Expression of occludin, tight-junction-associated protein, in human digestive tract

American Journal of Pathology

Volumn 151, Issue 1, 1997, Pages 45-54

  Kimura, Yutaka ^a,c   Shiozaki, Hitoshi ^a   Hirao, Motohiro ^a   Maeno, Yoshito ^a   Doki, Yuichiro ^b   Inoue, Masatoshi ^a   Monden, Takushi ^a   Ando Akatsuka, Yuhko ^a   Furuse, Mikio ^a   Tsukita, Shoichiro ^a   Monden, Morito ^a  

^a Osaka Medical School   (Japan)

^b Kyoto University   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANE PROTEIN;

ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; GASTROINTESTINAL CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DETERMINATION; SIGNAL TRANSDUCTION; TIGHT JUNCTION;

ADENOCARCINOMA; CARCINOMA, SQUAMOUS CELL; CELL LINE; COLONIC NEOPLASMS; DIGESTIVE SYSTEM; ESOPHAGEAL NEOPLASMS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; PHOSPHOPROTEINS; STOMACH NEOPLASMS; TIGHT JUNCTIONS;

EID: 0030787772     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Anderson JM, Van-ltallie CM: Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 1995, 269:G467-G475
2. Anderson JM, Balda MS, Fanning AS: The structure and regulation of tight junctions. Curr Opin Cell Biol 1993, 5:772-778
3. Schneeberger EE, Lynch RD: Structure, function, and regulation of cellular tight junctions. Am J Physiol 1992, 262:L647-L661
4. Gumbiner B: Structure, biochemistry, and assembly of epithelial tight junctions. Am J Physiol 1987, 253:C749-C758
5. Stevenson BR, Anderson JM, Bullivant S: The epithelial tight junction: structure, function and preliminary biochemical characterization. Mol Cell Biochem 1988, 83: 129-145
6. Tsukita S, Itoh M, Nagafuchi A, Yonemura S, Tsukita S: Submembranous junctional plaque proteins include potential tumor suppressor molecules. J Cell Biol 1993, 123:1049-1053
7. Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA: Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol 1986, 103:755-766
8. Gumbiner B, Lowenkopf T, Apatira D: Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1. Proc Natl Acad Sci USA 1991, 88:3460-3464
9. Citi S, Sabanay H, Jakes R, Geiger B, Kendrick-Jones J: Cingulin, a new peripheral component of tight junctions. Nature 1988, 333:272-276
10. Citi S, Amorosi A, Franconi F, Giotti A, Zampi G: Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues. Am J Pathol 1991, 138:781-789
11. Balda MS, Gonzalez-Mariscal L, Matter K, Cereijido M, Anderson JM: Assembly of the tight junction: the role of diacylglycerol. J Cell Biol 1993, 123:293-302
12. Zhong Y, Saitoh T, Minase T, Sawada N, Enomoto K, Mori M: Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2. J Cell Biol 1993, 120:477-483
13. Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S: Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993, 123:1777-1788
14. Ando-Akatsuka Y, Saitou M, Hirase T, Kishi M, Sakakibara A, Itoh M, Yonemura S, Furuse M, Tsukita S: Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol 1996, 133:43-47
15. Furuse M, Fujimoto K, Sato N, Hirase T, Tsukita S, Tsukita S: Overexpression of occludin, a tight junctionassociated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J Cell Sci 1996, 109:429-435
16. McCarthy KM, Skare IB, Stankewich MC, Furuse M, Tsukita S, Rogers RA, Lynch RD, Schneeberger EE: Occludin is a functional component of the tight junction. J Cell Sci 1996, 109:2287-2298
17. Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S: Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol 1994, 127:1617-1626
18. Stevenson BR, Heintzelman MB, Anderson JM, Citi S, Mooseker MS: ZO-1 and cingulin: tight junction proteins with distinct identities and localizations. Am J Physiol 1989, 257:C621-C628
19. Balda MS, Whitney JA, Flores C, Gonzalez S, Cereijido M, Matter K: Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol 1996, 134:1031-1049
20. Rajasekaran AK, Hojo M, Huima T, Rodriguez-Boulan E: Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions. J Cell Biol 1996, 132:451-463
21. Kerjaschki D, Krisch K, Sleyter UB, Umrath W, Jakesz R, Depisch D, Kokoschka R, Horandner H: The structure of tight junctions in human thyroid tumors: a systematic freeze-fracture study. Am J Pathol 1979, 96: 207-225
22. Polak-Charcon S, Shoham J, Ben-Shaul Y: Tight junctions in epithelial cells of human fetal hindgut, normal colon, and colon adenocarcinoma. J Natl Cancer Inst 1980, 65:53-62
23. Gumbiner BM: Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996, 84:345-357
24. Woods DF, Bryant PJ: The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 1991, 66:451-464
25. Takeda H, Nagafuchi A, Yonemura S, Tsukita S, Behrens J, Birchmeier W, Tsukita S: V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and β catenin is not required for the shift. J Cell Biol 1995, 131:1839-1847
26. Zhong Y, Enomoto K, Tobioka H, Konishi Y, Satoh M, Mori M: Sequential decrease in tight junctions as revealed by 7H6 tight junction-associated protein during rat hepatocarcinogenesis. Jpn J Cancer Res 1994, 85:351-356
27. Itoh M, Nagafuchi A, Yonemura S, Kitani-Yasuda T, Tsukita S, Tsukita S: The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol 1993, 121:491-502
28. Shiozaki H, Tahara H, Oka H, Miyata M, Kobayashi K, Tamura S, lihara K, Doki Y, Hirano S, Takeichi M, Mori T: Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathoi 1991, 139:17-23
29. Pauli BU, Weinstein RS, Alroy J, Arai M: Ultrastructure of cell junctions in FANFT-induced urothelial tumors in urinary bladder of Fischer rats. Lab Invest 1977, 37: 609-621
30. Alroy J: Ultrastructure of canine urinary bladder carcinoma. Vet Pathol 1979, 16:693-701
31. Shiozaki H, lihara K, Oka H, Kadowaki T, Matsui S, Gofuku J, Inoue M, Nagafuchi A, Tsukita S, Mori T: Immunohistochemical detection of a-catenin expression in human cancers. Am J Pathol 1994, 144:667-674
32. Takayama T, Shiozaki H, Shibamoto S, Oka H, Kimura Y, Tamura S, Inoue M, Monden T, Ito F, Monden M: β-Catenin expression in human cancers. Am J Pathol 1996, 148:39-46
33. Gumbiner B, Simons K: A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J Cell Biol 1986, 102:457-468
34. Gonzalez-Mariscal L, Chavez-de-Ramirez B, Cereijido M: Tight junction formation in cultured epithelial cells (MDCK). J Membr Biol 1985, 86:113-125
35. Gumbiner B, Stevenson B, Grimaldi A: The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J Cell Biol 1988, 107:1575-1587
36. Behrens J, Birchmeier W, Goodman SL, Imhof BA: Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1 : mechanistic aspects and identification of the antigen as a component related to uvomorulin. J Cell Biol 1985, 101: 1307-1315
37. Watabe M, Nagafuchi A, Tsukita S, Takeichi M: Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line. J Cell Biol 1994, 127:247-256
38. McNeill H, Ozawa M, Kemler R, Nelson WJ: Novel function of cell adhesion molecule uvomorulin as inducer of cell surface polarity. Cell 1990, 62:309-316
39. Elias PM, McNutt NS, Friend DS: Membrane alterations during cornification of mammalian squamous epithelia: a freeze-fracture, tracer, and thin-section study. Anat Rec 1977, 189:577-594
40. Yonemura S, Itoh M, Nagafuchi A, Tsukita S: Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells. J Cell Sci 1995, 108:127-142
41. Jesaitis LA, Goodenough DA: Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discslarge tumor suppressor protein. J Cell Biol 1994, 124:949-961
42. Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg GH, Kawahara T, Kobayashi S, Okada M, Toyoshima K, Akiyama T: Binding of APC to the human homologue of the Drosophila discs large tumor suppressor protein. Science 1996, 272:1020-1023
43. Fidler IJ: Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 1978, 38: 2651-2660
44. Satoh H, Zhong Y, Isomura H, Saitoh M, Enomoto K, Sawada N, Mori M: Localization of 7H6 tight junctionassociated antigen along the cell border of vascular endothelial cells correlates with paracellular barrier function against ions, large molecules, and cancer cells. Exp Cell Res 1996, 222:269-274
45. Balda MS, Fallon MB, Van-ltallie CM, Anderson JM: Structure, regulation, and pathophysiology of tight junctions in the gastrointestinal tract. Yale J Biol Med 1992, 65:725-735
46. Fallon MB, Brecher AR, Balda MS, Matter K, Anderson JM: Altered hepatic localization and expression of occludin after common bile duct ligation. Am J Physiol 1995, 269:C1057-C1062