Methionine dependency of cancer cells: A new therapeutic approach?;Dépendance en méthionine des cellules cancéreuses: Une nouvelle approche thérapeutique?

Bulletin du Cancer

Volumn 95, Issue 1, 2008, Pages 69-76

  Durando, Xavier ^a   Thivat, Emilie ^a   Gimbergues, Pierre ^a   Cellarier, Eric ^a   Abrial, Catherine ^a   Dib, Mathilde ^a   Tacca, Olivier ^a   Chollet, Philippe ^a  

^a CENTRE JEAN PERRIN   (France)

Author keywords

Cancer; Chemotherapy; Methionine; Potentialisation

Indexed keywords

CARMUSTINE; DOXORUBICIN; FLUOROURACIL; METHIONINE; METHIONINE GAMMA LYASE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; L-METHIONINE GAMMA-LYASE; LYASE; UNCLASSIFIED DRUG;

CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER PATIENT; CELL ACTIVITY; CLINICAL EVALUATION; CLINICAL TRIAL; DIET RESTRICTION; DISEASE MODEL; ENZYME DEFECT; FOOD; HUMAN; IN VIVO CULTURE; REVIEW; TUMOR GROWTH; ANIMAL; METABOLISM; MOUSE; NEOPLASM;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; CARBON-SULFUR LYASES; FLUOROURACIL; HUMANS; METHIONINE; MICE; NEOPLASMS;

EID: 39149137882     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: 10.1684/bdc.2008.0550     Document Type: Review

References (71)

1. Breillout F, Antoine E, Poupon MF. Methionine dependency of malignant tumors : a possible approach for therapy. J Natl Cancer Inst 1990 ; 82 : 1628-32.
2. Guo H, Lishko VK, Herrera H, Groce A, Kubota T, Hoffman RM. Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo. Cancer Res 1993 ; 53 : 5676-9.
3. Poirson-Bichat F, Goncalves RA, Miccoli L, Dutrillaux B, Poupon MF. Methionine depletion enhances the antitumoral efficacy of cytotoxic agents in drug-resistant human tumor xenografts. Clin Cancer Res 2000 ; 6 : 643-53.
4. Kokkinakis DM, Hoffman RM, Frenkel EP, Wick JB, Han Q, Xu M, et al. Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice. Cancer Res 2001 ; 61 : 4017-23.
5. Guo HY, Herrera H, Groce A, Hoffman RM. Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture. Cancer Res 1993 ; 53 : 2479-83.
6. Poirier LA, Wilson MJ. The elevated requirement for methionine by transformed rat liver epithelial cells in vitro. Ann N Y Acad Sci 1980 ; 349 : 283-93.
7. Kenyon SH, Waterfield CJ, Timbrell JA, Nicolaou A. Methionine synthase activity and sulphur amino acid levels in the rat liver tumour cells HTC and Phi-1. Biochem Pharmacol 2002 ; 63 : 381-91.
8. Judde JG, Ellis M, Frost P. Biochemical analysis of the role of transmethylation in the methionine dependence of tumor cells. Cancer Res 1989 ; 49 : 4859-65.
9. Fiskerstrand T, Christensen B, Tysnes OB, Ueland PM, Refsum H. Development and reversion of methionine dependence in a human glioma cell line : relation to homocysteine remethylation and cobalamin status. Cancer Res 1994 ; 54 : 4899-906.
10. van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, et al. A second common mutation in the methylenetetrahydrofolate reductase gene : an additional risk factor for neural-tube defects? Am J Hum Genet 1998 ; 62 : 1044-51.
11. Dumontet C, Roch AM, Quash G. Methionine dependence of tumor cells : programmed cell survival? Oncol Res 1996 ; 8 : 469-71.
12. Nobori T, Szinai I, Amox D, Parker B, Olopade OI, Buchhagen DL, et al. Methylthioadenosine phosphorylase deficiency in human non-small cell lung cancers. Cancer Res 1993 ; 53 : 1098-101.
13. Traweek ST, Riscoe MK, Ferro AJ, Braziel RM, Magenis RE, Fitchen JH. Methylthioadenosine phosphorylase deficiency in acute leukemia : pathologic, cytogenetic, and clinical features. Blood 1988 ; 71 : 1568-73.
14. Nobori T, Karras JG, Della Ragione F, Waltz TA, Chen PP, Carson DA. Absence of methylthioadenosine phosphorylase in human gliomas. Cancer Res 1991 ; 51 : 3193-7.
15. Fichten JH, Riscoe MK, Dana BW, Lawrence HJ, Ferro AJ. Methylthioadenosine phosphorylase deficiency in human leukemias ans solid tumors. Cancer Res 1986 ; 46 : 5409-12.
16. Hoffman RM. Altered methionine metabolism and transmethylation in cancer. Anticancer Res 1985 ; 5 : 1-30.
17. Torii K, Tsuyuguchi N, Kawabe J, Sunada I, Hara M, Shiomi S. Correlation of amino-acid uptake using methionine PET and histological classifications in various gliomas. Ann Nucl Med 2005 ; 19 : 677-83.
18. Giammarile F, Cinotri LE, Jouvet A, Ramackers JM, Saint Pierre G, Thiesse P, et al. High and low grade oligodendrogliomas (ODG) : correlation of amino-acid and glucose uptakes using PET and histological classifications. J Neurooncol 2004 ; 68 : 263-74.
19. Nariai T, Tanaka Y, Wakimoto H, Aoyagi M, Tamaki M, Ishiwata K, et al. Usefulness of L- {methyl-HC} methionine-positron emission tomography as a biological monitoring tool in the treatment of glioma. J Neurosurg 2005 ; 103 : 498-507.
20. Theuer RC. Effect of essential amino acid restriction on the growth of female C57BL mice and their implanted BW10232 adenocarcinomas. J Nutr 1971 ; 101 : 223-32.
21. Breillout F, Hadida F, Echinard-Garin P, Lascaux V, Poupon MF. Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet. Anticancer Res 1987 ; 7 : 861-7.
22. Kokkinakis DM, Schold Jr. SC, Hori H, Nobori T. Effect of long-term depletion of plasma methionine on the growth and survival of human brain tumor xenografts in athymic mice. Nutr Cancer 1997 ; 29 : 195-204.
23. Goseki N. L-Methionine and Its Potential Effects for Cancer Therapy. In : Latifi R, ed. Amino Acids in Critical Care and Cancer. Boca Raton : CRC Press, 1994 : 183-202.
24. Komninou D, Leutzinger Y, Reddy BS, Richie Jr. JP. Methionine restriction inhibits colon carcinogenesis. Nutr Cancer 2006 ; 54 : 202-8.
25. Kokkinakis DM, Wick JB, Zhou QX. Metabolic response of normal and malignant tissue to acute and chronic methionine stress in athymic mice bearing human glial tumor xenografts. Chem Res Toxicol 2002 ; 15 : 1472-9.
26. Kreis W, Hession C. Biological effects of enzymatic deprivation of L-methionine in cell culture and an experimental tumor. Cancer Res 1973 ; 33 : 1866-9 ; (1973a).
27. Kreis W, Hession C. Isolation and purification of L-methionine-alpha- deamino-gamma-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes. Cancer Res 1973 ; 33 : 1862-5 ; (1973b).
28. Tan Y, Zavala Sr. J, Xu M, Zavala Jr. J, Hoffman RM. Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients. Anticancer Res 1996 ; 16 : 3937-42.
29. Tan Y, Zavala Sr. J, Han Q, Xu M, Sun X, Tan X, et al. Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients. Anticancer Res 1997 ; 17 : 3857-60.
30. Yang Z, Wang J, Yoshioka T, Li B, Lu Q, Li S, et al. Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates. Clin Cancer Res 2004 ; 10 : 2131-8.
31. Tan Y, Sun X, Xu M, An Z, Tan X, Han Q, et al. Polyethylene glycol conjugation of recombinant methioninase for cancer therapy. Protein Expr Purif 1998 ; 12 : 45-52.
32. Yang Z, Wang J, Lu Q, Xu J, Kobayashi Y, Takakura T, et al. PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates. Cancer Res 2004 ; 64 : 6673-8 ; (2004b).
33. Miki K, Xu M, An Z, Wang X, Yang M, Al-Refaie W, et al. Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model. Cancer Gene Ther 2000 ; 7 : 332-8.
34. Poirson-Bichat F, Gonfalone G, Bras-Goncalves RA, Dutrillaux B, Poupon MF. Growth of methionine-dependent human prostate cancer (PC-3) is inhibited by ethionine combined with methionine starvation. Br J Cancer 1997 ; 75 : 1605-12.
35. Poirson-Bichat F, Lopez R, Bras Goncalves RA, Miccoli L, Bourgeois Y, Demerseman P, et al. Methionine deprivation and methionine analogs inhibit cell proliferation and growth of human xenografted gliomas. Life Sci 1997 ; 60 : 919-31.
36. Guo H, Tan Y, Kubota T, Moossa AR, Hoffman RM. Methionine depletion modulates the antitumor and antimetastatic efficacy of ethionine. Anticancer Res 1996 ; 16 : 2719-23.
37. Miki K, Xu M, Gupta A, Ba Y, Tan Y, Al-Refaie W, et al. Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate. Cancer Res 2001 ; 61 : 6805-10.
38. Porter CW, Sufrin JR, Keith DD. Growth inhibition by methionine analog inhibitors of S-adenosylmethionine biosynthesis in the absence of polyamine depletion. Biochem Biophys Res Commun 1984 ; 122 : 350-7.
39. Breillout F, Poupon MF, Blanchard P, Lascaux V, Echinard-Garin P, Robert-Gero M. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis 1988 ; 6 : 3-16.
40. Machover D, Zittoun J, Saffroy R, Broet P, Giraudier S, Magnaldo T, et al. Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis. Cancer Res 2002 ; 62 : 4685-9.
41. Kokkinakis DM, Liu X, Chada S, Ahmed MM, Shareef MM, Sin gha UK, et al. Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress. Cancer Res 2004 ; 64 : 7513-25.
42. Kokkinakis DM, Brickner AG, Kirkwood JM, Liu X, Goldwasser JE, Kastrama A, et al. Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress. Mol Cancer Res 2006 ; 4 : 575-89.
43. Kokkinakis DM, Liu X, Neuner RD. Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress) : implications to the therapy of pancreatic adenocarcinoma. Mol Cancer Ther 2005 ; 4 : 1338-48.
44. Pavillard V, Drbal AA, Swaine DJ, Phillips RM, Double JA, Nicolaou A. Analysis of cell-cycle kinetics and sulfur amino acid metabolism in methionine-dependent tumor cell lines ; the effect of homocysteine supplementation. Biochem Pharmacol 2004 ; 67 : 1587-99.
45. Lu S, Hoestje SM, Choo EM, Epner DE. Methionine restriction induces apoptosis of prostate cancer cells via the c-Jun N-terminal kinase-mediated signaling pathway. Cancer Lett 2002 ; 179 : 51-8.
46. Lu S, Chen GL, Ren C, Kwabi-Addo B, Epner DE. Methionine restriction selectively targets thymidylate synthase in prostate cancer cells. Biochem Pharmacol 2003 ; 66 : 791-800.
47. Goseki N, Endo M, Onodera T, Kosaki G. Anti-tumor effect of L-methionine-deprived total parenteral nutrition with 5-fluorouracil administration on Yoshida sarcoma-bearing rats. Ann Surg 1991 ; 214 : 83-8.
48. Hoshiya Y, Kubota T, Inada T, Kitajima M, Hoffman RM. Methionine-depletion modulates the efficacy of 5-fluorouracil in human gastric cancer in nude mice. Anticancer Res 1997 ; 17 : 4371-5.
49. Machover D, Zittoun J, Broet P, Metzger G, Orrico M, Goldschmidt E, et al. Cytotoxic synergism of methioninase in combination with 5-fluorouracil and folinic acid. Biochem Pharmacol 2001 ; 61 : 867-76.
50. Yoshioka T, Wada T, Uchida N, Maki H, Yoshida H, Ide N, et al. Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase. Cancer Res 1998 ; 58 : 2583-7.
51. Goseki N, Yamazaki S, Shimojyu K, Kando F, Maruyama M, Endo M, et al. Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer : a randomized, prospective clinical trial. Jpn J Cancer Res 1995 ; 86 : 484-9.
52. Goseki N, Yamazaki S, Endo M, Onodera T, Kosaki G, Hibino Y, et al. Antitumor effect of methionine-depleting total parenteral nutrition with doxorubicin administration on Yoshida sarcoma-bearing rats. Cancer 1992 ; 69 : 1865-72.
53. Gupta A, Miki K, Xu M, Yamamoto N, Moossa AR, Hoffman RM. Combination efficacy of doxorubicin and adenoviral methioninase gene therapy with prodrug selenomethionine. Anticancer Res 2003 ; 23 : 1181-8.
54. Stern PH, Hoffman RM. Enhanced in vitro selective toxicity of chemotherapeutic agents for human cancer cells based on a metabolic defect. J Natl Cancer Inst 1986 ; 76 : 629-39-
55. Nagahama T, Goseki N, Endo M. Doxorubicin and vincristine with methionine depletion contributed to survival in the Yoshida sarcoma bearing rats. Anticancer Res 1998 ; 18 : 25-31.
56. Pavillatd V, Nicolaou A, Double JA, Phillips RM. Methionine dependence of tumours : a biochemical strategy for optimizing paclitaxel chemosensitivity in vitro. Biochem Pharmacol 2006 ; 71 : 772-8.
57. Mineura K, Sasajima T, Sasajima H, Kowada M. Inhibition of methionine uptake by cis-diamminedichloroplatinum (II) in experimental brain tumors. Int J Cancer 1996 ; 67 : 681-3 ; (1996b).
58. Boisdron-Celle M, Lebouil A, Allain P, Gamelin E. Pharmacokinetic properties of platinium derivatives. Bull Cancer 2001 ; 88 : S14-S19.
59. Cao WX, Ou JM, Fei XF, Zhu ZG, Yin HR, Yan M, et al. Methionine-dependence and combination chemotherapy on human gastric cancer cells in vitro. World J Gastroenterol 2002 ; 8 : 230-2.
60. Tan Y, Sun X, Xu M, Tan X, Sasson A, Rashidi B, et al. Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice. Clin Cancer Res 1999 ; 5 : 2157-63.
61. Hoshiya Y, Kubota T, Matsuzaki SW, Kitajima M, Hoffman RM. Methionine starvation modulates the efficacy of cisplatin on human breast cancer in nude mice. Anticancer Res 1996 ; 16 : 3515-7.
62. Goseki N, Endo M. Thiol depletion and chemosensirization on nimustine hydrochloride by methionine-depleting total parenteral nurrition. Tohoku J Exp Med 1990 ; 161 : 227-39 ; (1990).
63. Morvan D, Papon J, Madelmont JC, Demidem A. Methionine deprivation potentiates the effect of cystémustine treatment on B16 melanoma tumors in syngeneic recipients. In. Proceedings AACR 2002 ; 43 : 771 ; (2002a).
64. Goseki N, Maruyama M, Nagai K, Kando F, Endo M, Shimoju K, et al. Clinical evaluation of anticancer effect of methionine-depleting total parenteral nutrition with 5-fluorouracil and/or mitomycin C. Gan To Kagaku Ryoho 1995 ; 22 : 1028-35.
65. Lakshmanan FL, Perera WD, Scrimshaw NS, Young VR. Plasma and urinary amino acids and selected sulfur metabolites in young men fed a diet devoid of methionine and cystine. Am J Clin Nutr 1976 ; 29 : 1367-71.
66. Cure H, Souteyrand P, Ouabdesselarn R, Roche H, Ravaud A, D'incan M, et al. Results of a phase II trial with cystemustine at 90 mg/m2 as a first- or second-line treatment in advanced malignant melanoma : a trial of the EORTC Clinical Studies Group. Melanoma Res 1999 ; 9 : 607-10.
67. 2 : a phase II trial. Anticancer Drugs 2005 ; 16 : 1003-7.
68. Durando X, Thivat E, Farges MC, Cellarier E, D'Incan M, Demidem A, et al. Optimal methionine free diet duration for nitrosourea treatment : a phase I clinical trial. Nutr Cancer 2008 ; (in press).
69. Durando X, Thivat E, Roche H, Bay JO, Lemaire JJ, Verrelle P, et al. Cystemustine in recurrent high grade glioma. J Neurooncol 2006 ; 79 : 33-7.
70. Thivat E, Durando X, Demidem A, Farges MC, Rapp M, Cellarier E, et al. Methionine-free diet associated with nitrosourea treatment down-regulate MGMT activity in patients with metastatic cancer. Anticancer Res 2007 ; 27 : 2779-83.
71. Thivat E, Durando X, Farges M-C, D'Incan M, Demidem A, Morvan D, et al. Efficacity of the association of a methionine-free diet with nitrosourea in metastatic cancer treatment : preliminary results of a phase II clinical trial. In : Proceeding AACR. 2007 ; (abstract 2656).