-
1
-
-
0031278019
-
Perspectives in antisense therapeutics
-
AGRAWAL, S., and IYER, R.P. (1997). Perspectives in antisense therapeutics. Pharmacol. Ther. 76, 151-160.
-
(1997)
Pharmacol. Ther.
, vol.76
, pp. 151-160
-
-
Agrawal, S.1
Iyer, R.P.2
-
2
-
-
0000397940
-
Pharmacokinetics and bioavailability of antisense oligonucleotides following oral and colorectal administrations in experimental animals
-
"Antisense Research and Application." S.T. Crooke, ed. (Springer-Verlag, Berlin, Heidelberg)
-
AGRAWAL, S., and ZHANG, R. (1998). Pharmacokinetics and bioavailability of antisense oligonucleotides following oral and colorectal administrations in experimental animals. In: Handbook of Experimental Pharmacology, "Antisense Research and Application." S.T. Crooke, ed. (Springer-Verlag, Berlin, Heidelberg), vol. 131, 525-543.
-
(1998)
Handbook of Experimental Pharmacology
, vol.131
, pp. 525-543
-
-
Agrawal, S.1
Zhang, R.2
-
3
-
-
0029100397
-
Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration
-
AGRAWAL, S., ZHANG, X., LU, Z., ZHAO, H., TAMBURIN, J.M., YAN, J., CAI, H., DIASIO, R.G., HABUS, I., JLANG, Z., IYER, R.P., YU, D., and ZHANG, R. (1995). Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration. Biochem. Pharmacol. 50, 571-576.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 571-576
-
-
Agrawal, S.1
Zhang, X.2
Lu, Z.3
Zhao, H.4
Tamburin, J.M.5
Yan, J.6
Cai, H.7
Diasio, R.G.8
Habus, I.9
Jlang, Z.10
Iyer, R.P.11
Yu, D.12
Zhang, R.13
-
4
-
-
0027981853
-
Efficient synthesis of antisense oligodeoxyribonucleotide phosphorothioates
-
ANDRADE, M., SCOZZARI, A., COLE, D.L., and RAVIJUMAR, V.T. (1994). Efficient synthesis of antisense oligodeoxyribonucleotide phosphorothioates. Bioorg. Med. Chem. Lett. 4, 2017-2022.
-
(1994)
Bioorg. Med. Chem. Lett.
, vol.4
, pp. 2017-2022
-
-
Andrade, M.1
Scozzari, A.2
Cole, D.L.3
Ravijumar, V.T.4
-
5
-
-
0031889133
-
Effects of size and sequence on the iontophoretic delivery of oligonucleotides
-
BRAND, R.M., WAHL, A., and IVERSEN, P.L. (1997). Effects of size and sequence on the iontophoretic delivery of oligonucleotides. J. Pharm. Sci. 87, 49-52.
-
(1997)
J. Pharm. Sci.
, vol.87
, pp. 49-52
-
-
Brand, R.M.1
Wahl, A.2
Iversen, P.L.3
-
6
-
-
12644302203
-
Pharmacokinetic properties of several novel oligonucleotide analogs in mice
-
CROOKE, S.T., GRAHAM, M.J, ZUCKERMAN, J.E., BROOKS, D., CONKLIN, B.S., CUMMINS, L.L., GREIG, M.J., GUINOSSO, C.J., KORNBRUST, D., MANOHARAN, M., SASMOR, H.M., SCHLEICH, T., TIVEL, K.L., and GRIFFEY, R.H. (1996). Pharmacokinetic properties of several novel oligonucleotide analogs in mice. J. Pharm. Exp. Ther. 277, 923-937.
-
(1996)
J. Pharm. Exp. Ther.
, vol.277
, pp. 923-937
-
-
Crooke, S.T.1
Graham, M.J.2
Zuckerman, J.E.3
Brooks, D.4
Conklin, B.S.5
Cummins, L.L.6
Greig, M.J.7
Guinosso, C.J.8
Kornbrust, D.9
Manoharan, M.10
Sasmor, H.M.11
Schleich, T.12
Tivel, K.L.13
Griffey, R.H.14
-
7
-
-
0029077840
-
Characterization of fully 2′-modified oligoribonucleotide hetero- And homoduplex hybridization and nuclease sensitivity
-
CUMMINS, L.L., OWENS, S.R., RISEN, L.M., LESNIK, E.A., FREIER, S.M., McGEE, D., GUINOSSO, C.J., and COOK, P.D. (1995). Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity. Nucleic Acids Res. 23, 2019-2024.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 2019-2024
-
-
Cummins, L.L.1
Owens, S.R.2
Risen, L.M.3
Lesnik, E.A.4
Freier, S.M.5
McGee, D.6
Guinosso, C.J.7
Cook, P.D.8
-
8
-
-
0030839546
-
Identification and characterization of second-generation antisense oligonucleotides
-
DEAN, N.M., and GRIFFEY, R.H. (1997). Identification and characterization of second-generation antisense oligonucleotides. Antisense Nucleic Acid Drug Dev. 7, 229-233.
-
(1997)
Antisense Nucleic Acid Drug Dev.
, vol.7
, pp. 229-233
-
-
Dean, N.M.1
Griffey, R.H.2
-
9
-
-
0014589701
-
Drug absorption. I. An in situ rat gut technique yielding realistic absorption rates
-
DOLUISIO, J.T., BILLUPS, N.F., DITTERT, L.W., SUGITA, E.T., and SWINTOSKY, J.V. (1969). Drug absorption. I. An in situ rat gut technique yielding realistic absorption rates. J. Pharm. Sci. 58, 1196-1200.
-
(1969)
J. Pharm. Sci.
, vol.58
, pp. 1196-1200
-
-
Doluisio, J.T.1
Billups, N.F.2
Dittert, L.W.3
Sugita, E.T.4
Swintosky, J.V.5
-
10
-
-
0031847943
-
Antisense comes of age
-
FLANAGAN, W.M. (1998). Antisense comes of age. Cancer Metastasis Rev. 17, 169-176.
-
(1998)
Cancer Metastasis Rev.
, vol.17
, pp. 169-176
-
-
Flanagan, W.M.1
-
11
-
-
0030667690
-
Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression
-
GEARY, R.S. LEEDS, J.M., FITCHETT, J., BURCKIN, T., TROUNG, L., SPAINHOUR, C., CREEK, M., and LEVIN, A.A. (1997a). Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression. Drug Metab. Dispos. 25, 1272-1281.
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 1272-1281
-
-
Geary, R.S.1
Leeds, J.M.2
Fitchett, J.3
Burckin, T.4
Troung, L.5
Spainhour, C.6
Creek, M.7
Levin, A.A.8
-
12
-
-
0030797704
-
Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides
-
GEARY, R.S., LEEDS, J.M., HENRY, S.P., MONTEITH, D.M., and LEVIN, A.A. (1997b). Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides. Anti-Cancer Drug Design 12, 383-394.
-
(1997)
Anti-Cancer Drug Design
, vol.12
, pp. 383-394
-
-
Geary, R.S.1
Leeds, J.M.2
Henry, S.P.3
Monteith, D.M.4
Levin, A.A.5
-
13
-
-
0030987678
-
Phase I safety and pharmacokinetic profile of an ICAM-1 antisense oligodeoxynucleotide (ISIS 2302)
-
GLOVER, J.M., LEEDS, J.M., MANT, T.G.K., KISNER, D.L., ZUCKERMAN, J., LEVIN, A.A., and SHANAHAN, W.R. (1997). Phase I safety and pharmacokinetic profile of an ICAM-1 antisense oligodeoxynucleotide (ISIS 2302). J. Pharm. Exp. Ther. 282, 1173-1180.
-
(1997)
J. Pharm. Exp. Ther.
, vol.282
, pp. 1173-1180
-
-
Glover, J.M.1
Leeds, J.M.2
Mant, T.G.K.3
Kisner, D.L.4
Zuckerman, J.5
Levin, A.A.6
Shanahan, W.R.7
-
14
-
-
0032539676
-
Identification and characterization of a cell membrane nucleic acid channel
-
HANSS, B., LEAL-PINTO, E., BRUGGEMAN, L.A., COPELAND, T.D., and KLOTMAN, P.E. (1998). Identification and characterization of a cell membrane nucleic acid channel. Proc. Natl. Acad. Sci. USA 95, 1921-1926.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1921-1926
-
-
Hanss, B.1
Leal-Pinto, E.2
Bruggeman, L.A.3
Copeland, T.D.4
Klotman, P.E.5
-
15
-
-
0030797705
-
Toxicological and pharmacokinetic properties of chemically modified antisense oligonucleotide inhibitors of PKC-alpha and C-raf kinase
-
HENRY, S.P., MONTEITH, D., BENNETT, C.F., and LEVIN, A.A. (1997). Toxicological and pharmacokinetic properties of chemically modified antisense oligonucleotide inhibitors of PKC-alpha and C-raf kinase. Anti-Cancer Drug Design 12, 409-420.
-
(1997)
Anti-Cancer Drug Design
, vol.12
, pp. 409-420
-
-
Henry, S.P.1
Monteith, D.2
Bennett, C.F.3
Levin, A.A.4
-
16
-
-
0030984740
-
Simultaneous analysis of several non-steroidal anti-inflammatory drugs in human urine by high-performance liquid chromatography with normal solid-phase extraction
-
MIRAI, T., MATSUMOTO, S., and KISHI, I. (1997). Simultaneous analysis of several non-steroidal anti-inflammatory drugs in human urine by high-performance liquid chromatography with normal solid-phase extraction. J. Chromatogr. Biomed. Sci. Appl. 692, 375-388.
-
(1997)
J. Chromatogr. Biomed. Sci. Appl.
, vol.692
, pp. 375-388
-
-
Mirai, T.1
Matsumoto, S.2
Kishi, I.3
-
17
-
-
6744225571
-
Oligonucleotide transport across membranes and into cells: Effects of chemical modifications
-
S. Akhtar, ed. (CRC Press, Boca Raton, FL)
-
HUGHES, J., AVROUTSKAYA, A., SASMOR, H.M., GUINOSSO, C.J., DAN COOK, P., and JULIANO, R.L. (1995). Oligonucleotide transport across membranes and into cells: Effects of chemical modifications. In: Delivery Strategies Antisense Oligonucleotide Therapy. S. Akhtar, ed. (CRC Press, Boca Raton, FL), pp. 191-198.
-
(1995)
Delivery Strategies Antisense Oligonucleotide Therapy
, pp. 191-198
-
-
Hughes, J.1
Avroutskaya, A.2
Sasmor, H.M.3
Guinosso, C.J.4
Dan Cook, P.5
Juliano, R.L.6
-
18
-
-
0026919380
-
Binding of antisense phosphorothioate oligonucleotides to murine lymphocytes is lineage specific and inducible
-
IVERSEN, P.L., CROUSE, D., ZON, G., and PERRY, G. (1992). Binding of antisense phosphorothioate oligonucleotides to murine lymphocytes is lineage specific and inducible. Antisense Res. Dev. 2, 223-233.
-
(1992)
Antisense Res. Dev.
, vol.2
, pp. 223-233
-
-
Iversen, P.L.1
Crouse, D.2
Zon, G.3
Perry, G.4
-
19
-
-
0018850819
-
Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes
-
KOMIYA, J., PARK, A., KAMANI, A., HO, N.F.H., and HIGUCHI, W.J. (1980). Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes. Int. J. Pharm. 4, 249-262.
-
(1980)
Int. J. Pharm.
, vol.4
, pp. 249-262
-
-
Komiya, J.1
Park, A.2
Kamani, A.3
Ho, N.F.H.4
Higuchi, W.J.5
-
20
-
-
0029859233
-
The relationship between rat intestinal permeability and hydrophilic probe size
-
LANE, M.E., O'DRISCOLL, C.M., and CORRIGAN, O.I. (1996). The relationship between rat intestinal permeability and hydrophilic probe size. Pharm. Res. 13, 1554-1558.
-
(1996)
Pharm. Res.
, vol.13
, pp. 1554-1558
-
-
Lane, M.E.1
O'Driscoll, C.M.2
Corrigan, O.I.3
-
21
-
-
0030065059
-
Quantitation of phosphorothioate oligonucleotides in human plasma
-
LEEDS, J.M., GRAHAM, M.J., TROUNG, L., and CUMMINS, L.L. (1996). Quantitation of phosphorothioate oligonucleotides in human plasma. Anal. Biochem. 235, 36-43.
-
(1996)
Anal. Biochem.
, vol.235
, pp. 36-43
-
-
Leeds, J.M.1
Graham, M.J.2
Troung, L.3
Cummins, L.L.4
-
22
-
-
0030874388
-
Pharmacokinetics of a potential human cytomegalovirus therapeutic, a phosphorothioate oligonucleotide, after intravitreal injections in the rabbit
-
LEEDS, J.M., HENRY, S.P., TRUONG, L., ZUTSI, A., LEVIN, A.A., and KORNBRUST, D.J. (1997). Pharmacokinetics of a potential human cytomegalovirus therapeutic, a phosphorothioate oligonucleotide, after intravitreal injections in the rabbit. Drug Metab. Dispos. 25, 921-926.
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 921-926
-
-
Leeds, J.M.1
Henry, S.P.2
Truong, L.3
Zutsi, A.4
Levin, A.A.5
Kornbrust, D.J.6
-
23
-
-
0345570537
-
Characterization of oligonucleotide transport into living cells
-
LORE, S.L., STEIN, C.A., ZHANG, X.H., MORI, K., NAKANISHI, M., SUBASINGHE, C., COHEN, J.S., and NECKERS, L.M. (1989). Characterization of oligonucleotide transport into living cells. Proc. Natl. Acad. Sci. USA 86, 3474-3478.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 3474-3478
-
-
Lore, S.L.1
Stein, C.A.2
Zhang, X.H.3
Mori, K.4
Nakanishi, M.5
Subasinghe, C.6
Cohen, J.S.7
Neckers, L.M.8
-
24
-
-
0027076363
-
Chemical modifications to improve uptake and bioavailability of antisense
-
MANOHARAN, M., JOHNSON, L.K., McGEE, D.P.C., GUINOSSO, C.J., RAMASAMY, K., SPRINGER, R.H., BENNETT, C.F., ECKER, D.J., VICKERS, T., COWSERT, L., and COOK, P.D. (1992). Chemical modifications to improve uptake and bioavailability of antisense. Ann. NY Acad. Sci. 660, 306-309.
-
(1992)
Ann. NY Acad. Sci.
, vol.660
, pp. 306-309
-
-
Manoharan, M.1
Johnson, L.K.2
McGee, D.P.C.3
Guinosso, C.J.4
Ramasamy, K.5
Springer, R.H.6
Bennett, C.F.7
Ecker, D.J.8
Vickers, T.9
Cowsert, L.10
Cook, P.D.11
-
25
-
-
0028598284
-
Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-O-methyloligoribonucleotides
-
METELEV, V., LISZIEWWICZ, J., and AGRAWAL, S. (1994). Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-O-methyloligoribonucleotides. Bioorg. Med. Chem. 4, 2929-2934.
-
(1994)
Bioorg. Med. Chem.
, vol.4
, pp. 2929-2934
-
-
Metelev, V.1
Lisziewwicz, J.2
Agrawal, S.3
-
26
-
-
0027168725
-
Evaluation of 2′-modified oligonucleotides containing deoxy gaps as antisense inhibitors of gene expression
-
MONIA, B.P., LESNIK, E.A., GONZALEZ, C., LIMA, W.F., McGEE, D., GUINOSSO, C.J., KAWASAKI, A.M., COOK, P.D., and FREIER, S.M. (1993). Evaluation of 2′-modified oligonucleotides containing deoxy gaps as antisense inhibitors of gene expression. J. Biol. Chem. 268, 14514-14522.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14514-14522
-
-
Monia, B.P.1
Lesnik, E.A.2
Gonzalez, C.3
Lima, W.F.4
McGee, D.5
Guinosso, C.J.6
Kawasaki, A.M.7
Cook, P.D.8
Freier, S.M.9
-
27
-
-
0031950147
-
Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): Comparison with other delivery routes
-
NICKLIN, P.L., BAYLEY, D., GIDDINGS, J., CRAIG, S.J., CUMMINS, L.L., HASTEWELL, J.G., and PHILLIPS, J.A. (1998). Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): Comparison with other delivery routes. Pharm. Res. 15, 583-591.
-
(1998)
Pharm. Res.
, vol.15
, pp. 583-591
-
-
Nicklin, P.L.1
Bayley, D.2
Giddings, J.3
Craig, S.J.4
Cummins, L.L.5
Hastewell, J.G.6
Phillips, J.A.7
-
28
-
-
0029142539
-
Iontophoretic delivery of oligonucleotides across full thickness hairless mouse skin
-
OLDENBURG, K.R., VO, K.T., SMITH, G.A., and SELICK, H.E. (1995). Iontophoretic delivery of oligonucleotides across full thickness hairless mouse skin. J. Pharm. Sci. 84, 915-921.
-
(1995)
J. Pharm. Sci.
, vol.84
, pp. 915-921
-
-
Oldenburg, K.R.1
Vo, K.T.2
Smith, G.A.3
Selick, H.E.4
-
30
-
-
0003632935
-
-
Iowa State University Press, Ames, IA
-
SNEDECOR, G.W., and COCHRAN, W.G. (1980). Statistical Methods, 7th ed. (Iowa State University Press, Ames, IA).
-
(1980)
Statistical Methods, 7th Ed.
-
-
Snedecor, G.W.1
Cochran, W.G.2
-
31
-
-
0027161566
-
Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells
-
STEIN, C.A., TONKINSON, J.L., ZHANG, L.-M., YAKUBOV, L., GERVASONI, J., TAUB, R., and ROTENBERG, S.A. (1993). Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells. Biochemistry 32, 4855-4861.
-
(1993)
Biochemistry
, vol.32
, pp. 4855-4861
-
-
Stein, C.A.1
Tonkinson, J.L.2
Zhang, L.-M.3
Yakubov, L.4
Gervasoni, J.5
Taub, R.6
Rotenberg, S.A.7
-
32
-
-
0001929474
-
Shutting down a gene. Antisense drug wins approval
-
STIX, G. (1998). Shutting down a gene. Antisense drug wins approval. Sci. Am. 279, 46-50.
-
(1998)
Sci. Am.
, vol.279
, pp. 46-50
-
-
Stix, G.1
-
33
-
-
0025147202
-
Absorption rate of drugs in rats. Application of the improved modified Doluisio method to various classes of drugs
-
VONDERSCHER, J., BURI, P., DESHUSSES, J., and SUCKER, H. (1990). Absorption rate of drugs in rats. Application of the improved modified Doluisio method to various classes of drugs. Acta Pharm. Technol. 36, 133-138.
-
(1990)
Acta Pharm. Technol.
, vol.36
, pp. 133-138
-
-
Vonderscher, J.1
Buri, P.2
Deshusses, J.3
Sucker, H.4
-
34
-
-
0000407290
-
Mechanism of oligonucleotide uptake by cells: Involvement of specific receptors?
-
YAKUBOV, L.A., DEEVA, E.A., ZARYTOVA, V.F., IVANOVA, E.M., RYTE, A.S., YURCHENKO, L.V., and VLASSOV, V.V. (1980). Mechanism of oligonucleotide uptake by cells: Involvement of specific receptors? Proc. Natl. Acad. Sci. USA 86, 6454-6458.
-
(1980)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 6454-6458
-
-
Yakubov, L.A.1
Deeva, E.A.2
Zarytova, V.F.3
Ivanova, E.M.4
Ryte, A.S.5
Yurchenko, L.V.6
Vlassov, V.V.7
-
35
-
-
0029002066
-
In vivo stability and disposition of a self-stabilized oligodeoxynucleotide phosphorothioate in rats
-
ZHANG, R., LU, Z., ZHANG, X., ZHAO, H., DIASIO, R.B., LIU, T., JIANG, Z., and AGRAWAL, S. (1995). In vivo stability and disposition of a self-stabilized oligodeoxynucleotide phosphorothioate in rats. Clin. Chem. 41, 836-843.
-
(1995)
Clin. Chem.
, vol.41
, pp. 836-843
-
-
Zhang, R.1
Lu, Z.2
Zhang, X.3
Zhao, H.4
Diasio, R.B.5
Liu, T.6
Jiang, Z.7
Agrawal, S.8
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