-
1
-
-
0034708832
-
307
-
DOI 10.1074/jbc.275.12.9047
-
Aguirre V, Uchida T, Yenush L, Davis R, and White MF (2000) The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-9054. (Pubitemid 30180265)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.12
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
2
-
-
23644448924
-
Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle
-
DOI 10.2337/diabetes.54.8.2351
-
Bandyopadhyay GK, Yu JG, Ofrecio J, and Olefsky JM (2005) Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulinresistant human skeletal muscle. Diabetes 54:2351-2359. (Pubitemid 41134262)
-
(2005)
Diabetes
, vol.54
, Issue.8
, pp. 2351-2359
-
-
Bandyopadhyay, G.K.1
Yu, J.G.2
Ofrecio, J.3
Olefsky, J.M.4
-
3
-
-
0028214959
-
Insulin receptor down-regulation and impaired antilipolytic action of insulin in diabetic patients after pancreas/kidney transplantation
-
DOI 10.1210/jc.78.3.657
-
Boden G, Chen X, Ruiz J, Heifets M, Morris M, and Badosa F (1994) Insulin receptor down-regulation and impaired antilipolytic action of insulin in diabetic patients after pancreas/kidney transplantation. J Clin Endocrinol Metab 78:657-663. (Pubitemid 24083307)
-
(1994)
Journal of Clinical Endocrinology and Metabolism
, vol.78
, Issue.3
, pp. 657-663
-
-
Boden, G.1
Chen, X.2
Ruiz, J.3
Heifets, M.4
Morris, M.5
Badosa, F.6
-
4
-
-
52749093177
-
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
-
Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, et al. (2008) Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 8:325-332.
-
(2008)
Cell Metab
, vol.8
, pp. 325-332
-
-
Ebato, C.1
Uchida, T.2
Arakawa, M.3
Komatsu, M.4
Ueno, T.5
Komiya, K.6
Azuma, K.7
Hirose, T.8
Tanaka, K.9
Kominami, E.10
-
5
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
DOI 10.1210/er.2007-0015
-
Eizirik DL, Cardozo AK, and Cnop M (2008) The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29:42-61. (Pubitemid 351252746)
-
(2008)
Endocrine Reviews
, vol.29
, Issue.1
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
6
-
-
0027466662
-
Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action
-
Formisano P, Sohn KJ, Miele C, Di Finizio B, Petruzziello A, Riccardi G, Beguinot L, and Beguinot F (1993) Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action. J Biol Chem 268:5241-5248. (Pubitemid 23081654)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.7
, pp. 5241-5248
-
-
Formisano, P.1
Sohn, K.-J.2
Miele, C.3
Di Finizio, B.4
Petruzziello, A.5
Riccardi, G.6
Beguinot, L.7
Beguinot, F.8
-
7
-
-
3442895916
-
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
-
DOI 10.1210/me.2003-0383
-
Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, and Ye J (2004) Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol 18:2024-2034. (Pubitemid 39006506)
-
(2004)
Molecular Endocrinology
, vol.18
, Issue.8
, pp. 2024-2034
-
-
Gao, Z.1
Zhang, X.2
Zuberi, A.3
Hwang, D.4
Quon, M.J.5
Lefevre, M.6
Ye, J.7
-
8
-
-
0022656205
-
Insulin induces progressive insulin resistance in cultured rat adipocytes. Sequential effects at receptor and multiple postreceptor sites
-
Garvey WT, Olefsky JM, and Marshall S (1986) Insulin induces progressive insulin resistance in cultured rat adipocytes. Sequential effects at receptor and multiple postreceptor sites. Diabetes 35:258-267.
-
(1986)
Diabetes
, vol.35
, pp. 258-267
-
-
Garvey, W.T.1
Olefsky, J.M.2
Marshall, S.3
-
9
-
-
0027333074
-
Ala1048==Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance
-
Haruta T, Takata Y, Iwanishi M, Maegawa H, Imamura T, Egawa K, Itazu T, and Kobayashi M (1993) Ala1048→Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance. Diabetes 42:1837-1844. (Pubitemid 2016694)
-
(1993)
Diabetes
, vol.42
, Issue.12
, pp. 1837-1844
-
-
Haruta, T.1
Takata, Y.2
Iwanishi, M.3
Maegawa, H.4
Imamura, T.5
Egawa, K.6
Itazu, T.7
Kobayashi, M.8
-
10
-
-
23944475571
-
Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1
-
DOI 10.1016/j.bbrc.2005.07.152, PII S0006291X05016426
-
Hiratani K, Haruta T, Tani A, Kawahara J, Usui I, and Kobayashi M (2005) Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1. Biochem Biophys Res Commun 335:836-842. (Pubitemid 41188274)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.335
, Issue.3
, pp. 836-842
-
-
Hiratani, K.1
Haruta, T.2
Tani, A.3
Kawahara, J.4
Usui, I.5
Kobayashi, M.6
-
11
-
-
0027335557
-
1193) in the tyrosine kinase domain of the insulin receptor associated with type a syndrome of insulin resistance
-
Iwanishi M, Haruta T, Takata Y, Ishibashi O, Sasaoka T, Egawa K, Imamura T, Naitou K, Itazu T, and Kobayashi M (1993) A mutation (Trp1193→Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance. Diabetologia 36:414-422. (Pubitemid 23124045)
-
(1993)
Diabetologia
, vol.36
, Issue.5
, pp. 414-422
-
-
Iwanishi, M.1
Haruta, T.2
Takata, Y.3
Ishibashi, O.4
Sasaoka, T.5
Egawa, K.6
Imamura, T.7
Naitou, K.8
Itazu, T.9
Kobayashi, M.10
-
12
-
-
0029879127
-
Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality
-
Joshi RL, Lamothe B, Cordonnier N, Mesbah K, Monthioux E, Jami J, and Bucchini D (1996) Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J 15:1542-1547. (Pubitemid 26112375)
-
(1996)
EMBO Journal
, vol.15
, Issue.7
, pp. 1542-1547
-
-
Joshi, R.L.1
Lamothe, B.2
Cordonnier, N.3
Mesbah, K.4
Monthioux, E.5
Jami, J.6
Bucchini, D.7
-
13
-
-
52749094770
-
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
-
Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, et al. (2008) Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 8:318-324.
-
(2008)
Cell Metab
, vol.8
, pp. 318-324
-
-
Jung, H.S.1
Chung, K.W.2
Won Kim, J.3
Kim, J.4
Komatsu, M.5
Tanaka, K.6
Nguyen, Y.H.7
Kang, T.M.8
Yoon, K.H.9
Kim, J.W.10
-
14
-
-
3242888703
-
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
-
DOI 10.1242/jcs.01131
-
Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y, and Yoshimori T (2004) LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 117:2805-2812. (Pubitemid 38997262)
-
(2004)
Journal of Cell Science
, vol.117
, Issue.13
, pp. 2805-2812
-
-
Kabeya, Y.1
Mizushima, N.2
Yamamoto, A.3
Oshitani-Okamoto, S.4
Ohsumi, Y.5
Yoshimori, T.6
-
15
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
DOI 10.1038/nature05482, PII NATURE05482
-
Kahn SE, Hull RL, and Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-846. (Pubitemid 46024990)
-
(2006)
Nature
, vol.444
, Issue.7121
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
16
-
-
0034456568
-
Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
-
DOI 10.1210/jc.85.7.2402
-
Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, and Quon MJ (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410. (Pubitemid 32269192)
-
(2000)
Journal of Clinical Endocrinology and Metabolism
, vol.85
, Issue.7
, pp. 2402-2410
-
-
Katz, A.1
Nambi, S.S.2
Mather, K.3
Baron, A.D.4
Follmann, D.A.5
Sullivan, G.6
Quon, M.J.7
-
17
-
-
33846211417
-
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
-
DOI 10.1038/sj.cdd.4401984, PII 4401984
-
Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, and Momoi T (2007) ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ 14:230-239. (Pubitemid 46092226)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.2
, pp. 230-239
-
-
Kouroku, Y.1
Fujita, E.2
Tanida, I.3
Ueno, T.4
Isoai, A.5
Kumagai, H.6
Ogawa, S.7
Kaufman, R.J.8
Kominami, E.9
Momoi, T.10
-
18
-
-
0344270855
-
Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): A potential regulatory mechanism for PDK-1 function
-
Lim MA, Kikani CK, Wick MJ, and Dong LQ (2003) Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function. Proc Natl Acad Sci U S A 100:14006-14011.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14006-14011
-
-
Lim, M.A.1
Kikani, C.K.2
Wick, M.J.3
Dong, L.Q.4
-
19
-
-
33744972277
-
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
-
Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, et al. (2006) APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 8:516-523.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 516-523
-
-
Mao, X.1
Kikani, C.K.2
Riojas, R.A.3
Langlais, P.4
Wang, L.5
Ramos, F.J.6
Fang, Q.7
Christ-Roberts, C.Y.8
Hong, J.Y.9
Kim, R.Y.10
-
20
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
DOI 10.1007/BF00280883
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, and Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419. (Pubitemid 15018832)
-
(1985)
Diabetologia
, vol.28
, Issue.7
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
-
21
-
-
35848967804
-
How to interpret LC3 immunoblotting
-
Mizushima N and Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3:542-545.
-
(2007)
Autophagy
, vol.3
, pp. 542-545
-
-
Mizushima, N.1
Yoshimori, T.2
-
22
-
-
19944430402
-
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
-
DOI 10.1074/jbc.M411860200
-
Nakatani Y, Kaneto H, Kawamori D, Yoshiuchi K, Hatazaki M, Matsuoka TA, Ozawa K, Ogawa S, Hori M, Yamasaki Y, et al. (2005) Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem 280:847-851. (Pubitemid 40165054)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.1
, pp. 847-851
-
-
Nakatani, Y.1
Kaneto, H.2
Kawamori, D.3
Yoshiuchi, K.4
Hatazaki, M.5
Matsuoka, T.-A.6
Ozawa, K.7
Ogawa, S.8
Hori, M.9
Yamasaki, Y.10
Matsuhisa, M.11
-
23
-
-
33845459165
-
Autophagy is activated for cell survival after endoplasmic reticulum stress
-
DOI 10.1128/MCB.01453-06
-
Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, et al. (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26:9220-9231. (Pubitemid 44904418)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.24
, pp. 9220-9231
-
-
Ogata, M.1
Hino, S.-I.2
Saito, A.3
Morikawa, K.4
Kondo, S.5
Kanemoto, S.6
Murakami, T.7
Taniguchi, M.8
Tanii, I.9
Yoshinaga, K.10
Shiosaka, S.11
Hammarback, J.A.12
Urano, F.13
Imaizumi, K.14
-
24
-
-
0024296803
-
Post-translational changes in tertiary and quaternary structure of the insulin proreceptor. Correlation with acquisition of function
-
Olson TS, Bamberger MJ, and Lane MD (1988) Post-translational changes in tertiary and quaternary structure of the insulin proreceptor. Correlation with acquisition of function. J Biol Chem 263:7342-7351.
-
(1988)
J Biol Chem
, vol.263
, pp. 7342-7351
-
-
Olson, T.S.1
Bamberger, M.J.2
Lane, M.D.3
-
25
-
-
14644397903
-
The endoplasmic reticuluin chaperone improves insulin resistance in type 2 diabetes
-
DOI 10.2337/diabetes.54.3.657
-
Ozawa K, Miyazaki M, Matsuhisa M, Takano K, Nakatani Y, Hatazaki M, Tamatani T, Yamagata K, Miyagawa J, Kitao Y, et al. (2005) The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 54:657-663. (Pubitemid 40322067)
-
(2005)
Diabetes
, vol.54
, Issue.3
, pp. 657-663
-
-
Ozawa, K.1
Miyazaki, M.2
Matsuhisa, M.3
Takano, K.4
Nakatani, Y.5
Hatazaki, M.6
Tamatani, T.7
Yamagata, K.8
Miyagawa, J.-I.9
Kitao, Y.10
Hori, O.11
Yamasaki, Y.12
Ogawa, S.13
-
26
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
DOI 10.1126/science.1103160
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, and Hotamisligil GS (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461. (Pubitemid 39372439)
-
(2004)
Science
, vol.306
, Issue.5695
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.-H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
27
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
DOI 10.1126/science.1128294
-
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, and Hotamisligil GS (2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-1140. (Pubitemid 44300242)
-
(2006)
Science
, vol.313
, Issue.5790
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
28
-
-
0033978633
-
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pa7thways that control macroautophagy in HT-29 cells
-
DOI 10.1074/jbc.275.2.992
-
Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, and Codogno P (2000) Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 275:992-998. (Pubitemid 30051145)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.2
, pp. 992-998
-
-
Petiot, A.1
Ogier-Denis, E.2
Blommaart, E.F.C.3
Meijer, A.J.4
Codogno, P.5
-
29
-
-
33744928862
-
Grb10 mediates insulin-stimulated degradation of the insulin receptor: A mechanism of negative regulation
-
DOI 10.1152/ajpendo.00609.2005
-
Ramos FJ, Langlais PR, Hu D, Dong LQ, and Liu F (2006) Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation. Am J Physiol Endocrinol Metab 290:E1262-E1266. (Pubitemid 43847912)
-
(2006)
American Journal of Physiology - Endocrinology and Metabolism
, vol.290
, Issue.6
-
-
Ramos, F.J.1
Langlais, P.R.2
Hu, D.3
Dong, L.Q.4
Liu, F.5
-
30
-
-
33748789479
-
Mediators of endoplasmic reticulum stress-induced apoptosis
-
DOI 10.1038/sj.embor.7400779, PII 7400779
-
Szegezdi E, Logue SE, Gorman AM, and Samali A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7:880-885. (Pubitemid 44523966)
-
(2006)
EMBO Reports
, vol.7
, Issue.9
, pp. 880-885
-
-
Szegezdi, E.1
Logue, S.E.2
Gorman, A.M.3
Samali, A.4
-
31
-
-
0028899521
-
Insulin resistance in rats harboring growth hormone-secreting tumors: Decreased receptor number but increased kinase activity in liver
-
Venkatesan N and Davidson MB (1995) Insulin resistance in rats harboring growth hormone-secreting tumors: decreased receptor number but increased kinase activity in liver. Metabolism 44:75-84.
-
(1995)
Metabolism
, vol.44
, pp. 75-84
-
-
Venkatesan, N.1
Davidson, M.B.2
-
32
-
-
0038309329
-
The molecular mechanism of autophagy
-
Wang CW and Klionsky DJ (2003) The molecular mechanism of autophagy. Mol Med 9:65-76.
-
(2003)
Mol Med
, vol.9
, pp. 65-76
-
-
Wang, C.W.1
Klionsky, D.J.2
-
33
-
-
34548779732
-
Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo
-
DOI 10.1128/MCB.00679-07
-
Wang L, Balas B, Christ-Roberts CY, Kim RY, Ramos FJ, Kikani CK, Li C, Deng C, Reyna S, Musi N, et al. (2007) Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo. Mol Cell Biol 27:6497-6505. (Pubitemid 47435754)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.18
, pp. 6497-6505
-
-
Wang, L.1
Balas, B.2
Christ-Roberts, C.Y.3
Ryang, Y.K.4
Ramos, F.J.5
Kikani, C.K.6
Li, C.7
Deng, C.8
Reyna, S.9
Musi, N.10
Dong, L.Q.11
Defronzo, R.A.12
Liu, F.13
-
34
-
-
8944259440
-
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)
-
Wang XZ, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ, Boorstein R, Kreibich G, Hendershot LM, and Ron D (1996) Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol 16:4273-4280. (Pubitemid 26251229)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.8
, pp. 4273-4280
-
-
Wang, X.-Z.1
Lawson, B.2
Brewer, J.W.3
Zinszner, H.4
Sanjay, A.5
Mi, L.-J.6
Boorstein, R.7
Kreibich, G.8
Hendershot, L.M.9
Ron, D.10
-
35
-
-
0030447659
-
Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate
-
Werner ED, Brodsky JL, and McCracken AA (1996) Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate. Proc Natl Acad Sci U S A 93:13797-13801.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13797-13801
-
-
Werner, E.D.1
Brodsky, J.L.2
McCracken, A.A.3
-
36
-
-
0037424346
-
Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor
-
DOI 10.1074/jbc.M208518200
-
Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, and Liu F (2003) Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem 278:8460-8467. (Pubitemid 36800597)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.10
, pp. 8460-8467
-
-
Wick, K.R.1
Werner, E.D.2
Langlais, P.3
Ramos, F.J.4
Dong, L.Q.5
Shoelson, S.E.6
Liu, F.7
-
37
-
-
0034455274
-
Perspective: The insulin signaling system - A common link in the pathogenesis of type 2 diabetes
-
Withers DJ and White M (2000) Perspective: The insulin signaling system - a common link in the pathogenesis of type 2 diabetes. Endocrinology 141:1917-1921.
-
(2000)
Endocrinology
, vol.141
, pp. 1917-1921
-
-
Withers, D.J.1
White, M.2
-
38
-
-
33749579383
-
Endoplasmic reticulum stress triggers autophagy
-
DOI 10.1074/jbc.M607007200
-
Yorimitsu T, Nair U, Yang Z, and Klionsky DJ (2006) Endoplasmic reticulum stress triggers autophagy. J Biol Chem 281:30299-30304. (Pubitemid 44537037)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.40
, pp. 30299-30304
-
-
Yorimitsu, T.1
Nair, U.2
Yang, Z.3
Klionsky, D.J.4
-
39
-
-
33846548110
-
ER stress and diseases
-
Yoshida H (2007) ER stress and diseases. FEBS J 274:630-658.
-
(2007)
FEBS J
, vol.274
, pp. 630-658
-
-
Yoshida, H.1
-
40
-
-
0023886838
-
Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing
-
Yoshimasa Y, Seino S, Whittaker J, Kakehi T, Kosaki A, Kuzuya H, Imura H, Bell GI, and Steiner DF (1988) Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing. Science 240(4853):784-787. (Pubitemid 18129607)
-
(1988)
Science
, vol.240
, Issue.4853
, pp. 784-787
-
-
Yoshimasa, Y.1
Seino, S.2
Whittaker, J.3
Kakehi, T.4
Kosaki, A.5
Kuzuya, H.6
Imura, H.7
Bell, G.I.8
Steiner, D.F.9
|