Using Evolutionary Information and Ancestral Sequences to Understand the Sequence-Function Relationship in GLP-1 Agonists

Journal of Molecular Biology

Volumn 363, Issue 5, 2006, Pages 977-988

  Skovgaard, Marie ^a   Kodra, Janos T ^a   Gram, Dorte Xenia ^a   Knudsen, Sanne Møller ^a   Madsen, Dennis ^a   Liberles, David A ^b,c  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF BERGEN   (Norway)

^c UNIVERSITY OF WYOMING   (United States)

Author keywords

diabetes; molecular evolution; phylogeny; protein family; sequence function mapping

Indexed keywords

GLUCAGON LIKE PEPTIDE 1 AGONIST; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; UNCLASSIFIED DRUG;

AGONIST; AMINO ACID SEQUENCE; AMPHIBIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME STABILITY; FROG; GENE MAPPING; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN FAMILY; PROTEIN FUNCTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

AMPHIBIA; ANURA; REPTILIA;

EID: 33750018966     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.08.066     Document Type: Article

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