Ring-substituted 11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides with similar patterns of cytotoxicity to the dual topo I/II inhibitor DACA

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2801-2809

  Deady, Leslie W ^a   Desneves, José ^a   Kaye, Anthony J ^a   Thompson, Michelle ^a   Finlay, Graeme J ^b   Baguley, Bruce C ^b   Denny, William A ^b  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Antitumour compounds; Chemotherapy; Enzyme inhibitors; Topoisomerase

Indexed keywords

11 OXO 11H INDENO[1,2B]QUINOLINE 6 CARBOXAMIDE; AMSACRINE; CAMPTOTHECIN; DNA TOPOISOMERASE INHIBITOR; ISATIN 7 CARBOXYLIC ACID; ISATIN DERIVATIVE; N (2 DIMETHYLAMINOETHYL) 4 ACRIDINECARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DECARBOXYLATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEWIS CARCINOMA; NONHUMAN; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; LEUKEMIA P388; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0033391196     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00231-X     Document Type: Article

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