Trinity revealed: Stoichiometric complex assembly of a bacterial multidrug efflux pump (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 17, (6893-6894) DOI:10.1073/pnas.0902837106);Trinity revealed: Stoichiometric complex assembly of a bacterial multidrug efflux pump

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 17, 2009, Pages 6893-6894

  Pos, Klaas M ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACRA PROTEIN; ARCB PROTEIN; BACTERIAL PROTEIN; TOLC PROTEIN; UNCLASSIFIED DRUG; MULTIDRUG RESISTANCE PROTEIN;

ANTIBIOTIC RESISTANCE; DRUG TRANSPORT; EFFUSION; ESCHERICHIA COLI; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STOICHIOMETRY; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION;

BACTERIA (MICROORGANISMS);

ESCHERICHIA COLI; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN MULTIMERIZATION;

EID: 66349106810     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904722106     Document Type: Erratum

References (21)

1. Piddock LJ (2006) Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev 19:382-402.
2. NikaidoH(2009)Multidrugresistanceinbacteria.AnnuRev Biochem,10.1146/annurev.biochem.78.082907.145923.
3. Symmons MF, Bokma E, Koronakis E, Hughes C, Koronakis V (2009) The assembled structure of a complete tripartite bacterial multidrug efflux pump. Proc Natl Acad Sci USA 106:7173-7178.
4. Koronakis V, Sharff A, Koronakis E, Luisi B, Hughes C (2000) Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 405:914-919.
5. Murakami S, Nakashima R, Yamashita E, Yamaguchi A (2002) Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 419:587-593.
6. Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A (2006) Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 443:173-179.
7. Seeger MA, et al. (2006) Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science 313:1295-1298.
8. Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grut- ter MG (2007) Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol 5:e7.
9. Mikolosko J, Bobyk K, Zgurskaya HI, Ghosh P (2006) Conformational flexibility in the multidrug efflux system protein AcrA. Structure (London) 14:577-587.
10. Akama H, et al. (2004) Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa. J Biol Chem 279:25939-25942.
11. Higgins MK, Bokma E, Koronakis E, Hughes C, Koronakis V (2004) Structure of the periplasmic component of a bacterial drug efflux pump. Proc Natl Acad Sci USA 101:9994-9999.
12. Fernandez-Recio J, et al. (2004) A model of a transmem-brane drug-efflux pump from Gram-negative bacteria.FEBS Lett 578:5-9.
13. Misra R, Bavro VN (2009) Assembly and transport mechanism of tripartite drug efflux systems. Biochim Bio-phys Acta, 10.1016/j.bbapap.2009.02.017.
14. Touze T, et al. (2004) Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system. Mol Microbiol 53:697-706.
15. Elkins CA, Nikaido H (2003) Chimeric analysis of AcrA function reveals the importance of its C-terminal do- main in its interaction with the AcrB multidrug efflux pump. J Bacteriol 185:5349-5356.
16. Yum S, et al. (2009) Crystal structure of the periplasmic component of a tripartite macrolide-specific efflux pump. J Mol Biol 16:1286-1297.
17. Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI (2007) Reconstitution of the Escherichia coli macrolide transporter: The periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB. Mol Mi-crobiol 63:895-910.
18. Reffay M, et al. (2009) Tracking membrane protein association in model membranes. PLoS One 4:e5035.
19. Zgurskaya HI, Yamada Y, Tikhonova EB, Ge Q, Krish-namoorthy G (2008) Structural and functional diversity of bacterial membrane fusion proteins. Biochim Bio-phys Acta, 10.1016/j.bbapap.2008.10.010.
20. Krishnamoorthy G, Tikhonova EB, Zgurskaya HI (2008) Fitting periplasmic membrane fusion proteins to inner membrane transporters: Mutations that enable Esche-richia coli AcrA to function with Pseudomonas aerugi-nosa MexB. J Bacteriol 190:691-698.
21. Vaccaro L, Scott KA, Sansom MS (2008) Gating at both ends and breathing in the middle: Conformational dynamics of TolC. Biophys J 95:5681-5691.