Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells

Experimental Cell Research

Volumn 299, Issue 1, 2004, Pages 257-266

  Henry, Matthew K ^a   Nimbalkar, Dipali ^a   Hohl, Raymond J ^a   Quelle, Frederick W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

CDK2; Erythropoietin; Interleukin 3; Phosphoinositide 3 kinase; Proliferation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYTOKINE; ERYTHROPOIETIN; INTERLEUKIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P27;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; HEMATOPOIETIC CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

EID: 4043179100     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.06.003     Document Type: Article

References (52)

1. Morgan D.O. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13:1997;261-291
2. Harper Z.W., Adams P.D. Cyclin-dependent kinases. Chem. Rev. 101:2001;2511-2526
3. Harbour J.W., Dean D.C. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 14:2000;2393-2409
4. Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1999;1501-1512
5. Ekholm S.V., Reed S.I. Regulation of G(1) cyclin dependent kinases in the mammalian cell cycle. Curr. Opin. Cell Biol. 12:2000;676-684
6. Kaldis P. The cdk-activating kinase (CAK): from yeast to mammals. Cell. Mol. Life Sci. 55:1999;284-296
7. Harper J.W., Elledge S.J. The role of Cdk7 in CAK function, a retro-retrospective. Genes Dev. 12:1998;285-289
8. Gadina M., Hilton D., Johnston J.A., Morinobu A., Lighvani A., Zhou Y.J., Visconti R., O'Shea J.J. Signaling by type I and II cytokine receptors: ten years after. Curr. Opin. Immunol. 13:2001;363-373
9. Witthuhn B.A., Quelle F.W., Silvennoinen O., Yi T., Tang B., Miura O., Ihle J.N. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 74:1993;227-236
10. Miura O., Nakamura N., Quelle F.W., Witthuhn B.A., Ihle J.N., Aoki N. Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo. Blood. 84:1994;1501-1507
11. Zhuang H., Patel S.V., He T.C., Sonsteby S.K., Niu Z., Wojchowski D.M. Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J. Biol. Chem. 269:1994;21411-21414
12. Quelle F.W., Wang D., Nosaka T., Thierfelder W.E., Stravopodis D., Weinstein Y., Ihle J.N. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol. Cell. Biol. 16:1996;1622-1631
13. Zang H.S., Sato K., Nakajima H., McKay C., Ney P.A., Ihle J.N. The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J. 20:2001;3156-3166
14. Miura O., D'Andrea A., Kabat D., Ihle J.N. Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis. Mol. Cell. Biol. 11:1991;4895-4902
15. Miura O., Nakamura N., Ihle J.N., Aoki N. Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor. J. Biol. Chem. 269:1994;614-620
16. Cantrell D.A. Phosphoinositide 3-kinase signalling pathways. J. Cell. Sci. 114:2001;1439-1445
17. Cantley L.C. The phosphoinositide 3-kinase pathway. Science. 296:2002;1655-1657
18. Toker A. Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol. Pharmacol. 57:2000;652-658
19. Sato N., Sakamaki K., Terada N., Arai K., Miyajima A. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J. 12:1993;4181-4189
20. Mathieu A.L., Gonin S., Leverrier Y., Blanquier B., Thomas J., Dantin C., Martin G., Baverel G., Marvel J. Activation of the phosphatidylinositol 3-kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis. J. Biol. Chem. 276:2001;10935-10942
21. Songyang Z., Baltimore D., Cantley L.C., Kaplan D.R., Franke T.F. Interleukin 3-dependent survival by the Akt protein kinase. Proc. Natl. Acad. Sci. 94:1997;11345-11350
22. Craddock B.L., Orchiston E.A., Hinton H.J., Welham M.J. Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling. J. Biol. Chem. 274:1999;10633-10640
23. Haseyama Y., Sawada K., Oda A., Koizumi K., Takano H., Tarumi T., Nishio, Handa M., Ikeda Y., Koike T. Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis. Blood. 94:1999;1568-1577
24. Bao H., Jacobs-Helber S.M., Lawson A.E., Penta K., Wickrema A., Sawyer S.T. Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells). Blood. 93:1999;3757-3773
25. Craddock B.L., Hobbs J., Edmead C.E., Welham M.J. Phosphoinositide 3-Kinase-dependent Regulation of Interleukin-3-induced Proliferation. Involvement of mitogen-activated protein kinases, SHP2 and Gab2. J. Biol. Chem. 276:2001;24274-24283
26. Brennan P., Babbage J.W., Thomas G., Cantrell D. p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol. Cell. Biol. 19:1999;4729-4738
27. Brennan P., Babbage J.W., Burgering B.M., Groner B., Reif K., Cantrell D.A. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity. 7:1997;679-689
28. Mahmud D.L., Amlak M., Deb D.K., Platanias L.C., Uddin S., Wickrema A. Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene. 21:2002;1556-1562
29. Bouscary D., Pene F., Claessens Y.E., Muller O., Chretien S., Fontenay-Roupie M., Gisselbrecht S., Mayeux P., Lacombe C. Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation. Blood. 101:2003;3436-3443
30. Henry M.K., Lynch J.T., Eapen A.K., Quelle F.W. DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway. Blood. 98:2001;834-841
31. Eapen A.K., Henry M.K., Quelle D.E., Quelle F.W. DNA damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2. Mol. Cell. Biol. 21:2001;6113-6121
32. Nimbalkar D., Henry M.K., Quelle F.W. Cytokine activation of phosphoinositide 3-kinase sensitizes hematopoietic cells to cisplatin-induced death. Cancer Res. 63:2003;1034-1039
33. Matsushime H., Quelle D.E., Shurtleff S.A., Shibuya M., Sherr C.J., Kato J.Y. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14:1994;2066-2076
34. Damen J.E., Cutler R.L., Jiao H., Yi T., Krystal G. Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity. J. Biol. Chem. 270:1995;23402-23408
35. Klingmuller U., Wu H., Hsiao J.G., Toker A., Duckworth B.C., Cantley L.C., Lodish H.F. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc. Natl. Acad. Sci. 94:1997;3016-3021
36. Brugarolas J., Moberg K., Boyd S.D., Taya Y., Jacks T., Lees J.A. Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proc. Natl. Acad. Sci. 96:1999;1002-1007
37. Verdier F., Chretien S., Billat C., Gisselbrecht S., Lacombe C., Mayeux P. Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation. J. Biol. Chem. 272:1997;26173
38. Wang L.M., Myers M.G., Sun X.J., Aaronson S.A., White M., Pierce J.H. IRS-1 - Essential for insulin-stimulated and il-4-stimulated mitogenesis in hematopoietic-cells. Science. 261:1993;1591-1594
39. Wickrema A., Uddin S., Sharma A., Chen F., Alsayed Y., Ahmad S., Sawyer S.T., Krystal G., Yi T., Nishada K., Hibi M., Hirano T., Platanias L.C. Engagement of Gab1 and Gab2 in erythropoietin signaling. J. Biol. Chem. 274:1999;24469-24474
40. Medema R.H., Kops G.J.P.L., Bos J.L., Burgering B.M.T. AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27(kip1). Nature. 404:2000;782-787
41. Dijkers P.F., Medema R.H., Pals C., Banerji L., Thomas N.S., Lam E.W., Burgering B.M., Raaijmakers J.A., Lammers J.W., Koenderman L., Coffer P.J. Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol. Cell. Biol. 20:2000;9138-9148
42. Montagnoli A., Fiore F., Eytan E., Carrano A.C., Draetta G.F., Hershko A., Pagano M. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13:1999;1181-1189
43. Shirane M., Harumiya Y., Ishida N., Hirai A., Miyamoto C., Hatakeyama S., Nakayama K., Kitagawa M. Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing. J. Biol. Chem. 274:1999;13886-13893
44. Diehl J.A., Cheng M., Roussel M.F., Sherr C.J. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12:1998;3499-3511
45. Kato J.Y., Sherr C.J. Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1. Proc. Natl. Acad. Sci. 90:1993;11513-11517
46. Tetsu O., McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell. 3:2003;233-245
47. Ortega S., Prieto I., Odajima J., Martin A., Dubus P., Sotillo R., Barbero J.L., Malumbres M., Barbacid M. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35:2003;25-31
48. Roberts J.M., Sherr C.J. Bared essentials of CDK2 and cyclin E. Nat. Genet. 35:2003;9-10
49. Chiariello M., Gomez E., Gutkind J.S. Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G(1) phase. Biochem. J. 349:2000;869-876
50. Kaldis P., Solomon M.J. Analysis of CAK activities from human cells. Eur. J. Biochem. 267:2000;4213-4221
51. Nagahara H., Ezhevsky S.A., Vocero-Akbani A.M., Kaldis P., Solomon M.J., Dowdy S.F. Transforming growth factor beta targeted inactivation of cyclin E: cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proc. Natl. Acad. Sci. 96:1999;14961-14966
52. Liu Y., Wu C., Galaktionov K. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. J. Biol. Chem. 279:2004;4507-4514