The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3970-3980

  Bom, D ^a   Curran, D P ^a   Kruszewski, S ^d   Zimmer, S G ^b,c   Strode, J T ^b   Kohlhagen, G ^d   Du, W ^a   Chavan, A J ^e   Fraley, K A ^b   Bingcang, A L ^b   Latus, L J ^e   Pommier, Y ^d   Burke, T G ^b,e  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b University of Kentucky   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e Tigen Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 TERT BUTYLDIMETHYLSILYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DB 67; HUMAN SERUM ALBUMIN; IRINOTECAN; LACTONE DERIVATIVE; SILATECAN; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD; CYTOTOXICITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG STABILITY; HUMAN; LIPOPHILICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; ELECTROPHORESIS, AGAR GEL; HUMANS; HYDROLYSIS; KINETICS; MICE; MICE, NUDE; ORGANOSILICON COMPOUNDS; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034687233     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000144o     Document Type: Article

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