Structural simplification of bioactive natural products with multicomponent synthesis. 2. Antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones

Journal of Medicinal Chemistry

Volumn 51, Issue 8, 2008, Pages 2561-2570

  Magedov, Igor V ^a,b   Manpadi, Madhuri ^a   Ogasawara, Marcia A ^a   Dhawan, Adriana S ^a   Rogelj, Snezna ^a   Van Slambrouck, Severine ^a   Steelant, Wim F A ^a   Evdokimov, Nikolai M ^b   Uglinskii, Pavel Y ^b   Elias, Ecrik M ^a   Knee, Erica J ^a   Tongwa, Paul ^c   Antipin, Mikhail Yu ^c,d   Kornienko, Alexander ^a  

^a NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

^b RUSSIAN STATE AGRARIAN UNIVERSITY   (Russian Federation)

^c NEW MEXICO HIGHLANDS UNIVERSITY   (United States)

^d A N NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 (2 FURYL) 6 METHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 4 (2,3 DICHLOROPHENYL) 6 METHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 4 (2,6 DICHLOROPHENYL) 6 METHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 4 (3 BROMO 4 ETHOXY 5 METHOXYPHENYL) 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (3 BROMO 4 FLUOROPHENYL) 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (3 BROMO 4 HYDROXY 5 METHOXYPHENYL) 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (3 BROMOPHENYL) 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (3 BROMOPHENYL) 7 METHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (3 HYDROXY 4 METHOXYPHENYL) 6 METHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 4 (3,4 DICHLOROPHENYL) 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (4 HYDROXY 3 METHOXY 5 NITROPHENYL) 6 METHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 4 (4 HYDROXY 3 METHOXYPHENYL) 6 METHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 4 (4 ISOPROPHENYL) 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 [3 BROMO 4 (DIMETHYLAMINO)PHENYL 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6 (3,4 DIMETHOXYPHENETHYL) 7 METHYL 5 OXO 4 (3,4,5, TRIMETHOXYPHENYL) 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6 METHYL 4 (2 NITROPHENYL) 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 6 METHYL 4 (3 NITROPHENYL) 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 6 METHYL 4 (5 METHYL 2 FURYL) 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 6 METHYL 5 OXO 4 (3 PYRIDINYL) 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 6 METHYL 5 OXO 4 (3,4,5, TRIMETHOXYPHENYL) 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6 METHYL 5 OXO 4 (4 PYRIDINYL) 5,6 DIHYDRO 4H PYRANO[3,2 C]QUINOLINE 3 CARBONITRILE; 2 AMINO 6 METHYL 5 OXO 4 PHENYL 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6,7 DIMETHYL 4 (3 NITROPHENYL) 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6,7 DIMETHYL 5 OXO 4 (3,4,5 TRIMETHOXYPHENYL) 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 4 (2 AMINO 3 CYANO 6,7 DIMETHYL 5 OXO 5,6 DIHYDRO 4H PYRANO[3,2 C]PYRID 4 YL) 2 BROMO 6 METHOXYPHENYL ACETATE; ANTINEOPLASTIC ALKALOID; PYRANO[3,2 C]PYRIDONE; PYRANO[3,2 C]QUINOLONE; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PYRIDONES; QUINOLONES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TUBULIN;

EID: 43049113156     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701499n     Document Type: Article

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