemotaxis in the absence of PIP3 gradients
-
Hoeller O., and Kay R.R. Chemotaxis in the absence of PIP3 gradients. Curr Biol 17 (2007) 813-817
-
(2007)
Curr Biol
, vol.17
, pp. 813-817
-
-
Hoeller, O.1
Kay, R.R.2
|