Role and mechanism of pancreatic β-cell death in diabetes: The emerging role of autophagy

Journal of Diabetes Investigation

Volumn 1, Issue 6, 2010, Pages 232-238

  Kim, Kyoung Ah ^a   Lee, Myung Shik ^b  

^a Dongguk University Ilsan Hospital   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

cell death; Autophagy; Diabetes

Indexed keywords

AUTOPHAGY RELATED 7 PROTEIN; CELL PROTEIN; FATTY ACID; GAMMA INTERFERON; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; REACTIVE OXYGEN METABOLITE; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AGING; APOPTOSIS; AUTOPHAGY; DISEASE ASSOCIATION; DISEASE COURSE; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; LIPID PEROXIDATION; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 79953747758     PISSN: 20401116     EISSN: 20401124     Source Type: Journal    
DOI: 10.1111/j.2040-1124.2010.00054.x     Document Type: Review

References (49)

1. Masini M, Bugliani M, Lupi R, et al. Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia 2009; 52: 1083-1086.
2. Kim YH, Kim S, Kim KA, et al. Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes. Eur J Immunol 1999; 29: 455-465.
3. O'Brien BA, Huang Y, Geng X, et al. Phagocytosis of apopto-tic cells by macrophages from NOD mice is reduced. Diabetes 2002; 51: 2481-2488.
4. Chervonsky AV, Wang Y, Wong FS, et al. The role of Fas in autoimmune diabetes. Cell 1997; 89: 17-24.
5. Kim S, Kim KA, Hwang DY, et al. Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved. J Immunol 2000; 164: 2931-2936.
6. -/-). Diabetes 2000; 49: 1116-1122.
7. Suk K, Kim S, Kim YH, et al. IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J Immunol 2001; 166: 4481-4489.
8. Gysemans CA, Ladriere L, Callewaert H, et al. Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes 2005; 54: 2396-2403.
9. Kim S, Kim HS, Chung KW, et al. Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice. Diabetes 2007; 56: 2561-2568.
10. Beg AA, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996; 274: 782-784.
11. Giannoukakis N, Rudert WA, Trucco M, et al. Protection of human islets from the effects of interleukin-1beta by adeno-viral gene transfer of an Ikappa B repressor. J Biol Chem 2000; 275: 36509-36513.
12. Kim S, Millet I, Kim HS, et al. NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci USA 2007; 104: 1913-1918.
13. Kim HS, Kim S, Lee MS. IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation. Biochem Biophys Res Commun 2005; 336: 847-853.
14. Butler AE, Janson J, Bonner-Weir S, et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102-110.
15. Yoon KH, Ko SH, Cho JH, et al. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 2003; 88: 2300-2308.
16. Kaneto H, Kajimoto Y, Miyagawa J, et al. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 1999; 48: 2398-2406.
17. Janson J, Ashley RH, Harrison D, et al. The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 1999; 48: 491-498.
18. Lorenzo A, Razzaboni B, Weir GC, et al. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 1994; 368: 756-760.
19. Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 1996; 97: 2859-2865.
20. Shimabukuro M, Zhou YT, Levi M, et al. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 1998; 95: 2498-2502.
21. Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994; 93: 870-876.
22. Paumen MB, Ishida Y, Muramatsu M, et al. Inhibition of camitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem 1997; 272: 3324-3329.
23. Martinez SC, Tanabe K, Cras-Meneur C, et al. Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 2008; 57: 846-859.
24. Solinas G, Naugler W, Galimi F, et al. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-medi-ated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci USA 2006; 103: 16454-16459.
25. Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008; 7: 45-56.
26. Montell E, Turini M, Marotta M, et al. DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. Am J Physiol Endocrinol Metab 2001; 280: E229-E237.
27. Perseghin G, Scifo P, De Cobelli F, et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 1999; 48: 1600-1606.
28. Han MS, Park SY, Shinzawa K, et al. Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. J Lipid Res 2008; 49: 84-97.
29. Takasu N, Komiya I, Asawa T, et al. Streptozocin- and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation. Diabetes 1991; 40: 1141-1145.
30. Bonner-Weir S. Life and death of the pancreatic beta cells. Trends Endocrinol Metab 2000; 11: 375-378.
31. Savill J, Dransfield I, Gregory C, et al. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2002; 2: 965-975.
32. Kim HS, Han MS, Chung KW, et al. Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes. Immunity 2007; 27: 321-333.
33. Ding WX, Ni HM, Gao W, et al. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol 2007; 171: 513-524.
34. Maiuri MC, Zalckvar E, Kimchi A, et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8: 741-752.
35. Uchizono Y, Alarcon C, Wicksteed BL, et al. The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead? Diabetes Obes Metab 2007; 9(Suppl. 2): 56-66.
36. Kaniuk NA, Kiraly M, Bates H, et al. Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 2007; 56: 930-939.
37. Twig G, Elorza A, Molina AJ, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 2008; 27: 433-446.
38. Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet homeostasis and compensatory increase of Beta cell mass in response to high-fat diet. Cell Metab 2008; 8: 325-332.
39. Jung HS, Chung KW, Won KJ, et al. Loss of autophagy diminishes pancreatic Beta cell mass and function with resultant hyperglycemia. Cell Metab 2008; 8: 318-324.
40. Choi SE, Lee SM, Lee YJ, et al. Protective role of autophagy in palmitate-induced INS-1 beta-cell death. Endocrinology 2009; 150: 126-134.
41. Fujimoto K, Hanson PT, Tran H, et al. Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J Biol Chem 2009; 284: 27664-27673.
42. Cavallini G, Donati A, Taddei M, et al. Evidence for selective mitochondrial autophagy and failure in aging. Autophagy 2007; 3: 21-27.
43. Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature 2009; 458: 1131-1135.
44. Shibata M, Yoshimura K, Furuya N, et al. The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun 2009; 382: 419-423.
45. Singh R, Xiang Y, Wang Y, et al. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 2009; 119: 3329-3339.
46. Zhang Y, Goldman S, Baerga R, et al. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci USA 2009; 106: 19860-19865.
47. Zhou L, Zhang J, Fang Q, et al. Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticu-lum stress-induced insulin resistance. Mol Pharmacol 2009; 76: 596-603.
48. Liu HY, Han J, Cao SY, et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key auto-phagy genes by insulin. J Biol Chem 2009; 284: 31484-31492.
49. Yang L, Li P, Fu S, et al. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 2010; 11: 467-478.