메뉴 건너뛰기




Volumn 85, Issue 9, 2011, Pages 4184-4197

The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; CD8ALPHA ANTIGEN; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN B; INTERLEUKIN 2; INTERLEUKIN 21; LAT PROTEIN; MESSENGER RNA; MUCIN; PROGRAMMED DEATH 1 RECEPTOR; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING PROTEIN 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 79955444899     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02290-10     Document Type: Article
Times cited : (105)

References (83)
  • 1
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
    • Agata, Y., et al. 1996. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8:765-772.
    • (1996) Int. Immunol. , vol.8 , pp. 765-772
    • Agata, Y.1
  • 2
    • 0035202413 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors
    • Ahmed, M., and N. W. Fraser. 2001. Herpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors. J. Virol. 75:12070-12080.
    • (2001) J. Virol. , vol.75 , pp. 12070-12080
    • Ahmed, M.1    Fraser, N.W.2
  • 3
    • 70349328120 scopus 로고    scopus 로고
    • + T cells to immune senescence
    • + T cells to immune senescence. J. Immunol. 183:4103-4108.
    • (2009) J. Immunol. , vol.183 , pp. 4103-4108
    • Albareda, M.C.1
  • 4
    • 78049511214 scopus 로고    scopus 로고
    • Immunization with different viral antigens alters the pattern of T cell exhaustion and latency in HSV-1 infected mice
    • Allen, S. J., K. R. Mott, M. Zandian, and H. Ghiasi. 2010. Immunization with different viral antigens alters the pattern of T cell exhaustion and latency in HSV-1 infected mice. J. Virol. 84:12315-12324.
    • (2010) J. Virol. , vol.84 , pp. 12315-12324
    • Allen, S.J.1    Mott, K.R.2    Zandian, M.3    Ghiasi, H.4
  • 5
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber, D. L., et al. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1
  • 6
    • 0028559731 scopus 로고
    • Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis
    • Barron, B. A., et al. 1994. Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. Ophthalmology 101:1871-1882.
    • (1994) Ophthalmology , vol.101 , pp. 1871-1882
    • Barron, B.A.1
  • 7
    • 21644436839 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 latency-associated transcript expression protects trigeminal ganglion neurons from apoptosis
    • Branco, F. J., and N. W. Fraser. 2005. Herpes simplex virus type 1 latency-associated transcript expression protects trigeminal ganglion neurons from apoptosis. J. Virol. 79:9019-9025.
    • (2005) J. Virol. , vol.79 , pp. 9019-9025
    • Branco, F.J.1    Fraser, N.W.2
  • 8
    • 35648957747 scopus 로고    scopus 로고
    • Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis
    • Carpenter, D., et al. 2007. Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis. Virology 369:12-18.
    • (2007) Virology , vol.369 , pp. 12-18
    • Carpenter, D.1
  • 9
    • 78651367729 scopus 로고    scopus 로고
    • Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B
    • Chen, J., et al. 2011. Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B. Inflamm. Res. 60:47-53.
    • (2011) Inflamm. Res. , vol.60 , pp. 47-53
    • Chen, J.1
  • 10
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day, C. L., et al. 2006. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443:350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1
  • 11
    • 66149097304 scopus 로고    scopus 로고
    • The presence of lytic HSV-1 transcripts and clonally expanded T cells with a memory effector phenotype in human sensory ganglia
    • Derfuss, T., V. Arbusow, M. Strupp, T. Brandt, and D. Theil. 2009. The presence of lytic HSV-1 transcripts and clonally expanded T cells with a memory effector phenotype in human sensory ganglia. Ann. N. Y. Acad. Sci. 1164:300-304.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1164 , pp. 300-304
    • Derfuss, T.1    Arbusow, V.2    Strupp, M.3    Brandt, T.4    Theil, D.5
  • 13
    • 67649217469 scopus 로고    scopus 로고
    • IL-21 is required to control chronic viral infection
    • Elsaesser, H., K. Sauer, and D. G. Brooks. 2009. IL-21 is required to control chronic viral infection. Science 324:1569-1572.
    • (2009) Science , vol.324 , pp. 1569-1572
    • Elsaesser, H.1    Sauer, K.2    Brooks, D.G.3
  • 14
    • 0026025927 scopus 로고
    • Herpes simplex virus latency-associated transcript is a stable intron
    • Farrell, M. J., A. T. Dobson, and L. T. Feldman. 1991. Herpes simplex virus latency-associated transcript is a stable intron. Proc. Natl. Acad. Sci. U. S. A 88:790-794.
    • (1991) Proc. Natl. Acad. Sci. U. S. A , vol.88 , pp. 790-794
    • Farrell, M.J.1    Dobson, A.T.2    Feldman, L.T.3
  • 15
    • 0037154150 scopus 로고    scopus 로고
    • Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice
    • Feldman, L. T., et al. 2002. Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc. Natl. Acad. Sci. U. S. A. 99:978-983.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 978-983
    • Feldman, L.T.1
  • 16
    • 29144435156 scopus 로고    scopus 로고
    • + T cells in healthy carriers are continuously driven to replicative exhaustion
    • + T cells in healthy carriers are continuously driven to replicative exhaustion. J. Immunol. 175: 8218-8225.
    • (2005) J. Immunol. , vol.175 , pp. 8218-8225
    • Fletcher, J.M.1
  • 17
    • 77957723967 scopus 로고    scopus 로고
    • + T cell dysfunction in melanoma patients
    • + T cell dysfunction in melanoma patients. J. Exp. Med. 207:2175-2186.
    • (2010) J. Exp. Med. , vol.207 , pp. 2175-2186
    • Fourcade, J.1
  • 18
    • 0025909415 scopus 로고
    • A review of the molecular mechanism of HSV-1 latency
    • Fraser, N. W., et al. 1991. A review of the molecular mechanism of HSV-1 latency. Curr. Eye Res. 10:1-13.
    • (1991) Curr. Eye Res. , vol.10 , pp. 1-13
    • Fraser, N.W.1
  • 19
    • 0027453647 scopus 로고
    • Viral, neuronal and immune factors which may influence herpes simplex virus (HSV) latency and reactivation
    • Fraser, N. W., and T. Valyi-Nagy. 1993. Viral, neuronal and immune factors which may influence herpes simplex virus (HSV) latency and reactivation. Microb. Pathog. 15:83-91.
    • (1993) Microb. Pathog. , vol.15 , pp. 83-91
    • Fraser, N.W.1    Valyi-Nagy, T.2
  • 20
    • 67649234772 scopus 로고    scopus 로고
    • IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    • Frohlich, A., et al. 2009. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 324:1576-1580.
    • (2009) Science , vol.324 , pp. 1576-1580
    • Frohlich, A.1
  • 21
    • 0033771293 scopus 로고    scopus 로고
    • A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon
    • Goepfert, P. A., et al. 2000. A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon. J. Virol. 74:10249-10255.
    • (2000) J. Virol. , vol.74 , pp. 10249-10255
    • Goepfert, P.A.1
  • 22
    • 34548191951 scopus 로고    scopus 로고
    • + T cells associated with reversible immune dysfunction
    • + T cells associated with reversible immune dysfunction. J. Virol. 81:9249-9258.
    • (2007) J. Virol. , vol.81 , pp. 9249-9258
    • Golden-Mason, L.1
  • 24
    • 0025204528 scopus 로고
    • Pathogenesis and latency of herpes simplex virus type 1 (HSV-1): An ophthalmologist's view of the eye as a model for the study of the virus-host relationship
    • Gordon, Y. J. 1990. Pathogenesis and latency of herpes simplex virus type 1 (HSV-1): an ophthalmologist's view of the eye as a model for the study of the virus-host relationship. Adv. Exp. Med. Biol. 278:205-209.
    • (1990) Adv. Exp. Med. Biol. , vol.278 , pp. 205-209
    • Gordon, Y.J.1
  • 25
    • 0035000769 scopus 로고    scopus 로고
    • + T lymphocytes after infection with hepatitis C virus
    • + T lymphocytes after infection with hepatitis C virus. J. Virol. 75:5550-5558.
    • (2001) J. Virol. , vol.75 , pp. 5550-5558
    • Gruener, N.H.1
  • 26
    • 0025166428 scopus 로고
    • Herpes simplex virus latent phase transcription facilitates in vivo reactivation
    • Hill, J. M., F. Sedarati, R. T. Javier, E. K. Wagner, and J. G. Stevens. 1990. Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174:117-125.
    • (1990) Virology , vol.174 , pp. 117-125
    • Hill, J.M.1    Sedarati, F.2    Javier, R.T.3    Wagner, E.K.4    Stevens, J.G.5
  • 27
    • 78649479185 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Blood 116:4501-4511.
    • (2010) Blood , vol.116 , pp. 4501-4511
    • Hobo, W.1
  • 28
    • 64049108928 scopus 로고    scopus 로고
    • Fewer latent herpes simplex virus type 1 and cytotoxic T cells occur in the ophthalmic division than in the maxillary and mandibular divisions of the human trigeminal ganglion and nerve
    • Hufner, K., et al. 2009. Fewer latent herpes simplex virus type 1 and cytotoxic T cells occur in the ophthalmic division than in the maxillary and mandibular divisions of the human trigeminal ganglion and nerve. J. Virol. 83:3696-3703.
    • (2009) J. Virol. , vol.83 , pp. 3696-3703
    • Hufner, K.1
  • 29
    • 0035087392 scopus 로고    scopus 로고
    • Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture
    • Inman, M., et al. 2001. Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture. J. Virol. 75:3636-3646.
    • (2001) J. Virol. , vol.75 , pp. 3636-3646
    • Inman, M.1
  • 30
    • 77957059176 scopus 로고    scopus 로고
    • Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
    • Jin, H. T., et al. 2010. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. U. S. A. 107:14733-14738.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 14733-14738
    • Jin, H.T.1
  • 31
    • 0037688165 scopus 로고    scopus 로고
    • Identification of herpes simplex virus type 1 latency-associated transcript sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype
    • Jin, L., et al. 2003. Identification of herpes simplex virus type 1 latency-associated transcript sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype. J. Virol. 77:6556-6561.
    • (2003) J. Virol. , vol.77 , pp. 6556-6561
    • Jin, L.1
  • 32
    • 34047120879 scopus 로고    scopus 로고
    • Reactivation phenotype in rabbits of a herpes simplex virus type 1 mutant containing an unrelated antiapoptosis gene in place of latency-associated transcript
    • Jin, L., et al. 2007. Reactivation phenotype in rabbits of a herpes simplex virus type 1 mutant containing an unrelated antiapoptosis gene in place of latency-associated transcript. J. Neurovirol. 13:78-84.
    • (2007) J. Neurovirol. , vol.13 , pp. 78-84
    • Jin, L.1
  • 33
    • 58149277359 scopus 로고    scopus 로고
    • Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
    • Jones, R. B., et al. 2008. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J. Exp. Med. 205:2763-2779.
    • (2008) J. Exp. Med. , vol.205 , pp. 2763-2779
    • Jones, R.B.1
  • 34
    • 47949107182 scopus 로고    scopus 로고
    • Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis
    • Jurado, J. O., et al. 2008. Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis. J. Immunol. 181:116-125.
    • (2008) J. Immunol. , vol.181 , pp. 116-125
    • Jurado, J.O.1
  • 35
    • 77951887482 scopus 로고    scopus 로고
    • + T cells and relieves the lupus-like nephritis of NZB/W F1 mice
    • + T cells and relieves the lupus-like nephritis of NZB/W F1 mice. J. Immunol. 184:2337-2347.
    • (2010) J. Immunol. , vol.184 , pp. 2337-2347
    • Kasagi, S.1
  • 36
    • 11144279261 scopus 로고    scopus 로고
    • HSV-1 DNA in tears and saliva of normal adults
    • Kaufman, H. E., et al. 2005. HSV-1 DNA in tears and saliva of normal adults. Invest. Ophthalmol. Vis. Sci. 46:241-247.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 241-247
    • Kaufman, H.E.1
  • 38
    • 33645846313 scopus 로고    scopus 로고
    • Tissue expression of PD-L1 mediates peripheral T cell tolerance
    • Keir, M. E., et al. 2006. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J. Exp. Med. 203:883-895.
    • (2006) J. Exp. Med. , vol.203 , pp. 883-895
    • Keir, M.E.1
  • 39
    • 24944509220 scopus 로고    scopus 로고
    • T cells and viral persistence: Lessons from diverse infections
    • Klenerman, P., and A. Hill. 2005. T cells and viral persistence: lessons from diverse infections. Nat. Immunol. 6:873-879.
    • (2005) Nat. Immunol. , vol.6 , pp. 873-879
    • Klenerman, P.1    Hill, A.2
  • 40
    • 0028833335 scopus 로고
    • Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus
    • Kramer, M. F., and D. M. Coen. 1995. Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J. Virol. 69:1389-1399.
    • (1995) J. Virol. , vol.69 , pp. 1389-1399
    • Kramer, M.F.1    Coen, D.M.2
  • 41
    • 3242677686 scopus 로고    scopus 로고
    • PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells
    • Latchman, Y. E., et al. 2004. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl. Acad. Sci. U. S. A. 101:10691-10696.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10691-10696
    • Latchman, Y.E.1
  • 42
    • 35148901007 scopus 로고    scopus 로고
    • Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory ganglia
    • Margolis, T. P., et al. 2007. Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory ganglia. J. Virol. 81:11069-11074.
    • (2007) J. Virol. , vol.81 , pp. 11069-11074
    • Margolis, T.P.1
  • 43
    • 0023899276 scopus 로고
    • The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1
    • McGeoch, D. J., et al. 1988. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69:1531-1574.
    • (1988) J. Gen. Virol. , vol.69 , pp. 1531-1574
    • McGeoch, D.J.1
  • 44
    • 0036150004 scopus 로고    scopus 로고
    • Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication
    • Mossman, K. L., and J. R. Smiley. 2002. Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication. J. Virol. 76:1995-1998.
    • (2002) J. Virol. , vol.76 , pp. 1995-1998
    • Mossman, K.L.1    Smiley, J.R.2
  • 45
    • 60049096721 scopus 로고    scopus 로고
    • + T cells in trigeminal ganglia of latently infected mice
    • + T cells in trigeminal ganglia of latently infected mice. J. Virol. 83:2246-2254.
    • (2009) J. Virol. , vol.83 , pp. 2246-2254
    • Mott, K.R.1
  • 46
    • 34948878071 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Mol. Vis. 13:1802-1812.
    • (2007) Mol. Vis. , vol.13 , pp. 1802-1812
    • Mott, K.R.1
  • 47
    • 36348929456 scopus 로고    scopus 로고
    • A recombinant herpes simplex virus type 1 expressing two additional copies of gK is more pathogenic than wild-type virus in two different strains of mice
    • Mott, K. R., G. C. Perng, Y. Osorio, K. G. Kousoulas, and H. Ghiasi. 2007. A recombinant herpes simplex virus type 1 expressing two additional copies of gK is more pathogenic than wild-type virus in two different strains of mice. J. Virol. 81:12962-12972.
    • (2007) J. Virol. , vol.81 , pp. 12962-12972
    • Mott, K.R.1    Perng, G.C.2    Osorio, Y.3    Kousoulas, K.G.4    Ghiasi, H.5
  • 49
    • 66649119445 scopus 로고    scopus 로고
    • A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages
    • Mott, K. R., D. Underhill, S. L. Wechsler, T. Town, and H. Ghiasi. 2009. A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. Virol. J. 6:56.
    • (2009) Virol. J. , vol.6 , pp. 56
    • Mott, K.R.1    Underhill, D.2    Wechsler, S.L.3    Town, T.4    Ghiasi, H.5
  • 50
    • 66649114758 scopus 로고    scopus 로고
    • High antigen levels are the cause of T cell exhaustion during chronic viral infection
    • Mueller, S. N., and R. Ahmed. 2009. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. U. S. A. 106:8623-8628.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 8623-8628
    • Mueller, S.N.1    Ahmed, R.2
  • 51
    • 77954966127 scopus 로고    scopus 로고
    • PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
    • Mueller, S. N., et al. 2010. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J. Clin. Invest. 120:2508-2515.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2508-2515
    • Mueller, S.N.1
  • 52
    • 0028007586 scopus 로고
    • The HSV-1 2-kb latency-associated transcript is found in the cytoplasm comi-grating with ribosomal subunits during productive infection
    • Nicosia, M., J. M. Zabolotny, R. P. Lirette, and N. W. Fraser. 1994. The HSV-1 2-kb latency-associated transcript is found in the cytoplasm comi-grating with ribosomal subunits during productive infection. Virology 204: 717-728.
    • (1994) Virology , vol.204 , pp. 717-728
    • Nicosia, M.1    Zabolotny, J.M.2    Lirette, R.P.3    Fraser, N.W.4
  • 53
    • 0038709570 scopus 로고    scopus 로고
    • Comparison of adjuvant efficacy of herpes simplex virus type 1 recombinant viruses expressing TH1 and TH2 cytokine genes
    • Osorio, Y., and H. Ghiasi. 2003. Comparison of adjuvant efficacy of herpes simplex virus type 1 recombinant viruses expressing TH1 and TH2 cytokine genes. J. Virol. 77:5774-5783.
    • (2003) J. Virol. , vol.77 , pp. 5774-5783
    • Osorio, Y.1    Ghiasi, H.2
  • 54
    • 4344659547 scopus 로고    scopus 로고
    • Mapping herpes simplex virus type 1 latency-associated transcript sequences that protect from apoptosis mediated by a plasmid expressing caspase-8
    • Peng, W., et al. 2004. Mapping herpes simplex virus type 1 latency-associated transcript sequences that protect from apoptosis mediated by a plasmid expressing caspase-8. J. Neurovirol. 10:260-265.
    • (2004) J. Neurovirol. , vol.10 , pp. 260-265
    • Peng, W.1
  • 55
    • 0028138560 scopus 로고
    • The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency
    • Perng, G. C, et al. 1994. The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J. Virol. 68:8045-8055.
    • (1994) J. Virol. , vol.68 , pp. 8045-8055
    • Perng, G.C.1
  • 56
    • 0034712014 scopus 로고    scopus 로고
    • Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript
    • Perng, G. C, et al. 2000. Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. Science 287:1500-1503.
    • (2000) Science , vol.287 , pp. 1500-1503
    • Perng, G.C.1
  • 57
    • 0036145527 scopus 로고    scopus 로고
    • A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels
    • Perng, G. C, et al. 2002. A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J. Virol. 76:1224-1235.
    • (2002) J. Virol. , vol.76 , pp. 1224-1235
    • Perng, G.C.1
  • 58
    • 0033934284 scopus 로고    scopus 로고
    • The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits
    • Perng, G. C, et al. 2000. The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits. J. Virol. 74:1885-1891.
    • (2000) J. Virol. , vol.74 , pp. 1885-1891
    • Perng, G.C.1
  • 59
    • 33749338938 scopus 로고    scopus 로고
    • + T cell survival in HIV infection
    • + T cell survival in HIV infection. J. Exp. Med. 203:2281-2292.
    • (2006) J. Exp. Med. , vol.203 , pp. 2281-2292
    • Petrovas, C.1
  • 60
    • 34547931898 scopus 로고    scopus 로고
    • + T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
    • + T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110:928-936.
    • (2007) Blood , vol.110 , pp. 928-936
    • Petrovas, C.1
  • 62
    • 0141794181 scopus 로고    scopus 로고
    • Herpes simplex virus DNA in corneal transplants: Prospective study of 38 recipients
    • Robert, P. Y., J. P. Adenis, F. Denis, S. Alain, and S. Ranger-Rogez. 2003. Herpes simplex virus DNA in corneal transplants: prospective study of 38 recipients. J. Med. Virol. 71:69-74.
    • (2003) J. Med. Virol. , vol.71 , pp. 69-74
    • Robert, P.Y.1    Adenis, J.P.2    Denis, F.3    Alain, S.4    Ranger-Rogez, S.5
  • 63
    • 0023502309 scopus 로고
    • Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1
    • Rock, D. L., et al. 1987. Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. J. Virol. 61:3820-3826.
    • (1987) J. Virol. , vol.61 , pp. 3820-3826
    • Rock, D.L.1
  • 65
    • 0242539820 scopus 로고    scopus 로고
    • Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    • Sabatos, C. A., et al. 2003. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4:1102-1110.
    • (2003) Nat. Immunol. , vol.4 , pp. 1102-1110
    • Sabatos, C.A.1
  • 66
    • 77955012984 scopus 로고    scopus 로고
    • Immune exhaustion occurs concomitantly with immune activation and decrease in regulatory T cells in viremic chronically HIV-1-infected patients
    • Sachdeva, M., M. A. Fischl, R. Pahwa, N. Sachdeva, and S. Pahwa. 2010. Immune exhaustion occurs concomitantly with immune activation and decrease in regulatory T cells in viremic chronically HIV-1-infected patients. J. Acquir. Immune Defic. Syndr. 54:447-454.
    • (2010) J. Acquir. Immune Defic. Syndr. , vol.54 , pp. 447-454
    • Sachdeva, M.1    Fischl, M.A.2    Pahwa, R.3    Sachdeva, N.4    Pahwa, S.5
  • 67
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi, K., et al. 2010. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 207:2187- 2194.
    • (2010) J. Exp. Med. , vol.207
    • Sakuishi, K.1
  • 68
    • 0030972161 scopus 로고    scopus 로고
    • Comprehensive quantification of herpes simplex virus latency at the single-cell level
    • Sawtell, N. M. 1997. Comprehensive quantification of herpes simplex virus latency at the single-cell level. J. Virol. 71:5423-5431.
    • (1997) J. Virol. , vol.71 , pp. 5423-5431
    • Sawtell, N.M.1
  • 69
    • 0031746198 scopus 로고    scopus 로고
    • The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation
    • Sawtell, N. M., D. K. Poon, C. S. Tansky, and R. L. Thompson. 1998. The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation. J. Virol. 72:5343- 5350.
    • (1998) J. Virol. , vol.72
    • Sawtell, N.M.1    Poon, D.K.2    Tansky, C.S.3    Thompson, R.L.4
  • 70
    • 0029658206 scopus 로고    scopus 로고
    • Human herpes viruses latent infection in the nervous system
    • Steiner, I. 1996. Human herpes viruses latent infection in the nervous system. Immunol. Rev. 152:157-173.
    • (1996) Immunol. Rev. , vol.152 , pp. 157-173
    • Steiner, I.1
  • 71
    • 0024470257 scopus 로고
    • Human herpesviruses: A consideration of the latent state
    • Stevens, J. G. 1989. Human herpesviruses: a consideration of the latent state. Microbiol. Rev. 53:318-332.
    • (1989) Microbiol. Rev. , vol.53 , pp. 318-332
    • Stevens, J.G.1
  • 72
    • 33749009709 scopus 로고    scopus 로고
    • + T cells leads to reversible immune dysfunction
    • + T cells leads to reversible immune dysfunction. Nat. Med. 12:1198-1202.
    • (2006) Nat. Med. , vol.12 , pp. 1198-1202
    • Trautmann, L.1
  • 73
    • 33750691709 scopus 로고    scopus 로고
    • PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    • Urbani, S., et al. 2006. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J. Virol. 80: 11398-11403.
    • (2006) J. Virol. , vol.80 , pp. 11398-11403
    • Urbani, S.1
  • 74
    • 77956459371 scopus 로고    scopus 로고
    • HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression
    • Vali, B., et al. 2010. HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression. Eur. J. Immunol. 40:2493-2505.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 2493-2505
    • Vali, B.1
  • 75
    • 0024205630 scopus 로고
    • The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection
    • Wagner, E. K., et al. 1988. The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection. J. Virol. 62:4577-4585.
    • (1988) J. Virol. , vol.62 , pp. 4577-4585
    • Wagner, E.K.1
  • 76
    • 0024230295 scopus 로고
    • Fine mapping of the major latency-related RNA of herpes simplex virus type 1 in humans
    • Wechsler, S. L., A. B. Nesburn, R. Watson, S. Slanina, and H. Ghiasi. 1988. Fine mapping of the major latency-related RNA of herpes simplex virus type 1 in humans. J. Gen. Virol. 69:3101-3106.
    • (1988) J. Gen. Virol. , vol.69 , pp. 3101-3106
    • Wechsler, S.L.1    Nesburn, A.B.2    Watson, R.3    Slanina, S.4    Ghiasi, H.5
  • 77
    • 0023774515 scopus 로고
    • Fine mapping of the latency-related gene of herpes simplex virus type 1: Alternative splicing produces distinct latency-related RNAs containing open reading frames
    • Wechsler, S. L., A. B. Nesburn, R. Watson, S. M. Slanina, and H. Ghiasi. 1988. Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames. J. Virol. 62:4051-4058.
    • (1988) J. Virol. , vol.62 , pp. 4051-4058
    • Wechsler, S.L.1    Nesburn, A.B.2    Watson, R.3    Slanina, S.M.4    Ghiasi, H.5
  • 78
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    • Wherry, E. J., J. N. Blattman, K. Murali-Krishna, R. van der Most, and R. Ahmed. 2003. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77:4911-4927.
    • (2003) J. Virol. , vol.77 , pp. 4911-4927
    • Wherry, E.J.1    Blattman, J.N.2    Murali-Krishna, K.3    van der Most, R.4    Ahmed, R.5
  • 79
    • 35349014587 scopus 로고    scopus 로고
    • Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    • Wherry, E. J., et al. 2007. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27:670-684.
    • (2007) Immunity , vol.27 , pp. 670-684
    • Wherry, E.J.1
  • 80
    • 0029850568 scopus 로고    scopus 로고
    • Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group
    • Wilhelmus, K. R., et al. 1996. Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group. Br. J. Ophthalmol. 80:969-972.
    • (1996) Br. J. Ophthalmol. , vol.80 , pp. 969-972
    • Wilhelmus, K.R.1
  • 81
    • 0021232989 scopus 로고
    • Reactivation of murine latent HSV infection by epinephrine iontophoresis
    • Willey, D. E., M. D. Trousdale, and A. B. Nesburn. 1984. Reactivation of murine latent HSV infection by epinephrine iontophoresis. Invest. Ophthalmol. Vis. Sci. 25:945-950.
    • (1984) Invest. Ophthalmol. Vis. Sci. , vol.25 , pp. 945-950
    • Willey, D.E.1    Trousdale, M.D.2    Nesburn, A.B.3
  • 82
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi, J. S., M. Du, and A. J. Zajac. 2009. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324:1572-1576.
    • (2009) Science , vol.324 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 83
    • 0032416085 scopus 로고    scopus 로고
    • Viral immune evasion due to persistence of activated T cells without effector function
    • Zajac, A. J., et al. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188:2205-2213.
    • (1998) J. Exp. Med. , vol.188 , pp. 2205-2213
    • Zajac, A.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.