Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: High-affinity, selective probes for α5-containing GABAA receptors

Journal of Medicinal Chemistry

Volumn 39, Issue 9, 1996, Pages 1928-1934

  Liu, Ruiyan ^a   Hu, Rona J ^b   Zhang, Puwen ^a   Skolnick, Phil ^b   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; 5,6 DIHYDRO 5 METHYL 6 OXO 8 [(TRIMETHYLSILYL)ETHYNYL] 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; 5,6 DIHYDRO 5 METHYL 6 OXO 8 [(TRIMETHYLSILYL)ETHYNYL] 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID TERT BUTYL ESTER; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; 8 ETHYNYL 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; 8 ETHYNYL 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID TERT BUTYL ESTER; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; CONVULSANT AGENT; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; IMIDAZOBENZODIAZEPINE DERIVATIVE; RO 14 4513; RO 15 1310; TRITIUM; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CEREBELLUM; CONTROLLED STUDY; CONVULSION; DRUG RECEPTOR BINDING; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; OOCYTE; XENOPUS;

ANIMALS; BENZODIAZEPINES; CEREBELLUM; FLUNITRAZEPAM; HIPPOCAMPUS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MOLECULAR PROBES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029881508     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950887n     Document Type: Article

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