Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents

Journal of Medicinal Chemistry

Volumn 54, Issue 7, 2011, Pages 2012-2021

  Evdokimov, Nikolai M ^a   Van Slambrouck, Severine ^a   Heffeter, Petra ^b   Tu, Lee ^a   Le Calvé, Benjamin ^c   Lamoral Theys, Delphine ^c   Hooten, Carla J ^a   Uglinskii, Pavel Y ^d   Rogelj, Snezna ^a   Kiss, Robert ^c   Steelant, Wim F A ^a   Berger, Walter ^b   Yang, Jeremy J ^e   Bologa, Cristian G ^e   Kornienko, Alexander ^a   Magedov, Igor V ^a  

^a NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d RUSSIAN STATE AGRARIAN UNIVERSITY   (Russian Federation)

^e UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H INDENO[2',1':5,6]DIHYDROPYRIDO[2,3 D]PYRIMIDINE; 5 (2,3 DIHYDRO 1,4 BENZODIOXIN 6 YL) 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (2,3,4 TRIMETHOXYPHENYL) 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (2,4 DICHLOROPHENYL) 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (3 BROMO 4 FLUOROPHENYL) 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (3 BROMO 4,5 DIMETHOXYPHENYL) 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (3,4 DICHLOROPHENYL) 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (3,4 DICHLOROPHENYL) 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (3,4 DIMETHOXYPHENYL) 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (3,4 DIMETHYLPHENYL) 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (4 ETHOXYPHENYL) 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (4 FLUOROPHENYL) 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (4 ISOPROPYLPHENYL) 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (4 METHOXYPHENYL) 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (4 METHYLPHENYL) 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 (4 QUINOLINYL) 5,11 DIHYDRO 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 [4 (METHYLSULFANYL)PHENYL] 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 [4 (TRIFLUOROMETHOXY)PHENYL] 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; 5 [4 (TRIFLUOROMETHYL)PHENYL] 1H INDENO[2',1':5,6]PYRIDO[2,3 D]PYRIMIDINE 2,4,6(3H) TRIONE; BATRACYCLIN; CAMPTOTHECIN; DNA TOPOISOMERASE (ATP HYDROLYSING); INDENOPYRIDINE; LUOTONIN A; NATURAL PRODUCT; SILATECAN; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; OXIDATION;

ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; HUMANS; INHIBITORY CONCENTRATION 50; TOPOISOMERASE II INHIBITORS; URACIL;

EID: 79953775167     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1009428     Document Type: Article

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