GABAA receptor subtype-selective Modulators. II. α5-selective inverse agonists for cognition enhancement

Current Topics in Medicinal Chemistry

Volumn 11, Issue 9, 2011, Pages 1203-1214

  Atack, John R ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

5 subtype; Benzodiazepine; Cognition; GABAA receptor; Subtype selective

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR INVERSE STIMULATING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; DIAZEPAM; L 655708; PHTHALAZINE DERIVATIVE; PYRIDAZINE; RO4938581; RY 080; TETRALIN DERIVATIVE; THIOPHENE; TRIAZINE DERIVATIVE; TRIAZOLOPYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG; ZOLPIDEM; 3 TERT BUTYL 7 (5 METHYLISOXAZOL 3 YL) 2 (1 METHYL 1H 1,2,4 TRIAZOL 5 YLMETHOXY)PYRAZOLO(1,5 D)(1,2,4)TRIAZINE; 3-TERT-BUTYL-7-(5-METHYLISOXAZOL-3-YL)-2-(1-METHYL-1H-1,2,4-TRIAZOL-5-YLMETHOXY)PYRAZOLO(1,5-D)(1,2,4)TRIAZINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ALPHA5IA II; ALPHA5IA-II; FLUOROBENZENE; ISOPROTEIN; ISOXAZOLE DERIVATIVE; L 838,417; NOOTROPIC AGENT; PYRIDAZINE DERIVATIVE; PYRIDINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ARTICLE; COGNITION; DISEASE ASSOCIATION; DRUG BINDING; DRUG EFFICACY; HIPPOCAMPUS; HUMAN; HYPOTHESIS; LEARNING; MEMORY; NONHUMAN; PROTEIN LOCALIZATION; ANIMAL; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; FEMALE; MALE; MAZE TEST; METABOLISM; MOUSE; PHYSIOLOGY; RAT; REVIEW; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BENZODIAZEPINES; COGNITION; DIAZEPAM; FEMALE; FLUOROBENZENES; GABA-A RECEPTOR AGONISTS; HIPPOCAMPUS; HUMANS; ISOXAZOLES; MALE; MAZE LEARNING; MEMORY; MICE; NOOTROPIC AGENTS; PROTEIN ISOFORMS; PYRIDAZINES; PYRIDINES; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRIAZINES; TRIAZOLES;

EID: 79954471349     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802611795371314     Document Type: Article

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