The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines

Molecular Cancer

Volumn 5, Issue , 2006, Pages

  Alao, John P ^a   Gamble, Simon C ^a   Stavropoulou, Alexandra V ^a   Pomeranz, Karen M ^a   Lam, Eric W F ^a   Coombes, R Charles ^a   Vigushin, David M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLOHEXIMIDE; CYTOPLASM PROTEIN; EXPORTIN 1; GLYCOGEN SYNTHASE KINASE 3BETA; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CELL RECEPTOR; ENZYME INHIBITOR; EXPORTIN 1 PROTEIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; KARYOPHERIN; LEPTOMYCIN B; LEUPEPTIN; PROTEASOME; PROTEIN SYNTHESIS INHIBITOR; TRICHOSTATIN A; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL FRACTIONATION; CELL NUCLEUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MAMMAL CELL; MOUSE; NONHUMAN; PROTEIN LOCALIZATION; PROTO ONCOGENE; RAT; REGULATORY MECHANISM; ACTIVE TRANSPORT; ANIMAL; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HELA CELL; METABOLISM; PROTEIN PROCESSING;

ANIMALIA; MAMMALIA; MINK CELL FOCUS-FORMING VIRUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL CYCLE; CELL NUCLEUS; CYCLIN D1; CYCLOHEXIMIDE; CYTOPLASM; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; KARYOPHERINS; LEUPEPTINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SYNTHESIS INHIBITORS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSFECTION;

EID: 33644785694     PISSN: 14764598     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-5-7     Document Type: Article

References (23)

1. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G: Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 1993, 7:812-821.
2. Guo Y, Yang K, Harwalkar J, Nye JM, Mason DR, Garrett MD, Hitomi M, Stacey DW: Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis. Oncogene 2005, 24:2599-2612.
3. Diehl JA, Cheng M, Roussel MF, Sherr CJ: Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998, 12:3499-3511.
4. Agami R, Bernards R: Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell 2000, 102:55-66.
5. Germain D, Russell A, Thompson A, Hendley J: Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286. J Biol Chem 2000, 275:12074-12079.
6. Zou Y, Ewton DZ, Deng X, Mercer SE, Friedman E Mirk/dyrk IB kinase destabilizes cyclin D1 by phosphorylation at threonine 288. J Biol Chem 2004, 279:27790-27798.
7. Coqueret O: Linking cyclins to transcriptional control. Gene 2002, 299:35-55.
8. Ewen ME, Lamb J: The activities of cyclin D1 that drive tumorigenesis. Trends Mol Med 2004, 10:158-162.
9. Tamamori-Adachi M, Ito H, Sumrejkanchanakij P, Adachi S, Hiroe M, Shimizu M, Kawauchi J, Sunamori M, Marumo F, Kitajima S. Ikeda MA: Critical role of cyclin D1 nuclear Import in cardiomyocyte proliferation. Circ Res 2003, 92:e12-9.
10. Sumrejkanchanakij P, Tamamori-Adachi M, Matsunaga Y, Eto K, Ikeda MA: Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons. Oncogene 2003, 22:8723-8730.
11. Alao JP, Lam EW, Ali S, Buluwela L, Bordogna W, Lockey P. Varshochi R, Stavropoulou AV, Coombes RC, Vigushin DM: Histone deacety. lase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. Clin Cancer Res 2004, 10:8094-8104.
12. Ganiatsas S, Dow R, Thompson A, Schulman B, Germain D: A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SKUT. Oncogene 2001, 20:3641-3650.
13. Russell A, Thompson MA, Hendley J, Trute L, Armes J, Germain D: Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer. Oncogene 1999, 18:1983-1991.
14. De Falco M, Fedele V, De Luca L, Penta R, Cottone G, Cavallotti I, Laforgia V, De Luca A: Evaluation of cyclin D1 expression and its subcellular distribution in mouse tissues. J Anat 2004, 205:405-412.
15. Foster JS, Henley DC, Bukovsky A, Seth P, Wimalasena J: Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function. Mot Cell Biol 2001, 21:794-810.
16. Prall OW, Sarcevic B, Musgrove EA, Watts CK, Sutherland RL: Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J Biol Chem 1997, 272:10882-10894.
17. Sabbah M, Courilleau D, Mester J, Redeuilh G: Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element. Proc Natl Acad Sci U S A 1999, 96:11217-11222.
18. Yu ZK, Gervais JL, Zhang H: Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIPI/WAFI) and cyclin D proteins. Proc Natl Acad Sci U S A 1998, 95:11324-11329.
19. Choi YH, Lee SJ, Nguyen P, Jang JS, Lee J, Wu ML, Takano E, Maki M, Henkart PA, Trepel JB: Regulation of cyclin D1 by calpain protease. J Biol Chem 1997, 272:28479-28484.
20. Alt JR, Cleveland JL, Hannink M, Diehl JA: Phosphorylationdependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 2000, 14:3102-3114.
21. Solomon DA, Wang, Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Conti CJ, Knudsen ES: Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem 2003, 278:30339-30347.
22. Ino H, Chiba T: Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo. J Neurosci 2001, 21:6086-6094.
23. Kranenburg O, van der Eb AJ, Zantema A: Cyclin D1 is an essential mediator of apoptotic neuronal cell death. Embo J 1996, 15:46-54.