PKCε regulation of an α5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells

Science Signaling

Volumn 2, Issue 77, 2009, Pages

  Tuomi, Saara ^a   Mai, Anja ^a   Nevo, Jonna ^a   Laine, Jukka O ^a   Vilkki, Vesa ^b   Öhman, Tiina J ^c   Gahmberg, Carl G ^c   Parker, Peter J ^d,e   Ivaska, Johanna ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; PROTEIN KINASE C EPSILON; PROTEIN ZO1; RAC PROTEIN; SERINE; CD51 ANTIGEN; MEMBRANE PROTEIN; PHOSPHOPROTEIN; ZONULA OCCLUDENS 1 PROTEIN; ZONULA OCCLUDENS-1 PROTEIN;

ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; ENZYMOLOGY; LUNG TUMOR; METABOLISM; METASTASIS; PATHOLOGY; PHOSPHORYLATION;

HUMANS; INTEGRIN ALPHAV; LUNG NEOPLASMS; MEMBRANE PROTEINS; NEOPLASM METASTASIS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C-EPSILON;

EID: 69849101598     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000135     Document Type: Article

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59. We thank A. Fanning, W. Hunziker, and A. Horwitz for DNA constructs; H. Marttila, J. Siivonen, L. Uotila, and I. Leinonen for the excellent technical assistance; andJ. Westermarck andM. Salmi for critically reading themanuscript. This research has been supported by a European Research Council starting grant, Academy of Finland, Finnish Cancer Organizations and Sigrid Juselius Foundation, Emil Aaltonen Foundation, EMBO Young Investigators Program, and ENLIGHT (LSHB-CT-2006-037545). S.T. and J.N. are supported by Turku Graduate School for Biomedical Sciences and A.M. is supported by Drug Discovery Graduate School.