-
1
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
DOI 10.1038/35078107
-
Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8 (Pubitemid 32494397)
-
(2001)
Nature
, vol.411
, Issue.6836
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
2
-
-
0020417286
-
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena
-
Kruger K, Grabowski PJ, Zaug AJ, et al. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell 1982;31:147-57 (Pubitemid 13215202)
-
(1982)
Cell
, vol.31
, Issue.1
, pp. 147-157
-
-
Kruger, K.1
Grabowski, P.J.2
Zaug, A.J.3
-
3
-
-
77952881006
-
Inhibition of gene expression by RNase P
-
Lundblad EW, Altman S. Inhibition of gene expression by RNase P. Nat Biotechnol 2010;27:212-21
-
(2010)
Nat Biotechnol
, vol.27
, pp. 212-21
-
-
Lundblad, E.W.1
Altman, S.2
-
4
-
-
0442307970
-
In search of antisense
-
DOI 10.1016/j.tibs.2003.12.002
-
Lavorgna G, Dahary D, Lehner B, et al. In search of antisense. Trends Biochem Sci 2004;29:88-94 (Pubitemid 38186579)
-
(2004)
Trends in Biochemical Sciences
, vol.29
, Issue.2
, pp. 88-94
-
-
Lavorgna, G.1
Dahary, D.2
Lehner, B.3
Sorek, R.4
Sanderson, C.M.5
Casari, G.6
-
5
-
-
72049125603
-
The plasticity of the mammalian transcriptome
-
Lindberg J, Lundeberg J. The plasticity of the mammalian transcriptome. Genomics 2010;95:1-6
-
(2010)
Genomics
, vol.95
, pp. 1-6
-
-
Lindberg, J.1
Lundeberg, J.2
-
6
-
-
77955941659
-
What are natural antisense transcripts good for?
-
Werner A, Swan D. What are natural antisense transcripts good for? Biochem Soc Trans 2010;38:1144-9
-
(2010)
Biochem Soc Trans
, vol.38
, pp. 1144-9
-
-
Werner, A.1
Swan, D.2
-
7
-
-
77952744176
-
Natural antisense transcripts regulate gene expression in an epigenetic manner
-
Su WY, Xiong H, Fang JY. Natural antisense transcripts regulate gene expression in an epigenetic manner. Biochem Biophys Res Commun 2010;396:177-81
-
(2010)
Biochem Biophys Res Commun
, vol.396
, pp. 177-81
-
-
Su, W.Y.1
Xiong, H.2
Fang, J.Y.3
-
8
-
-
2442576104
-
Natural antisense transcripts of hypoxia-inducible factor 1alpha are detected in different normal and tumour human tissues
-
DOI 10.1016/S0378-1119(02)01049-1, PII S0378111902010491
-
Rossignol F, Vache C, Clottes E. Natural antisense transcripts of hypoxia-inducible factor 1alpha are detected in different normal and tumour human tissues. Gene 2002;299:135-40 (Pubitemid 35379835)
-
(2002)
Gene
, vol.299
, Issue.1-2
, pp. 135-140
-
-
Rossignol, F.1
Vache, C.2
Clottes, E.3
-
9
-
-
79955443659
-
A natural antisense transcript of interferon-alpha1 gene regulates viral infection-mediated mRNA expression level and further induction of interferon-alpha1 protein
-
Kimura T, Shiwen J, Nishizawa M, et al. A natural antisense transcript of interferon-alpha1 gene regulates viral infection-mediated mRNA expression level and further induction of interferon-alpha1 protein. Cytokine 2009;48:124
-
(2009)
Cytokine
, vol.48
, pp. 124
-
-
Kimura, T.1
Shiwen, J.2
Nishizawa, M.3
-
10
-
-
55649099207
-
Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain
-
Smalheiser NR, Lugli G, Torvik VI, et al. Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain. Neurosci Res 2008;62:236-9
-
(2008)
Neurosci Res
, vol.62
, pp. 236-9
-
-
Smalheiser, N.R.1
Lugli, G.2
Torvik, V.I.3
-
11
-
-
78650912040
-
Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Pagets disease
-
Kurihara N, Hiruma Y, Yamana K, et al. Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Pagets disease. Cell Metab 2011;13:23-34
-
(2011)
Cell Metab
, vol.13
, pp. 23-34
-
-
Kurihara, N.1
Hiruma, Y.2
Yamana, K.3
-
12
-
-
79251584041
-
Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2alpha via both NF-kappaB and CREB transcription factors
-
Hadad N, Tuval L, Elgazar-Carmom V, et al. Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2alpha via both NF-kappaB and CREB transcription factors. J Immunol 2011;186:1816-27
-
(2011)
J Immunol
, vol.186
, pp. 1816-1827
-
-
Hadad, N.1
Tuval, L.2
Elgazar-Carmom, V.3
-
13
-
-
55049111537
-
Design and development of antisense drugs
-
Malik R, Roy I. Design and development of antisense drugs. Expert Opin Drug Discov 2008;3:1189-207
-
(2008)
Expert Opin Drug Discov
, vol.3
, pp. 1189-207
-
-
Malik, R.1
Roy, I.2
-
15
-
-
0024041180
-
Role of RNase H in hybrid-arrested translation by antisense oligonucleotides
-
Walder RY, Walder JA. Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc Natl Acad Sci USA 1988;85:5011-15
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 5011-15
-
-
Walder, R.Y.1
Walder, J.A.2
-
16
-
-
0021932392
-
Influence of base-pairing in the leader region on in vitro translation of Rous sarcoma virus RNA
-
DOI 10.1016/0168-1702(85)90004-8
-
Borchelt D, Perdue ML. Influence of base-pairing in the leader region on in vitro translation of Rous sarcoma virus RNA. Virus Res 1985;3:141-51 (Pubitemid 15233694)
-
(1985)
Virus Research
, vol.3
, Issue.2
, pp. 141-151
-
-
Borchelt, D.1
Perdue, M.L.2
-
17
-
-
56649103774
-
Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro
-
Alotte C, Martin A, Caldarelli SA, et al. Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro. Antiviral Res 2008;80:280-7
-
(2008)
Antiviral Res
, vol.80
, pp. 280-7
-
-
Alotte, C.1
Martin, A.2
Caldarelli, S.A.3
-
19
-
-
33646158501
-
Natural antisense transcripts: Sound or silence?
-
DOI 10.1152/physiolgenomics.00124.2005
-
Werner A, Berdal A. Natural antisense transcripts: sound or silence? Physiol Genomics 2005;23:125-31 (Pubitemid 44437972)
-
(2005)
Physiological Genomics
, vol.23
, Issue.2
, pp. 125-131
-
-
Werner, A.1
Berdal, A.2
-
20
-
-
33846083393
-
Regulation of microRNA by antagomirs: A new class of pharmacological antagonists for the specific regulation of gene function?
-
DOI 10.1165/rcmb.2006-0227TR
-
Mattes J, Yang M, Foster PS. Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function? Am J Respir Cell Mol Biol 2007;36:8-12 (Pubitemid 46067702)
-
(2007)
American Journal of Respiratory Cell and Molecular Biology
, vol.36
, Issue.1
, pp. 8-12
-
-
Mattes, J.1
Yang, M.2
Foster, P.S.3
-
21
-
-
28444469246
-
Silencing of microRNAs in vivo with antagomirs
-
Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with antagomirs. Nature 2005;438:685-9
-
(2005)
Nature
, vol.438
, pp. 685-9
-
-
Krutzfeldt, J.1
Rajewsky, N.2
Braich, R.3
-
22
-
-
0030612405
-
Evaluation of l toxicity and efficacy of anti-cytomegalovirus and anti- herpes simplex virus antiviral phosphorothioate oligonucleotides ISIS 2922 and ISIS 4015
-
Flores-Aguilar M, Besen G, Vuong C, et al. Evaluation of retinal toxicity and efficacy of anti-cytomegalovirus and anti-herpes simplex virus antiviral phosphorothioate oligonucleotides ISIS 2922 and ISIS 4015. J Infect Dis 1997;175:1308-16 (Pubitemid 27225032)
-
(1997)
Journal of Infectious Diseases
, vol.175
, Issue.6
, pp. 1308-1316
-
-
Flores-Aguilar, M.1
Besen, G.2
Vuong, C.3
Tatebayashi, M.4
Munguia, D.5
Gangan, P.6
Wiley, C.A.7
Freeman, W.R.8
-
24
-
-
79551573789
-
Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice
-
Menke J, Bork T, Kutska B, et al. Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice. Kidney Int 2011;79:452-63
-
(2011)
Kidney Int
, vol.79
, pp. 452-63
-
-
Menke, J.1
Bork, T.2
Kutska, B.3
-
25
-
-
0037745879
-
q/11 reduces the severity of murine lupus
-
DOI 10.1016/S0300-9084(03)00106-8
-
Ansari MA, Dhar M, Muthukrishnan V, et al. Administration of antisense oligonucleotides to Galpha(Q/11) reduces the severity of murine lupus. Biochimie 2003;85:627-32 (Pubitemid 36798237)
-
(2003)
Biochimie
, vol.85
, Issue.6
, pp. 627-632
-
-
Ansari, M.A.1
Dhar, M.2
Muthukrishnan, V.3
Morton, T.L.4
Bakht, N.5
Jacobson, J.D.6
-
26
-
-
0035036641
-
Gonadotropin-releasing hormone: Potential role in autoimmunity
-
DOI 10.1016/S1567-5769(01)00038-8, PII S1567576901000388
-
Jacobson JD. Gonadotropin-releasing hormone: potential role in autoimmunity. Int Immunopharmacol 2001;1:1077-83 (Pubitemid 32434425)
-
(2001)
International Immunopharmacology
, vol.1
, Issue.6
, pp. 1077-1083
-
-
Jacobson, J.D.1
-
27
-
-
79951512546
-
Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis
-
Diaz-Gallo L, Gourh P, Broen J, et al. Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Ann Rheum Dis 2011;70:454-62
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 454-62
-
-
Diaz-Gallo, L.1
Gourh, P.2
Broen, J.3
-
28
-
-
63749120634
-
Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes
-
Delogu LG, Magrini A, Bergamaschi A, et al. Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. Bioconjug Chem 2009;20:427-31
-
(2009)
Bioconjug Chem
, vol.20
, pp. 427-31
-
-
Delogu, L.G.1
Magrini, A.2
Bergamaschi, A.3
-
29
-
-
45249084126
-
Antisense treatment for myasthenia gravis: Experience with Monarsen
-
DOI 10.1196/annals.1405.022, Myasthenia Gravis and Related Disorders 11th International Conference
-
Sussman JD, Argov Z, McKee D, et al. Antisense treatment for myasthenia gravis: experience with monarsen. Ann NY Acad Sci 2008;1132:283-90 (Pubitemid 351841365)
-
(2008)
Annals of the New York Academy of Sciences
, vol.1132
, pp. 283-290
-
-
Sussman, J.D.1
Argov, Z.2
McKee, D.3
Hazum, E.4
Brawer, S.5
Soreq, H.6
-
30
-
-
53449092024
-
Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/ alginate polyelectrolyte complex
-
Hong HJ, Jin SE, Park JS, et al. Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/ alginate polyelectrolyte complex. Biomaterials 2008;29:4831-7
-
(2008)
Biomaterials
, vol.29
, pp. 4831-7
-
-
Hong, H.J.1
Jin, S.E.2
Park, J.S.3
-
31
-
-
36749049831
-
Propionic and methylmalonic acidemia: Antisense therapeutics for intronic variations causing aberrantly spliced messenger RNA
-
DOI 10.1086/522376
-
Ugarte M, Aguado C, Desviat LR, et al. Propionic and methylmalonic acidemia: Antisense therapeutics for intronic variations causing aberrantly spliced messenger RNA. Am J Hum Genet 2007;81:1262-70 (Pubitemid 350211454)
-
(2007)
American Journal of Human Genetics
, vol.81
, Issue.6
, pp. 1262-1270
-
-
Rincon, A.1
Aguado, C.2
Desviat, L.R.3
Sanchez-Alcudia, R.4
Ugarte, M.5
Perez, B.6
-
32
-
-
77956060846
-
Present and future of antisense therapy for splicing modulation in inherited metabolic disease
-
Perez B, Rodriguez-Pascau L, Vilageliu L, et al. Present and future of antisense therapy for splicing modulation in inherited metabolic disease. J Inherit Metab Dis 2010;33:397-403
-
(2010)
J Inherit Metab Dis
, vol.33
, pp. 397-403
-
-
Perez, B.1
Rodriguez-Pascau, L.2
Vilageliu, L.3
-
33
-
-
72449129516
-
Inhibition of cell proliferation and glucose uptake in human laryngeal carcinoma cells by antisense oligonucleotides against glucose transporter-1
-
Zhou SH, Fan J, Chen XM, et al. Inhibition of cell proliferation and glucose uptake in human laryngeal carcinoma cells by antisense oligonucleotides against glucose transporter-1. Head Neck 2009;31:1624-33
-
(2009)
Head Neck
, vol.31
, pp. 1624-33
-
-
Zhou, S.H.1
Fan, J.2
Chen, X.M.3
-
34
-
-
60749109793
-
Inhibitory effects of c-erbB-2 antisense oligonucleotide transfection on uterine endometrial cancer Ishikawa cell lines
-
Zhao FJ, Zhang SL, Ma L, et al. Inhibitory effects of c-erbB-2 antisense oligonucleotide transfection on uterine endometrial cancer Ishikawa cell lines. Eur J Gynaecol Oncol 2009;30:54-9
-
(2009)
Eur J Gynaecol Oncol
, vol.30
, pp. 54-9
-
-
Zhao, F.J.1
Zhang, S.L.2
Ma, L.3
-
35
-
-
79955406031
-
-
Available from: www.avibio.com.
-
-
-
-
36
-
-
24744470522
-
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer
-
DOI 10.1093/jnci/dji252
-
Chi KN, Eisenhauer E, Fazli L, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst 2005;97:1287-96 (Pubitemid 41535369)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, Issue.17
, pp. 1287-1296
-
-
Chi, K.N.1
Eisenhauer, E.2
Fazli, L.3
Jones, E.C.4
Goldenberg, S.L.5
Powers, J.6
Tu, D.7
Gleave, M.E.8
-
37
-
-
38949153810
-
A phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer
-
DOI 10.1158/1078-0432.CCR-07-1310
-
Chi KN, Siu LL, Hirte H, et al. A phase I study of OGX-011, a 2-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clin Cancer Res 2008;14:833-9 (Pubitemid 351231167)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.3
, pp. 833-839
-
-
Chi, K.N.1
Siu, L.L.2
Hirte, H.3
Hotte, S.J.4
Knox, J.5
Kollmansberger, C.6
Gleave, M.7
Guns, E.8
Powers, J.9
Walsh, W.10
Tu, D.11
Eisenhauer, E.12
-
38
-
-
78751503892
-
Phase i trial of TGF-{beta}2 antisense GM-CSF gene-modified autologous tumor cell (TAG) vaccine
-
Olivares J, Kumar P, Yu Y, et al. Phase I trial of TGF-{beta}2 antisense GM-CSF gene-modified autologous tumor cell (TAG) vaccine. Clin Cancer Res 2011;17:183-92
-
(2011)
Clin Cancer Res
, vol.17
, pp. 183-92
-
-
Olivares, J.1
Kumar, P.2
Yu, Y.3
-
39
-
-
0029041842
-
Prevalence of human papillomavirus in cervical cancer: A worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group
-
Bosch FX, Manos MM, Munoz N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst 1995;87:796-802
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 796-802
-
-
Bosch, F.X.1
Manos, M.M.2
Munoz, N.3
-
40
-
-
77949873027
-
Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo
-
Wang W, Sima N, Kong D, et al. Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo. Cancer Lett 2010;291:67-75
-
(2010)
Cancer Lett
, vol.291
, pp. 67-75
-
-
Wang, W.1
Sima, N.2
Kong, D.3
-
41
-
-
79251627826
-
Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expressionof interleukin-32 controls the expression of the humanpapillomavirus oncogene
-
Lee S, Kim JH, Kim H, et al. Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expressionof interleukin-32 controls the expression of the humanpapillomavirus oncogene. Immunology 2011;132:410-20
-
(2011)
Immunology
, vol.132
, pp. 410-20
-
-
Lee, S.1
Kim, J.H.2
Kim, H.3
-
42
-
-
77956436149
-
Advanced antisense therapies for postexposure protection against lethal filovirus infections
-
Warren TK, Warfield KL, Wells J, et al. Advanced antisense therapies for postexposure protection against lethal filovirus infections. Nat Med 2010;16:991-4
-
(2010)
Nat Med
, vol.16
, pp. 991-4
-
-
Warren, T.K.1
Warfield, K.L.2
Wells, J.3
-
43
-
-
0037131968
-
Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood
-
DOI 10.1084/jem.20020943
-
Culley FJ, Pollott J, Openshaw PJ. Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J Exp Med 2002;196:1381-6 (Pubitemid 35375557)
-
(2002)
Journal of Experimental Medicine
, vol.196
, Issue.10
, pp. 1381-1386
-
-
Culley, F.J.1
Pollott, J.2
Openshaw, P.J.M.3
-
44
-
-
78049517831
-
Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease
-
Ripple MJ, You D, Honnegowda S, et al. Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease. J Immunol 2010;185:4804-11
-
(2010)
J Immunol
, vol.185
, pp. 4804-11
-
-
Ripple, M.J.1
You, D.2
Honnegowda, S.3
-
45
-
-
33644773580
-
Gene silencing of HIV chemokine receptors using ribozymes and single-stranded antisense RNA
-
DOI 10.1042/BJ20051268
-
Qureshi A, Zheng R, Parlett T, et al. Gene silencing of HIV chemokine receptors using ribozymes and single-stranded antisense RNA. Biochem J 2006;394:511-18 (Pubitemid 43342552)
-
(2006)
Biochemical Journal
, vol.394
, Issue.2
, pp. 511-518
-
-
Qureshi, A.1
Zheng, R.2
Parlett, T.3
Shi, X.4
Balaraman, P.5
Cheloufi, S.6
Murphy, B.7
Guntermann, C.8
Eagles, P.9
-
47
-
-
77951069859
-
Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia
-
Akdim F, Visser ME, Tribble DL, et al. Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia. Am J Cardiol 2010;105:1413-19
-
(2010)
Am J Cardiol
, vol.105
, pp. 1413-19
-
-
Akdim, F.1
Visser, M.E.2
Tribble, D.L.3
-
48
-
-
74049140301
-
Trial watch Antisense agent reduces LDL-cholesterol levels in high-risk patients
-
Trial watch. Antisense agent reduces LDL-cholesterol levels in high-risk patients. Nat Rev Drug Discov 2010;9:10
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 10
-
-
-
49
-
-
78651350647
-
PCSK9: An emerging target for treatment of hypercholesterolemia
-
Duff CJ, Hooper NM. PCSK9: an emerging target for treatment of hypercholesterolemia. Expert Opin Ther Targets 2011;15:157-68
-
(2011)
Expert Opin Ther Targets
, vol.15
, pp. 157-68
-
-
Duff, C.J.1
Hooper, N.M.2
-
50
-
-
34147136507
-
Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
-
DOI 10.1194/jlr.C600025-JLR200
-
Graham MJ, Lemonidis KM, Whipple CP, et al. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J Lipid Res 2007;48:763-7 (Pubitemid 46557881)
-
(2007)
Journal of Lipid Research
, vol.48
, Issue.4
, pp. 763-767
-
-
Graham, M.J.1
Lemonidis, K.M.2
Whipple, C.P.3
Subramaniam, A.4
Monia, B.P.5
Crooke, S.T.6
Crooke, R.M.7
-
51
-
-
77956519356
-
A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo
-
Gupta N, Fisker N, Asselin MC, et al. A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. PLoS One 2010;5:e10682
-
(2010)
PLoS One
, vol.5
-
-
Gupta, N.1
Fisker, N.2
Asselin, M.C.3
-
52
-
-
74449086309
-
Progress in therapeutic antisense applications for neuromuscular disorders
-
Aartsma-Rus A, van Ommen GJ. Progress in therapeutic antisense applications for neuromuscular disorders. Eur J Hum Genet 2010;18:146-53
-
(2010)
Eur J Hum Genet
, vol.18
, pp. 146-53
-
-
Aartsma-Rus, A.1
Van Ommen, G.J.2
-
53
-
-
77957850598
-
Antisense modulation of both exonic and intronic splicing motifs induces skipping of a DMD pseudo-exon responsible for X-linked dilated cardiomyopathy
-
Rimessi P, Fabris M, Bovolenta M, et al. Antisense modulation of both exonic and intronic splicing motifs induces skipping of a DMD pseudo-exon responsible for X-linked dilated cardiomyopathy. Hum Gene Ther 2010;21:1137-46
-
(2010)
Hum Gene Ther
, vol.21
, pp. 1137-46
-
-
Rimessi, P.1
Fabris, M.2
Bovolenta, M.3
-
54
-
-
36849035575
-
Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy
-
DOI 10.1172/JCI33355
-
Wheeler TM, Lueck JD, Swanson MS, et al. Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy. J Clin Invest 2007;117:3952-7 (Pubitemid 350224104)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.12
, pp. 3952-3957
-
-
Wheeler, T.M.1
Lueck, J.D.2
Swanson, M.S.3
Dirksen, R.T.4
Thornton, C.A.5
-
55
-
-
67349278762
-
The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation
-
Kelley NW, Huang X, Tam S, et al. The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation. J Mol Biol 2009;388:919-27
-
(2009)
J Mol Biol
, vol.388
, pp. 919-27
-
-
Kelley, N.W.1
Huang, X.2
Tam, S.3
-
56
-
-
0035282594
-
Loss of normal huntingtin function: New developments in Huntington's disease research
-
DOI 10.1016/S0166-2236(00)01721-5, PII S0166223600017215
-
Cattaneo E, Rigamonti D, Goffredo D, et al. Loss of normal huntingtin function: new developments in Huntingtons disease research. Trends Neurosci 2001;24:182-8 (Pubitemid 32166824)
-
(2001)
Trends in Neurosciences
, vol.24
, Issue.3
, pp. 182-188
-
-
Cattaneo, E.1
Rigamonti, D.2
Goffredo, D.3
Zuccato, C.4
Squitieri, F.5
Sipione, S.6
-
57
-
-
78649379362
-
Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat
-
Gagnon KT, Pendergraff HM, Deleavey GF, et al. Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry 2010;49:10166-78
-
(2010)
Biochemistry
, vol.49
, pp. 10166-78
-
-
Gagnon, K.T.1
Pendergraff, H.M.2
Deleavey, G.F.3
-
58
-
-
59849090939
-
Antisense oligonucleotides effectively inhibit the co-transcriptional splicing of a Candida group i intron in vitro and in vivo: Implications for antifungal therapeutics
-
Zhang L, Leibowitz MJ, Zhang Y. Antisense oligonucleotides effectively inhibit the co-transcriptional splicing of a Candida group I intron in vitro and in vivo: implications for antifungal therapeutics. FEBS Lett 2009;583:734-8
-
(2009)
FEBS Lett
, vol.583
, pp. 734-8
-
-
Zhang, L.1
Leibowitz, M.J.2
Zhang, Y.3
-
59
-
-
78650054331
-
Drug delivery trends in clinical trials and translational medicine: Challenges and opportunities in the delivery of nucleic acid-based therapeutics
-
Xu L, Anchordoquy T. Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. J Pharm Sci 2011;100:38-52
-
(2011)
J Pharm Sci
, vol.100
, pp. 38-52
-
-
Xu, L.1
Anchordoquy, T.2
-
61
-
-
67650403364
-
Controlled delivery of antisense oligonucleotides: A brief review of current strategies
-
Zhao X, Pan F, Holt CM, et al. Controlled delivery of antisense oligonucleotides: a brief review of current strategies. Expert Opin Drug Deliv 2009;6:673-86
-
(2009)
Expert Opin Drug Deliv
, vol.6
, pp. 673-86
-
-
Zhao, X.1
Pan, F.2
Holt, C.M.3
-
62
-
-
77956556303
-
Free-radical ring closure to conformationally locked alpha-L-carba- LNAs and synthesis of their oligos: Nuclease stability, target RNA specificity, and elicitation of RNase H
-
Li Q, Yuan F, Zhou C, et al. Free-radical ring closure to conformationally locked alpha-L-carba- LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H. J Org Chem 2010;75:6122-40
-
(2010)
J Org Chem
, vol.75
, pp. 6122-40
-
-
Li, Q.1
Yuan, F.2
Zhou, C.3
-
63
-
-
48149099287
-
2-O-Lysylaminohexyl oligonucleotides: Modifications for antisense and siRNA
-
Winkler J, Gilbert M, Kocourkova A, et al. 2-O-Lysylaminohexyl oligonucleotides: modifications for antisense and siRNA. ChemMedChem 2008;3:102-10
-
(2008)
ChemMedChem
, vol.3
, pp. 102-10
-
-
Winkler, J.1
Gilbert, M.2
Kocourkova, A.3
-
64
-
-
67349159358
-
Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide G3139 in a murine k562 xenograft model
-
Zhang X, Koh CG, Yu B, et al. Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide G3139 in a murine k562 xenograft model. Pharm Res 2009;26:1516-24
-
(2009)
Pharm Res
, vol.26
, pp. 1516-24
-
-
Zhang, X.1
Koh, C.G.2
Yu, B.3
-
65
-
-
51849110440
-
An efficient biodelivery system for antisense polyamide nucleic acid (PNA)
-
Mehiri M, Upert G, Tripathi S, et al. An efficient biodelivery system for antisense polyamide nucleic acid (PNA). Oligonucleotides 2008;18:245-56
-
(2008)
Oligonucleotides
, vol.18
, pp. 245-56
-
-
Mehiri, M.1
Upert, G.2
Tripathi, S.3
-
66
-
-
77249148273
-
Peptide nucleic acids (PNAs) antisense effect to bacterial growth and their application potentiality in biotechnology
-
Hatamoto M, Ohashi A, Imachi H. Peptide nucleic acids (PNAs) antisense effect to bacterial growth and their application potentiality in biotechnology. Appl Microbiol Biotechnol 2010;86:397-402
-
(2010)
Appl Microbiol Biotechnol
, vol.86
, pp. 397-402
-
-
Hatamoto, M.1
Ohashi, A.2
Imachi, H.3
-
67
-
-
0034060189
-
Absorption of antisense oligonucleotides in rat intestine: Effect of chemistry and length
-
Khatsenko O, Morgan R, Truong L, et al. Absorption of antisense oligonucleotides in rat intestine: effect of chemistry and length. Antisense Nucleic Acid Drug Dev 2000;10:35-44 (Pubitemid 30148188)
-
(2000)
Antisense and Nucleic Acid Drug Development
, vol.10
, Issue.1
, pp. 35-44
-
-
Khatsenko, O.1
Morgan, R.2
Truong, L.3
York-Defalco, C.4
Sasmor, H.5
Conklin, B.6
Geary, R.S.7
-
68
-
-
0036830625
-
Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs
-
DOI 10.1016/S0928-0987(02)00162-8, PII S0928098702001628
-
Raoof AA, Ramtoola Z, McKenna B, et al. Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs. Eur J Pharm Sci 2002;17:131-8 (Pubitemid 35248266)
-
(2002)
European Journal of Pharmaceutical Sciences
, vol.17
, Issue.3
, pp. 131-138
-
-
Raoof, A.A.1
Ramtoola, Z.2
McKenna, B.3
Yu, R.Z.4
Hardee, G.5
Geary, R.S.6
-
69
-
-
2642556483
-
Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate
-
DOI 10.1002/jps.20051
-
Raoof AA, Chiu P, Ramtoola Z, et al. Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate. J Pharm Sci 2004;93:1431-9 (Pubitemid 38725017)
-
(2004)
Journal of Pharmaceutical Sciences
, vol.93
, Issue.6
, pp. 1431-1439
-
-
Raoof, A.A.1
Chiu, P.2
Ramtoola, Z.3
Cumming, I.K.4
Teng, C.5
Weinbach, S.P.6
Hardee, G.E.7
Levin, A.A.8
Geary, R.S.9
-
70
-
-
38349171887
-
Oral delivery of antisense oligonucleotides in man
-
Tillman LG, Geary RS, Hardee GE. Oral delivery of antisense oligonucleotides in man. J Pharm Sci 2008;97:225-36
-
(2008)
J Pharm Sci
, vol.97
, pp. 225-36
-
-
Tillman, L.G.1
Geary, R.S.2
Hardee, G.E.3
-
71
-
-
0035874053
-
Integration of adeno-associated virus 2 dna in human MKR melanoma cells induces a peptide with oncosuppressive properties
-
DOI 10.1002/ijc.1230
-
Bantel-Schaal U. Integration of adeno-associated virus 2 DNA in human MKR melanoma cells induces a peptide with oncosuppressive properties. Int J Cancer 2001;92:537-44 (Pubitemid 32319427)
-
(2001)
International Journal of Cancer
, vol.92
, Issue.4
, pp. 537-544
-
-
Bantel-Schaal, U.1
-
72
-
-
46249108952
-
Long-term benefit of adeno-associated virus/antisense-mediated exon skipping in dystrophic mice
-
DOI 10.1089/hum.2008.012
-
Denti MA, Incitti T, Sthandier O, et al. Long-term benefit of adeno-associated virus/antisense-mediated exon skipping in dystrophic mice. Hum Gene Ther 2008;19:601-8 (Pubitemid 351913531)
-
(2008)
Human Gene Therapy
, vol.19
, Issue.6
, pp. 601-608
-
-
Denti, M.A.1
Incitti, T.2
Sthandier, O.3
Nicoletti, C.4
Angelis, F.G.D.5
Rizzuto, E.6
Auricchio, A.7
Musaro, A.8
Bozzoni, I.9
-
73
-
-
64049098319
-
Antisense hypoxia-inducible factor-1alpha augments transcatheter arterial embolization in the treatment of hepatocellular carcinomas in rats
-
Sun X, Jiang H, Jiang X, et al. Antisense hypoxia-inducible factor-1alpha augments transcatheter arterial embolization in the treatment of hepatocellular carcinomas in rats. Hum Gene Ther 2009;20:314-24
-
(2009)
Hum Gene Ther
, vol.20
, pp. 314-24
-
-
Sun, X.1
Jiang, H.2
Jiang, X.3
-
74
-
-
20944449117
-
Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1
-
DOI 10.1016/j.radonc.2005.01.009, PII S0167814005000551
-
Williams KJ, Telfer BA, Xenaki D, et al. Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1. Radiother Oncol 2005;75:89-98 (Pubitemid 40616800)
-
(2005)
Radiotherapy and Oncology
, vol.75
, Issue.1
, pp. 89-98
-
-
Williams, K.J.1
Telfer, B.A.2
Xenaki, D.3
Sheridan, M.R.4
Desbaillets, I.5
Peters, H.J.W.6
Honess, D.7
Harris, A.L.8
Dachs, G.U.9
Van Der Kogel, A.10
Stratford, I.J.11
-
75
-
-
77955500315
-
Robust, reversible gene knockdown using a single lentiviral short hairpin RNA vector
-
Brown CY, Sadlon T, Gargett T, et al. Robust, reversible gene knockdown using a single lentiviral short hairpin RNA vector. Hum Gene Ther 2010;21:1005-17
-
(2010)
Hum Gene Ther
, vol.21
, pp. 1005-17
-
-
Brown, C.Y.1
Sadlon, T.2
Gargett, T.3
-
76
-
-
77951122502
-
Knocking down gene expression with dendritic vectors
-
Ravina M, Paolicelli P, Seijo B, et al. Knocking down gene expression with dendritic vectors. Mini Rev Med Chem 2010;10:73-86
-
(2010)
Mini Rev Med Chem
, vol.10
, pp. 73-86
-
-
Ravina, M.1
Paolicelli, P.2
Seijo, B.3
-
77
-
-
77956937217
-
Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment
-
Wang P, Zhao XH, Wang ZY, et al. Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment. Cancer Lett 2010;298:34-49
-
(2010)
Cancer Lett
, vol.298
, pp. 34-49
-
-
Wang, P.1
Zhao, X.H.2
Wang, Z.Y.3
-
78
-
-
0035878071
-
Overexpression of α4 chain-containing laminins in human glial tumors identified by gene microarray analysis
-
Ljubimova JY, Lakhter AJ, Loksh A, et al. Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis. Cancer Res 2001;61:5601-10 (Pubitemid 32694948)
-
(2001)
Cancer Research
, vol.61
, Issue.14
, pp. 5601-5610
-
-
Ljubimova, J.Y.1
Lakhter, A.J.2
Loksh, A.3
Yong, W.H.4
Riedinger, M.S.5
Miner, J.H.6
Sorokin, L.M.7
Ljubimov, A.V.8
Black, K.L.9
-
79
-
-
78149245451
-
Inhibition of brain tumor growth by intravenous poly(beta-L-malic acid) nanobioconjugate with pH-dependent drug release
-
Ding H, Inoue S, Ljubimov AV, et al. Inhibition of brain tumor growth by intravenous poly(beta-L-malic acid) nanobioconjugate with pH-dependent drug release. Proc Natl Acad Sci USA 2010;107:18143-8
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18143-8
-
-
Ding, H.1
Inoue, S.2
Ljubimov, A.V.3
-
80
-
-
77953766334
-
Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance
-
Garbuzenko OB, Saad M, Pozharov VP, et al. Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance. Proc Natl Acad Sci USA 2010;107:10737-42
-
Proc Natl Acad Sci USA
, vol.2010
, Issue.107
, pp. 10737-42
-
-
Garbuzenko, O.B.1
Saad, M.2
Pozharov, V.P.3
-
81
-
-
77954131966
-
Topical application of antisense oligonucleotide-loaded chitosan nanoparticles to rats
-
Ozbas-Turan S, Akbuga J, Sezer AD. Topical application of antisense oligonucleotide-loaded chitosan nanoparticles to rats. Oligonucleotides 2010;20:147-53
-
(2010)
Oligonucleotides
, vol.20
, pp. 147-53
-
-
Ozbas-Turan, S.1
Akbuga, J.2
Sezer, A.D.3
-
82
-
-
70349294051
-
Antitumor vectorized oligonucleotides in a model of ewing sarcoma: Unexpected role of nanoparticles
-
Elhamess H, Bertrand JR, Maccario J, et al. Antitumor vectorized oligonucleotides in a model of ewing sarcoma: unexpected role of nanoparticles. Oligonucleotides 2009;19:255-64
-
(2009)
Oligonucleotides
, vol.19
, pp. 255-64
-
-
Elhamess, H.1
Bertrand, J.R.2
MacCario, J.3
-
83
-
-
77954314021
-
Topical and intravitreous administration of cationic nanoemulsions to deliver antisense oligonucleotides directed towards VEGF KDR receptors to the eye
-
Hagigit T, Abdulrazik M, Orucov F, et al. Topical and intravitreous administration of cationic nanoemulsions to deliver antisense oligonucleotides directed towards VEGF KDR receptors to the eye. J Control Release 2010;145:297-305
-
(2010)
J Control Release
, vol.145
, pp. 297-305
-
-
Hagigit, T.1
Abdulrazik, M.2
Orucov, F.3
-
84
-
-
33645095226
-
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
-
Ng EW, Shima DT, Calias P, et al. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov 2006;5:123-32
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 123-32
-
-
Ng, E.W.1
Shima, D.T.2
Calias, P.3
-
85
-
-
0033672976
-
Influence of emulsion droplet surface charge on indomethacin ocular tissue distribution
-
Klang S, Abdulrazik M, Benita S. Influence of emulsion droplet surface charge on indomethacin ocular tissue distribution. Pharm Dev Technol 2000;5:521-32
-
(2000)
Pharm Dev Technol
, vol.5
, pp. 521-32
-
-
Klang, S.1
Abdulrazik, M.2
Benita, S.3
-
86
-
-
77958176981
-
Cellular delivery and antisense effects of peptide nucleic acid conjugated to polyethyleneimine via disulphide linkers
-
Berthold PR, Shiraishi T, Nielsen PE. Cellular delivery and antisense effects of peptide nucleic acid conjugated to polyethyleneimine via disulphide linkers. Bioconjug Chem 2010;21:1933-8
-
(2010)
Bioconjug Chem
, vol.21
, pp. 1933-8
-
-
Berthold, P.R.1
Shiraishi, T.2
Nielsen, P.E.3
-
87
-
-
56749104670
-
Cellular delivery and biological activity of antisense oligonucleotides conjugated to a targeted protein carrier
-
Kang H, Alam MR, Dixit V, et al. Cellular delivery and biological activity of antisense oligonucleotides conjugated to a targeted protein carrier. Bioconjug Chem 2008;19:2182-8
-
(2008)
Bioconjug Chem
, vol.19
, pp. 2182-8
-
-
Kang, H.1
Alam, M.R.2
Dixit, V.3
-
88
-
-
67650784376
-
Inhibition of ataxia-telangiectasia mutated by antisense oligonucleotide nanoparticles induces radiosensitization of head and neck squamous-cell carcinoma in mice
-
Zou J, Qiao X, Ye H, et al. Inhibition of ataxia-telangiectasia mutated by antisense oligonucleotide nanoparticles induces radiosensitization of head and neck squamous-cell carcinoma in mice. Cancer Biother Radiopharm 2009;24:339-46
-
(2009)
Cancer Biother Radiopharm
, vol.24
, pp. 339-46
-
-
Zou, J.1
Qiao, X.2
Ye, H.3
-
89
-
-
40849100332
-
Antitumor mechanisms of systemically administered epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck
-
DOI 10.1124/mol.107.041160
-
Thomas SM, Ogagan MJ, Freilino ML, et al. Antitumor mechanisms of systemically administered epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck. Mol Pharmacol 2008;73:627-38 (Pubitemid 351397868)
-
(2008)
Molecular Pharmacology
, vol.73
, Issue.3
, pp. 627-638
-
-
Thomas, S.M.1
Ogagan, M.J.2
Freilino, M.L.3
Strychor, S.4
Walsh, D.R.5
Gooding, W.E.6
Grandis, J.R.7
Zamboni, W.C.8
-
90
-
-
77957957234
-
Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer
-
Chi KN, Hotte SJ, Yu EY, et al. Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer. J Clin Oncol 2010;28:4247-54
-
(2010)
J Clin Oncol
, vol.28
, pp. 4247-54
-
-
Chi, K.N.1
Hotte, S.J.2
Yu, E.Y.3
-
91
-
-
17244377075
-
Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi
-
DOI 10.1042/BJ20041956
-
Bilanges B, Stokoe D. Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi. Biochem J 2005;388:573-83 (Pubitemid 40839935)
-
(2005)
Biochemical Journal
, vol.388
, Issue.2
, pp. 573-583
-
-
Bilanges, B.1
Stokoe, D.2
-
92
-
-
35448973406
-
Restoration of the balanced alpha/betaglobin gene expression in beta654-thalassemia mice using combined RNAi and antisense RNA approach
-
Xie SY, Ren ZR, Zhang JZ, et al. Restoration of the balanced alpha/betaglobin gene expression in beta654-thalassemia mice using combined RNAi and antisense RNA approach. Hum Mol Genet 2007;16:2616-25
-
(2007)
Hum Mol Genet
, vol.16
, pp. 2616-25
-
-
Xie, S.Y.1
Ren, Z.R.2
Zhang, J.Z.3
-
93
-
-
84948984545
-
The molecular pathology of the thalassemias
-
4th edition. Blackwell Science, Oxford
-
Higgs DR, Thein SL, Woods WG. The molecular pathology of the thalassemias. In: Weatherall DJ, Clegg B, editors, The thalassemia syndromes. 4th edition. Blackwell Science, Oxford; 2001. p. 133-91
-
(2001)
The Thalassemia Syndromes
, pp. 133-91
-
-
Higgs, D.R.1
Thein, S.L.2
Woods, W.G.3
-
94
-
-
1942499451
-
Improving the efficiency of RNA interference in mammals
-
DOI 10.1038/nrg1323
-
Mittal V. Improving the efficiency of RNA interference in mammals. Nat Rev Genet 2004;5:355-65 (Pubitemid 38529407)
-
(2004)
Nature Reviews Genetics
, vol.5
, Issue.5
, pp. 355-365
-
-
Mittal, V.1
-
95
-
-
0030996469
-
Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation
-
Williams BR. Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation. Biochem Soc Trans 1997;25:509-13 (Pubitemid 27260861)
-
(1997)
Biochemical Society Transactions
, vol.25
, Issue.2
, pp. 509-513
-
-
Williams, B.R.G.1
-
96
-
-
0032079356
-
The 2-5A system: Modulation of viral and cellular processes through acceleration of RNA degradation
-
DOI 10.1016/S0163-7258(97)00167-8
-
Player MR, Torrence PF. The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation. Pharmacol Ther 1998;78:55-113 (Pubitemid 28202386)
-
(1998)
Pharmacology and Therapeutics
, vol.78
, Issue.2
, pp. 55-113
-
-
Player, M.R.1
Torrence, P.F.2
-
98
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
DOI 10.1101/gad.862301
-
Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 2001;15:188-200 (Pubitemid 32107664)
-
(2001)
Genes and Development
, vol.15
, Issue.2
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
99
-
-
0038798081
-
Genomewide view of gene silencing by small interfering RNAs
-
DOI 10.1073/pnas.1037853100
-
Chi JT, Chang HY, Wang NN, et al. Genomewide view of gene silencing by small interfering RNAs. Proc Natl Acad Sci USA 2003;100:6343-6 (Pubitemid 36666583)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.11
, pp. 6343-6346
-
-
Chi, J.-T.1
Chang, H.Y.2
Wang, N.N.3
Chang, D.S.4
Dunphy, N.5
Brown, P.O.6
-
100
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
DOI 10.1038/ncb1038
-
Sledz CA, Holko M, de Veer MJ, et al. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 2003;5:834-9 (Pubitemid 37087172)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.9
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
De Veer, M.J.3
Silverman, R.H.4
Williams, B.R.G.5
-
101
-
-
79955422518
-
-
Availaible from: www.isip.com
-
-
-
-
102
-
-
79955365772
-
-
Availaible from: www.genzyme.com
-
-
-
-
103
-
-
44649097840
-
AEG-35156, an antisense oligonucleotide against X-linked inhibitor of apoptosis for the potential treatment of cancer
-
Tamm I. AEG-35156, an antisense oligonucleotide against X-linked inhibitor of apoptosis for the potential treatment of cancer. Curr Opin Investig Drugs 2008;9:638-46 (Pubitemid 351777167)
-
(2008)
Current Opinion in Investigational Drugs
, vol.9
, Issue.6
, pp. 638-646
-
-
Tamm, I.1
-
104
-
-
79955454347
-
-
Availaible from: www.antisensepharma. de
-
-
-
-
105
-
-
79951602633
-
Targeted therapy for high-grade glioma with the TGF-{beta}2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
-
Bogdahn U, Hau P, Stockhammer G, et al. Targeted therapy for high-grade glioma with the TGF-{beta}2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neurooncol 2010;13:132-42
-
(2010)
Neurooncol
, vol.13
, pp. 132-42
-
-
Bogdahn, U.1
Hau, P.2
Stockhammer, G.3
-
106
-
-
79955404976
-
-
Available from: www.tevapharm.com
-
-
-
-
107
-
-
79955431333
-
-
Available from: www.oncogenex.ca.
-
-
-
-
108
-
-
79955413176
-
-
Available from: www.bms.com.
-
-
-
-
109
-
-
79955443658
-
-
Available from: www.excaliard.com.
-
-
-
-
110
-
-
79955447026
-
-
Available from: www.lilly.com
-
-
-
-
111
-
-
79955433328
-
-
Available from: www.enzo.com.
-
-
-
-
112
-
-
65649152375
-
Phase i study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors
-
Plummer R, Vidal L, Griffin M, et al. Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors. Clin Cancer Res 2009;15:3177-83
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3177-83
-
-
Plummer, R.1
Vidal, L.2
Griffin, M.3
-
113
-
-
67650423961
-
Spleen-specific suppression of TNF-alpha by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models
-
Dong L, Xia S, Chen H, et al. Spleen-specific suppression of TNF-alpha by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models. Biomaterials 2009;30:4416-26
-
(2009)
Biomaterials
, vol.30
, pp. 4416-26
-
-
Dong, L.1
Xia, S.2
Chen, H.3
-
114
-
-
77949656381
-
Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles
-
Wang J, Tao X, Zhang Y, et al. Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles. Biomaterials 2010;31:4426-33
-
(2010)
Biomaterials
, vol.31
, pp. 4426-33
-
-
Wang, J.1
Tao, X.2
Zhang, Y.3
-
115
-
-
64749094374
-
Development of an antisense RNA delivery system using conjugates of the MS2 bacteriophage capsids and HIV-1 TAT cell-penetrating peptide
-
Wei B, Wei Y, Zhang K, et al. Development of an antisense RNA delivery system using conjugates of the MS2 bacteriophage capsids and HIV-1 TAT cell-penetrating peptide. Biomed Pharmacother 2009;63:313-18
-
(2009)
Biomed Pharmacother
, vol.63
, pp. 313-18
-
-
Wei, B.1
Wei, Y.2
Zhang, K.3
-
116
-
-
50249188836
-
Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain
-
Koppelhus U, Shiraishi T, Zachar V, et al. Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain. Bioconjug Chem 2008;19:1526-34
-
(2008)
Bioconjug Chem
, vol.19
, pp. 1526-34
-
-
Koppelhus, U.1
Shiraishi, T.2
Zachar, V.3
-
117
-
-
77049123764
-
Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach
-
Pillai VC, Yesudas R, Shaik IH, et al. Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach. Bioconjug Chem 2010;21:203-7
-
(2010)
Bioconjug Chem
, vol.21
, pp. 203-7
-
-
Pillai, V.C.1
Yesudas, R.2
Shaik, I.H.3
-
118
-
-
70350697818
-
A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice
-
Yin H, Moulton HM, Betts C, et al. A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice. Hum Mol Genet 2009;18:4405-14
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4405-14
-
-
Yin, H.1
Moulton, H.M.2
Betts, C.3
|