Gastrin inhibits motility, decreases cell death levels and increases proliferation in human glioblastoma cell lines

Journal of Neurobiology

Volumn 37, Issue 3, 1998, Pages 373-382

  De Hauwer, Christophe ^a   Camby, Isabelle ^a,c   Darro, Francis ^a   Migeotte, Isabelle ^a   Decaestecker, Christine ^a   Verbeek, Claude ^a   Danguy, André ^a   Pasteels, Jean Lambert ^a   Brotchi, Jacques ^b   Salmon, Isabelle ^b   Van Ham, Philippe ^a   Kiss, Robert ^a,d  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c FNRS   (Belgium)

^d NONE

Author keywords

Cell death; Gastrin; Glioblastoma; In vitro; Motility; Proliferation

Indexed keywords

GASTRIN;

ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; GLIOBLASTOMA; HORMONE ACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; CELL CYCLE; CELL DEATH; CELL DIVISION; CELL MOVEMENT; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; TUMOR CELLS, CULTURED; VIDEO RECORDING;

EID: 0006552764     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(19981115)37:3<373::AID-NEU3>3.0.CO;2-H     Document Type: Article

References (63)

1. BALDWIN, G. S. (1994). Antiproliferative gastrin/cholecystokinin receptor antagonists target the 78-kDa gastrin-binding protein. Proc. Natl. Acad. Sci. USA 91:7593-7597.
2. BOLD, R. J., ISHIZUKA, J., TOWNSEND, C. M. JR., and THOMPSON, J. C. (1994). Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK-A or CCK-B. Biochem. Biophys. Res. Commun. 202:1222-1226.
3. CAMBY, I., DECAESTECKER, C., MIGEOTTE, I., MARTINEZ, J., SALMON, I., and KISS, R. (1997). Prototype detection by means of a neural network for the prediction of the mechanistic category of anticancer compounds. In: Proceedings of the 88th Annual Meeting of the American Association for Cancer Research, Vol. 38, p. 604 (abstr. 4057).
4. CAMBY, I., SALMON, I., DANGUY, A., PASTEELS, J. L., BROTCHI, J., MARTINEZ, J., and KISS, R. (1996a). Influence of gastrin on human astrocytic tumor cell proliferation. J. Natl. Cancer Inst. 88:594-600.
5. CAMBY, I., SALMON, I., OIRY, C., GALLEYRAND, J. C., NAGY, N., DANGLY, A., BROTCHI, J., PASTEELS, J. L., MARTINEZ, J., and KISS, R. (1996b). The influence of gastrin and/or cholecystokinin antagonists and agonists on the proliferation of three human astrocytic tumor cell lines. Neuropeptides 30:433-437.
6. CAMBY, I., SALMON, I., RORIVE, S., GRAS, T., DARRO, F., KRUCZYNSKI, A., DANGUY, A., PASTEELS, J. L., and KISS, R. (1994). Characterization of the influence of anti-hormone and/or anti-growth factor neutralizing antibodies on cell clone architecture and the growth of human neoplastic astrocytic cell lines. J. Neurooncol. 20:67-80.
7. CARRASCO, M., DEL RIO, M., HERNANZ, A., and DE LA FUENTE, M. (1997a). Inhibition of human neutrophil by sulfated and nonsulfated cholecystokinin octapeptides. Peptides 18:415-422.
8. CARRASCO, M., HERNANZ, A., and DE LA FUENTE, M. (1997b). Effect of cholecystokinin and gastrin on human peripheral blood lymphocyte functions, implication of cyclic AMP and interleukin 2. Regul. Pept. 70:135-142.
9. CHAMBERS, A. F., and MATRISIAN, L. M. (1997). Changing views of the role of matrix metalloproteinases in metastasis: review. J. Natl. Cancer Inst. 89:1260-1270.
10. CHEN, C. S., MRKSICH, M., HUANG, S., WHITESIDES, G. M., and INGBER, D. E. (1997). Geometric control of cell life and death. Science 276:1425-1428.
11. CHICOINE, M. R., and SILBERGELD, D. L. (1995). Assessment of brain tumor cell motility in vivo and in vitro. J. Neurosurg. 82:615-622.
12. CHINTALA, S. K., GOKASLAN, Z. L., Go, Y., SAWAYA, R., NICOLSON, G. L., and RAO, J. S. (1996). Role of extracellular matrix proteins in regulation of human glioma cell invasion in vitro. Clin. Exp. Metastasis 14:358-366.
13. DECAESTECKER, C., CAMBY, I., NAGY, N., BROTCHI, J., KISS, R., and SALMON, I. (1998). Improving morphology-based malignancy grading schemes in astrocytic tumors by means of computer-assisted techniques. Brain Pathol. 8:29-38.
14. DECAESTECKER, C., SALMON, I., CAMBY, I., DEWITTE, O., PASTEELS, J. L., BROTCHI, J., VAN HAM, P., and KISS, R. (1995). Identification of high versus lower risk clinical subgroups in a group of adult patients with supratentorial anaplastic astrocytomas. J. Neuropathol. Exp. Neurol. 54:371-384.
15. DECAESTECKER, C., SALMON, I., DEWITTE, O., CAMBY, I., VAN HAM, P., PASTEELS, J. L., BROTCHI, J., and KISS, R. (1997). Nearest-neighbour method of classification for the identification of aggressive versus non-aggressive low-grade astrocytic tumors by means of image-cytometry-generated variables. J. Neurosurg. 86:532-537.
16. DE HAUWER, C., CAMBY, I., DARRO, F., DECAESTECKER, C., GRAS, T., SALMON, L, KISS, R., and VAN HAM, P. (1997). Dynamic characterization of glioblastoma cell motility. Biochem. Biophys. Res. Commun. 232:267-272.
17. DE LA FUENTE, M., CAMPOS, M., DEL RIO, M., and HERNANZ, A. (1995). Inhibition of murine peritoneal macrophage functions by sulfated cholecystokinin octapeptide. Regul. Pept. 55:47-56.
18. DE LA FUENTE, M., CARRASCO, M., and HERNANZ, A. (1997). Modulation of human neutrophil function in vitro by gastrin. J. Endocrinol. 153:475-483.
19. DE LA FUENTE, M., DRUMMOND, J., DEL RIO, M., CARRASCO, M., and HERNANZ, A. (1996). Modulation of murine peritoneal macrophage functions by gastrin. Peptides 17: 219-224.
20. ECHTERMEYER, F., SCHOBER, S., POSCHL, E., VON DER MARK, H., and VON DER MARK, K. (1996). Specific induction of cell motility on laminin by alpha 7 integrin. 7. Biol. Chem. 271:2071-2075.
21. FABER-ELMAN, A., MISKIN, R., and SCHWARTZ, M. (1995). Components of the plasminogen activator system in astrocytes are modulated by tumor necrosis factor-α and interleukin-1β through similar signal transduction pathways. J. Neurochem. 65:1524-1535.
22. FIDLER, I. J. (1997). Molecular biology of cancer: invasion and metastasis. In: V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg, Eds. Cancer: Principles and Practice of Oncology, Vol. 1, 5th ed. JB Lippincott. Philadelphia, pp. 135-152.
23. GAGELIN, C., PIERRE, M., GAVARET, J. M., and TORU-DELBAUFFE, D. (1995). Rapid TGF-β1 effect on actin cytoskeleton of astrocytes: comparison with other factors and implications for cell motility. Glia 13:283-293.
24. GARCIA, L. J., ROSADO, J. A., GONZALEZ, A., and JENSEN, R. T. (1997). Cholecystokinin-stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho. Biochem. J. 327:461-472.
25. GIESE, A., Loo, M., NORMAN, S., TREASURYWALA, S., and BERENS, M. (1996a). Contrasting migratory response of astrocytoma cells to tenascin mediated by different integrins. J. Cell Sci. 109:2161-2168.
26. GIESE, A., Loo, M. A., TRAN, N., HASKETT, D., COONS, S. W., and BERENS, M. E. (1996b). Dichotomy of astrocytoma migration and proliferation. Int. J. Cancer 67: 275-282.
27. GRIMMELIKHUIZEN, C. J., SUNDLER, F., and REHFELD, J. F. (1980). Gastrin/CCK-like immunoreactivity in the nervous system of coelenterates. Histochemistry 69:61-68.
28. HILSTED, L. (1991). Glycine-extended gastrin precursors. Regul. Pept. 36:323-343.
29. HIMICK, B. A., and PETER, R. E. (1994). CCK/gastrin-like immunoreactivity in brain and gut, and CCK suppression of feeding in goldfish. Am. J. Physiol. 267:r841-r851.
30. HOKFELT, T., CORTES, R., SCHALLING, M., CECCATELLI, S., PELTO-HUIKKO, M., PERSSON, H., and VILLAR, M. J. (1991). Distribution patterns of CCK and CCK mRNA in some neuronal and non-neuronal tissues. Neuropeptides 19:31-43.
31. HYNES, R. O. (1987). Integrins: a family of cell surface receptors. Cell 48:549-554.
32. IWASAKI, K., ROGERS, L. R., BARNETT, G. H., ESTES, M. L., and BARNA, B. P. (1993). Effect of recombinant tumor necrosis factor-alpha on three-dimensional growth, morphology, and invasiveness of human glioblastoma cells in vitro. J. Neurosurg. 78:952-958.
33. KISS, R., CAMBY, I., SALMON, I., VAN HAM, P., BROTCHI, J., and PASTEELS, J. L. (1995). Relationship between DNA ploidy level and tumor sociology behavior in 12 nervous cell lines. Cytometry 20:118-126.
34. KLEIHUES, P., BURGER, P. C., and SCHEITHAUER, B. W. (1992). Histological Typing of the Tumours of the Central Nervous System. World Health Organization. Springer-Verlag, Berlin.
35. KLEIHUES, P., SOYLEMEZOGLU, F., SCHAUBLE, B., SCHEITHAUER, B. W., and BURGER, P. C. (1995). Histopathology, classification, and grading of gliomas. Glia 15:211-221.
36. KONO, S., RAO, J. S., BRUNER, J. M., and SAWAYA, R. (1994). Immunohistochemical localization of plasminogen activator inhibitor type 1 in human brain tumors. J. Neuropathol. Exp. Neurol 53:256-262.
37. KRUCZYNSKI, A., SALMON, I., CAMBY, I., LIMOUZY, A., ROMBAUT, K., PASTEELS, J. L., DELSOL, G., BROTCHI, J., and KISS, R. (1995). The characterization of nuclear DNA content, the proliferative activity and the immunohistochemical expression of GFAP, VIM, LEU-7, S-100, p53 and cathepsin D in human glioblastoma multiformes (hG-BMs) versus GBM cell lines grafted into the brains of nude mice. Int. J. Oncol. 6:473-481.
38. LAMPSON, L. A. (1994). Mechanisms of cell migration in the adult CNS. Brain Pathol. 4:123-124.
39. MATSUMOTO, M., PARK, J., SUGANO, K., and YAMADA, T. (1987). Biological activity of progastrin posttranslational processing intermediates. Am. J. Physiol. 252:G315-G319.
40. MATSUZAWA, K., FUKUYAMA, K., HUBBARD, S. L., DIRKS, P. B., and RUTKA, J. T. (1996). Transfection of an invasive human astrocytoma cell line with a TIMP-1 cDNA: modulation of astrocytoma invasive potential. J. Neuropathol. Exp. Neurol. 55:88-96.
41. MURPHY, G. M., JR, LEE, Y. L., JIA, X. C., Yu, A. C., MAJEWSKA, A., SONG, Y., SCHMIDT, K., and ENG, L. F. (1995). Tumor necrosis factor-α and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte cultures and glioblastoma cells. J. Neurochem. 65:2716-2724.
42. PAULUS, W., BAUR, I., HUETTNER, C., SCHMAUSSER, B., ROGGENDORF, W., SCHLINGENSIEPEN, K. H., and BRYSCH, W. (1995). Effects of transforming growth factor-β1 on collagen synthesis, integrin expression, adhesion and invasion of glioma cells. J. Neuropathol. Exp. Neurol. 54:236-244.
43. PILKINGTON, G. J. (1994). Tumour cell migration in the central nervous system: review. Brain Pathol. 4:157-166.
44. PRAISSMAN, M., Fox, R. L., WALDEN, M., PRAISSMAN, L. A., KROMHOLZ, N. W., ZAHRA, T., ABRAR, N., FEFFER, S. E., and GRANT, M. (1998). A novel gastrin-binding protein in the human eosinophil. Biochem. Biophys. Res. Commun. 243:779-784.
45. RADOTRA, B., and MCCORMICK, D. (1997). Glioma invasion in vitro is mediated by CD44-hyaluronan interactions. J. Pathol. 181:434-438.
46. REHFELD, J. F. (1991). Progastrin and its products in the cerebellum. Neuropeptides 20:239-245.
47. REHFELD, J. F., and HANSEN, H. F. (1986). Characterization of preprocholecystokinin products in the porcine cerebral cortex. Evidence of different processing pathways. J. Biol. Chem. 261:5832-5840.
48. REHFELD, J. F., and KRUSE-LARSEN, C. (1978). Gastrin and cholecystokinin in human cerebrospinal fluid: immunochemical determination of concentrations and molecular heterogeneity. Brain Res. 155:19-26.
49. REHFELD, J. F., LARSSON, L. I., GOLTERMANN, N. R., SCHWARTZ, T. W., HOLST, J. J., JENSEN, S. L., and MORLEY, J. S. (1980). Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK. Nature 284:33-38.
50. REHFELD, J. F., and VAN SOLINGE, W. W. (1994). The tumor biology of gastrin and cholecystokinin. Adv. Cancer Res. 63:295-347.
51. REUBI, J. C., SCHAER, J. C., and WASER, B. (1997). Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors. Cancer Res. 57:1377-1386.
52. ROMANIC, A. M., and MADRI, J. A. (1994). Extracellular matrix-degrading proteinase in the nervous system. Brain Pathol. 4:145-156.
53. RUOSLAHTI, E. (1997). Stretching is good for a cell. Science 276:1345-1346.
54. SEUFFERLEIN, T., WITHERS, D. J., BROAD, S., HERGET, T., WALSH, J. H., and ROZENGURT, E. (1995). The human CCKB/gastrin receptor transfected into rat 1 fibroblasts mediates activation of MAP kinase, p74raf-1 kinase, and mitogenesis. Cell Growth Differ. 6:383-393.
55. SEVA, C., DICKINSON, C. J., and YAMADA, T. (1994). Growth-promoting effects of glycine-extended progastrin. Science 265:410-412.
56. SINGH, P., OWLIA, A., ESPEIJO, R., and DAI, B. (1995). Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. Absence of detectable cholecystokinin (CCK)-A and CCK-B receptors. J. Biol. Chem. 270:8429-8438.
57. TAMARELLE, M., ROMEUF, M., and VANDERHAEGHEN, J. J. (1988). Immunohistochemical localization of gastrin-cholecystokinin-like material in the central nervous system of the migratory locusta. Histochemistry 89:201-207.
58. TANIGUCHI, T., TAKAISHI, K., MURAYAMA, T., ITO, M., IWATA, N., CHIHARA, K., SASAKI, T., TAKAI, Y., and MATSUI, T. (1969). Cholecystokinin-B/gastrin receptors mediate rapid formation of actin stress fibers. Oncogene 12:1357-1360.
59. TAWIL, N., WILSON, P., and CARBONETTO, S. (1993). Integrins in point contacts mediate cell spreading: factors that regulate integrin accumulation in point contacts vs. focal contacts. J. Cell Biol. 120:261-271.
60. VANDENBERG, S. R. (1992). Current diagnostic concepts of astrocytic tumors. J. Neuropathol Exp. Neurol. 51:644-657.
61. VANDERHAEGHEN, J. J., LOTSTRA, F., DE MEY, J., and GILLES, C. (1980). Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat. Proc. Natl. Acad. Sci. USA 77: 1190-1194.
62. VAN SOLINGE, W. W., NIELSEN, F. C., FRIIS-HANSEN, L., FALKMER, U. G., and REHFELD, J. F. (1993a). Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterology 104:1099-1107.
63. VAN SOUNGE, W. W., ODUM, L., and REHFELD, J. F. (1993b). Ovarian cancers express and process progastrin. Cancer Res. 53:1823-1828.