DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3, 2-de]quinoline derivatives as cytotoxic agents

Journal of Medicinal Chemistry

Volumn 47, Issue 14, 2004, Pages 3665-3673

  Catoen Chackal, Sarah ^a,d   Facompré, Michael ^c   Houssin, Raymond ^a   Pommery, Nicole ^a   Goossens, Jean François ^a   Colson, Pierre ^b   Bailly, Christian ^c,e   Hénichart, Jean Pierre ^a  

^a Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c INSERM   (France)

^d GEORGIA STATE UNIVERSITY   (United States)

^e INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4,5 DIMETHOXY 10 [3 (4 METHYL)PIPERAZIN 1 YLPROPOXY] 1,2,3,12 TETRAHYDROINDENO[1,2 B]PYRIDO[4,3,2 DE]QUINOLINE; 4,5 DIMETHOXY 3 [2 (4 METHYL)PIPERAZIN 1 YLACETYL] 10 [3 (4 METHYL)PIPERAZIN 1 YLPROPOXYL] 1,2,3,12 TETRAHYDROINDENO[1,2 B]PYRIDO[4,3,2 DE]QUINOLINE; CYTOTOXIC AGENT; INTERCALATING AGENT; QUINOLINE DERIVATIVE; TETRAHYDROINDENO[1,2 B]PYRIDO[4,3,2 DE]QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AT RICH SEQUENCE; BINDING AFFINITY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG POTENCY; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; DNA FOOTPRINTING; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROMETRY; HUMANS; INTERCALATING AGENTS; PIPERAZINES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE;

EID: 3042588256     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0400193     Document Type: Article

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