-
1
-
-
21744440783
-
Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins
-
P. Amstutz, H.K. Binz, P. Parizek, M.T. Stumpp, A. Kohl, M.G. Grütter, P. Forrer, and A/ Plückthun Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins J. Biol. Chem. 280 2005 24715 24722
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 24715-24722
-
-
Amstutz, P.1
Binz, H.K.2
Parizek, P.3
Stumpp, M.T.4
Kohl, A.5
Grütter, M.G.6
Forrer, P.7
Plückthun, A.8
-
2
-
-
0141676629
-
The process of structure-based drug design
-
A. Anderson The process of structure-based drug design Chem. Biol. 10 2003 787 797
-
(2003)
Chem. Biol.
, vol.10
, pp. 787-797
-
-
Anderson, A.1
-
3
-
-
0033954256
-
The Protein Data Bank
-
H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, and P.E. Bourne The Protein Data Bank Nucleic Acids Res. 28 2000 235 242
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
Weissig, H.6
Shindyalov, I.N.7
Bourne, P.E.8
-
4
-
-
0042780350
-
Designing repeat proteins: Well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins
-
H.K. Binz, M.T. Stumpp, P. Forrer, P. Amstutz, and A. Plückthun Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins J. Mol. Biol. 332 2003 489 503
-
(2003)
J. Mol. Biol.
, vol.332
, pp. 489-503
-
-
Binz, H.K.1
Stumpp, M.T.2
Forrer, P.3
Amstutz, P.4
Plückthun, A.5
-
5
-
-
2342624119
-
High-affinity binders selected from designed ankyrin repeat protein libraries
-
H.K. Binz, P. Amstutz, A. Kohl, M.T. Stumpp, C. Briand, P. Forrer, M.G. Grütter, and A. Plückthun High-affinity binders selected from designed ankyrin repeat protein libraries Nat. Biotechnol. 22 2004 575 582
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 575-582
-
-
Binz, H.K.1
Amstutz, P.2
Kohl, A.3
Stumpp, M.T.4
Briand, C.5
Forrer, P.6
Grütter, M.G.7
Plückthun, A.8
-
6
-
-
0035968312
-
Molecular mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa. Roles of conserved active site residues
-
D.D. Boehr, P.R. Thompson, and G.D. Wright Molecular mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa. Roles of conserved active site residues J. Biol. Chem. 276 2001 23929 23936
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23929-23936
-
-
Boehr, D.D.1
Thompson, P.R.2
Wright, G.D.3
-
7
-
-
0037330532
-
Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes
-
D.D. Boehr, K. Draker, K. Koteva, M. Bains, R.E. Hancock, and G.D. Wright Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes Chem. Biol. 10 2003 189 196
-
(2003)
Chem. Biol.
, vol.10
, pp. 189-196
-
-
Boehr, D.D.1
Draker, K.2
Koteva, K.3
Bains, M.4
Hancock, R.E.5
Wright, G.D.6
-
8
-
-
0032541640
-
INK4d
-
INK4d Nature 395 1998 244 250
-
(1998)
Nature
, vol.395
, pp. 244-250
-
-
Brotherton, D.1
Dhanaraj, V.2
Wick, S.3
Brizuela, L.4
Domaille, P.5
Volyanik, E.6
Xu, X.7
Parisini, E.8
Smith, B.9
Archer, S.10
-
9
-
-
3543012707
-
Crystallography & NMR system: A new software suite for macromolecular structure determination
-
A.T. Brünger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, R.W. Grosse-Kunstleve, J.-S. Jiang, J. Kuszewski, M. Nilges, and N.S. Pannu Crystallography & NMR system: a new software suite for macromolecular structure determination Acta Crystallogr. D Biol. Crystallogr. 54 1998 905 921
-
(1998)
Acta Crystallogr. D Biol. Crystallogr.
, vol.54
, pp. 905-921
-
-
Brünger, A.T.1
Adams, P.D.2
Clore, G.M.3
Delano, W.L.4
Gros, P.5
Grosse-Kunstleve, R.W.6
Jiang, J.-S.7
Kuszewski, J.8
Nilges, M.9
Pannu, N.S.10
-
10
-
-
0035979336
-
Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase
-
D. Burk, W. Hon, A. Leung, and A. Berghuis Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase Biochemistry 40 2001 8756 8764
-
(2001)
Biochemistry
, vol.40
, pp. 8756-8764
-
-
Burk, D.1
Hon, W.2
Leung, A.3
Berghuis, A.4
-
11
-
-
0028103275
-
The CCP4 suite: Programs for protein crystallography
-
CCP4 (Collaborative Computational Project, Number 4)
-
CCP4 (Collaborative Computational Project, Number 4) The CCP4 suite: programs for protein crystallography Acta Crystallogr. D Biol. Crystallogr. 50 1994 760 763
-
(1994)
Acta Crystallogr. D Biol. Crystallogr.
, vol.50
, pp. 760-763
-
-
-
12
-
-
0030848695
-
Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors
-
D.M. Daigle, G.A. McKay, and G.D. Wright Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors J. Biol. Chem. 272 1997 24755 24758
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24755-24758
-
-
Daigle, D.M.1
McKay, G.A.2
Wright, G.D.3
-
13
-
-
0034759115
-
Regulation of MAP kinases by docking domains
-
H. Enslen, and R.J. Davis Regulation of MAP kinases by docking domains Biol. Cell. 93 2001 5 14
-
(2001)
Biol. Cell.
, vol.93
, pp. 5-14
-
-
Enslen, H.1
Davis, R.J.2
-
14
-
-
0037468685
-
A novel strategy to design binding molecules harnessing the modular nature of repeat proteins
-
P. Forrer, M.T. Stumpp, H.K. Binz, and A. Plückthun A novel strategy to design binding molecules harnessing the modular nature of repeat proteins FEBS Lett. 539 2003 2 6
-
(2003)
FEBS Lett.
, vol.539
, pp. 2-6
-
-
Forrer, P.1
Stumpp, M.T.2
Binz, H.K.3
Plückthun, A.4
-
16
-
-
0030830868
-
Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases
-
W. Hon, G. McKay, P. Thompson, R. Sweet, D. Yang, G. Wright, and A. Berghuis Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases Cell 89 1997 887 895
-
(1997)
Cell
, vol.89
, pp. 887-895
-
-
Hon, W.1
McKay, G.2
Thompson, P.3
Sweet, R.4
Yang, D.5
Wright, G.6
Berghuis, A.7
-
17
-
-
0028582185
-
Crystal structure of the tyrosine kinase domain of the human insulin receptor
-
S.R. Hubbard, L. Wei, L. Ellis, and W.A. Hendrickson Crystal structure of the tyrosine kinase domain of the human insulin receptor Nature 372 1994 22 29
-
(1994)
Nature
, vol.372
, pp. 22-29
-
-
Hubbard, S.R.1
Wei, L.2
Ellis, L.3
Hendrickson, W.A.4
-
18
-
-
0037013143
-
The conformational plasticity of protein kinases
-
M. Huse, and J. Kuriyan The conformational plasticity of protein kinases Cell 109 2002 275 282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
19
-
-
0034671563
-
Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors
-
P.D. Jeffrey, L. Tong, and N.P. Pavletich Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors Genes Dev. 14 2000 3115 3125
-
(2000)
Genes Dev.
, vol.14
, pp. 3115-3125
-
-
Jeffrey, P.D.1
Tong, L.2
Pavletich, N.P.3
-
21
-
-
84889120137
-
Improved methods for building protein models in electron density maps and the location of errors in these models
-
T.A. Jones, J.Y. Zou, S.W. Cowan, and M. Kjeldgaard Improved methods for building protein models in electron density maps and the location of errors in these models Acta Crystallogr. D Biol. Crystallogr. 47 1991 110 119
-
(1991)
Acta Crystallogr. D Biol. Crystallogr.
, vol.47
, pp. 110-119
-
-
Jones, T.A.1
Zou, J.Y.2
Cowan, S.W.3
Kjeldgaard, M.4
-
22
-
-
0037452697
-
Designed to be stable: Crystal structure of a consensus ankyrin repeat protein
-
A. Kohl, H.K. Binz, P. Forrer, M.T. Stumpp, A. Plückthun, and M.G. Grütter Designed to be stable: crystal structure of a consensus ankyrin repeat protein Proc. Natl. Acad. Sci. USA 100 2003 1700 1705
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1700-1705
-
-
Kohl, A.1
Binz, H.K.2
Forrer, P.3
Stumpp, M.T.4
Plückthun, A.5
Grütter, M.G.6
-
23
-
-
0029902679
-
Program DYNAFIT for the analysis of enzyme kinetic data: Application to HIV proteinase
-
P. Kuzmic Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase Anal. Biochem. 237 1996 260 273
-
(1996)
Anal. Biochem.
, vol.237
, pp. 260-273
-
-
Kuzmic, P.1
-
24
-
-
0003187567
-
The atomic structure of protein-protein recognition sites
-
L. Lo Conte, C. Chothia, and J. Janin The atomic structure of protein-protein recognition sites J. Mol. Biol. 285 1999 2177 2198
-
(1999)
J. Mol. Biol.
, vol.285
, pp. 2177-2198
-
-
Lo Conte, L.1
Chothia, C.2
Janin, J.3
-
25
-
-
0037032835
-
The protein kinase complement of the human genome
-
G. Manning, D.B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam The protein kinase complement of the human genome Science 298 2002 1912 1934
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
26
-
-
0028358078
-
Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: Overexpression, purification, and substrate specificity
-
G.A. McKay, P.R. Thompson, and G.D. Wright Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity Biochemistry 33 1994 6936 6944
-
(1994)
Biochemistry
, vol.33
, pp. 6936-6944
-
-
McKay, G.A.1
Thompson, P.R.2
Wright, G.D.3
-
27
-
-
0032897075
-
Efficient anisotropic refinement of macromolecular structures using FFT
-
G.N. Murshudov, A. Lebedev, A.A. Vagin, K.S. Wilson, and E.J. Dodson Efficient anisotropic refinement of macromolecular structures using FFT Acta Crystallogr. D Biol. Crystallogr. 55 1999 247 255
-
(1999)
Acta Crystallogr. D Biol. Crystallogr.
, vol.55
, pp. 247-255
-
-
Murshudov, G.N.1
Lebedev, A.2
Vagin, A.A.3
Wilson, K.S.4
Dodson, E.J.5
-
28
-
-
84920325457
-
AMoRe: An automated package for molecular replacement
-
J. Navaza AMoRe: an automated package for molecular replacement Acta Crystallogr. A 50 1994 157 163
-
(1994)
Acta Crystallogr. a
, vol.50
, pp. 157-163
-
-
Navaza, J.1
-
29
-
-
0035788101
-
Implementation of molecular replacement in AMoRe
-
J. Navaza Implementation of molecular replacement in AMoRe Acta Crystallogr. D Biol. Crystallogr. 57 2001 1367 1372
-
(2001)
Acta Crystallogr. D Biol. Crystallogr.
, vol.57
, pp. 1367-1372
-
-
Navaza, J.1
-
30
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design from structure
-
M.E.M. Noble, J.A. Endicott, and L.N. Johnson Protein kinase inhibitors: insights into drug design from structure Science 303 2004 1800 1805
-
(2004)
Science
, vol.303
, pp. 1800-1805
-
-
Noble, M.E.M.1
Endicott, J.A.2
Johnson, L.N.3
-
31
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
C.W. Carter J. R.M. Sweets Academic Press New York
-
Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode C.W. Carter J. R.M. Sweets Methods in Enzymology 1997 Academic Press New York 307 326
-
(1997)
Methods in Enzymology
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
32
-
-
8744252619
-
Thermodynamics of aminoglycoside binding to aminoglycoside- 3′-phosphotransferase IIIa studied by isothermal titration calorimetry
-
C. Ozen, and E.H. Serpersu Thermodynamics of aminoglycoside binding to aminoglycoside- 3′-phosphotransferase IIIa studied by isothermal titration calorimetry Biochemistry 43 2004 14667 14675
-
(2004)
Biochemistry
, vol.43
, pp. 14667-14675
-
-
Ozen, C.1
Serpersu, E.H.2
-
33
-
-
0033574614
-
Mechanisms of cyclin-dependent kinase regulation: Structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors
-
N.P. Pavletich Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors J. Mol. Biol. 287 1999 821 828
-
(1999)
J. Mol. Biol.
, vol.287
, pp. 821-828
-
-
Pavletich, N.P.1
-
34
-
-
0037453510
-
Assembly of cell regulatory systems through protein interaction domains
-
T. Pawson, and P. Nash Assembly of cell regulatory systems through protein interaction domains Science 300 2003 445 452
-
(2003)
Science
, vol.300
, pp. 445-452
-
-
Pawson, T.1
Nash, P.2
-
36
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
T. Schindler, W. Bornmann, P. Pellicena, W.T. Miller, B. Clarkson, and J. Kuriyan Structural mechanism for STI-571 inhibition of abelson tyrosine kinase Science 289 2000 1938 1942
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
37
-
-
0032792551
-
The ankyrin repeat: A diversity of interactions on a common structural framework
-
S.G. Sedgwick, and S.J. Smerdon The ankyrin repeat: a diversity of interactions on a common structural framework Trends Biochem. Sci. 24 1999 311 316
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 311-316
-
-
Sedgwick, S.G.1
Smerdon, S.J.2
-
38
-
-
0034284131
-
Docking domains and substrate-specificity determination for MAP kinases
-
A.D. Sharrocks, S.-H. Yang, and A. Galanis Docking domains and substrate-specificity determination for MAP kinases Trends Biochem. Sci. 25 2000 448 453
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 448-453
-
-
Sharrocks, A.D.1
Yang, S.-H.2
Galanis, A.3
-
39
-
-
0024288477
-
A re-evaluation of the kinetic equations for hyperbolic tight-binding inhibition
-
S.E. Szedlacsek, V. Ostafe, M. Serban, and M.O. Vlad A re-evaluation of the kinetic equations for hyperbolic tight-binding inhibition Biochem. J. 254 1988 311 312
-
(1988)
Biochem. J.
, vol.254
, pp. 311-312
-
-
Szedlacsek, S.E.1
Ostafe, V.2
Serban, M.3
Vlad, M.O.4
-
40
-
-
0037400611
-
Molecular recognitions in the MAP kinase cascades
-
T. Tanoue, and E. Nishida Molecular recognitions in the MAP kinase cascades Cell. Signal. 15 2003 455 462
-
(2003)
Cell. Signal.
, vol.15
, pp. 455-462
-
-
Tanoue, T.1
Nishida, E.2
-
41
-
-
0032724177
-
The COOH terminus of aminoglycoside phosphotransferase (3′)-IIIa is critical for antibiotic recognition and resistance
-
P.R. Thompson, J. Schwartzenhauer, D.W. Hughes, A.M. Berghuis, and G.D. Wright The COOH terminus of aminoglycoside phosphotransferase (3′)-IIIa is critical for antibiotic recognition and resistance J. Biol. Chem. 274 1999 30697 30706
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30697-30706
-
-
Thompson, P.R.1
Schwartzenhauer, J.2
Hughes, D.W.3
Berghuis, A.M.4
Wright, G.D.5
-
42
-
-
0037018922
-
Mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa: Role of the nucleotide positioning loop
-
P.R. Thompson, D.D. Boehr, A.M. Berghuis, and G.D. Wright Mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa: role of the nucleotide positioning loop Biochemistry 41 2002 7001 7007
-
(2002)
Biochemistry
, vol.41
, pp. 7001-7007
-
-
Thompson, P.R.1
Boehr, D.D.2
Berghuis, A.M.3
Wright, G.D.4
-
43
-
-
0030911867
-
The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution
-
Z. Wang, P.C. Harkins, R.J. Ulevitch, J. Han, M.H. Cobb, and E.J. Goldsmith The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution Proc. Natl. Acad. Sci. USA 94 1997 2327 2332
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2327-2332
-
-
Wang, Z.1
Harkins, P.C.2
Ulevitch, R.J.3
Han, J.4
Cobb, M.H.5
Goldsmith, E.J.6
|