Increased tight junctional permeability is associated with the development of colon cancer

Carcinogenesis

Volumn 20, Issue 8, 1999, Pages 1425-1431

  Soler, Alejandro Peralta ^c   Miller, R Daniel ^c   Laughlin, Kathleen V ^c   Carp, Ned Z ^a   Klurfeld, David M ^b   Mullin, James M ^c  

^a LANKENAU HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; DIMETHYLBENZ[A]ANTHRACENE; MANNITOL;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; COLON CARCINOGENESIS; COLON CARCINOMA; COLON MUCOSA; CONTROLLED STUDY; ELECTRIC RESISTANCE; ELECTRON MICROSCOPY; HUMAN; HUMAN TISSUE; INTESTINE CRYPT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

1,2-DIMETHYLHYDRAZINE; ANIMALS; CARCINOGENS; CELL MEMBRANE PERMEABILITY; COLON; COLONIC NEOPLASMS; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; HUMANS; INTESTINAL MUCOSA; MALE; MICROSCOPY, ELECTRON; PRECANCEROUS CONDITIONS; RATS; RATS, SPRAGUE-DAWLEY; TIGHT JUNCTIONS;

EID: 0032820577     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.8.1425     Document Type: Article

References (58)

1. Schneeberger, E.E. and Lynch, R.D. (1992) Structure, function and regulation of cellular tight junctions. Am. J. Physiol., 262, L647-L661.
2. Furuse, M., Itoh, M., Hirase, T., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S. (1994) Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J. Cell Biol., 127, 1617-1626.
3. Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K. and Tsukita, S. (1998) Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol., 141, 1539-1550.
4. Mitic, L.L. and Anderson, J.M. (1998) Molecular architecture of tight junctions. Annu. Rev. Physiol., 60, 121-142.
5. Tsukita, S. and Furuse, M. (1998) Overcoming barriers in the study of tight junction functions: from occluding to claudin. Genes Cells, 3, 569-573.
6. Fanning, A.S., Jameson, B.J., Jesaitis, L.A. and Anderson, J.M. (1998) The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J. Biol. Chem., 273, 29745-29753.
7. Haskins, J., Gu, L., Wittchen, E.S., Hibbard, J. and Stevenson, B.R. (1998) ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occudin. J. Cell Biol., 141, 199-208.
8. Cereijido, M., Valdes, J., Shoshani, L. and Contreras, R.G. (1998) Role of tight junctions in establishing and maintaining cell polarity. Annu. Rev. Physiol., 60, 161-177.
9. Madara, J.L. (1998) Regulation of the movement of solutes across tight junctions. Annu. Rev. Physiol., 60, 143-159.
10. 1 renal epithelial cells. Am. J. Physiol., 270, F869-F879.
11. McCartney, M.D. and Cantu-Crouch, D. (1992) Rabbit corneal epithelial wound repair: tight junction reformation. Curr. Eye Res., 11, 15-24.
12. Madara, J.L., Parkos, C., Colgan, S., Nusrat, A., Atisook, K. and Koustzani,P. (1992) The movement of solutes and cells across tight junctions. Ann. NY Acad. Sci., 664, 47-60.
13. Riehl, T.E. and Stenson, W.F. (1994) Mechanisms of transit of lipid mediators of inflammation and bacterial peptides across intestinal epithelia. Am. J. Physiol., 267, G687-G695.
14. Mullin, J.M. (1997) Potential interplay between luminal growth factors and increased tight junction permeability in epithelial carcinogenesis. J. Exp. Zool., 279, 484-489.
15. Martinez-Palomo, A. (1970) Ultrastructural modifications of intercellular junctions between tumor cells. In Vitro, 6, 15-20.
16. Swift, J.G., Mukherjee, T.M. and Rowland, R. (1983) Intercellular junctions in hepatocellular carcinoma. J. Submicrosc. Cytol., 15, 799-810.
17. Schoenenberger, C.A., Zuk, A., Kendall, D. and Matlin, K.S. (1991) Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras. J. Cell Biol., 112, 873-889.
18. Mullin, J.M., Snock, K.V., Shurina, R.D., Noe, J., George, K., Misner, L., Imaizumi, S. and O'Brien, T.G. (1992) Effects of acute vs. chronic phorbol ester exposure on transepithelial permeability and epithelial morphology. J. Cell Physiol., 152, 35-47.
19. 1 epithelia to the phorbol ester, TPA, produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization. Exp. Cell Res., 221, 12-22.
20. Mullin, J.M., Kampherstein, J.A., Laughlin, K.V., Saladik, D.T. and Peralta Soler, A. (1997) Transepithelial paracellular leakiness induced by chronic phorbol ester exposure correlates with polyp-like foci and redistribution of protein kinase C-α. Carcinogenesis, 18, 2339-2345.
21. Collares-Buzato, C.B., Jepson, M.A., Simmons, N.L. and Hirst, B.H. (1998) Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia. Eur. J. Cell Biol., 76, 85-92.
22. Tice, L.W., Carter, R.L. and Cahill, M.B. (1979) Changes in tight junctions of rat intestinal crypt cells associated with changes in their mitotic activity. Tissue Cell, 11, 293-316.
23. 1) tight junction permeability and cell division. Exp. Cell Res., 207, 398-406.
24. Polak-Charcon, S. and Ben-Shaul, Y. (1979) Degradation of tight junctions in HT29, a human colon adenocarcinoma cell line. J. Cell Sci., 35, 393-402.
25. Polak-Charcon, S., Shoham, J. and Ben-Shaul, Y. (1980) Tight junctions in epithelial cells of human hindgut, normal colon and colon adenocarcinoma. J. Natl Cancer Inst., 65, 53-62.
26. Kimura, Y., Shiozaki, H., Hirao, M., Maeno, Y., Doki, Y., Inoue, M., Monden, T., Ando-Akatsuka, Y., Furuse, M., Tsukita, S. and Monden, M. (1997) Expression of occluding, tight-junction-associated protein, in human digestive tract. Am. J. Pathol., 151, 45-54.
27. Klurfeld, D.M. (1990) Insoluble dietary fiber and experimental colon cancer. Are we asking the proper questions? In Kritchevsky, D., Bonfield, C. and Anderson, J.W. (eds) Dietary Fiber: Chemistry, Physiology and Health Effects. Plenum Press, New York, NY, pp. 403-415.
28. Simons, R.M., Laughlin, K.V., Kampherstein, J.A., Desai, D.C., Shurina, R.D. and Mullin, J.M. (1998) Pentobarbital affects transepithelial electrophysiological parameters regulated by protein kinase C in rat distal colon. Dig. Dis. Sci., 43, 632-640.
29. McLellan, E.A., Medline, A. and Bird, R.P. (1991) Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions. Cancer Res., 51, 5270-5274.
30. 1 renal epithelial tight junctions and transepithelial fluxes. Am. J. Physiol., 251, C597-C602.
31. Mullin, J.M. and McGinn, M.T. (1987) The phorbol ester, TPA, increases transepithelial growth factor flux. FEBS Lett., 221, 359-364.
32. Lengauer, C., Kinzler, K.W. and Volgelstein, B. (1997) Genetic instability and colorectal cancers. Nature, 386, 623-627.
33. McLellan, E.A. and Bird, R.P. (1988) Aberrant crypts: Potential preneoplastic lesions in the murine colon. Cancer Res., 48, 6187-6192.
34. Tudek, B., Bird, R.P. and Bruce, W.R. (1989) Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods. Cancer Res., 49, 1236-1240.
35. Pretlow, T.P., Barrow, B.J., Ashton, W.S., O'Riordan, M.A., Pretlow, T.G., Jurcisek, J.A. and Stellato, T.A. (1991) Aberrant crypts: putative preneoplastic foci in human colonie mucosa. Cancer Res., 51, 1564-1567.
36. Roncucci, L., Stamp, D., Medline, A., Cullen, J.B. and Bruce, W.R. (1991) Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum. Pathol., 22, 287-294.
37. Malecka-Panas, E., Fligiel, S.E.G., Relan, N.K., Dutta, S. and Majumdar, A.P.N. (1996) Azoxymethane enhances ligand-induced activation of EGF receptor tyrosine kinase in the colonie mucosa of rats. Carcinogenesis, 17, 233-237.
38. Park, H.-S., Goodlad, R.A., Ahnen, D.J., Winnett, A., Sasieni, P., Lee, C.Y. and Wright, N.A. (1997) Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation and crypt fission in the rat colon. Am. J. Pathol., 151, 843-852.
39. Park, H.-S., Goodlad, R.A. and Wright, N.A. (1997) The incidence of aberrant crypt foci and colonic carcinoma in dimethylhydrazine-treated rats varies in a site-specific manner and depends on tumor histology. Cancer Res., 57, 4507-4510.
40. Thorup, I. (1997) Histomorphological and immunohistochemical characterization of colonic aberrant crypt foci in rats: relationship to growth factor expression. Carcinogenesis, 18, 465-472.
41. Otori, K., Sugiyama, K., Hasebe, T., Fukushima, S. and Esumi, H. (1995) Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation. Cancer Res., 55, 4743-4746.
42. Hammann, A., Arveux, P. and Martin, M. (1992) Effect of gut-associated lymphoid tissue on cellular proliferation in proximal and distal colon of the rat. Dig. Dis. Sci., 37, 1099-1104.
43. Carter, J.W., Lancaster, H.K., Hardman, W.E. and Cameron, I.L. (1994) Distribution of intestine-associated lymphoid tissue, aberrant crypt foci and tumors in the large bowel of 1,2-dimethylhydrazine-treated mice. Cancer Res., 54, 4304-4307.
44. Hardman, W.E. and Cameron, I.L. (1994) Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas. Carcinogenesis, 15, 2353-2361.
45. Cameron, J.L., Garza, J. and Hardman, W.E. (1996) Distribution of lymphoid nodules, aberrant crypt foci and tumours in the colon of carcinogen-treated rats. Br. J. Cancer, 73, 893-898.
46. Nauss, K.M., Locniskar, M., Pavlina, T. and Newberne, P.M. (1984) Morphology and distribution of 1,2-dimethyhydrazine dihydrochloride-induced colon tumors and their relationship to gut-associated lymphoid tissue in the rat. J. Natl Cancer Inst., 73, 915-924.
47. + exchange in rat colonic brush-border membrane vesicles. Biochim Biophys. Acta, 938, 483-488.
48. Davies, R.J., Joseph, R., Kaplan, D., Juncosa, R.D., Pempinello, C., Asbun, H. and Sedwitz, M.M. (1987) Epithelial impedance analysis in experimentally induced colon cancer. Biophys. J., 52, 783-790.
49. Davies, R.J., Joseph, R., Asbun, H. and Sedwitz, M.M. (1989) Detection of the cancer-prone colon, using transepithelial impedance analysis. Arch. Surg., 124, 480-484.
50. Playford, R.J., Hanby, A.M., Gschmeissner, S., Peiffer, L.P., Wright, N.A. and McGarrity, T. (1996) The epidermal growth factor receptor (EGF-R) is present in the basolateral, but not the apical, surface of enterocytes in the human gastrointestinal tract. Gut, 39, 262-266.
51. Ribbons, K.A., Howart, G.S., Davey, K.B., George-Nascimento, C. and Read, L.C. (1994) Subcutaneous but not intraluminal epidermal growth factor stimulates colonic growth in normal adult rats. Growth Factors, 10, 153-162.
52. Mullin, J.M., Marano, C.W., Laughlin, K.V., Nuciglio, M., Stevenson, B.R. and Peralla Soler, A. (1997) Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor-treated epithelial cell sheets. J. Cell. Physiol, 171, 226-233.
53. Mullin, J.M., Ginanni, N. and Laughlin, K.V. (1998) Protein kinase C activation increases transepithelial transport of biologically active insulin. Cancer Res., 58, 1641-1645.
54. Baghdiguian, S., Verrier, B., Gerard, C. and Fantini, J. (1992). Insulin like growth factor 1 is an autocrine regulator of human colon cancer cell differentiation and growth. Cancer Lett., 14, 23-33.
55. McRoberts, J.A. and Riley, N.E. (1992) Regulation of T84 cell monolayer permeability by insulin-like growth factors. Am. J. Physiol., 262, C207-C213.
56. Hollander, D., Vadheim, C.M., Brettholz, E., Petersen, G.M., Delahunty, T. and Rotter, J.I. (1986) Increased intestinal permeability in patients with Crohn's disease and their relatives. Ann. Intern. Med., 105, 883-885.
57. Nejdfors, P., Wang, Q., Ekelund, M., Westron, B.R., Jansson, O., Lindstrom, C.L., Karlsson, B. and Jeppsson, B. (1998) Increased colonic permeability in patients with ulcerative colitis: an in vitro study. Scand. J. Gastroenterol., 33, 749-753.
58. Schmitz, H., Barmeyer, C., Fromm, M., Runkel, N., Foss, H.D., Bentzel, C.J., Riecken, E.O. and Schulzke, J.D. (1999) Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology, 116, 301-309.