Synthesis and antitumor properties of N-[2- (dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: A new class of putative topoisomerase inhibitors

Journal of Medicinal Chemistry

Volumn 40, Issue 13, 1997, Pages 2040-2046

  Deady, Leslie W ^a   Kaye, Anthony J ^a   Finlay, Graeme J ^a   Baguley, Bruce C ^a   Denny, William A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACID ANHYDRIDE; AMSACRINE; CAMPTOTHECIN; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETHYLENEDIAMINE DERIVATIVE; ETOPOSIDE; FORMIC ACID DERIVATIVE; GYRASE INHIBITOR; N [2 (DIMETHYLAMINO)ETHYL] 11 OXO 11H INDENO[1,2 B]QUINOLINE 6 CARBOXAMIDE; N,N' DIMETHYLETHYLENEDIAMINE; QUINOLINE DERIVATIVE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DECARBOXYLATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TUMOR; TUMOR VOLUME;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MICE; MICE, INBRED C57BL; MODELS, CHEMICAL; PHENAZINES; QUINOLINES; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0030968181     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970044r     Document Type: Article

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