Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity

Journal of Medicinal Chemistry

Volumn 44, Issue 20, 2001, Pages 3264-3274

  Dallavalle, S ^a   Ferrari, A ^a   Biasotti, B ^a   Merlini, L ^a   Penco, S ^b   Gallo, G ^b   Marzi, M ^b   Tinti, M O ^b   Martinelli, R ^b   Pisano, C ^b   Carminati, P ^b   Carenini, N ^c   Beretta, G ^c   Perego, P ^c   De Cesare, M ^c   Pratesi, G ^c   Zunino, F ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b R and D   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; GIMATECAN; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CYTOTOXICITY; DRUG EFFICACY; PROTEIN DNA INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; DNA; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMINES; IMMUNOBLOTTING; INHIBITORY CONCENTRATION 50; MICE; MICE, NUDE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0035960061     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0108092     Document Type: Article

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