Adaptive mutations in bacteria: High rate and small effects

Science

Volumn 317, Issue 5839, 2007, Pages 813-815

  Perfeito, Lília ^a   Fernandes, Lisete ^a,b   Mota, Catarina ^a   Gordo, Isabel ^a  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^b INSTITUTO POLITÉCNICO DE LISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCE; COLIFORM BACTERIUM; FITNESS; GENOMICS; MUTATION; NATURAL SELECTION; PATHOGENICITY;

ADAPTIVE RADIATION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; ENVIRONMENTAL FACTOR; ESCHERICHIA COLI; EVOLUTION; EVOLUTIONARY ADAPTATION; EVOLUTIONARY RATE; GENETIC SELECTION; INTERSPECIFIC COMPETITION; MUTATION RATE; NATURAL SELECTION; NONHUMAN; PATHOGENICITY; POPULATION FITNESS; POPULATION GROWTH; PRIORITY JOURNAL;

ADAPTATION, BIOLOGICAL; ESCHERICHIA COLI; EVOLUTION; GENOME, BACTERIAL; MICROSATELLITE REPEATS; MUTATION; SELECTION (GENETICS);

ESCHERICHIA COLI;

EID: 34547924819     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1142284     Document Type: Article

References (31)

1. T. Bataillon, Heredity 84, 497 (2000).
2. R. A. Fisher, The Genetical Theory of Natural Selection (Clarendon Press, Oxford, UK, 1930).
3. H. A. Orr, Nat. Rev. Genet. 6, 119 (2005).
4. M. Imhof, C. Schlotterer, Proc. Natl. Acad. Sci. U.S.A. 98, 1113 (2001).
5. R. Miralles, P. J. Gerrish, A. Moya, S. F. Elena, Science 285, 1745 (1999).
6. C. L. Burch, L. Chao, Genetics 151, 921 (1999).
7. C. Zeyl, Genetics 169, 1825 (2005).
8. S. Estes, W. Lynch, Evol. Int. J. Org. Evol. 57, 1022 (2003).
9. R. D. Barrett, R. C. MacLean, G. Bell, Biol. Lett. 2, 236 (2006).
10. D. R. Rokyta, P. Joyce, S. Caudle, H. Wichman, Nat. Genet. 37, 441 (2005).
11. R. Kassen, T. Bataillon, Nat. Genet. 38, 484 (2006).
12. M. Kimura, The Neutral Theory of Molecular Evolution (Cambridge Univ. Press, Cambridge, 1983).
13. A. J. Betancourt, J. P. Bollback, Curr. Opin. Genet. Dev. 16, 618 (2006).
14. W. G. Hill, A. Robertson, Genet. Res. 8, 269 (1966).
15. P. Gerrish, R. Lenski, Genetica 102-103, 127 (1998).
16. D. E. Rozen, J. A. de Visser, P. Gerrish, Curr. Biol. 12, 1040 (2002).
17. M. Hegreness, N. Shoresh, D. Hartl, R. Kishony, Science 311, 1615 (2006).
18. C. Schlotterer, M. Imhof, H. Wang, V. Nolte, B. Harr, J. Evol. Biol. 19, 1671 (2006).
19. Materials and methods are available as supporting material on Science Online.
20. J. F. Crow, M. Kimura, An Introduction to Population Genetics Theory (Harper & Row, New York, 1970).
21. a.
22. a)·1000 = 0.14 in the small size populations.
23. H. A. Orr, Genetics 163, 1519 (2003).
24. R. D. H. Barrett, S. P. Otto, L. K. M'gonigle, Genetics 174, 2071 (2006).
25. Charlesworth, A. Eyre-Walker, Mol. Biol. Evol. 23, 1348 (2006).
26. B. Grimberg, C. Zeyl, Evol. Int. J. Org. Evol. 59, 431 (2005).
27. N. Colegrave, Nature 420, 664 (2002).
28. S. B. Joseph, D. W. Hall, Genetics 168, 1817 (2004).
29. R. G. Shaw, D. Byers, E. Darmo, Genetics 155, 369 (2000).
30. J. W. Drake, Proc. Natl. Acad. Sci. U.S.A. 88, 7160 (1991).
31. This work was supported by POCTI/BSE/46856/ 2002 and SFRH/BD/18161/2004 through Fundação para a Ciência e Tecnologia. We thank M. Imhof for help in the initial setup of this work and R. Azevedo, D. Bachtrog, A. Coutinho, F. Dionisio, K. Xavier, and anonymous reviewers for comments on the manuscript.