Human herpes viruses latent infection in the nervous system

Immunological Reviews

Volumn , Issue 152, 1996, Pages 157-173

  Steiner, Israel ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HERPES VIRUS INFECTION; HUMAN; IMMUNE RESPONSE; LATENT VIRUS INFECTION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; SENSORY GANGLION; VARICELLA ZOSTER VIRUS; VIRUS REACTIVATION; ANIMAL; CHICKENPOX; GENETICS; HERPES SIMPLEX; HERPES VIRUS; HERPES ZOSTER; IMMUNOLOGY; NERVOUS SYSTEM; PHYSIOLOGY; VIROLOGY; VIRUS LATENCY;

ANIMALS; CHICKENPOX; HERPES SIMPLEX; HERPES ZOSTER; HERPESVIRIDAE; HERPESVIRUS 1, HUMAN; HERPESVIRUS 3, HUMAN; HUMANS; NERVOUS SYSTEM; VIRUS LATENCY;

EID: 0029658206     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065x.1996.tb00915.x     Document Type: Review

References (110)

1. Anderson, M., Paabo, S., Nilsson, T. & Peterson, P. A. (1985) Impaired intracellular transport of class I MHC antigenes as a possible means for adenovirus to evade immune surveillance. Cell 43, 215.
2. Appelbaum, E., Kreps, S. I. & Sunshine, A. (1962) Herpes zoster encephalitis. Am. J. Med. 32, 25
3. Asbury, A. K., Arnason, B. G., Karp, H. R. & McFarlin, D. E. (1978) Criteria for diagnosis of Guillain-Barre syndrome. Ann. Neurol. 3, 565.
4. Ash, R. J. (1986) Butyrate-induced reversal of herpes simplex virus restriction in neuroblastoma cells. Virology 155, 584.
5. Beersma, M. F. C., Bijlmakers, M. J. E. & Ploegh, H. L. (1993) Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. J. Immunol. 151, 4455.
6. Berger, R., Florent, G. & Just, M. (1981) Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged. Infect. Immun. 32, 24.
7. Birmanns, B., Reibstein, I. & Steiner, I. (1993) Characterization of an in vivo reactivation model of herpes simplex virus from mice trigeminal ganglia. J. Gen. Virol. 74, 2487.
8. Block, T. M., Spivack, J. G., Steiner, I., Deshmane, S., McIntosh, M. T., Lirette, R. P. & Fraser, N. W. (1990) A herpes simplex virus type I latency-associated transcript mutant reactivates with normal kinetics from latent infection. J. Virol. 64, 3417.
9. Burgert, G.-H. & Kvist, S. (1985) An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens. Cell 41, 987.
10. Burgoon, C. F., Burgoon, J. S. & Baldridge, G. D. (1957) The natural history of herpes zoster. J. Am. Med. Assoc. 164, 265.
11. Bustamante, C. I. & Wade, J. C. (1991) Herpes simplex virus infection in the immunocompromised cancer patient. J. Clin. Oncol. 9, 1903.
12. Cesario, T. C., Poland, J. D., Wulff, H., Chin, T. D. & Wenner, H. A. (1969) Six years experience with herpes simplex virus in a children's home. Am. J. Epidemiol. 90, 416.
13. Chan, W. L., Tizard, M. L. & Faulkner, L. (1989) Proliferative T-cell response to glycoprotein B of the human herpes viruses: the influence of MHC and sequence of infection on the pattern of cross-reactivity. Immunology 68, 96.
14. Chen, X., Schmidt, M. C., Gions, W. F. & Glorioso, J. C. (1995) Two herpes virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infection. J. Virol. 69, 7899.
15. Constantine, V. S., Francis, R. D. & Montes, L. F. (1988) Association of recurrent herpes simplex with neuralgia. J. Am. Med. Assoc. 205, 181.
16. Cook, M. L. & Stevens, J. G. (1973) Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence of intra-axonal transport of infection. Infect. Immun. 7, 272.
17. Croen, K. D., Ostrove, J. M., Dragovic, L. J., Smialek, J. E. & Straus, S. E. (1987) Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene 'anti-sense' transcription by in situ hybridization. N. Engl. J. Med. 317, 1427.
18. Croen, K. D., Ostrove, J. M., Dragovic, L. J. & Straus, S. E. (1988) Patterns of gene expression and sites of latency in human nerve ganglia are different for varicella-zoster and herpes simplex viruses. Proc. Natl. Acad. Sci. USA 85, 9773.
19. Deatly, A. M., Spivack, J. G., Lavi, E. & Fraser, N. W. (1987) RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice. Proc. Natl. Acad. Sci. USA 84, 3204.
20. Dowling, P. C., Menonna, J. & Cook, S. (1977) Cytomegalovirus complement fixing antibody in Guillain-Barre syndrome. Neurology 27, 1153.
21. Efstathiou, S., Minson, A. C., Field, H. J., Anderson, J. R. & Wildy, P. (1986) Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans. J. Virol. 57, 446.
22. Fitzgerald-Bocarsly, P., Howell, D. M., Pettera, L., Teherani, S. & Lopez, C. (1991) Immediate-early gene expression is sufficient for induction of natural killer cell-mediated lysis of herpes simplex virus type 1 infected fibroblasts. J. Virol. 65, 3151.
23. Fraser, N. W., Spivack, J. G., Wroblewska, Z., Block, T., Deshmane, S. L., Valyi-Nagy, T., Natarajan, R. & Gesser, R. M. (1991) A review of the molecular mechanism of HSV-1 latency. Curr. Eye Res. 10 (Suppl), 1.
24. Froh, K., Ahn, K., Djaballah, H., Sempe, P., van Endert, P. M., Tampe, R., Peterson, P. A. & Yang, Y. (1995) A viral inhibitor of peptide transporters for antigen presentation. Nature 375, 415.
25. Gesser, R. M., Valyi-Nagi, T. & Fraser, N. W. (1994) Restricted herpes simplex virus type 1 gene expression within sensory neurons in the absence of functional B and T lymphocytes. Virology 200, 791.
26. Gilden, D. H., Mahalingam, R., Dueland, A. N. & Cohrs, R. (1992) Herpes zoster: pathogenesis and latency. In: Progress in Medical Virology, Vol. 39 (ed. Melnick, L.J.), pp. 19-75,S. Karger, Basel, Switzerland.
27. Gilden, D. H., Rosenman, Y., Murray, R., Devlin, M. & Vafai, A. (1987) Detection of varicella-zoster virus nucleic acid in neurons of normal human thoracic ganglia. Ann. Neurol. 22, 377.
28. Gilden, D. H., Vafai, A., Shtram, Y., Becker, Y., Devlin, M. & Wellish, M. (1983) Varicellazoster virus DNA in human sensory ganglia. Nature 306, 478.
29. Giller, R. H., Winistorfer, S. & Grose, C. (1989) Cellular and humoral immunity to varicella zoster glycoproteins in immune and susceptible human subjects. J. Infect. Dis. 160, 919.
30. Goins, W. F., Sternberg, L. R., Croen, K. D., Krause, P. R., Hendricks, R. L., Fink, D. J., Straus, S. E., Levine, M. & Glorioso, J. C. (1994) A novel latency-active promoter is contained within the herpes simplex virus type 1 U1 flanking repeats. J. Virol. 68, 2239.
31. Gominak, S., Cros, D. & Paydarfar, D. (1990) Herpes simplex labialis and trigeminal neuropathy. Neurology 40, 151.
32. Gordon, Y. J., Johnson, B., Romanowski, E. & Araullo-Cruz, T. (1988) RNA complementary to herpes simplex virus type 1 ICPO gene demonstrated in neurons of human trigeminal ganglia. J. Virol. 62, 1832.
33. Grose, C., Henle, W., Henle, G. & Feorino, P. M. (1975) Epstein-Barr virus infections in acute neurologic diseases. N. Engl. J. Med. 292, 392.
34. Harnisch, J. P. (1984) Zoster in the elderly: clinical, immunologic and therapeutic considerations. J. Am. Geriat. Soc. 32, 789.
35. Hayward, A. R. & Herberger, M. (1987) Lymphocyte response to varicella zoster virus in the elderly. J. Clin. Immunol. 7, 174.
36. Hill, A., Jugovic, P., York, I., Russ, G., Bennink, J., Yewdell, J., Ploegh, H. & Johnson, D. (1995) Herpes simplex virus turns off the TAP to evade host immunity. Nature 375, 411.
37. Hill, J. M., Sedarati, F., Javier, R. T., Wagner, E. K. & Stevens, J. G. (1990) Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174, 117.
38. Ho, D. Y. & Mocarski, E. S. (1989) Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc Natl. Acad. Sci. USA 86, 7596.
39. Hope-Simpson, R. E. (1965) The nature of herpes zoster: a long term study and a new hypothesis. Proc. Royal Soc. Med. 58, 9.
40. Javier, R. T., Stevens, J. G., Dissette, V. B. & Wagner, E. K. (1988) A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state. Virology 166, 254.
41. Juel-Jensen, B. E. (1970) The natural history of shingles. Events associated with reactivation of varicella-zoster virus. J. Royal College Gen. Pract. 20, 323.
42. Kapoor, A. K., Nash, A. A. & Wildy, P. (1982a) Pathogenesis of herpes simplex virus in B cell suppressed mice: the relative roles of cell-mediated and humoral immunity. J. Gen. Virol. 61, 127.
43. Kapoor, A. K., Nash, A. A., Wildy, P., Phelan, J., McLean, C. S. & Field, H. J. (1982b) Pathogenesis of herpes simplex virus in congenitally athymic mice: the relative roles of cell-mediated and humoral immunity. J. Gen. Virol. 60, 225.
44. Kemp, L. M., Dent, C. L. & Latchman, D.S. (1990) Octamer motif mediates transcriptional repression of HSV immediate early genes and octamer-containing cellular promoters in neuronal cells. Neuron. 4, 215.
45. Kennedy, P. G. E. (1987) Neurological complications of varicella zoster virus. In: Infections of the Nervous System (eds Kennedy, P.G.E & Johnson, R.T.) pp. 177-208. Butterworth, London, England.
46. Kennedy, P. G. E. & Steiner, I. (1994) A molecular and cellular model to explain the differences in reactivation from latency by herpes simplex and varicella-zoster viruses. Neuropathol. Appl. Neurobiol. 20, 368.
47. Kino, Y., Hayashi, Y., Hayashida, I. & Mori, R. (1982) Dissemination of herpes simplex virus in nude mice after intracutaneous inoculation and effect of antibody on the course of infection. J. Gen. Virol. 63, 475.
48. Kristensson, K., Lycke, E., Roytta, M., Svennerholm, B. & Vahlne, A. (1986) Neuritic transport of herpes simplex in rat sensory neurons in vitro. Effects of substances interacting with microtubular function and axonal flow [nocodazole, taxol, and erythro-9-3-(2-hydroxynonyl)-adenine]. J. Gen. Virol. 67, 2023
49. Lawman, M. J. P., Rouse, B. T., Courtney, R. J. & Walker, R. D. (1980) Cell-mediated immunity against herpes simplex: induction of cytotoxic T lymphocytes. Infect. Immun. 27, 133.
50. Lieb, D. A., Bogard, C. L., Kosz-Vnenchak, M., Hicks, K. A., Coen, D. M., Knipe, D. M. & Schaffer, P. A. (1989) A deletion mutant of the latency-associated transcript of herpes simplex virus type I reactivates from latent state with reduced frequency. J. Virol. 63, 2893.
51. Lungo, O., Annunziato, P. W., Gershon, A., Staugaitis, S. M., Josephson, D., LaRussa, P. & Silverstein, S. J. (1995) Reactivated and latent varicella-zoster virus in human dorsal root ganglia. Proc. Natl. Acad. Sci. USA 92, 10980.
52. McDermott, M. R., Graham, F. L., Hanke, T. & Johnson, D. C. (1989) Protection of mice against lethal challenge with herpes simplex virus by vaccination with an adenovirus vector expressing HSV glycoprotlein B. Virology 169, 244.
53. McFarlin, D. E. (1990) Immunological parameters in Guillain-Barre syndrome. Ann. Neurol. 27 (Suppl), S25.
54. Mador, N., Panet, A., Latchman, D. & Steiner, I. (1995) Expression and splicing of the latency-associated transcripts of herpes simplex virus type I in neuronal and non-neuronal cell lines. J. Biochem. 117, 1288.
55. Mahalingam, R., Wellish, M., Lederer, D., Forghani, B., Cohrs, R. & Gilden, D. (1993) Quantitation of latent varicella-zoster virus DNA in human trigeminal ganglia by polymerase chain reaction. J. Virol. 67, 2381.
56. Mahalingam, R., Wellish, M., Wolf, W., Dueland, A. N., Cohrs, R., Vafai, A. & Gilden, D. H. (1990) Latent varicella-zoster viral DNA in human trigeminal and thoracic ganglia. N. Engl. J. Med. 323, 627.
57. Mazur, M. H. & Dolin, R. (1978) Herpes zoster at the NIH: a 20 year experience. Am. J. Med. 65, 738.
58. Meier, J. L., Holman, R. P., Croen, K. D., Smialek, J. E. & Straus, S. E. (1993) Varicellazoster transcription in human trigeminal ganglia. Virology 193, 193.
59. Melbye, M., Grossman, R. J., Goedert, J. J., Eyster, M. E. & Bigger, R. J. (1987) Risk of AIDS after herpes zoster. Lancet i, 728.
60. Mellerick, D. M. & Fraser, N. W. (1987) Physical state of the latent herpes simplex virus genome in mouse model system. Evidence suggesting an episomal state. Virology 158, 265.
61. Merigan, T. C. & Stevens, D. A. (1971) Viral infections in man associated with acquired immunological deficiency states. Fed. Proc. 30, 1858.
62. Mester, J. C., Glorioso, J. C. & Rouse, B. T. (1990) Protection against the zostiform spread of herpes simplex virus by monoclonal antibodies. J. Infect. Dis. 163, 263.
63. Miller, A. E. (1980) Selective decline in cellular immune response in varicella-zoster in the elderly. Neurology 30, 582.
64. Momin, F. & Chandrasekar, P. H. (1995) Antimicrobial prophylaxis in bone marrow transplantation. Ann. Intern. Med. 123, 205.
65. Moriyama, K., Mohri, S., Watanabe, T. & Mori, R. (1992) Latent infection of SCID mice with herpes simplex virus 1 and lethal cutaneous lesions in pregnancy. Microbiol. Immunol. 36, 841.
66. Morrison, A. L. & Knipe, D. M. (1994) Immunization with replication-defective mutants of herpes simplex virus type 1: sites of immune intervention in pathogenesis of challenge virus infection. J. Virol. 68, 689.
67. Nguyen, L. H., Knipe, D. M. & Finberg, R. W. (1992) Replication defective mutants of herpes simplex virus (HSV) induce cellular immunity and protect against lethal HSV infection. J. Virol. 66, 7067.
68. Nicosia, M., Deshmane, S. L., Zabolotny, J. M., Valyi-Nagy, T. & Fraser, N. W. (1993) Herpes simplex virus type 1 latency associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. J. Virol. 67, 7276.
69. Oakes, J. E. (1975) Role for cell-mediated immunity in the resistance of mice to subcutaneous herpes simplex virus infection. Infect. Immun. 12, 166.
70. Oakes, J. E. & Lausch, R. N. (1984) Monoclonal antibodies suppress replication of herpes simplex virus type 1 in trigeminal ganglia. J. Virol. 51, 656
71. Oldstone, M. B. (1991) Molecular anatomy of viral persistence. J. Virol. 65, 6381.
72. Openshaw, H., Sharina-Asher, L. W., Wohlenberg, C., Sekizawa, T. & Nokins, A. L. (1979) Acute and latent infection of sensory ganglia with herpes simplex virus: immune control and virus reactivation. J. Gen. Virol. 44, 205.
73. van de Perre, P., Bakkeres, E., Battungwanyo, J., Kestelyn, P., Lepage, P., Nzaramba, D., Bogaerts, J., Serufilira, A., Rouvroy, D., Uwimana, A. & Butzler, J.-P. (1988) Herpes zoster in African patients: an early manifestation of HIV infection. Scand. J. Infect. Dis. 20, 277.
74. Preblud, S. R. (1978) Varicella: complications and costs. Pediatrics 78 (Suppl), 728.
75. Price, R. W. (1981) Herpes zoster. Neurol. Neurosurg. Update Series Vol 2 21, 1.
76. Rager-Zisman, B. & Allison, Å. C. (1976) Mechanism of immunologic resistance to herpes simplex virus (HSV-1) infection. J. Immunol. 116, 35.
77. Ramakrishnan, R., Levine, M. & Fink, D. J. (1994) PCR-analysis of herpes simplex virus type 1 latency in rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J. Virol. 68, 7083.
78. Read, G. S. & Frenkel, N. (1983) Herpes simplex virus mutants defective in the virion associated shut-off of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides. J. Virol. 46, 498.
79. Rock, D. L. & Fraser, N. W. (1983) Detection of HSV-1 genome in the central nervous system of latently infected mice. Nature 302, 523.
80. Rock, D. L. & Fraser, N. W. (1985) Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region. J. Virol. 55, 849.
81. Roizman, B. & Sears, A. E. (1987) An inquiry into the mechanisms of herpes simplex virus latency. Annu. Rev. Microbiol. 41, 543.
82. Roizman, B. & Sears, A. E. (1990) Herpes simplex viruses and their replication. In: Virology (eds Fields, B.N., Knipe, D.M. et al.), 2nd edition, Chap 65, pp. 1795-1841. Raven Press Ltd, New York, USA.
83. Sawetell, N. M. & Thompson, R. L. (1992) Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site dependent establishment and reactivation from latency. J. Virol. 66, 2157.
84. Schimpff, J., Serpick, A., Stoler, B., Rumack, B., Mellin, H., Joseph, J. M. & Block, J. (1972) Varicella-zoster infection in patients with cancer. Ann. Intern. Med. 765, 241.
85. Sedarati, F., Izumi, K. M., Wagner, E. K. & Stevens, J. G. (1989) Herpes simplex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine sensory neurons. J. Virol. 63, 4455.
86. Simmons, A. & Nash, A. A. (1985) Role of antibody in primary and recurrent herpes simplex virus infection. J. Virol. 53, 944.
87. Simmons, A. & Nash, A. A. (1987) Effect of B-cell suppression on primary infection and reinfection of mice with herpes simplex virus. J. Infect. Dis. 155, 649.
88. Simmons, A. & Tscharke, D. C. (1992) Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: implication for the fate of the virally infected neurons. J. Exp. Med. 175, 1337.
89. Spivack, J. G. & Fraser, N. W. (1987) Detection of herpes simplex type 1 transcripts during latent infection in mice. J. Virol. 61, 3841.
90. Spivack, J. G. & Fraser, N. W. (1988) Expression of herpes simplex type 1 (HSV-1) latency-associated transcripts and transcripts affected by the deletion in avirulent mutant HFEM: evidence for a new class of HSV-1 genes. J. Virol. 62, 3281.
91. Spivack, J. G, Woods, G. M. & Fraser, N. W. (1991) Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT); translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT. J. Virol. 65, 6800.
92. Steiner, I. & Abramsky, O. (1985) Immunology of Guillain-Barre syndrome. Springer Semin. Immunopathol. 8, 165.
93. Steiner, I. & Kennedy, P. G. E. (1991) Herpes simplex virus latency in the nervous system - a new model. Neuropathol. Appl. Neurobiol. 17, 433.
94. Steiner, I. & Kennedy, P. G. E. (1993) The molecular biology of herpes simplex virus type 1 latency in the nervous system. Molec. Neurobiol. 7, 137.
95. Steiner, I., Mador, N., Reibstein, I., Spivack, J. G., & Fraser, N. W. (1994) Herpes simplex virus type 1 latency in human and mouse central nervous systems. Neuropathol. Applied Neurobiol. 20, 253.
96. Steiner, I., Spivack, J.G., Deshmane, S. L., Ace, C. I., Preston, C. M. & Fraser, N. W. (1990) A herpes simplex virus type 1 mutant containing a non-transinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia. J. Virol. 64, 1630.
97. Steiner, I., Spivack, J. G., Lirette, R. P., Brown, S. M., MacLean, A. R., Subak-Sharpe, J. & Fraser, N.W. (1989) Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection. EMBO J. 8, 505.
98. Steiner, I., Spivack, J. G., O'Boyle, D. R., Lavi, E. & Fraser, N. W. (1988) Latent herpes virus type 1 transcription in human trigeminal ganglia. J. Virol. 62, 3493.
99. Stevens, J. G., Haarr, L., Porter, D. D., Cook, M. L. & Wagner, E. K. (1988) Prominence of the herpes simplex virus latency-associated transcript in trigeminal ganglia from seropositive humans. J. Infect. Dis. 158, 117.
100. Stevens, J. G., Wagner, E. K., Devi-Rao, G. B., Cook, M. L. & Feldman, L. T. (1987) RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 235, 1056.
101. Tanaka, S., Minagawa, H., Toh, Y., Liu, Y. & Mori, R. (1994) Analysis by RNA-PCR of latency and reactivation of herpes simplex virus in multiple neuronal tissues. J. Gen. Virol. 75, 2691
102. Trousdale, M. D., Steiner, I., Spivack, J. G., Deshmane, S. L., Brown, S. M., MacLean, A. R., Subak-Sharp, J. H. & Fraser, N. W. (1991) In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model. J. Virol. 65, 6989.
103. Vafai, A., Wellish, M. & Gilden, D. H. (1988) Expression of varicella zoster virus in blood mononuclear cells of patients with postherpetic neuralgia. Proc. Natl. Acad. Sci. USA 85, 2767.
104. del Val, M., Hengel, H., Hecker, H., Hartlaub, U., Ruppert, T., Lucin, P. & Koszinowski, U. H. (1992) Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loading major histocompatibility class I molecules into the medial-Golgi compartment. J. Exp. Med. 176, 729.
105. Valyi-Nagy, T., Deshmane, S. L., Raengsakulrach, B., Nicosia, M., Gesser, R. M., Wysocka, M., Dillner, A. & Fraser, N. W. (1992) Herpes simplex virus type 1 mutant strain in 1814 establishes a unique, slowly progressing infection in SCID mice. J. Virol. 66, 7336.
106. Wheatley, S. C., Dent, C. L., Wood, J. N. & Latchman, D. S. (1991) A cellular factor binding to the TAATGARAT DNA sequence prevents the expression of the HSV immediate-early genes following infection of nonpermissive cell lines derived from dorsal root ganglion neurons. Exp. Cell Res. 194, 78.
107. Whitley, R. J. (1990) Herpes simplex viruses. In: Virology (eds Fields, B. N., Knipe, D. M. et al.). 2nd edn, Chap. 66, pp. 1843-1886. Raven Press, New York, USA.
108. Yewdell, J. W. & Bennink, J. R. (1992) Cell biology of antigen processing and presentation to major histocompatability complex class I molecule restricted T lymphocytes. Adv. Immunol. 52, 1.
109. + T lymphocytes. Cell 77, 525.
110. Zweernik, H. J. & Stanton, L. W. (1981) Immune response to herpes simplex virus infections: virus specific antibodies in the sera from patients with recurrent facial infections. Infect. Immun. 31, 624.