Antisense oligonucleotides effectively inhibit the co-transcriptional splicing of a Candida group I intron in vitro and in vivo: Implications for antifungal therapeutics

FEBS Letters

Volumn 583, Issue 4, 2009, Pages 734-738

  Zhang, Libin ^a   Leibowitz, Michael J ^b   Zhang, Yi ^a  

^a School of Pharmaceutical Sciences   (China)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Antimicrobial; Antisense oligonucleotide (AON); Candida albicans; Group I ribozyme; P3 P7 core

Indexed keywords

26S RRNA; ANTIFUNGAL AGENT; ANTISENSE OLIGONUCLEOTIDE; RIBOSOME RNA; RIBOZYME; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG TARGETING; FLOW CYTOMETRY; FUNGAL STRAIN; FUNGICIDAL ACTIVITY; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; INTRON; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HUMANS; INHIBITORY CONCENTRATION 50; INTRONS; KINETICS; OLIGONUCLEOTIDES, ANTISENSE; RNA SPLICING; RNA, CATALYTIC;

CANDIDA; CANDIDA ALBICANS;

EID: 59849090939     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.01.040     Document Type: Article

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