Tight junctions in cancer metastasis

Frontiers in Bioscience

Volumn 16, Issue 3, 2011, Pages 898-936

  Martin, Tracey A ^a   Mason, Malcolm D ^a   Jiang, Wen G ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Barrier function; Cancer; Metastasis; Review; Tight Junction

Indexed keywords

CELL ADHESION MOLECULE; CLAUDIN; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; COXSACKIE-ADENOVIRUS RECEPTOR; IMMUNOGLOBULIN; JUNCTIONAL ADHESION MOLECULE A , HUMAN; JUNCTIONAL ADHESION MOLECULE-A , HUMAN; MEMBRANE PROTEIN; NECTINS; OCCLUDIN; VIRUS RECEPTOR;

ANIMAL; BIOSYNTHESIS; BLADDER TUMOR; BRAIN TUMOR; BREAST TUMOR; CANCER INVASION; COLORECTAL TUMOR; CONNECTIVE TISSUE TUMOR; EPITHELIUM; ESOPHAGUS TUMOR; FEMALE; FEMALE GENITAL TRACT TUMOR; HUMAN; KIDNEY TUMOR; LIVER TUMOR; LUNG TUMOR; MALE; MELANOMA; METASTASIS; NEOPLASM; PANCREAS TUMOR; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSTATE TUMOR; REVIEW; STOMACH TUMOR; THYROID TUMOR; TIGHT JUNCTION;

ANIMALS; BRAIN NEOPLASMS; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CLAUDINS; COLORECTAL NEOPLASMS; EPITHELIUM; ESOPHAGEAL NEOPLASMS; FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; IMMUNOGLOBULINS; KIDNEY NEOPLASMS; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MELANOMA; MEMBRANE PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; PANCREATIC NEOPLASMS; PROSTATIC NEOPLASMS; RECEPTORS, VIRUS; SARCOMA, SYNOVIAL; STOMACH NEOPLASMS; THYROID NEOPLASMS; TIGHT JUNCTIONS; URINARY BLADDER NEOPLASMS;

EID: 79955029145     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3726     Document Type: Review

References (201)

1. W. G. Jiang, R. P. Bryce, D. F. Horrobin and R. E. Mansel: Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. Biochem Biophys Res Commun, 244(2), 414-20 (1998) (Pubitemid 28414097)
2. W. G. Jiang, T. A. Martin, K. Matsumoto, T. Nakamura and R. E. Mansel: Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells. J Cell Physiol, 181(2), 319-29 (1999) (Pubitemid 29463647)
3. S. Tsukita and M. Furuse: Occludin and claudins in tight-junction strands: leading or supporting players? Trends Cell Biol, 9(7), 268-73 (1999) (Pubitemid 29305516)
4. V. Wong: Phosphorylation of occludin correlates with occludin localization and function at the tight junction. Am J Physiol, 273(6 Pt 1), C1859-67 (1997)
5. F. Hollande, E. M. Blanc, J. P. Bali, R. H. Whitehead, A. Pelegrin, G. S. Baldwin and A. Choquet: HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line. Am J Physiol Gastrointest Liver Physiol, 280(5), G910-21 (2001)
6. T. A. Martin, R. E. Mansel and W. G. Jiang: Antagonistic effect of NK4 on HGF/SF induced changes in the transendothelial resistance (TER) and paracellular permeability of human vascular endothelial cells. J Cell Physiol, 192(3), 268-75 (2002) (Pubitemid 34827604)
7. T. Hoevel, R. Macek, O. Mundigl, K. Swisshelm and M. Kubbies: Expression and targeting of the tight junction protein CLDN1 in CLDN1-negative human breast tumor cells. J Cell Physiol, 191(1), 60-8 (2002) (Pubitemid 34195218)
8. J. Ren, J. Hamada, N. Takeichi, S. Fujikawa and H. Kobayashi: Ultrastructural differences in junctional intercellular communication between highly and weakly metastatic clones derived from rat mammary carcinoma. Cancer Res, 50(2), 358-62 (1990) (Pubitemid 20041241)
9. H. Satoh, Y. Zhong, H. Isomura, M. Saitoh, K. Enomoto, N. Sawada and M. Mori: Localization of 7H6 tight junction-associated antigen along the cell border of vascular endothelial cells correlates with paracellular barrier function against ions, large molecules, and cancer cells. Exp Cell Res, 222(2), 269-74 (1996) (Pubitemid 26045833)
10. A. Martinez-Paloma: Ultrastructural modifications of intercellular junctions in some epithelial tumors. Laboratory Investigation, 22(6), 9 (1970)
11. T. Inoue, M. Shimono, T. Yamamura, I. Saito, O. Watanabe and H. Kawahara: Acinic cell carcinoma arising in the glossopalatine glands: a report of two cases with electron microscopic observations. Oral Surg Oral Med Oral Pathol, 57(4), 398-407 (1984) (Pubitemid 14128660)
12. J. M. Mullin and T. G. O'Brien: Effects of tumor promoters on LLC-PK1 renal epithelial tight junctions and transepithelial fluxes. Am J Physiol, 251(4 Pt 1), C597-602 (1986)
13. K. Borka, P. Kaliszky, E. Szabo, G. Lotz, P. Kupcsulik, Z. Schaff and A. Kiss: Claudin expression in pancreatic endocrine tumors as compared with ductal adenocarcinomas. Virchows Arch, 450(5), 549-57 (2007) (Pubitemid 46676254)
14. T. Kaihara, H. Kawamata, J. Imura, S. Fujii, K. Kitajima, F. Omotehara, N. Maeda, T. Nakamura and T. Fujimori: Redifferentiation and ZO-1 reexpression in livermetastasized colorectal cancer: possible association with epidermal growth factor receptor-induced tyrosine phosphorylation of ZO-1. Cancer Sci, 94(2), 166-72 (2003) (Pubitemid 36575876)
15. Y. Kimura, H. Shiozaki, M. Hirao, Y. Maeno, Y. Doki, M. Inoue, T. Monden, Y. Ando-Akatsuka, M. Furuse, S. Tsukita and M. Monden: Expression of occludin, tightjunction-associated protein, in human digestive tract. Am J Pathol, 151(1), 45-54 (1997) (Pubitemid 27283956)
16. M. B. Resnick, T. Konkin, J. Routhier, E. Sabo and V. E. Pricolo: Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study. Mod Pathol, 18(4), 511-8 (2005) (Pubitemid 40478114)
17. P. Michl, M. Buchholz, M. Rolke, S. Kunsch, M. Lohr, B. McClane, S. Tsukita, G. Leder, G. Adler and T. M. Gress: Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gastroenterology, 121(3), 678-84 (2001) (Pubitemid 32822583)
18. J. Bell, S. Walsh, A. Nusrat and C. Cohen: Zonula occludens-1 and Her-2/neu expression in invasive breast carcinoma. Appl Immunohistochem Mol Morphol, 11(2), 125-9 (2003) (Pubitemid 36749564)
19. A. Chlenski, K. V. Ketels, G. I. Korovaitseva, M. S. Talamonti, R. Oyasu and D. G. Scarpelli: Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues. Biochim Biophys Acta, 1493(3), 319-24 (2000)
20. K. B. Hoover, S. Y. Liao and P. J. Bryant: Loss of the tight junction MAGUK ZO-1 in breast cancer: relationship to glandular differentiation and loss of heterozygosity. Am J Pathol, 153(6), 1767-73 (1998) (Pubitemid 28550664)
21. S. L. Kominsky, P. Argani, D. Korz, E. Evron, V. Raman, E. Garrett, A. Rein, G. Sauter, O. P. Kallioniemi and S. Sukumar: Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene, 22(13), 2021-33 (2003) (Pubitemid 36523639)
22. F. Kramer, K. White, M. Kubbies, K. Swisshelm and B. H. Weber: Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. Hum Genet, 107(3), 249-56 (2000)
23. T. A. Martin, G. Watkins, R. E. Mansel and W. G. Jiang: Loss of tight junction plaque molecules in breast cancer tissues is associated with a poor prognosis in patients with breast cancer. Eur J Cancer, 40(18), 2717-25 (2004) (Pubitemid 39574723)
24. T. A. Martin, G. Watkins, R. E. Mansel and W. G. Jiang: Hepatocyte growth factor disrupts tight junctions in human breast cancer cells. Cell Biol Int, 28(5), 361-71 (2004) (Pubitemid 38748926)
25. J. Ikenouchi, M. Matsuda, M. Furuse and S. Tsukita: Regulation of tight junctions during the epitheliummesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci, 116(Pt 10), 1959-67 (2003) (Pubitemid 36622294)
26. T. A. Martin, A. Goyal, G. Watkins and W. G. Jiang: Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol, 12(6), 488-96 (2005) (Pubitemid 40884264)
27. T. Ohkubo and M. Ozawa: The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation. J Cell Sci, 117(Pt 9), 1675-85 (2004) (Pubitemid 38559300)
28. S. Gopalakrishnan, N. Raman, S. J. Atkinson and J. A. Marrs: Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion. Am J Physiol, 275(3 Pt 1), C798-809 (1998)
29. Y. Chen, C. Merzdorf, D. L. Paul and D. A. Goodenough: COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J Cell Biol, 138(4), 891-9 (1997) (Pubitemid 27365050)
30. M. Furuse, K. Fujita, T. Hiiragi, K. Fujimoto and S. Tsukita: Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol, 141(7), 1539-50 (1998) (Pubitemid 28309169)
31. T. A. Martin and W. G. Jiang: Tight junctions and their role in cancer metastasis. Histol Histopathol, 16(4), 1183-95 (2001) (Pubitemid 32994462)
32. A. S. Fanning, L. L. Mitic and J. M. Anderson: Transmembrane proteins in the tight junction barrier. J Am Soc Nephrol, 10(6), 1337-45 (1999) (Pubitemid 29247001)
33. A. Chlenski, K. V. Ketels, M. S. Tsao, M. S. Talamonti, M. R. Anderson, R. Oyasu and D. G. Scarpelli: Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma. Int J Cancer, 82(1), 137-44 (1999) (Pubitemid 29266119)
34. K. Shin, V. C. Fogg and B. Margolis: Tight junctions and cell polarity. Annu Rev Cell Dev Biol, 22, 207-35 (2006)
35. I. J. Latorre, M. H. Roh, K. K. Frese, R. S. Weiss, B. Margolis and R. T. Javier: Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells. J Cell Sci, 118(Pt 18), 4283-93 (2005) (Pubitemid 41488965)
36. V. T. DeVita, Jr., R. C. Young and G. P. Canellos: Combination versus single agent chemotherapy: a review of the basis for selection of drug treatment of cancer. Cancer, 35(1), 98-110 (1975)
37. P. C. Brooks: Cell adhesion molecules in angiogenesis. Cancer Metastasis Rev, 15(2), 187-94 (1996) (Pubitemid 26236116)
38. J. Folkman: Fighting cancer by attacking its blood supply. Sci Am, 275(3), 150-4 (1996)
39. J. Folkman and Y. Shing: Angiogenesis. J Biol Chem, 267(16), 10931-4 (1992)
40. M. Ono, H. Torisu, J. Fukushi, A. Nishie and M. Kuwano: Biological implications of macrophage infiltration in human tumor angiogenesis. Cancer Chemother Pharmacol, 43 Suppl, S69-71 (1999) (Pubitemid 29244636)
41. I. R. Hart, N. T. Goode and R. E. Wilson: Molecular aspects of the metastatic cascade. Biochim Biophys Acta, 989(1), 65-84 (1989) (Pubitemid 19180351)
42. W. G. Jiang, M. C. Puntis and M. B. Hallett: Molecular and cellular basis of cancer invasion and metastasis: implications for treatment. Br J Surg, 81(11), 1576-90 (1994) (Pubitemid 24349926)
43. H. Tobioka, N. Sawada, Y. Zhong and M. Mori: Enhanced paracellular barrier function of rat mesothelial cells partially protects against cancer cell penetration. Br J Cancer, 74(3), 439-45 (1996) (Pubitemid 26254575)
44. J. P. Fedwick, T. K. Lapointe, J. B. Meddings, P. M. Sherman and A. G. Buret: Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability. Infect Immun, 73(12), 7844-52 (2005) (Pubitemid 41740267)
45. G. Da Violante, N. Zerrouk, I. Richard, G. Provot, J. C. Chaumeil and P. Arnaud: Evaluation of the cytotoxicity effect of dimethyl sulfoxide (DMSO) on Caco2/TC7 colon tumor cell cultures. Biol Pharm Bull, 25(12), 1600-3 (2002) (Pubitemid 39663677)
46. J. M. Mullin, J. M. Leatherman, M. C. Valenzano, E. R. Huerta, J. Verrechio, D. M. Smith, K. Snetselaar, M. Liu, M. K. Francis and C. Sell: Ras mutation impairs epithelial barrier function to a wide range of nonelectrolytes. Mol Biol Cell, 16(12), 5538-50 (2005)
47. V. M. Stucke, E. Timmerman, J. Vandekerckhove, K. Gevaert and A. Hall: The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Mol Biol Cell, 18(5), 1744-55 (2007) (Pubitemid 46717556)
48. A. P. Soler, R. D. Miller, K. V. Laughlin, N. Z. Carp, D. M. Klurfeld and J. M. Mullin: Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis, 20(8), 1425-31 (1999) (Pubitemid 29385425)
49. J. M. Mullin, K. V. Laughlin, N. Ginanni, C. W. Marano, H. M. Clarke and A. Peralta Soler: Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers. Ann N Y Acad Sci, 915, 231-6 (2000) (Pubitemid 32059384)
50. H. Clarke, A. P. Soler and J. M. Mullin: Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. J Cell Sci, 113 ( Pt 18), 3187-96 (2000)
51. N. Utoguchi, H. Mizuguchi, A. Dantakean, H. Makimoto, Y. Wakai, Y. Tsutsumi, S. Nakagawa and T. Mayumi: Effect of tumour cell-conditioned medium on endothelial macromolecular permeability and its correlation with collagen. Br J Cancer, 73(1), 24-8 (1996) (Pubitemid 26026255)
52. P. R. Clark, T. D. Manes, J. S. Pober and M. S. Kluger: Increased ICAM-1 expression causes endothelial cell leakiness, cytoskeletal reorganization and junctional alterations. J Invest Dermatol, 127(4), 762-74 (2007) (Pubitemid 46434665)
53. P. J. Morin: Claudin proteins in human cancer: promising new targets for diagnosis and therapy. Cancer Res, 65(21), 9603-6 (2005)
54. A. Ouban and A. A. Ahmed: Claudins in human cancer: a review. Histol Histopathol, 25(1), 83-90 (2010)
55. H. Tobioka, H. Isomura, Y. Kokai, Y. Tokunaga, J. Yamaguchi and N. Sawada: Occludin expression decreases with the progression of human endometrial carcinoma. Hum Pathol, 35(2), 159-64 (2004) (Pubitemid 38240897)
56. H. Tobioka, Y. Tokunaga, H. Isomura, Y. Kokai, J. Yamaguchi and N. Sawada: Expression of occludin, a tightjunction-associated protein, in human lung carcinomas. Virchows Arch, 445(5), 472-6 (2004) (Pubitemid 39592750)
57. Y. Myal, E. Leygue and A. A. Blanchard: Claudin 1 in breast tumorigenesis: revelation of a possible novel "claudin high" subset of breast cancers. J Biomed Biotechnol, 2010, 956897 (2010)
58. K. Swisshelm, A. Machl, S. Planitzer, R. Robertson, M. Kubbies and S. Hosier: SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily. Gene, 226(2), 285-95 (1999) (Pubitemid 29087109)
59. K. Zhang, H. P. Yao and M. H. Wang: Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility. Carcinogenesis, 29(3), 552-9 (2008) (Pubitemid 351404871)
60. T. H. Kim, J. H. Huh, S. Lee, H. Kang, G. I. Kim and H. J. An: Down-regulation of claudin-2 in breast carcinomas is associated with advanced disease. Histopathology, 53(1), 48-55 (2008) (Pubitemid 351861978)
61. S. Morohashi, T. Kusumi, F. Sato, H. Odagiri, H. Chiba, S. Yoshihara, K. Hakamada, M. Sasaki and H. Kijima: Decreased expression of claudin-1 correlates with recurrence status in breast cancer. Int J Mol Med, 20(2), 139-43 (2007)
62. J. Kulka, A. M. Szasz, Z. Nemeth, L. Madaras, Z. Schaff, I. A. Molnar and A. M. Tokes: Expression of tight junction protein claudin-4 in basal-like breast carcinomas. Pathol Oncol Res, 15(1), 59-64 (2009)
63. F. Lanigan, E. McKiernan, D. J. Brennan, S. Hegarty, R. C. Millikan, J. McBryan, K. Jirstrom, G. Landberg, F. Martin, M. J. Duffy and W. M. Gallagher: Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. Int J Cancer, 124(9), 2088-97 (2009)
64. A. M. Tokes, J. Kulka, S. Paku, A. Szik, C. Paska, P. K. Novak, L. Szilak, A. Kiss, K. Bogi and Z. Schaff: Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res, 7(2), R296-305 (2005)
65. Y. Soini, S. Tommola, H. Helin and P. Martikainen: Claudins 1, 3, 4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype. Virchows Arch, 448(1), 52-8 (2006) (Pubitemid 43177415)
66. A. A. Blanchard, P. H. Watson, R. P. Shiu, E. Leygue, A. Nistor, P. Wong and Y. Myal: Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouse. DNA Cell Biol, 25(2), 79-86 (2006) (Pubitemid 43271411)
67. M. Osanai, M. Murata, H. Chiba, T. Kojima and N. Sawada: Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells. Cancer Sci, 98(10), 1557-62 (2007) (Pubitemid 47308450)
68. Q. Wu, Y. F. Liu, Y. Ren, X. M. Xu, L. N. Yu, Y. L. Li and C. S. Quan: [Effects of stable up-regulation of tight junction protein claudin-6 upon biological phenotypes of breast cancer cell MCF-7]. Zhonghua Yi Xue Za Zhi, 90(6), 407-12 (2010)
69. M. Kulawiec, A. Safina, M. M. Desouki, I. Still, S. Matsui, A. Bakin and K. K. Singh: Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion. Cancer Biol Ther, 7(11), 1732-43 (2008)
70. T. Sauer, M. K. Pedersen, K. Ebeltoft and O. Naess: Reduced expression of Claudin-7 in fine needle aspirates from breast carcinomas correlate with grading and metastatic disease. Cytopathology, 16(4), 193-8 (2005) (Pubitemid 41112978)
71. w. g. martin t a, manse r e, jiang w g: Reduction of levels of paracellin-1 and vinculin are associated with poor clinical outcome in patients with breast cancer. Proceedings of the American Association for Cacner Research, 44, 1 (2003)
72. S. Fabre-Lafay, F. Monville, S. Garrido-Urbani, C. Berruyer-Pouyet, C. Ginestier, N. Reymond, P. Finetti, R. Sauvan, J. Adelaide, J. Geneix, E. Lecocq, C. Popovici, P. Dubreuil, P. Viens, A. Goncalves, E. Charafe-Jauffret, J. Jacquemier, D. Birnbaum and M. Lopez: Nectin-4 is a new histological and serological tumor associated marker for breast cancer. BMC Cancer, 7, 73 (2007) (Pubitemid 46785011)
73. M. Osanai, M. Murata, N. Nishikiori, H. Chiba, T. Kojima and N. Sawada: Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells. Cancer Sci, 98(7), 1027-34 (2007) (Pubitemid 46865387)
74. U. P. Naik and M. U. Naik: Putting the brakes on cancer cell migration: JAM-A restrains integrin activation. Cell Adh Migr, 2(4), 249-51 (2008)
75. T. A. Martin, G. Watkins and W. G. Jiang: The Coxsackie-adenovirus receptor has elevated expression in human breast cancer. Clin Exp Med, 5(3), 122-8 (2005) (Pubitemid 41597272)
76. M. D. Haynes, T. A. Martin, S. A. Jenkins, H. G. Kynaston, P. N. Matthews and W. G. Jiang: Tight junctions and bladder cancer (review). Int J Mol Med, 16(1), 3-9 (2005)
77. S. Boireau, M. Buchert, M. S. Samuel, J. Pannequin, J. L. Ryan, A. Choquet, H. Chapuis, X. Rebillard, C. Avances, M. Ernst, D. Joubert, N. Mottet and F. Hollande: DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma. Carcinogenesis, 28(2), 246-58 (2007) (Pubitemid 46321840)
78. V. Hahn-Stromberg, H. Edvardsson, L. Bodin and L. Franzen: Disturbed expression of E-cadherin, beta-catenin and tight junction proteins in colon carcinoma is unrelated to growth pattern and genetic polymorphisms. APMIS, 116(4), 253-62 (2008) doi:APM894 [pii] 10.1111/j.1600-0463.2008.00894.x (Pubitemid 351499160)
79. S. R. Shiou, A. B. Singh, K. Moorthy, P. K. Datta, M. K. Washington, R. D. Beauchamp and P. Dhawan: Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res, 67(4), 1571-9 (2007) (Pubitemid 46383381)
80. P. Dhawan, A. B. Singh, N. G. Deane, Y. No, S. R. Shiou, C. Schmidt, J. Neff, M. K. Washington and R. D. Beauchamp: Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest, 115(7), 1765-76 (2005) (Pubitemid 40979715)
81. T. Kinugasa, Q. Huo, D. Higashi, H. Shibaguchi, M. Kuroki, T. Tanaka, K. Futami, Y. Yamashita, K. Hachimine, S. Maekawa, K. Nabeshima and H. Iwasaki: Selective up-regulation of claudin-1 and claudin-2 in colorectal cancer. Anticancer Res, 27(6A), 3729-34 (2007) (Pubitemid 47598437)
82. J. Grone, B. Weber, E. Staub, M. Heinze, I. Klaman, C. Pilarsky, K. Hermann, E. Castanos-Velez, S. Ropcke, B. Mann, A. Rosenthal and H. J. Buhr: Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12. Int J Colorectal Dis, 22(6), 651-9 (2007) (Pubitemid 47097036)
83. S. S. Oliveira and J. A. Morgado-Diaz: Claudins: multifunctional players in epithelial tight junctions and their role in cancer. Cell Mol Life Sci, 64(1), 17-28 (2007) (Pubitemid 46164492)
84. Y. Tokunaga, H. Tobioka, H. Isomura, Y. Kokai and N. Sawada: Expression of occludin in human rectal carcinoid tumours as a possible marker for glandular differentiation. Histopathology, 44(3), 247-50 (2004) (Pubitemid 38406617)
85. J. Ueda, S. Semba, H. Chiba, N. Sawada, Y. Seo, M. Kasuga and H. Yokozaki: Heterogeneous expression of claudin-4 in human colorectal cancer: decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis. Pathobiology, 74(1), 32-41 (2007) (Pubitemid 46745168)
86. N. Miwa, M. Furuse, S. Tsukita, N. Niikawa, Y. Nakamura and Y. Furukawa: Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. Oncol Res, 12(11-12), 469-76 (2001) (Pubitemid 33791807)
87. S. T. Mees, R. Mennigen, T. Spieker, E. Rijcken, N. Senninger, J. Haier and M. Bruewer: Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin. Int J Colorectal Dis, 24(4), 361-8 (2009)
88. Q. Huo, T. Kinugasa, L. Wang, J. Huang, J. Zhao, H. Shibaguchi, M. Kuroki, T. Tanaka, Y. Yamashita, K. Nabeshima and H. Iwasaki: Claudin-1 protein is a major factor involved in the tumorigenesis of colorectal cancer. Anticancer Res, 29(3), 851-7 (2009)
89. M. Krishnan, A. B. Singh, J. J. Smith, A. Sharma, X. Chen, S. Eschrich, T. J. Yeatman, R. D. Beauchamp and P. Dhawan: HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. Oncogene, 29(2), 305-12 (2010)
90. P. P. Aung, Y. Mitani, Y. Sanada, H. Nakayama, K. Matsusaki and W. Yasui: Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas. Virchows Arch, 448(4), 428-34 (2006)
91. T. Oshima, C. Kunisaki, K. Yoshihara, R. Yamada, N. Yamamoto, T. Sato, H. Makino, S. Yamagishi, Y. Nagano, S. Fujii, M. Shiozawa, M. Akaike, N. Wada, Y. Rino, M. Masuda, K. Tanaka and T. Imada: Reduced expression of the claudin-7 gene correlates with venous invasion and liver metastasis in colorectal cancer. Oncol Rep, 19(4), 953-9 (2008) (Pubitemid 351802665)
92. C. Darido, M. Buchert, J. Pannequin, P. Bastide, H. Zalzali, T. Mantamadiotis, J. F. Bourgaux, V. Garambois, P. Jay, P. Blache, D. Joubert and F. Hollande: Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells. Cancer Res, 68(11), 4258-68 (2008)
93. F. Nakayama, S. Semba, Y. Usami, H. Chiba, N. Sawada and H. Yokozaki: Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma. Pathobiology, 75(3), 177-85 (2008)
94. C. R. Weber, S. C. Nalle, M. Tretiakova, D. T. Rubin and J. R. Turner: Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest, 88(10), 1110-20 (2008)
95. M. N. Tanaka, B. L. Diaz, W. de Souza and J. A. Morgado-Diaz: Prostaglandin E2-EP1 and EP2 receptor signaling promotes apical junctional complex disassembly of Caco-2 human colorectal cancer cells. BMC Cell Biol, 9, 63 (2008)
96. W. M. Korn, M. Macal, C. Christian, M. D. Lacher, A. McMillan, K. A. Rauen, R. S. Warren and L. Ferrell: Expression of the coxsackievirus- and adenovirus receptor in gastrointestinal cancer correlates with tumor differentiation. Cancer Gene Ther, 13(8), 792-7 (2006) (Pubitemid 44100492)
97. K. Miyamoto, T. Kusumi, F. Sato, H. Kawasaki, S. Shibata, M. Ohashi, K. Hakamada, M. Sasaki and H. Kijima: Decreased expression of claudin-1 is correlated with recurrence status in esophageal squamous cell carcinoma. Biomed Res, 29(2), 71-6 (2008) (Pubitemid 351753465)
98. E. Montgomery, A. J. Mamelak, M. Gibson, A. Maitra, S. Sheikh, S. S. Amr, S. Yang, M. Brock, A. Forastiere, S. Zhang, K. M. Murphy and K. D. Berg: Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions. Appl Immunohistochem Mol Morphol, 14(1), 24-30 (2006)
99. Y. Usami, H. Chiba, F. Nakayama, J. Ueda, Y. Matsuda, N. Sawada, T. Komori, A. Ito and H. Yokozaki: Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus. Hum Pathol, 37(5), 569-77 (2006)
100. M. Lioni, P. Brafford, C. Andl, A. Rustgi, W. El-Deiry, M. Herlyn and K. S. Smalley: Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells. Am J Pathol, 170(2), 709-21 (2007) (Pubitemid 47342407)
101. H. Gyorffy, A. Holczbauer, P. Nagy, Z. Szabo, P. Kupcsulik, C. Paska, J. Papp, Z. Schaff and A. Kiss: Claudin expression in Barrett's esophagus and adenocarcinoma. Virchows Arch, 447(6), 961-8 (2005) (Pubitemid 41719551)
102. T. A. Demura, E. A. Kogan, O. A. Sklianskaia and R. Mol: [Role of tight junction claudins in the morphogenesis of adenocarcinoma in the presence of Barrett's esophagus]. Arkh Patol, 70(5), 20-4 (2008)
103. J. M. Mullin, M. C. Valenzano, S. Trembeth, P. D. Allegretti, J. J. Verrecchio, J. D. Schmidt, V. Jain, J. B. Meddings, G. Mercogliano and J. J. Thornton: Transepithelial leak in Barrett's esophagus. Dig Dis Sci, 51(12), 2326-36 (2006)
104. B. Jovov, C. M. Van Itallie, N. J. Shaheen, J. L. Carson, T. M. Gambling, J. M. Anderson and R. C. Orlando: Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance. Am J Physiol Gastrointest Liver Physiol, 293(6), G1106-13 (2007) (Pubitemid 350255034)
105. E. Rendon-Huerta, M. C. Valenzano, J. M. Mullin, S. E. Trembeth, R. Kothari, B. Hameed, G. Mercogliano and J. J. Thornton: Comparison of three integral tight junction barrier proteins in Barrett's epithelium versus normal esophageal epithelium. Am J Gastroenterol, 98(8), 1901-3 (2003) (Pubitemid 36959184)
106. E. Orban, E. Szabo, G. Lotz, P. Kupcsulik, C. Paska, Z. Schaff and A. Kiss: Different expression of occludin and ZO-1 in primary and metastatic liver tumors. Pathol Oncol Res, 14(3), 299-306 (2008)
107. L. J. Xue, Q. S. Su, J. H. Yang and Y. Lin: Autoimmune responses induced by Helicobacter pylori improve the prognosis of gastric carcinoma. Med Hypotheses, 70(2), 273-6 (2008) (Pubitemid 350297628)
108. Y. Matsuda, S. Semba, J. Ueda, T. Fuku, T. Hasuo, H. Chiba, N. Sawada, Y. Kuroda and H. Yokozaki: Gastric and intestinal claudin expression at the invasive front of gastric carcinoma. Cancer Sci, 98(7), 1014-9 (2007) (Pubitemid 46865385)
109. A. H. Johnson, H. F. Frierson, A. Zaika, S. M. Powell, J. Roche, S. Crowe, C. A. Moskaluk and W. El-Rifai: Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. Am J Pathol, 167(2), 577-84 (2005) (Pubitemid 43026111)
110. W. L. Kuo, L. Y. Lee, C. M. Wu, C. C. Wang, J. S. Yu, Y. Liang, C. H. Lo, K. H. Huang and T. L. Hwang: Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer. Oncol Rep, 16(4), 729-34 (2006)
111. M. B. Resnick, M. Gavilanez, E. Newton, T. Konkin, B. Bhattacharya, D. E. Britt, E. Sabo and S. F. Moss: Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation. Hum Pathol, 36(8), 886-92 (2005) (Pubitemid 41187907)
112. H. Jung, K. H. Jun, J. H. Jung, H. M. Chin and W. B. Park: The Expression of Claudin-1, Claudin-2, Claudin-3, and Claudin-4 in Gastric Cancer Tissue. J Surg Res (2010)
113. L. Y. Lee, C. M. Wu, C. C. Wang, J. S. Yu, Y. Liang, K. H. Huang, C. H. Lo and T. L. Hwang: Expression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expression. Histol Histopathol, 23(5), 515-21 (2008) (Pubitemid 351552337)
114. S. Ohtani, M. Terashima, J. Satoh, N. Soeta, Z. Saze, S. Kashimura, F. Ohsuka, Y. Hoshino, M. Kogure and M. Gotoh: Expression of tight-junction- associated proteins in human gastric cancer: downregulation of claudin-4 correlates with tumor aggressiveness and survival. Gastric Cancer, 12(1), 43-51 (2009)
115. X. Song, X. Li, Y. Tang, H. Chen, B. Wong, J. Wang and M. Chen: Expression of claudin-2 in the multistage process of gastric carcinogenesis. Histol Histopathol, 23(6), 673-82 (2008) (Pubitemid 351552352)
116. J. Y. Park, K. H. Park, T. Y. Oh, S. P. Hong, T. J. Jeon, C. H. Kim, S. W. Park, J. B. Chung, S. Y. Song and S. Bang: Up-regulated claudin 7 expression in intestinaltype gastric carcinoma. Oncol Rep, 18(2), 377-82 (2007)
117. K. Yano, T. Imaeda and T. Niimi: Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells. Am J Physiol Gastrointest Liver Physiol, 294(1), G336-43 (2008) (Pubitemid 351164862)
118. A. Shinozaki, T. Ushiku, T. Morikawa, R. Hino, T. Sakatani, H. Uozaki and M. Fukayama: Epstein-Barr virusassociated gastric carcinoma: a distinct carcinoma of gastric phenotype by claudin expression profiling. J Histochem Cytochem, 57(8), 775-85 (2009)
119. R. Agarwal, Y. Mori, Y. Cheng, Z. Jin, A. V. Olaru, J. P. Hamilton, S. David, F. M. Selaru, J. Yang, J. M. Abraham, E. Montgomery, P. J. Morin and S. J. Meltzer: Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells. PLoS One, 4(11), e8002 (2009)
120. K. Yoshida, S. Kanaoka, T. Takai, T. Uezato, N. Miura, M. Kajimura and A. Hishida: EGF rapidly translocates tight junction proteins from the cytoplasm to the cell-cell contact via protein kinase C activation in TMK-1 gastric cancer cells. Exp Cell Res, 309(2), 397-409 (2005) (Pubitemid 41317363)
121. R. Masuda, S. Semba, E. Mizuuchi, K. Yanagihara and H. Yokozaki: Negative regulation of the tight junction protein tricellulin by snail-induced epithelial-mesenchymal transition in gastric carcinoma cells. Pathobiology, 77(2), 106-13 (2010)
122. G. Sobel, I. Szabo, C. Paska, A. Kiss, I. Kovalszky, A. Kadar, F. Paulin and Z. Schaff: Changes of cell adhesion and extracellular matrix (ECM) components in cervical intraepithelial neoplasia. Pathol Oncol Res, 11(1), 26-31 (2005) (Pubitemid 40646272)
123. S. K. Lee, J. Moon, S. W. Park, S. Y. Song, J. B. Chung and J. K. Kang: Loss of the tight junction protein claudin 4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma. Oncol Rep, 13(2), 193-9 (2005)
124. R. A. Tassi, E. Bignotti, M. Falchetti, M. Ravanini, S. Calza, A. Ravaggi, E. Bandiera, F. Facchetti, S. Pecorelli and A. D. Santin: Claudin-7 expression in human epithelial ovarian cancer. Int J Gynecol Cancer, 18(6), 1262-71 (2008)
125. B. Litkouhi, J. Kwong, C. M. Lo, J. G. Smedley, 3rd, B. A. McClane, M. Aponte, Z. Gao, J. L. Sarno, J. Hinners, W. R. Welch, R. S. Berkowitz, S. C. Mok and E. I. Garner: Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a Cterminal fragment of Clostridium perfringens enterotoxin. Neoplasia, 9(4), 304-14 (2007) (Pubitemid 46608297)
126. Y. Zhu, M. Brannstrom, P. O. Janson and K. Sundfeldt: Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours. Int J Cancer, 118(8), 1884-91 (2006)
127. H. Honda, M. J. Pazin, H. Ji, R. P. Wernyj and P. J. Morin: Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells. J Biol Chem, 281(30), 21433-44 (2006) (Pubitemid 44115482)
128. T. D'Souza, R. Agarwal and P. J. Morin: Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J Biol Chem, 280(28), 26233-40 (2005) (Pubitemid 41022220)
129. Y. L. Choi, J. Kim, M. J. Kwon, J. S. Choi, T. J. Kim, D. S. Bae, S. S. Koh, Y. H. In, Y. W. Park, S. H. Kim, G. Ahn and Y. K. Shin: Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation. Histol Histopathol, 22(11), 1185-95 (2007) (Pubitemid 47470312)
130. Y. Zhu and K. Sundfeldt: Tight junction formation in epithelial ovarian adenocarcinoma. Acta Obstet Gynecol Scand, 86(8), 1011-9 (2007) (Pubitemid 47134685)
131. L. Kleinberg, A. Holth, C. G. Trope, R. Reich and B. Davidson: Claudin upregulation in ovarian carcinoma effusions is associated with poor survival. Hum Pathol, 39(5), 747-57 (2008) (Pubitemid 351618309)
132. M. J. Kwon, S. S. Kim, Y. L. Choi, H. S. Jung, C. Balch, S. H. Kim, Y. S. Song, V. E. Marquez, K. P. Nephew and Y. K. Shin: Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications. Carcinogenesis, 31(6), 974-83 (2010)
133. G. E. Konecny, R. Agarwal, G. A. Keeney, B. Winterhoff, M. B. Jones, A. Mariani, D. Riehle, C. Neuper, S. C. Dowdy, H. J. Wang, P. J. Morin and K. C. Podratz: Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. Gynecol Oncol, 109(2), 263-9 (2008)
134. X. Y. Pan, B. Wang, Y. C. Che, Z. P. Weng, H. Y. Dai and W. Peng: Expression of claudin-3 and claudin-4 in normal, hyperplastic, and malignant endometrial tissue. Int J Gynecol Cancer, 17(1), 233-41 (2007) (Pubitemid 46213996)
135. I. Szabo, A. Kiss, Z. Schaff and G. Sobel: Claudins as diagnostic and prognostic markers in gynecological cancer. Histol Histopathol, 24(12), 1607-15 (2009)
136. H. Long, C. D. Crean, W. H. Lee, O. W. Cummings and T. G. Gabig: Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium. Cancer Res, 61(21), 7878-81 (2001) (Pubitemid 33049378)
137. D. Reimer, I. Steppan, A. Wiedemair, N. Concin, G. Hofstetter, C. Marth, E. Muller-Holzner and A. G. Zeimet: Soluble isoforms but not the transmembrane form of coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancer. Int J Cancer, 120(12), 2568-75 (2007) (Pubitemid 46651276)
138. H. Koshiba, K. Hosokawa, A. Kubo, N. Tokumitsu, A. Watanabe and H. Honjo: Junctional adhesion molecule A [corrected] expression in human endometrial carcinoma. Int J Gynecol Cancer, 19(2), 208-13 (2009)
139. G. M. Sheehan, B. V. Kallakury, C. E. Sheehan, H. A. Fisher, R. P. Kaufman, Jr. and J. S. Ross: Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas. Hum Pathol, 38(4), 564-9 (2007) (Pubitemid 46399893)
140. C. Busch, T. A. Hanssen, C. Wagener and O. B. B: Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition. Hum Pathol, 33(3), 290-8 (2002) (Pubitemid 34461462)
141. J. Y. Zheng, D. Yu, M. Foroohar, E. Ko, J. Chan, N. Kim, R. Chiu and S. Pang: Regulation of the expression of the prostate-specific antigen by claudin-7. J Membr Biol, 194(3), 187-97 (2003) (Pubitemid 37013811)
142. S. Paschoud, M. Bongiovanni, J. C. Pache and S. Citi: Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod Pathol, 20(9), 947-54 (2007) (Pubitemid 47267821)
143. Y. Liu, W. Sun, K. Zhang, H. Zheng, Y. Ma, D. Lin, X. Zhang, L. Feng, W. Lei, Z. Zhang, S. Guo, N. Han, W. Tong, X. Feng, Y. Gao and S. Cheng: Identification of genes differentially expressed in human primary lung squamous cell carcinoma. Lung Cancer, 56(3), 307-17 (2007) (Pubitemid 46679087)
144. Y. C. Chao, S. H. Pan, S. C. Yang, S. L. Yu, T. F. Che, C. W. Lin, M. S. Tsai, G. C. Chang, C. H. Wu, Y. Y. Wu, Y. C. Lee, T. M. Hong and P. C. Yang: Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma. Am J Respir Crit Care Med, 179(2), 123-33 (2009)
145. J. H. Jung, C. K. Jung, H. J. Choi, K. H. Jun, J. Yoo, S. J. Kang and K. Y. Lee: Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas. Pathol Res Pract, 205(6), 409-16 (2009)
146. M. Yamashita, A. Ino, K. Kawabata, F. Sakurai and H. Mizuguchi: Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells. Int J Cancer, 121(8), 1690-6 (2007) (Pubitemid 47417284)
147. P. D. Leotlela, M. S. Wade, P. H. Duray, M. J. Rhode, H. F. Brown, D. T. Rosenthal, S. K. Dissanayake, R. Earley, F. E. Indig, B. J. Nickoloff, D. D. Taub, O. P. Kallioniemi, P. Meltzer, P. J. Morin and A. T. Weeraratna: Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility. Oncogene, 26(26), 3846-56 (2007) (Pubitemid 46880988)
148. M. L. Cohn, V. N. Goncharuk, A. H. Diwan, P. S. Zhang, S. S. Shen and V. G. Prieto: Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms. J Cutan Pathol, 32(8), 533-6 (2005) (Pubitemid 41224420)
149. X. Tan, H. Egami, S. Ishikawa, T. Kurizaki, M. Nakagawa, M. Hirota and M. Ogawa: Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells. Int J Oncol, 25(6), 1567-74 (2004)
150. B. Katalin: [Claudin expression in different pancreatic cancers and its significance in differential diagnostics]. Magy Onkol, 53(3), 273-8 (2009)
151. F. Comper, D. Antonello, S. Beghelli, S. Gobbo, L. Montagna, P. Pederzoli, M. Chilosi and A. Scarpa: Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreas. Am J Surg Pathol, 33(5), 768-74 (2009)
152. N. Oku, E. Sasabe, E. Ueta, T. Yamamoto and T. Osaki: Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1. Cancer Res, 66(10), 5251-7 (2006) (Pubitemid 43844949)
153. I. O. Bello, S. T. Vilen, A. Niinimaa, S. Kantola, Y. Soini and T. Salo: Expression of claudins 1, 4, 5, and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue. Hum Pathol, 39(8), 1212-20 (2008)
154. M. Schmitt, A. Horbach, R. Kubitz, A. Frilling and D. Haussinger: Disruption of hepatocellular tight junctions by vascular endothelial growth factor (VEGF): a novel mechanism for tumor invasion. J Hepatol, 41(2), 274-83 (2004) (Pubitemid 39177632)
155. N. P. Lee and J. M. Luk: Hepatic tight junctions: from viral entry to cancer metastasis. World J Gastroenterol, 16(3), 289-95 (2010)
156. Y. C. Ip, S. T. Cheung, Y. T. Lee, J. C. Ho and S. T. Fan: Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. Mol Cancer Ther, 6(11), 2858-67 (2007) (Pubitemid 350206764)
157. C. H. Yoon, M. J. Kim, M. J. Park, I. C. Park, S. G. Hwang, S. An, Y. H. Choi, G. Yoon and S. J. Lee: Claudin-1 acts through c-Abl-protein kinase Cdelta (PKCdelta) signaling and has a causal role in the acquisition of invasive capacity in human liver cells. J Biol Chem, 285(1), 226-33 (2010)
158. I. Kohaar, A. Ploss, E. Korol, K. Mu, J. W. Schoggins, T. R. O'Brien, C. M. Rice and L. Prokunina-Olsson: Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry. J Virol, 84(14), 6987-94 (2010)
159. Y. Kohno, T. Okamoto, T. Ishibe, S. Nagayama, Y. Shima, K. Nishijo, K. R. Shibata, K. Fukiage, S. Otsuka, D. Uejima, N. Araki, N. Naka, Y. Nakashima, T. Aoyama, T. Nakayama, T. Nakamura and J. Toguchida: Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3. J Biol Chem, 281(50), 38941-50 (2006) (Pubitemid 46042020)
160. V. N. Tzelepi, A. C. Tsamandas, H. D. Vlotinou, C. E. Vagianos and C. D. Scopa: Tight junctions in thyroid carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid neoplasms. Mod Pathol, 21(1), 22-30 (2008)
161. J. Nemeth, Z. Nemeth, P. Tatrai, I. Peter, A. Somoracz, A. M. Szasz, A. Kiss and Z. Schaff: High expression of claudin-1 protein in papillary thyroid tumor and its regional lymph node metastasis. Pathol Oncol Res, 16(1), 19-27 (2010)
162. K. P. Pummi, H. J. Aho, M. K. Laato, J. T. Peltonen and S. A. Peltonen: Tight junction proteins and perineurial cells in neurofibromas. J Histochem Cytochem, 54(1), 53-61 (2006) (Pubitemid 43049415)
163. F. R. Fritzsche, B. Oelrich, M. Johannsen, I. Kristiansen, H. Moch, K. Jung and G. Kristiansen: Claudin-1 protein expression is a prognostic marker of patient survival in renal cell carcinomas. Clin Cancer Res, 14(21), 7035-42 (2008)
164. A. O. Osunkoya, C. Cohen, D. Lawson, M. M. Picken, M. B. Amin and A. N. Young: Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Hum Pathol, 40(2), 206-10 (2009)
165. L. Li, J. L. Yao, P. A. di Sant'Agnese, P. A. Bourne, M. M. Picken, A. N. Young, S. S. Shen and J. Huang: Expression of claudin-7 in benign kidney and kidney tumors. Int J Clin Exp Pathol, 1(1), 57-64 (2008)
166. P. Gutwein, A. Schramme, B. Voss, M. S. Abdel-Bakky, K. Doberstein, A. Ludwig, P. Altevogt, M. L. Hansmann, H. Moch, G. Kristiansen and J. Pfeilschifter: Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma. Biochem Biophys Res Commun, 380(2), 387-91 (2009)
167. C. L. Sommers, S. W. Byers, E. W. Thompson, J. A. Torri and E. P. Gelmann: Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat, 31(2-3), 325-35 (1994) (Pubitemid 24323473)
168. M. Polette, C. Gilles, B. Nawrocki-Raby, J. Lohi, W. Hunziker, J. M. Foidart and P. Birembaut: Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells. Cancer Res, 65(17), 7691-8 (2005) (Pubitemid 41297243)
169. M. Sauermann, O. Sahin, H. Sultmann, F. Hahne, S. Blaszkiewicz, M. Majety, K. Zatloukal, L. Fuzesi, A. Poustka, S. Wiemann and D. Arlt: Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells. Oncogene, 27(9), 1320-6 (2008) (Pubitemid 351294693)
170. J. Chen, L. Xiao, J. N. Rao, T. Zou, L. Liu, E. Bellavance, M. Gorospe and J. Y. Wang: JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function. Mol Biol Cell, 19(9), 3701-12 (2008)
171. M. Breitman, A. Zilberberg, M. Caspi and R. Rosin-Arbesfeld: The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Biochim Biophys Acta, 1783(10), 1792-802 (2008)
172. M. Buchert, M. Papin, C. Bonnans, C. Darido, W. S. Raye, V. Garambois, A. Pelegrin, J. F. Bourgaux, J. Pannequin, D. Joubert and F. Hollande: Symplekin promotes tumorigenicity by up-regulating claudin-2 expression. Proc Natl Acad Sci U S A, 107(6), 2628-33 (2010)
173. S. Tuomi, A. Mai, J. Nevo, J. O. Laine, V. Vilkki, T. J. Ohman, C. G. Gahmberg, P. J. Parker and J. Ivaska: PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. Sci Signal, 2(77), ra32 (2009)
174. J. Kleeff, X. Shi, H. P. Bode, K. Hoover, S. Shrikhande, P. J. Bryant, M. Korc, M. W. Buchler and H. Friess: Altered expression and localization of the tight junction protein ZO-1 in primary and metastatic pancreatic cancer. Pancreas, 23(3), 259-65 (2001) (Pubitemid 32910974)
175. E. Takai, X. Tan, Y. Tamori, M. Hirota, H. Egami and M. Ogawa: Correlation of translocation of tight junction protein Zonula occludens-1 and activation of epidermal growth factor receptor in the regulation of invasion of pancreatic cancer cells. Int J Oncol, 27(3), 645-51 (2005)
176. L. Rosano, F. Spinella, V. Di Castro, S. Decandia, M. R. Nicotra, P. G. Natali and A. Bagnato: Endothelin-1 is required during epithelial to mesenchymal transition in ovarian cancer progression. Exp Biol Med (Maywood), 231(6), 1128-31 (2006) (Pubitemid 43845591)
177. C. Fink, R. Weigel, T. Hembes, H. Lauke-Wettwer, S. Kliesch, M. Bergmann and R. H. Brehm: Altered expression of ZO-1 and ZO-2 in Sertoli cells and loss of blood-testis barrier integrity in testicular carcinoma in situ. Neoplasia, 8(12), 1019-27 (2006) (Pubitemid 44936151)
178. V. Bangiyeva, A. Rosenbloom, A. E. Alexander, B. Isanova, T. Popko and A. R. Schoenfeld: Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. BMC Cancer, 9, 229 (2009)
179. F. Facchetti, F. Gentili, S. Lonardi, L. Bercich and A. Santin: Claudin-4 in mesothelioma diagnosis. Histopathology, 51(2), 261-3 (2007)
180. M. C. Papadopoulos, S. Saadoun, C. J. Woodrow, D. C. Davies, P. Costa-Martins, R. F. Moss, S. Krishna and B. A. Bell: Occludin expression in microvessels of neoplastic and non-neoplastic human brain. Neuropathol Appl Neurobiol, 27(5), 384-95 (2001) (Pubitemid 32990079)
181. G. Arismendi-Morillo and A. Castellano: Tumoral micro-blood vessels and vascular microenvironment in human astrocytic tumors. A transmission electron microscopy study. J Neurooncol, 73(3), 211-7 (2005) doi:10.1007/s11060-004-5674- 3 (Pubitemid 40974016)
182. D. C. Davies: Blood-brain barrier breakdown in septic encephalopathy and brain tumours. J Anat, 200(6), 639-46 (2002) (Pubitemid 34823055)
183. G. Rascher, A. Fischmann, S. Kroger, F. Duffner, E. H. Grote and H. Wolburg: Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin. Acta Neuropathol, 104(1), 85-91 (2002) (Pubitemid 36075363)
184. H. Ishihara, H. Kubota, R. L. Lindberg, D. Leppert, S. M. Gloor, M. Errede, D. Virgintino, A. Fontana, Y. Yonekawa and K. Frei: Endothelial cell barrier impairment induced by glioblastomas and transforming growth factor beta2 involves matrix metalloproteinases and tight junction proteins. J Neuropathol Exp Neurol, 67(5), 435-48 (2008) (Pubitemid 351653535)
185. S. M. Weis: Vascular permeability in cardiovascular disease and cancer. Curr Opin Hematol, 15(3), 243-9 (2008) (Pubitemid 351509347)
186. T. A. Martin, T. Das, R. E. Mansel and W. G. Jiang: Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation. J Cell Biochem, 98(5), 1308-19 (2006) (Pubitemid 44128368)
187. R. R. Koenen, J. Pruessmeyer, O. Soehnlein, L. Fraemohs, A. Zernecke, N. Schwarz, K. Reiss, A. Sarabi, L. Lindbom, T. M. Hackeng, C. Weber and A. Ludwig: Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood, 113(19), 4799-809 (2009)
188. T. Sakaguchi, S. Suzuki, H. Higashi, K. Inaba, S. Nakamura, S. Baba, T. Kato and H. Konno: Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma. J Surg Res, 147(1), 123-31 (2008) (Pubitemid 351626080)
189. T. A. Martin and W. G. Jiang: Loss of tight junction barrier function and its role in cancer metastasis. Biochim Biophys Acta, 1788(4), 872-91 (2009)
190. K. J. Hewitt, R. Agarwal and P. J. Morin: The claudin gene family: expression in normal and neoplastic tissues. BMC Cancer, 6, 186 (2006)
191. U. Sahin, M. Koslowski, K. Dhaene, D. Usener, G. Brandenburg, G. Seitz, C. Huber and O. Tureci: Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. Clin Cancer Res, 14(23), 7624-34 (2008)
192. X. Yuan, X. Lin, G. Manorek, I. Kanatani, L. H. Cheung, M. G. Rosenblum and S. B. Howell: Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptors. Mol Cancer Ther, 8(7), 1906-15 (2009)
193. R. Saeki, M. Kondoh, H. Kakutani, S. Tsunoda, Y. Mochizuki, T. Hamakubo, Y. Tsutsumi, Y. Horiguchi and K. Yagi: A novel tumor-targeted therapy using a claudin-4-targeting molecule. Mol Pharmacol, 76(4), 918-26 (2009)
194. H. Kakutani, M. Kondoh, R. Saeki, M. Fujii, Y. Watanabe, H. Mizuguchi and K. Yagi: Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin. Eur J Pharm Biopharm, 75(2), 213-7 (2010)
195. A. D. Santin, S. Bellone, M. Marizzoni, M. Palmieri, E. R. Siegel, J. K. McKenney, L. Hennings, F. Comper, E. Bandiera and S. Pecorelli: Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE). Cancer, 109(7), 1312-22 (2007) doi:10.1002/cncr.22536 (Pubitemid 46466558)
196. M. Ishida, R. Kushima and H. Okabe: Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors). Oncol Rep, 21(1), 113-7 (2009)
197. Y. H. Choi, W. Y. Choi, S. H. Hong, S. O. Kim, G. Y. Kim, W. H. Lee and Y. H. Yoo: Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells. Chem Biol Interact, 179(2-3), 185-91 (2009)
198. S. Skrovanek, M. C. Valenzano and J. M. Mullin: Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function. Am J Physiol Regul Integr Comp Physiol, 293(3), R1046-55 (2007) (Pubitemid 47358923)
199. X. Durando, E. Thivat, P. Gimbergues, E. Cellarier, C. Abrial, M. Dib, O. Tacca and P. Chollet: [Methionine dependency of cancer cells: a new therapeutic approach?]. Bull Cancer, 95(1), 69-76 (2008) (Pubitemid 351262485)
200. D. Kerjaschki, K. Krisch, U. B. Sleyter, W. Umrath, R. Jakesz, D. Depisch, R. Kokoschka and H. Horandner: The structure of tight junctions in human thyroid tumors. A systematic freeze-fracture study. Am J Pathol, 96(1), 207-26 (1979)
201. S. Polak-Charcon, J. Shoham and Y. Ben-Shaul: Tight junctions in epithelial cells of human fetal hindgut, normal colon, and colon adenocarcinoma. J Natl Cancer Inst, 65(1), 53-62 (1980) (Pubitemid 10071596)