Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 3823-3833

  Lamoral Theys, Delphine ^a   Pottier, Laurent ^b   Kerff, Frédéric ^c   Dufrasne, François ^b   Proutière, Fabien ^b   Wauthoz, Nathalie ^b   Neven, Philippe ^d   Ingrassia, Laurent ^b   Antwerpen, Pierre Van ^b   Lefranc, Florence ^b   Gelbcke, Michel ^b   Pirotte, Bernard ^d   Kraus, Jean Louis ^e   Nève, Jean ^b   Kornienko, Alexander ^f   Kiss, Robert ^b   Dubois, Jacques ^a  

^a Institut de Pharmacie   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d Universite de Liege   (Belgium)

^e CNRS   (France)

^f NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

Author keywords

Apoptosis resistance; Cancer; Cytostatic activity; Kinase; Polyphenol

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA B KINASE; AURORA C KINASE; CELL PROTEIN; CURCUMIN; DIVANILLATE; METHYL VANILLATE; TRIVANILLATE; UNCLASSIFIED DRUG; VANILLIC ACID; WEE1 KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL MEMBRANE RESISTANCE; CELL STIMULATION; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; PHASE CONTRAST MICROSCOPE;

APOPTOSIS; CELL CYCLE PROTEINS; CYTOSTATIC AGENTS; INHIBITORY CONCENTRATION 50; NEOPLASMS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; VANILLIC ACID;

EID: 77953132333     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.047     Document Type: Article

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