Exploiting models of molecular evolution to efficiently direct protein engineering

Journal of Molecular Evolution

Volumn 72, Issue 2, 2011, Pages 193-203

  Cole, Megan F ^a   Gaucher, Eric A ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Directed evolution; Evolutionary models; Functional divergence; Protein engineering

Indexed keywords

DNA DIRECTED DNA POLYMERASE;

AMINO ACID SUBSTITUTION; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; DIRECTED MOLECULAR EVOLUTION; DNA SHUFFLING; GENE LIBRARY; GENETIC VARIABILITY; GENETICS; METHODOLOGY; MOLECULAR EVOLUTION; MUTAGENESIS; PHYLOGENY; PROTEIN ENGINEERING; REVIEW; SEQUENCE HOMOLOGY;

AMINO ACID SUBSTITUTION; DIRECTED MOLECULAR EVOLUTION; DNA SHUFFLING; DNA-DIRECTED DNA POLYMERASE; EVOLUTION, MOLECULAR; GENE LIBRARY; GENETIC VARIATION; MODELS, GENETIC; MODELS, MOLECULAR; MUTAGENESIS; PHYLOGENY; PROTEIN ENGINEERING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79953326533     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-010-9415-2     Document Type: Review

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