3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

Journal of Medicinal Chemistry

Volumn 47, Issue 7, 2004, Pages 1807-1822

  Carling, Robert W ^a   Moore, Kevin W ^a   Street, Leslie J ^a   Wild, Deborah ^a   Isted, Catherine ^a   Leeson, Paul D ^a   Thomas, Steven ^a   O'Connor, Desmond ^a   McKernan, Ruth M ^a   Quirk, Katherine ^a   Cook, Susan M ^a   Atack, John R ^a   Wafford, Keith A ^a   Thompson, Sally A ^a   Dawson, Gerard R ^a   Ferris, Pushpinder ^a   Castro, José L ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYL 6 (2 PYRIDYL)METHYLOXY 1,2,4 TRIAZOLO[3,4 A]PHTHALAZINE DERIVATIVE; 3 PHENYL 6 (2 PYRIDYL)METHYLOXY 1,2,4 TRIAZOLO[3,4,A]PHTHALAZINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 6 BENZYLOXY 3 (4 METHOXY)PHENYL 1,2,4 TRIAZOLO[3,4 A]PHTHALAZINE; 7,8,9,10 TETRAHYDRO (7,10 ETHANO)PHTHALAZINE; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; PHTHALAZINE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG SCREENING; DRUG SELECTIVITY; OOCYTE; XENOPUS;

ANIMALS; ANTI-ANXIETY AGENTS; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; CELL LINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MAZE LEARNING; OOCYTES; PATCH-CLAMP TECHNIQUES; PHTHALAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; XENOPUS;

EID: 12144291687     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031020p     Document Type: Article

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