Isolation of a 40-kDa Huntingtin-associated Protein

Journal of Biological Chemistry

Volumn 276, Issue 5, 2001, Pages 3188-3194

  Peters, Matthew F ^a   Ross, Christopher A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CYTOLOGY; DISEASES; GENES; IMMUNOLOGY; NEUROLOGY; TOXICITY;

NEUROTOXICITY;

PROTEINS;

HUNTINGTIN; HUNTINGTIN ASSOCIATED PROTEIN; HUNTINGTIN ASSOCIATED PROTEIN 40KDA; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; F8A PROTEIN, MOUSE; HD PROTEIN, HUMAN; HDH PROTEIN, MOUSE; HDH PROTEIN, RAT; NERVE PROTEIN; NUCLEAR PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE EXPRESSION; HUNTINGTON CHOREA; MOLECULAR CLONING; MOUSE; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; RAT; TRINUCLEOTIDE REPEAT; AMINO ACID SEQUENCE; ANIMAL; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; HUMANS; HUNTINGTON DISEASE; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RATS;

EID: 0035793637     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008099200     Document Type: Article

References (49)

1. The Huntington's Disease Collaborative Research Group. (1993) Cell 72, 971-983
2. Wells, R. D., and Warren, S. T. (1998) Genetic Instabilities and Hereditary Neurological Diseases, Academic Press, San Diego, CA
3. Perutz, M. F. (1999) Trends Biochem. Sci. 24, 58-63
4. Perutz, M. F. (1995) Mol. Med. 1, 718-721
5. Ross, C. A. (1997) Neuron 19, 1147-1150
6. Sharp, A. H., Loev, S. J., Schilling, G., Li, S. H., Li, X. J., Bao, J., Wagster, M. V., Kotzuk, J. A., Steiner, J. P., Lo, A., Hedreen, J., Sisodia, S., Snyder, S. H., Dawson, T. M., Ryugo, D. K., and Ross, C. A. (1995) Neuron 14, 1065-1074
7. Gusella, J. F. (2000) NeuroScience News 3, 15-22
8. DiFiglia, M., Sapp, E., Chase, K., Schwarz, C., Meloni, A., Young, C., Martin, E., Vonsattel, J. P., Carraway, R., Reeves, S. A., Boyce, F. M., and Aronin, N. (1995) Neuron 14, 1075-1081
9. White, J. K., Auerbach, W., Duyao, M. P., Vonsattel, J. P., Gusella, J. F., Joyner, A. L., and MacDonald, M. E. (1997) Nat. Genet. 17, 404-410
10. Duyao, M. P., Auerbach, A. B., Ryan, A., Persichetti, F., Barnes, G. T., McNeil, S. M., Ge, P., Vonsattel, J. P., Gusella, J. F., Joyner, A. L., and MacDonald, M. E. (1995) Science 269, 407-410
11. Nasir, J., Floresco, S. B., O'Kusky, J. R., Diewert, V. M., Richman, J. M., Zeisler, J., Borowski, A., Marth, J. D., Phillips, A. G., and Hayden, M. R. (1995) Cell 81, 811-823
12. Zeitlin, S., Liu, J. P., Chapman, D. L., Papaioannou, V. E., and Efstratiadis, A. (1995) Nat. Genet. 11, 155-163
13. Rigamonti, D., Bauer, J. H., De-Fraja, C., Conti, L., Sipione, S., Sciorati, C., Clementi, E., Hackam, A., Hayden, M. R., Li, Y., Cooper, J. K., Ross, C. A., Govoni, S., Vincenz, C., and Cattaneo, E. (2000) J. Neurosci. 20, 3705-3713
14. Jones, L. (2000) NeuroScience News 3, 55-63
15. Li, X. J., Li, S. H., Sharp, A. H., Nucifora, F. C., Jr., Schilling, G., Lanahan, A., Worley, P., Snyder, S. H., and Ross, C. A. (1995) Nature 378, 398-402
16. Li, S. H., Gutekunst, C. A., Hersch, S. M., and Li, X. J. (1998) J. Neurosci. 18, 1261-1269
17. Colomer, V., Engelender, S., Sharp, A. H., Duan, K., Cooper, J. K., Lanahan, A., Lyford, G., Worley, P., and Ross, C. A. (1997) Hum. Mol. Genet. 6, 1519-1525
18. Engelender, S., Sharp, A. H., Colomer, V., Tokito, M. K., Lanahan, A., Worley, P., Holzbaur, E. L., and Ross, C. A. (1997) Hum. Mol. Genet. 6, 2205-2212
19. Sittler, A., Walter, S., Wedemeyer, N., Hasenbank, R., Scherzinger, E., Eickhoff, H., Bates, G. P., Lehrach, H., and Wanker, E. E. (1998) Mol. Cell 2, 427-436
20. Faber, P. W., Barnes, G. T., Srinidhi, J., Chen, J., Gusella, J. F., and MacDonald, M. E. (1998) Hum. Mol. Genet. 7, 1463-1474
21. Singaraja, R., Hadano, S., Metzler, M., Wellington, C., Leavitt, B., Bannykh, S., Fichter, K., Hackam, A., Gan, L., and Hayden, M. (2000) Am. J. Hum. Genet. 65, A112
22. Boutell, J. M., Thomas, P., Neal, J. W., Weston, V. J., Duce, J., Harper, P. S., and Jones, A. L. (1999) Hum. Mol. Genet. 8, 1647-1655
23. Kalchman, M. A., Koide, H. B., McCutcheon, K., Graham, R. K., Nichol, K., Nishiyama, K., Kazemi-Esfarjani, P., Lynn, F. C., Wellington, C., Metzler, M., Goldberg, Y. P., Kanazawa, I., Gietz, R. D., and Hayden, M. R. (1997) Nat. Genet. 16, 44-53
24. Wanker, E. E., Rovira, C., Scherzinger, E., Hasenbank, R., Walter, S., Tait, D., Colicelli, J., and Lehrach, H. (1997) Hum. Mol. Genet. 6, 487-495
25. Kalchman, M. A., Graham, R. K., Xia, G., Koide, H. B., Hodgson, J. G., Graham, K. C., Goldberg, Y. P., Gietz, R. D., Pickart, C. M., and Hayden, M. R. (1996) J. Biol. Chem. 271, 19385-19394
26. Boutell, J. M., Wood, J. D., Harper, P. S., and Jones, A. L. (1998) Hum. Mol. Genet. 7, 371-378
27. Huang, C. C., Faber, P. W., Persichetti, F., Mittal, V., Vonsattel, J. P., MacDonald, M. E., and Gusella, J. F. (1998) Somatic Cell Mol. Genet. 24, 217-233
28. Bao, J., Sharp, A. H., Wagster, M. V., Becher, M., Schilling, G., Ross, C. A., Dawson, V. L., and Dawson, T. M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5037-5042
29. Liu, Y. F., Deth, R. C., and Devys, D. (1997) J. Biol. Chem. 272, 8121-8124
30. Steffan, J. S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y. Z., Gohler, H., Wanker, E. E., Bates, G. P., Housman, D. E., and Thompson, L. M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6763-6768
31. Kazantsev, A., Preisinger, E., Dranovsky, A., Goldgaber, D., and Housman, D. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11404-11409
32. Liu, Y. F., Dorow, D., and Marshall, J. (2000) J. Biol. Chem. 275, 19035-19040
33. Peters, M. F., Adams, M. E., and Froehner, S. C. (1997) J. Cell Biol. 138, 81-93
34. Harlow, E., and Lane, D. (1999) Using Antibodies: a Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor, NY
35. Peters, M. F., Nucifora, F. C., Jr., Kushi, J., Seaman, H. C., Cooper, J. K., Herring, W. J., Dawson, V. L., Dawson, T. M., and Ross, C. A. (1999) Mol. Cell. Neurosci. 14, 121-128
36. Schilling, G., Becher, M. W., Sharp, A. H., Jinnah, H. A., Duan, K., Kotzuk, J. A., Slunt, H. H., Ratovitski, T., Cooper, J. K., Jenkins, N. A., Copeland, N. G., Price, D. L., Ross, C. A., and Borchelt, D. R. (1999) Hum. Mol. Genet. 8, 397-407
37. Li, H., Li, S. H., Cheng, A. L., Mangiarini, L., Bates, G. P., and Li, X. J. (1999) Hum. Mol. Genet. 8, 1227-1236
38. Wood, J. D., MacMillan, J. C., Harper, P. S., Lowenstein, P. R., and Jones, A. L. (1996) Hum. Mol. Genet. 5, 481-487
39. Levinson, B., Bermingham, J. R., Jr., Metzenberg, A., Kenwrick, S., Chapman, V., and Gitschier, J. (1992) Genomics 13, 862-865
40. Naylor, J. A., Buck, D., Green, P., Williamson, H., Bentley, D., and Giannelli, F. (1995) Hum. Mol. Genet. 4, 1217-1224
41. Bessert, D. A., Gutridge, K. L., Dunbar, J. C., and Carlock, L. R. (1995) Brain Res. Mol. Brain Res. 33, 165-173
42. Andrade, M. A., and Bork, P. (1995) Nat. Genet. 11, 115-116
43. Wheeler, V. C., White, J. K., Gutekunst, C. A., Vrbanac, V., Weaver, M., Li, X. J., Li, S. H., Yi, H., Vonsattel, J. P., Gusella, J. F., Hersch, S., Auerbach, W., Joyner, A. L., and MacDonald, M. E. (2000) Hum. Mol. Genet. 9, 503-513
44. De Rooij, K. E., Dorsman, J. C., Smoor, M. A., Den Dunnen, J. T., and Van Ommen, G. J. (1996) Hum. Mol. Genet. 5, 1093-1099
45. Li, H., Li, S. H., Johnston, H., Shelbourne, P. F., and Li, X. J. (2000) Nat. Genet. 4, 385-389
46. Klement, I. A., Skinner, P. J., Kaytor, M. D., Yi, H., Hersch, S. M., Clark, H. B., Zoghbi, H. Y., and Orr, H. T. (1998) Cell 95, 41-53
47. Saudou, F., Finkbeiner, S., Devys, D., and Greenberg, M. E. (1998) Cell 95, 55-66
48. McCampbell, A., Taylor, J. P., Taye, A. A., Robitschek, J., Li, M., Walcott, J., Merry, D., Paulson, H., Chai, Y., Sobue, G., and Fischbeck, K. H. (2000) Hum. Mol. Genet. 9, 2197-2202
49. Nucifora, F. C., Sasaki, M., Huang, H., Troncoso, J., Dawson, V. L., Dawson, T. M., and Ross, C. A. (2000) Soc. Neurosci. Abstr. 26, 1030s