메뉴 건너뛰기




Volumn 63, Issue 5, 2011, Pages 405-413

NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes

Author keywords

Co activators; CYP2C9; HNF4 ; NCOA6; PXR; Synergistic transactivation

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4ALPHA; NUCLEAR RECEPTOR COACTIVATOR; NUCLEAR RECEPTOR COACTIVATOR 6; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG;

EID: 79955468688     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.01.013     Document Type: Article
Times cited : (10)

References (48)
  • 2
    • 0028590127 scopus 로고
    • Biochemistry and molecular biology of the human CYP2C subfamily
    • J.A. Goldstein, and S.M. de Morais Biochemistry and molecular biology of the human CYP2C subfamily Pharmacogenetics 4 1994 285 299
    • (1994) Pharmacogenetics , vol.4 , pp. 285-299
    • Goldstein, J.A.1    De Morais, S.M.2
  • 3
    • 0034792584 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
    • DOI 10.1046/j.0306-5251.2001.01499.x
    • J.A. Goldstein Clinical relevance of genetic polymorphisms in the human CYP2C subfamily Br J Clin Pharmacol 52 2001 349 355 (Pubitemid 32939439)
    • (2001) British Journal of Clinical Pharmacology , vol.52 , Issue.4 , pp. 349-355
    • Goldstein, J.A.1
  • 4
    • 0030758131 scopus 로고    scopus 로고
    • 359 allele as low-K(m) catalysts of cyclophosphamide and ifosfamide activation
    • DOI 10.1097/00008571-199706000-00006
    • T.K. Chang, L. Yu, J.A. Goldstein, and D.J. Waxman Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-km catalysts of cyclophosphamide and ifosfamide activation Pharmacogenetics 7 1997 211 221 (Pubitemid 27290635)
    • (1997) Pharmacogenetics , vol.7 , Issue.3 , pp. 211-221
    • Chang, T.K.H.1    Yu, L.2    Goldstein, J.A.3    Waxman, D.J.4
  • 6
    • 0036784511 scopus 로고    scopus 로고
    • A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system
    • J. Raucy, L. Warfe, M.F. Yueh, and S.W. Allen A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system J Pharmacol Exp Ther 303 2002 412 423
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 412-423
    • Raucy, J.1    Warfe, L.2    Yueh, M.F.3    Allen, S.W.4
  • 9
    • 0016758480 scopus 로고
    • Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance
    • W. Zilly, D.D. Breimer, and E. Richter Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance Eur J Clin Pharmacol 9 1975 219 227
    • (1975) Eur J Clin Pharmacol , vol.9 , pp. 219-227
    • Zilly, W.1    Breimer, D.D.2    Richter, E.3
  • 10
    • 0022376426 scopus 로고
    • Influence of rifampicin and isoniazid on the kinetics of phenytoin
    • L. Kay, J.P. Kampmann, T.L. Svendsen, B. Vergman, J.E. Hansen, and L. Skovsted Influence of rifampicin and isoniazid on the kinetics of phenytoin Br J Clin Pharmacol 20 1985 323 326 (Pubitemid 16236886)
    • (1985) British Journal of Clinical Pharmacology , vol.20 , Issue.4 , pp. 323-326
    • Kay, L.1    Kampmann, J.P.2    Svendsen, T.L.3
  • 13
    • 0036765751 scopus 로고    scopus 로고
    • Regulation of human CYP2C9 by the constitutive androstane receptor: Discovery of a new distal binding site
    • DOI 10.1124/mol.62.3.737
    • S.S. Ferguson, E.L. LeCluyse, M. Negishi, and J.A. Goldstein Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site Mol Pharmacol 62 2002 737 746 (Pubitemid 36329394)
    • (2002) Molecular Pharmacology , vol.62 , Issue.3 , pp. 737-746
    • Ferguson, S.S.1    Lecluyse, E.L.2    Negishi, M.3    Goldstein, J.A.4
  • 15
    • 1642498178 scopus 로고    scopus 로고
    • Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor
    • DOI 10.1124/jpet.103.058818
    • Y. Chen, S.S. Ferguson, M. Negishi, and J.A. Goldstein Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor J Pharmacol Exp Ther 308 2004 495 501 (Pubitemid 38134210)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.308 , Issue.2 , pp. 495-501
    • Chen, Y.1    Ferguson, S.S.2    Negishi, M.3    Goldstein, J.A.4
  • 17
    • 0036209248 scopus 로고    scopus 로고
    • Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
    • S.A. Kliewer, and T.M. Willson Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor J Lipid Res 43 2002 359 364 (Pubitemid 34252265)
    • (2002) Journal of Lipid Research , vol.43 , Issue.3 , pp. 359-364
    • Kliewer, S.A.1    Willson, T.M.2
  • 18
    • 0033525886 scopus 로고    scopus 로고
    • The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
    • DOI 10.1074/jbc.274.10.6043
    • T. Sueyoshi, T. Kawamoto, I. Zelko, P. Honkakoski, and M. Negishi The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene J Biol Chem 274 1999 6043 6046 (Pubitemid 29111006)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.10 , pp. 6043-6046
    • Sueyoshi, T.1    Kawamoto, T.2    Zelko, I.3    Honkakoski, P.4    Negishi, M.5
  • 19
    • 0033999734 scopus 로고    scopus 로고
    • The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
    • DOI 10.1128/MCB.20.9.2951-2958.2000
    • I. Tzameli, P. Pissios, E.G. Schuetz, and D.D. Moore The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR Mol Cell Biol 20 2000 2951 2958 (Pubitemid 30215008)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.9 , pp. 2951-2958
    • Tzameli, I.1    Pissios, P.2    Schuetz, E.G.3    Moore, D.D.4
  • 20
    • 0036256351 scopus 로고    scopus 로고
    • Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors
    • DOI 10.1210/me.16.5.977
    • L.B. Moore, J.M. Maglich, D.D. McKee, B. Wisely, T.M. Willson, and S.A. Kliewer Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors Mol Endocrinol 16 2002 977 986 (Pubitemid 34478535)
    • (2002) Molecular Endocrinology , vol.16 , Issue.5 , pp. 977-986
    • Moore, L.B.1    Maglich, J.M.2    McKee, D.D.3    Wisely, B.4    Willson, T.M.5    Kliewer, S.A.6    Lambert, M.H.7    Moore, J.T.8
  • 22
    • 33847024555 scopus 로고    scopus 로고
    • CAR and PXR: The xenobiotic-sensing receptors
    • DOI 10.1016/j.steroids.2006.12.006, PII S0039128X06002649
    • Y.E. Timsit, and M. Negishi CAR and PXR: the xenobiotic-sensing receptors Steroids 72 2007 231 246 (Pubitemid 46273513)
    • (2007) Steroids , vol.72 , Issue.3 , pp. 231-246
    • Timsit, Y.E.1    Negishi, M.2
  • 23
    • 0033638960 scopus 로고    scopus 로고
    • Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
    • W. Xie, J.L. Barwick, C.M. Simon, A.M. Pierce, S. Safe, and B. Blumberg Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR Genes Dev 14 2000 3014 3023
    • (2000) Genes Dev , vol.14 , pp. 3014-3023
    • Xie, W.1    Barwick, J.L.2    Simon, C.M.3    Pierce, A.M.4    Safe, S.5    Blumberg, B.6
  • 26
    • 0035918186 scopus 로고    scopus 로고
    • Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics
    • D. Smirlis, R. Muangmoonchai, M. Edwards, I.R. Phillips, and E.A. Shephard Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics J Biol Chem 276 2001 12822 12826
    • (2001) J Biol Chem , vol.276 , pp. 12822-12826
    • Smirlis, D.1    Muangmoonchai, R.2    Edwards, M.3    Phillips, I.R.4    Shephard, E.A.5
  • 27
    • 0031968936 scopus 로고    scopus 로고
    • Activation by diverse xenochemicals of the 51-base pair phenobarbital- responsive enhancer module in the CYP2B10 gene
    • P. Honkakoski, R. Moore, K.A. Washburn, and M. Negishi Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene Mol Pharmacol 53 1998 597 601 (Pubitemid 28196480)
    • (1998) Molecular Pharmacology , vol.53 , Issue.4 , pp. 597-601
    • Honkakoski, P.1    Moore, R.2    Washburn, K.A.3    Negishi, M.4
  • 28
    • 0032766430 scopus 로고    scopus 로고
    • Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
    • T. Kawamoto, T. Sueyoshi, I. Zelko, R. Moore, K. Washburn, and M. Negishi Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene Mol Cell Biol 19 1999 6318 6322 (Pubitemid 29399336)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.9 , pp. 6318-6322
    • Kawamoto, T.1    Sueyoshi, T.2    Zelko, I.3    Moore, R.4    Washburn, K.5    Negishi, M.6
  • 30
    • 10944250224 scopus 로고    scopus 로고
    • The nuclear xenobiotic receptor CAR: Structural determinants of constitutive activation and heterodimerization
    • DOI 10.1016/j.molcel.2004.11.036, PII S1097276504007270
    • K. Suino, L. Peng, R. Reynolds, Y. Li, J.Y. Cha, and J.J. Repa The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization Mol Cell 16 2004 893 905 (Pubitemid 40018400)
    • (2004) Molecular Cell , vol.16 , Issue.6 , pp. 893-905
    • Suino, K.1    Peng, L.2    Reynolds, R.3    Li, Y.4    Cha, J.-Y.5    Repa, J.J.6    Kliewer, S.A.7    Xu, H.E.8
  • 31
    • 23144447399 scopus 로고    scopus 로고
    • CAR: Three new models for a problem child
    • DOI 10.1016/j.cmet.2004.12.006, PII S1550413104000129
    • D.D. Moore CAR: three new models for a problem child Cell Metab 1 2005 6 8 (Pubitemid 43960590)
    • (2005) Cell Metabolism , vol.1 , Issue.1 , pp. 6-8
    • Moore, D.D.1
  • 32
    • 0029035904 scopus 로고
    • Transcriptional regulation of human CYP2C genes: Functional comparison of CYP2C9 and CYP2C18 promoter regions
    • G.C. Ibeanu, and J.A. Goldstein Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions Biochemistry 34 1995 8028 8036
    • (1995) Biochemistry , vol.34 , pp. 8028-8036
    • Ibeanu, G.C.1    Goldstein, J.A.2
  • 33
    • 0035124052 scopus 로고    scopus 로고
    • Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: A study using adenovirus-mediated antisense targeting
    • DOI 10.1053/jhep.2001.22176
    • R. Jover, R. Bort, M.J. Gomez-Lechon, and J.V. Castell Cytochrome p450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting Hepatology 33 2001 668 675 (Pubitemid 32185230)
    • (2001) Hepatology , vol.33 , Issue.3 , pp. 668-675
    • Jover, R.1    Bort, R.2    Gomez-Lechon, M.J.3    Castell, J.V.4
  • 34
    • 23944510035 scopus 로고    scopus 로고
    • The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4α to synergistically activate the human CYP2C9 promoter
    • DOI 10.1124/jpet.105.087072
    • Y. Chen, G. Kissling, M. Negishi, and J.A. Goldstein The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter J Pharmacol Exp Ther 314 2005 1125 1133 (Pubitemid 41205977)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.314 , Issue.3 , pp. 1125-1133
    • Chen, Y.1    Kissling, G.2    Negishi, M.3    Goldstein, J.A.4
  • 35
    • 0026847794 scopus 로고
    • Mechanisms of liver-specific gene expression
    • F.M. Sladek, and J.E. Darnell Mechanisms of liver-specific gene expression Curr Opin Genet Dev 2 1992 256 259
    • (1992) Curr Opin Genet Dev , vol.2 , pp. 256-259
    • Sladek, F.M.1    Darnell, J.E.2
  • 36
    • 33746471838 scopus 로고    scopus 로고
    • Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line CACO-2 by HNF-1alpha and HNF-4
    • C. Hu, and D.H. Perlmutter Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line CACO-2 by HNF-1alpha and HNF-4 Am J Physiol 276 1999 G1181 1194
    • (1999) Am J Physiol , vol.276 , pp. 1181-1194
    • Hu, C.1    Perlmutter, D.H.2
  • 37
    • 50449108070 scopus 로고    scopus 로고
    • Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome p-450 2c9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha
    • S. Surapureddi, R. Rana, J.K. Reddy, and J.A. Goldstein Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome p-450 2c9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha Mol Pharmacol 74 2008 913 923
    • (2008) Mol Pharmacol , vol.74 , pp. 913-923
    • Surapureddi, S.1    Rana, R.2    Reddy, J.K.3    Goldstein, J.A.4
  • 38
    • 0038153901 scopus 로고    scopus 로고
    • Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor γ (PPARγ)-interacting protein, is required for PPARγ-mediated adipogenesis
    • DOI 10.1074/jbc.C300175200
    • C. Qi, S. Surapureddi, Y.J. Zhu, S. Yu, P. Kashireddy, and M.S. Rao Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis J Biol Chem 278 2003 25281 25284 (Pubitemid 36835274)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.28 , pp. 25281-25284
    • Qi, C.1    Surapureddi, S.2    Zhu, Y.-J.3    Yu, S.4    Kashireddy, P.5    Rao, M.S.6    Reddy, J.K.7
  • 39
    • 0034607983 scopus 로고    scopus 로고
    • Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR
    • DOI 10.1074/jbc.275.18.13510
    • Y. Zhu, L. Kan, C. Qi, Y.S. Kanwar, A.V. Yeldandi, and M.S. Rao Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR J Biol Chem 275 2000 13510 13516 (Pubitemid 30257416)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.18 , pp. 13510-13516
    • Zhu, Y.1    Kan, L.2    Qi, C.3    Kanwar, Y.S.4    Yeldandi, A.V.5    Rao, M.S.6    Reddy, J.K.7
  • 40
    • 36849015299 scopus 로고    scopus 로고
    • Tissue- and nuclear receptor-specific function of the c-terminal LXXLL motif of coactivator NCOA6/AIB3 in mice
    • Q. Li, M.J. Chu, and J. Xu Tissue- and nuclear receptor-specific function of the c-terminal LXXLL motif of coactivator NCOA6/AIB3 in mice Mol Cell Biol 2007
    • (2007) Mol Cell Biol
    • Li, Q.1    Chu, M.J.2    Xu, J.3
  • 42
    • 34548301080 scopus 로고    scopus 로고
    • The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4α in the regulation of human steroid-/bile acid-sulfotransferase
    • DOI 10.1210/me.2007-0002
    • I. Echchgadda, C.S. Song, T. Oh, M. Ahmed, I.J. De La Cruz, and B. Chatterjee The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4{alpha} in the regulation of human steroid-/bile acid-sulfotransferase Mol Endocrinol 21 2007 2099 2111 (Pubitemid 47347375)
    • (2007) Molecular Endocrinology , vol.21 , Issue.9 , pp. 2099-2111
    • Echchgadda, I.1    Song, C.S.2    Oh, T.3    Ahmed, M.4    De La Cruz, I.J.5    Chatterjee, B.6
  • 43
    • 33748750262 scopus 로고    scopus 로고
    • Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor α, and the coactivator peroxisome proliferator-activated receptor γ coactivator-1α
    • DOI 10.1074/jbc.M600931200
    • X. Ding, K. Lichti, I. Kim, F.J. Gonzalez, and J.L. Staudinger Regulation of constitutive androstane receptor and its target genes by fasting, camp, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha J Biol Chem 281 2006 26540 26551 (Pubitemid 44401863)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.36 , pp. 26540-26551
    • Ding, X.1    Lichti, K.2    Kim, I.3    Gonzalez, F.J.4    Staudinger, J.L.5
  • 44
    • 46749149713 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha
    • C. Chung, J.A. Doll, V.M. Stellmach, J. Gonzales, S. Surapureddi, and M. Cornwell Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha Adv Exp Med Biol 617 2008 591 597
    • (2008) Adv Exp Med Biol , vol.617 , pp. 591-597
    • Chung, C.1    Doll, J.A.2    Stellmach, V.M.3    Gonzales, J.4    Surapureddi, S.5    Cornwell, M.6
  • 45
    • 44849100002 scopus 로고    scopus 로고
    • Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome p450 2b6 gene
    • K. Inoue, and M. Negishi Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome p450 2b6 gene J Biol Chem 283 2008 10425 10432
    • (2008) J Biol Chem , vol.283 , pp. 10425-10432
    • Inoue, K.1    Negishi, M.2
  • 46
    • 66649126626 scopus 로고    scopus 로고
    • Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha
    • K. Inoue, and M. Negishi Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha FEBS Lett 583 2009 2126 2130
    • (2009) FEBS Lett , vol.583 , pp. 2126-2130
    • Inoue, K.1    Negishi, M.2
  • 47
    • 35548997887 scopus 로고    scopus 로고
    • Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: Roles of hepatocyte nuclear factor 4{alpha} and pregnane X receptor
    • H.L. Fang, S.C. Strom, E. Ellis, Z. Duanmu, J. Fu, and Z. Duniec-Dmuchowski Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4{alpha} and pregnane X receptor J Pharmacol Exp Ther 2007
    • (2007) J Pharmacol Exp Ther
    • Fang, H.L.1    Strom, S.C.2    Ellis, E.3    Duanmu, Z.4    Fu, J.5    Duniec-Dmuchowski, Z.6
  • 48
    • 33645808917 scopus 로고    scopus 로고
    • Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression
    • T. Li, and J.Y. Chiang Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression Drug Metab Dispos 34 2006 756 764
    • (2006) Drug Metab Dispos , vol.34 , pp. 756-764
    • Li, T.1    Chiang, J.Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.