Determination of a Selective GABA-A α5 Receptor Inverse Agonist in Human Plasma by High-Performance Liquid Chromatography with Tandem Mass Spectrometric Detection

Journal of Liquid Chromatography and Related Technologies

Volumn 27, Issue 4, 2004, Pages 689-704

  Xue, Lingling ^a   Lin, Li ^a   Hsieh, John Y K ^a   Matuszewski, Bogdan K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

96 well solid phase extraction; GABA A 5 receptor inverse agonist; High performance liquid chromatography; MS MS detection

Indexed keywords

CONCENTRATION (PROCESS); EXTRACTION; ORGANIC COMPOUNDS; STANDARDS;

SELECTIVE RECEPTORS;

LIQUID CHROMATOGRAPHY;

3 (5 METHYLISOXAZOL 3 YL) 6 (1 METHYL 1H 1,2,3 TRIAZOL 4 YLMETHOXY) 1,2,4 TRIAZOLO[3,4 A]PHTHALAZINE; 4 AMINOBUTYRIC ACID A ALPHA5 RECEPTOR INVERSE AGONIST; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 5 HYDROXYMETHYLISOXAZOLE; BENZODIAZEPINE DERIVATIVE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; AUTOANALYSIS; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 1542314257     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120028257     Document Type: Article

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