Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis

Journal of Medicinal Chemistry

Volumn 50, Issue 21, 2007, Pages 5183-5192

  Magedov, Igor V ^a,c   Manpadi, Madhuri ^b   Van Slambrouck, Severine ^b   Steelant, Wim F A ^b   Rozhkova, Elena ^a   Przheval'skii, Nikolai M ^a   Rogelj, Snezna ^b   Kornienko, Alexander ^b  

^a RUSSIAN STATE AGRARIAN UNIVERSITY   (Russian Federation)

^b NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

^c Intelbioscan Ltd   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

PODOPHYLLOTOXIN DERIVATIVE; PYRAZOLE DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE CULTURE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; LYMPHOCYTES; PODOPHYLLOTOXIN; PYRAZOLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35348813795     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070528f     Document Type: Article

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