Expression of tight-junction-associated proteins in human gastric cancer: Downregulation of claudin-4 correlates with tumor aggressiveness and survival

Gastric Cancer

Volumn 12, Issue 1, 2009, Pages 43-51

  Ohtani, Satoshi ^a   Terashima, Masanori ^b   Satoh, Jun ^a   Soeta, Nobutoshi ^a   Saze, Zenichiroh ^a   Kashimura, Seigo ^a   Ohsuka, Fumihiko ^a   Hoshino, Yutaka ^a   Kogure, Michihiko ^a   Gotoh, Mitsukazu ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b SHIZUOKA CANCER CENTER   (Japan)

Author keywords

Metastasis; Occludin; Zonula occludens 1 protein

Indexed keywords

CLAUDIN 4; MESSENGER RNA; OCCLUDIN; PROTEIN ZO1;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER SURVIVAL; CANCER TISSUE; CLINICAL EVALUATION; DISEASE SEVERITY; DOWN REGULATION; FEMALE; GASTRECTOMY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; INTESTINE METAPLASIA; INTESTINE MUCOSA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CARCINOMA; TUMOR GROWTH; UNDIFFERENTIATED CARCINOMA;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHATIC METASTASIS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 65449143935     PISSN: 14363291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10120-008-0497-0     Document Type: Article

References (24)

1. S. Tsukita M. Furuse M. Itoh 2001 Multifunctional strands in tight junctions Nat Rev Mol Cell Biol 2 285 293 (Pubitemid 33676971)
2. K. Morita M. Furuse K. Fujimoto S. Tsukita 1999 Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands Proc Natl Acad Sci U S A 96 511 516 (Pubitemid 29061239)
3. M. Furuse T. Hirase M. Itoh A. Nagafuchi S. Yonemura S. Tsukita 1993 Occludin: a novel integral membrane protein localizing at tight junctions J Cell Biol 123 6Pt2 1777 1788 (Pubitemid 24012933)
4. M. Saitou K. Fujimoto Y. Doi M. Itoh T. Fujimoto M. Furuse 1998 Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions J Cell Biol 141 397 408 (Pubitemid 28237088)
5. Y. Matsuda S. Semba J. Ueda T. Fuku T. Hasuo H. Chiba 2007 Gastric and intestinal claudin expression at the invasive front of gastric carcinoma Cancer Sci 98 1014 1019 (Pubitemid 46865385)
6. M. Terashima C. Maesawa K. Oyama S. Ohtani Y. Akiyama S. Ogasawara 2005 Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis Br J Cancer 92 1130 1136 (Pubitemid 40546680)
7. C.M. Wu Y.S. Lee T.H. Wang L.Y. Lee W.H. Kong E.S. Chen 2006 Identification of differential gene expression between intestinal and diffuse gastric cancer using cDNA microarray Oncol Rep 15 57 64
8. M.B. Resnick M. Gavilanez E. Newton T. Konkin B. Bhattacharya D.E. Britt 2005 Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation Hum Pathol 36 886 892 (Pubitemid 41187907)
9. S.C. Cunningham F. Kamangar M.P. Kim S. Hammoud R. Haque C.A. Iacobuzio-Donahue 2006 Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions Cancer Epidemiol Biomarkers Prev 15 281 287 (Pubitemid 43342175)
10. J.P. Fedwick T.K. Lapointe J.B. Meddings P.M. Sherman A.G. Buret 2005 Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability Infect Immun 73 7844 7852 (Pubitemid 41740267)
11. S. Satake S. Semba Y. Matsuda Y. Usami H. Chiba N. Sawada 2008 Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma Pathol Int 58 156 163
12. S.K. Lee J. Moon S.W. Park S.Y. Song J.B. Chung J.K. Kang 2005 Loss of the tight junction protein claudin 4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma Oncol Rep 13 193 199
13. W.L. Kuo L.Y. Lee C.M. Wu C.C. Wang J.S. Yu Y. Liang 2006 Differential expression of claudin-4 between intestinal and diffuse-type gastric cancer Oncol Rep 16 729 734
14. Y. Kimura H. Shiozaki M. Hirao Y. Maeno Y. Doki M. Inoue 1997 Expression of occludin, tight-junction-associated protein, in human digestive tract Am J Pathol 151 45 54 (Pubitemid 27283956)
15. Japanese Gastric Cancer Association. 1998 Japanese Classification of Gastric Carcinoma-2nd English Editon- Gastric Cancer 1 10 24
16. T. Yamamoto N. Harada K. Kano S. Taya E. Canaani Y. Matsuura 1997 The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells J Cell Biol 139 785 795 (Pubitemid 27485842)
17. T. Yamamoto N. Harada Y. Kawano S. Taya K. Kaibuchi 1999 In vivo interaction of AF-6 with activated Ras and ZO-1 Biochem Biophys Res Commun 259 103 107 (Pubitemid 29264001)
18. H. Honda M.J. Pazin H. Ji R.P. Wernyj P.J. Morin 2006 Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells J Biol Chem 281 21433 21444 (Pubitemid 44115482)
19. I.J. Fidler 2003 The pathogenesis of cancer metastasis: the "seed and soil" hypothesis revisited Nat Rev Cancer 3 453 458 (Pubitemid 37328849)
20. J. Kawanishi J. Kato K. Sasaki S. Fujii N. Watanabe Y. Niitsu 1995 Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39 Mol Cell Biol 15 1175 1181
21. T. Oyama Y. Kanai A. Ochiai S. Akimoto T. Oda K. Yanagihara 1994 A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines Cancer Res 54 6282 6287 (Pubitemid 24378666)
22. H. Shiozaki K. Iihara H. Oka T. Kadowaki S. Matsui J. Gofuku 1994 Immunohistochemical detection of alpha-catenin expression in human cancers Am J Pathol 144 667 674 (Pubitemid 24172055)
23. J. Ren J. Hamada N. Takeichi S. Fujikawa H. Kobayashi 1990 Ultrastructural differences in junctional intercellular communication between highly and weakly metastatic clones derived from rat mammary carcinoma Cancer Res 50 358 362 (Pubitemid 20041241)
24. P. Michl C. Barth M. Buchholz M.M. Lerch M. Rolke K.H. Holzmann 2003 Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer Cancer Res 63 6265 6271 (Pubitemid 37255173)