Translokin (Cep57) Interacts with Cyclin D1 and Prevents Its Nuclear Accumulation in Quiescent Fibroblasts

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Volumn 12, Issue 5, 2011, Pages 549-562

  Ruiz Miró, Maria ^a   Colomina, Neus ^a   Fernández, Rita M H ^a   Garí, Eloi ^a   Gallego, Carme ^a,b   Aldea, Martí ^a,b  

^a UNIVERSITY OF LLEIDA   (Spain)

^b INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

Author keywords

Cell cycle; Cell proliferation; Cell quiescence; Cep57; Cyclin D1; Translokin

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN CEP57; TRANSLOKIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; CARRIER PROTEINS; CELL CYCLE; CELL NUCLEUS; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; FIBROBLASTS; HUMANS; MICE; MICE, KNOCKOUT; RETINOBLASTOMA PROTEIN;

EID: 79953750627     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/j.1600-0854.2011.01176.x     Document Type: Article

References (61)

1. PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 1992;71:323-334.
2. Bockstaele L, Coulonval K, Kooken H, Paternot S, Roger PP. Regulation of CDK4. Cell Div 2006;1:25.
3. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 1991;65:701-713.
4. Xiong Y, Connolly T, Futcher B, Beach D. Human D-type cyclin. Cell 1991;65:691-699.
5. Sherr CJ. D-type cyclins. Trends Biochem Sci 1995;20:187-190.
6. Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004;8:2699-2711.
7. Lamb J, Ramaswamy S, Ford HL, Contreras B, Martinez RV, Kittrell FS, Zahnow CA, Patterson N, Golub TR, Ewen ME. A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 2003;114:323-334.
8. Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 2006;9:13-22.
9. Kim JK, Diehl JA. Nuclear cyclin D1: an oncogenic driver in human cancer. J Cell Physiol 2009;220:292-296.
10. Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009;9:153-166.
11. Klein EA, Assoian RK. Transcriptional regulation of the cyclin D1 gene at a glance. J Cell Sci 2008;121:3853-3857.
12. Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998;12:3499-3511.
13. INK4b is a potential effector of TGF-β-induced cell cycle arrest. Nature 1994;371:257-261.
14. Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 1995;375:503-506.
15. INK4b. Nat Cell Biol 2001;3:400-408.
16. Pei XH, Xiong Y. Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues. Oncogene 2005;24:2787-2795.
17. Petropavlovskaia M, Bodnar CA, Behie LA, Rosenberg L. Pancreatic small cells: analysis of quiescence, long-term maintenance and insulin expression in vitro. Exp Cell Res 2007;313:931-942.
18. Blain SW. Switching cyclin D-Cdk4 kinase activity on and off. Cell Cycle 2008;7:892-898.
19. LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E. New functional activities for the p21 family of CDK inhibitors. Genes Dev 1997;11:847-862.
20. Kip1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999;18:1571-1583.
21. Cheng M, Sexl V, Sherr CJ, Roussel MF. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sci U S A 1998;95:1091-1096.
22. Ladha MH, Lee KY, Upton TM, Reed MF, Ewen ME. Regulation of exit from quiescence by p27 and cyclin D1-CDK4. Mol Cell Biol 1998;18:6605-6615.
23. KIP2 in the control of tissue growth and development. Genes Dev 1998;12:3162-3167.
24. Ezoe S, Matsumura I, Satoh Y, Tanaka H, Kanakura Y. Cell cycle regulation in hematopoietic stem/progenitor cells. Cell Cycle 2004;3:314-318.
25. Walkley CR, Fero ML, Chien WM, Purton LE, McArthur GA. Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells. Nat Cell Biol 2005;7:172-178.
26. Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 2006;20:47-64.
27. KIP1 are directly regulated by oncogenic tyrosine kinases. Cell 2007;128:269-280.
28. Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol Cell Biol 2008;28:498-510.
29. KIP1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol 2008;28:6462-6472.
30. Diehl JA, Sherr CJ. A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase. Mol Cell Biol 1997;17:7362-7374.
31. Litovchick L, Sadasivam S, Florens L, Zhu X, Swanson SK, Velmurugan S, Chen R, Washburn MP, Liu XS, DeCaprio JA. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol Cell 2007;26:539-551.
32. Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001;411:1017-1021.
33. Min mice. Mol Cell Biol 2004;24:7598-7611.
34. Aggarwal P, Lessie MD, Lin DI, Pontano L, Gladden AB, Nuskey B, Goradia A, Wasik MA, Klein-Szanto AJ, Rustgi AK, Bassing CH, Diehl JA. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev 2007;21:2908-2922.
35. Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, Nakagawa H, Lu F, Rustgi AK, Diehl JA. Mutations in Fbx4 inhibit dimerization of the SCF (Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 2008;14:68-78.
36. Alt JR, Cleveland JL, Hannink M, Diehl JA. Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 2000;14: 3102-3114.
37. FBX4-αBcrystallin complex. Mol Cell 2006;24:355-366.
38. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 1993;7:812-821.
39. Sumrejkanchanakij P, Tamamori-Adachi M, Matsunaga Y, Eto K, Ikeda MA. Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons. Oncogene 2003;22:8723-8730.
40. Campa VM, Gutiérrez-Lanza R, Cerignoli F, Díaz-Trelles R, Nelson B, Tsuji T, Barcova M, Jiang W, Mercola M. Notch activates cell cycle reentry and progression in quiescent cardiomyocytes. J Cell Biol 2008;183:129-141.
41. Garí E, Volpe T, Wang H, Gallego C, Futcher B, Aldea M. Whi3 binds the mRNA of the G1 cyclin CLN3 to modulate cell fate in budding yeast. Genes Dev 2001;15:2803-2808.
42. Wang H, Garí E, Vergés E, Gallego C, Aldea M. Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin-CDK complex to late G1. EMBO J 2004;23:180-190.
43. Vergés E, Colomina N, Garí E, Gallego C, Aldea M. Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry. Mol Cell 2007;26:649-662.
44. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M. Proteomic characterization of the human centrosome by protein correlation profiling. Nature 2003;426:570-574.
45. Momotani K, Khromov AS, Miyake T, Stukenberg PT, Somlyo AV. Cep57, a multidomain protein with unique microtubule and centrosomal localization domains. Biochem J 2008;412:265-273.
46. Emanuele MJ, Stukenberg PT. Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment. Cell 2007;130:893-905.
47. Bossard C, Laurell H, Van den Berghe L, Meunier S, Zanibellato C, Prats H. Translokin is an intracellular mediator of FGF-2 trafficking. Nat Cell Biol 2003;5:433-439.
48. Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Mol Cell Biol 2003;23:7285-7290.
49. Diehl JA, Zindy F, Sherr CJ. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev 1997;11:957-972.
50. Hinds PW, Dowdy SF, Eaton EN, Arnold A, Weinberg RA. Function of a human cyclin gene as an oncogene. Proc Natl Acad Sci U S A 1994;91:709-713.
51. Day PJ, Cleasby A, Tickle IJ, O'Reilly M, Coyle JE, Holding FP, McMenamin RL, Yon J, Chopra R, Lengauer C, Jhoti H. Crystal structure of human CDK4 in complex with a D-type cyclin. Proc Natl Acad Sci U S A 2009;106:4166-4170.
52. Kip1 for restriction point control of the fibroblast cell cycle. Science 1996;272:877-880.
53. Kitagawa M, Higashi H, Jung HK, Suzuki-Takahashi I, Ikeda M, Tamai K, Kato J, Segawa K, Yoshida E, Nishimura S, Taya Y. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 1996;15:7060-7069.
54. Sherr CJ. G1 phase progression: cycling on cue. Cell 1994;79: 551-555.
55. Alao JP. The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 2007;6:24-34.
56. Alao JP, Gamble SC, Stavropoulou AV, Pomeranz KM, Lam EW, Coombes RC, Vigushin DM. The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. Mol Cancer 2006;5:7-17.
57. Meunier S, Navarro MG, Bossard C, Laurell H, Touriol C, Lacazette E, Prats H. Pivotal role of translokin/CEP57 in the unconventional secretion versus nuclear translocation of FGF2. Traffic 2009;10:1765-1772.
58. Taulés M, Rius E, Talaya D, López-Girona A, Bachs O, Agell N. Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1. J Biol Chem 1998;273:33279-33286.
59. Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K, Roger PP. Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase. Cell Cycle 2010;9:689-699.
60. Lents NH, Keenan SM, Bellone C, Baldassare JJ. Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted Cdk2. J Biol Chem 2002;277:47469-47475.
61. Henry MK, Nimbalkar D, Hohl RJ, Quelle FW. Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells. Exp Cell Res 2004;299:257-266.