Crystal structure of human CDK4 in complex with a D-type cyclin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 11, 2009, Pages 4166-4170

  Day, Philip J ^a   Cleasby, Anne ^a   Tickle, Ian J ^a   O'Reilly, Marc ^a   Coyle, Joe E ^a   Holding, Finn P ^a   McMenamin, Rachel L ^a   Yon, Jeff ^a   Chopra, Rajiv ^b   Lengauer, Christoph ^c   Jhoti, Harren ^a  

^a ASTEX PHARMACEUTICALS   (United Kingdom)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c SANOFI   (France)

Author keywords

CDK4; Cell cycle; Cyclind; Kinase; X ray

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; HETERODIMER;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL CYCLE G1 PHASE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME REGULATION; GENE MUTATION; GENETIC VARIABILITY; MULTIPLE CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T WAVE; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; HUMANS; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 63149148791     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809645106     Document Type: Article

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