-
1
-
-
0033906634
-
Structure and function of the type 1 insulin-like growth factor receptor
-
Adams, T. E., Epa, V. C., Garrett, T. P. J., and Ward, C. W. (2000). Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57, 1050-1093.
-
(2000)
Cell Mol Life Sci
, vol.57
, pp. 1050-1093
-
-
Adams, T.E.1
Epa, V.C.2
Garrett, T.P.J.3
Ward, C.W.4
-
2
-
-
0141483330
-
Partially folded intermediates in insulin fibrillation
-
Ahmad, A., Millett, I. S., Doniach, S., Uversky, V. N., and Fink, A. L. (2003). Partially folded intermediates in insulin fibrillation. Biochemistry 42, 11404-11416.
-
(2003)
Biochemistry
, vol.42
, pp. 11404-11416
-
-
Ahmad, A.1
Millett, I.S.2
Doniach, S.3
Uversky, V.N.4
Fink, A.L.5
-
3
-
-
0015859467
-
Principles that govern the folding of protein chains
-
Anfinsen, C. B. (1973). Principles that govern the folding of protein chains. Science 181, 223-230.
-
(1973)
Science
, vol.181
, pp. 223-230
-
-
Anfinsen, C.B.1
-
4
-
-
0000574657
-
Structure of the pig insulin dimer in the cubic crystal
-
Badger, J., Harris, M. R., Reynolds, C. D., Evans, A. C., Dodson, E. J., Dodson, G. G., and North, A. C. (1991). Structure of the pig insulin dimer in the cubic crystal. Acta Crystallogr B 47, 127-136.
-
(1991)
Acta Crystallogr B
, vol.47
, pp. 127-136
-
-
Badger, J.1
Harris, M.R.2
Reynolds, C.D.3
Evans, A.C.4
Dodson, E.J.5
Dodson, G.G.6
North, A.C.7
-
5
-
-
0024280106
-
The structure of 2Zn pig insulin crystals at 1.5 A resolution
-
Baker, E. N., Blundell, T. L., Cutfield, J. F., Cutfield, S. M., Dodson, E. J., Dodson, G. G., Hodgkin, D. M., Hubbard, R. E., Isaacs, N. W., Reynolds, C. D., et al. (1988). The structure of 2Zn pig insulin crystals at 1. 5 A resolution. Philos Trans R Soc Lond B Biol Sci 319, 369-456.
-
(1988)
Philos Trans R Soc Lond B Biol Sci
, vol.319
, pp. 369-456
-
-
Baker, E.N.1
Blundell, T.L.2
Cutfield, J.F.3
Cutfield, S.M.4
Dodson, E.J.5
Dodson, G.G.6
Hodgkin, D.M.7
Hubbard, R.E.8
Isaacs, N.W.9
Reynolds, C.D.10
-
6
-
-
0030961788
-
Crystal structure of desheptapeptide(B24-B30)insulin at 1.6 A resolution: implications for receptor binding
-
Bao, S. J., Xie, D. L., Zhang, J. P., Chang, W. R., and Liang, D. C. (1997). Crystal structure of desheptapeptide(B24-B30)insulin at 1. 6 A resolution: implications for receptor binding. Proc Natl Acad Sci U S A 94, 2975-2980.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 2975-2980
-
-
Bao, S.J.1
Xie, D.L.2
Zhang, J.P.3
Chang, W.R.4
Liang, D.C.5
-
7
-
-
0017195548
-
Structure of insulin in 4-zinc insulin
-
Bentley, G., Dodson, E., Dodson, G., Hodgkin, D., and Mercola, D. (1976). Structure of insulin in 4-zinc insulin. Nature 261, 166-168.
-
(1976)
Nature
, vol.261
, pp. 166-168
-
-
Bentley, G.1
Dodson, E.2
Dodson, G.3
Hodgkin, D.4
Mercola, D.5
-
8
-
-
0015239642
-
Atomic positions in rhombohedral 2-zinc insulin crystals
-
Blundell, T. L., Cutfield, J. F., Cutfield, S. M., Dodson, E. J., Dodson, G. G., Hodgkin, D. C., Mercola, D. A., and Vijayan, M. (1971). Atomic positions in rhombohedral 2-zinc insulin crystals. Nature 231, 506-511.
-
(1971)
Nature
, vol.231
, pp. 506-511
-
-
Blundell, T.L.1
Cutfield, J.F.2
Cutfield, S.M.3
Dodson, E.J.4
Dodson, G.G.5
Hodgkin, D.C.6
Mercola, D.A.7
Vijayan, M.8
-
10
-
-
0030959947
-
Toward understanding insulin fibrillation
-
Brange, J., Andersen, L., Laursen, E. D., Meyn, G., and Rasmussen, E. (1997a). Toward understanding insulin fibrillation. J Pharm Sci 86, 517-525.
-
(1997)
J Pharm Sci
, vol.86
, pp. 517-525
-
-
Brange, J.1
Andersen, L.2
Laursen, E.D.3
Meyn, G.4
Rasmussen, E.5
-
11
-
-
0030907673
-
A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin)
-
Brange, J., Dodson, G. G., Edwards, D. J., Holden, P. H., and Whittingham, J. L. (1997b). A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin). Proteins 27, 507-516.
-
(1997)
Proteins
, vol.27
, pp. 507-516
-
-
Brange, J.1
Dodson, G.G.2
Edwards, D.J.3
Holden, P.H.4
Whittingham, J.L.5
-
12
-
-
0030629665
-
Insulin formulation and delivery
-
Brange, J., and Langkjaer, L. (1997). Insulin formulation and delivery. Pharm Biotechnol 10, 343-409.
-
(1997)
Pharm Biotechnol
, vol.10
, pp. 343-409
-
-
Brange, J.1
Langkjaer, L.2
-
13
-
-
0037041420
-
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
-
Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M., and Stefani, M. (2002). Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 416, 507-511.
-
(2002)
Nature
, vol.416
, pp. 507-511
-
-
Bucciantini, M.1
Giannoni, E.2
Chiti, F.3
Baroni, F.4
Formigli, L.5
Zurdo, J.6
Taddei, N.7
Ramponi, G.8
Dobson, C.M.9
Stefani, M.10
-
14
-
-
0020614069
-
Transmission of conformational change in insulin
-
Chothia, C., Lesk, A. M., Dodson, G. G., and Hodgkin, D. C. (1983). Transmission of conformational change in insulin. Nature 302, 500-505.
-
(1983)
Nature
, vol.302
, pp. 500-505
-
-
Chothia, C.1
Lesk, A.M.2
Dodson, G.G.3
Hodgkin, D.C.4
-
15
-
-
0028266674
-
Crystallographic evidence for dual coordination around zinc in the T3R3 human insulin hexamer
-
Ciszak, E., and Smith, G. D. (1994). Crystallographic evidence for dual coordination around zinc in the T3R3 human insulin hexamer. Biochemistry 33, 1512-1517.
-
(1994)
Biochemistry
, vol.33
, pp. 1512-1517
-
-
Ciszak, E.1
Smith, G.D.2
-
16
-
-
0032742943
-
Protein misfolding and prion diseases
-
Cohen, F. E. (1999). Protein misfolding and prion diseases. J Mol Biol 293, 313-320.
-
(1999)
J Mol Biol
, vol.293
, pp. 313-320
-
-
Cohen, F.E.1
-
17
-
-
45749104374
-
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus
-
the Early Onset Diabetes Study Group of the Italian Society of Pediatric EndocrinologyDiabetes
-
Colombo, C., Porzio, O., Liu, M., Massa, O., Vasta, M., Salardi, S., Beccaria, L., Monciotti, C., Toni, S., Pedersen, O., et al., and the Early Onset Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (SIEDP). (2008). Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus. J Clin Invest 118, 2148-2156.
-
(2008)
J Clin Invest
, vol.118
, pp. 2148-2156
-
-
Colombo, C.1
Porzio, O.2
Liu, M.3
Massa, O.4
Vasta, M.5
Salardi, S.6
Beccaria, L.7
Monciotti, C.8
Toni, S.9
Pedersen, O.10
-
18
-
-
0025822851
-
Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study
-
Cooke, R. M., Harvey, T. S., and Campbell, I. D. (1991). Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study. Biochemistry 30, 5484-5491.
-
(1991)
Biochemistry
, vol.30
, pp. 5484-5491
-
-
Cooke, R.M.1
Harvey, T.S.2
Campbell, I.D.3
-
19
-
-
0030586703
-
Characteristic, activity and conformational studies of [A6-Ser, A11-Ser]-insulin
-
Dai, Y., and Tang, J. G. (1996). Characteristic, activity and conformational studies of [A6-Ser, A11-Ser]-insulin. Biochim Biophys Acta 1296, 63-68.
-
(1996)
Biochim Biophys Acta
, vol.1296
, pp. 63-68
-
-
Dai, Y.1
Tang, J.G.2
-
20
-
-
0028146822
-
The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling
-
De Meyts, P. (1994). The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia 37, S135-S148.
-
(1994)
Diabetologia
, vol.37
-
-
de Meyts, P.1
-
21
-
-
0036782071
-
Structural biology of insulin and IGF1 receptors: implications for drug design
-
De Meyts, P., and Whittaker, J. (2002). Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov 1, 769-783.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 769-783
-
-
de Meyts, P.1
Whittaker, J.2
-
22
-
-
0029806712
-
Solution structure of a mini IGF-1
-
De Wolf, E., Gill, R., Geddes, S., Pitts, J., Wollmer, A., and Grötzinger, J. (1996). Solution structure of a mini IGF-1. Protein Sci 5, 2193-2202.
-
(1996)
Protein Sci
, vol.5
, pp. 2193-2202
-
-
de Wolf, E.1
Gill, R.2
Geddes, S.3
Pitts, J.4
Wollmer, A.5
Grötzinger, J.6
-
23
-
-
0025880180
-
X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue
-
Derewenda, U., Derewenda, Z., Dodson, E. J., Dodson, G. G., Bing, X., and Markussen, J. (1991). X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue. J Mol Biol 220, 425-433.
-
(1991)
J Mol Biol
, vol.220
, pp. 425-433
-
-
Derewenda, U.1
Derewenda, Z.2
Dodson, E.J.3
Dodson, G.G.4
Bing, X.5
Markussen, J.6
-
24
-
-
0024968311
-
Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer
-
Derewenda, U., Derewenda, Z., Dodson, E. J., Dodson, G. G., Reynolds, C. D., Smith, G. D., Sparks, C., and Swenson, D. (1989). Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer. Nature 338, 594-596.
-
(1989)
Nature
, vol.338
, pp. 594-596
-
-
Derewenda, U.1
Derewenda, Z.2
Dodson, E.J.3
Dodson, G.G.4
Reynolds, C.D.5
Smith, G.D.6
Sparks, C.7
Swenson, D.8
-
25
-
-
0033200063
-
Protein misfolding, evolution and disease
-
Dobson, C. M. (1999). Protein misfolding, evolution and disease. Trends Biochem Sci 24, 329-332.
-
(1999)
Trends Biochem Sci
, vol.24
, pp. 329-332
-
-
Dobson, C.M.1
-
26
-
-
0032054714
-
The role of assembly in insulin's biosynthesis
-
Dodson, G., and Steiner, D. (1998). The role of assembly in insulin's biosynthesis. Curr Opin Struct Biol 8, 189-194.
-
(1998)
Curr Opin Struct Biol
, vol.8
, pp. 189-194
-
-
Dodson, G.1
Steiner, D.2
-
27
-
-
0043179085
-
Conditions for successful resynthesis of insulin from its glycyl and phenylalanyl chains
-
Du, Y. C., Jiang, R. Q., and Tsou, C. L. (1965). Conditions for successful resynthesis of insulin from its glycyl and phenylalanyl chains. Sci Sin 14, 229-236.
-
(1965)
Sci Sin
, vol.14
, pp. 229-236
-
-
Du, Y.C.1
Jiang, R.Q.2
Tsou, C.L.3
-
28
-
-
0031895566
-
New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling
-
Duret, L., Guex, N., Peitsch, M. C., and Bairoch, A. (1998). New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling. Genome Res 8, 348-353.
-
(1998)
Genome Res
, vol.8
, pp. 348-353
-
-
Duret, L.1
Guex, N.2
Peitsch, M.C.3
Bairoch, A.4
-
29
-
-
42449134450
-
Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood
-
the Neonatal Diabetes International Collaborative Group
-
Edghill, E. L., Flanagan, S. E., Patch, A. M., Boustred, C., Parrish, A., Shields, B., Shepherd, M. H., Hussain, K., Kapoor, R. R., Malecki, M., et al., and the Neonatal Diabetes International Collaborative Group. (2008). Insulin mutation screening in 1, 044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes 57, 1034-1042.
-
(2008)
Diabetes
, vol.57
, pp. 1034-1042
-
-
Edghill, E.L.1
Flanagan, S.E.2
Patch, A.M.3
Boustred, C.4
Parrish, A.5
Shields, B.6
Shepherd, M.H.7
Hussain, K.8
Kapoor, R.R.9
Malecki, M.10
-
30
-
-
0025812626
-
X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants
-
Eigenbrot, C., Randal, M., Quan, C., Burnier, J., O"Connell, L., Rinderknecht, E., and Kossiakoff, A. A. (1991). X-ray structure of human relaxin at 1. 5 A. Comparison to insulin and implications for receptor binding determinants. J Mol Biol 221, 15-21.
-
(1991)
J Mol Biol
, vol.221
, pp. 15-21
-
-
Eigenbrot, C.1
Randal, M.2
Quan, C.3
Burnier, J.4
O"Connell, L.5
Rinderknecht, E.6
Kossiakoff, A.A.7
-
31
-
-
0041743075
-
Native-like partially folded conformations and folding process revealed in the N-terminal large fragments of staphylococcal nuclease: a study by NMR spectroscopy
-
Feng, Y., Liu, D., and Wang, J. (2003). Native-like partially folded conformations and folding process revealed in the N-terminal large fragments of staphylococcal nuclease: a study by NMR spectroscopy. J Mol Biol 330, 821-837.
-
(2003)
J Mol Biol
, vol.330
, pp. 821-837
-
-
Feng, Y.1
Liu, D.2
Wang, J.3
-
32
-
-
79953182489
-
-
Kerala, India: Transworld Research Network
-
Feng, Y. M. (2010). Chinese work on insulin (Kerala, India: Transworld Research Network).
-
(2010)
Chinese Work on Insulin
-
-
Feng, Y.M.1
-
33
-
-
0032930155
-
Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding
-
Gill, R., Verma, C., Wallach, B., Ursø, B., Pitts, J., Wollmer, A., De Meyts, P., and Wood, S. (1999). Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding. Protein Eng 12, 297-303.
-
(1999)
Protein Eng
, vol.12
, pp. 297-303
-
-
Gill, R.1
Verma, C.2
Wallach, B.3
Ursø, B.4
Pitts, J.5
Wollmer, A.6
de Meyts, P.7
Wood, S.8
-
34
-
-
0035037739
-
Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin
-
Guo, Z. Y., and Feng, Y. M. (2001). Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin. Biol Chem 382, 443-448.
-
(2001)
Biol Chem
, vol.382
, pp. 443-448
-
-
Guo, Z.Y.1
Feng, Y.M.2
-
35
-
-
36148978188
-
The in vitro oxidative folding of the insulin superfamily
-
Guo, Z. Y., Qiao, Z. S., and Feng, Y. M. (2008). The in vitro oxidative folding of the insulin superfamily. Antioxid Redox Signal 10, 127-139.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 127-139
-
-
Guo, Z.Y.1
Qiao, Z.S.2
Feng, Y.M.3
-
36
-
-
0030932132
-
Disulfide exchange folding of disulfide mutants of insulin-like growth factor I in vitro
-
Hober, S., Uhlén, M., and Nilsson, B. (1997). Disulfide exchange folding of disulfide mutants of insulin-like growth factor I in vitro. Biochemistry 36, 4616-4622.
-
(1997)
Biochemistry
, vol.36
, pp. 4616-4622
-
-
Hober, S.1
Uhlén, M.2
Nilsson, B.3
-
37
-
-
1642501551
-
Insight into folding, binding and stability of insulin by NMR
-
Hua, Q. X. (2004). Insight into folding, binding and stability of insulin by NMR. Prog Biochem Biophys 31, 1-26.
-
(2004)
Prog Biochem Biophys
, vol.31
, pp. 1-26
-
-
Hua, Q.X.1
-
38
-
-
0037044828
-
Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
-
Hua, Q. X., Chu, Y. C., Jia, W., Phillips, N. F., Wang, R. Y., Katsoyannis, P. G., and Weiss, M. A. (2002a). Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing. J Biol Chem 277, 43443-43453.
-
(2002)
J Biol Chem
, vol.277
, pp. 43443-43453
-
-
Hua, Q.X.1
Chu, Y.C.2
Jia, W.3
Phillips, N.F.4
Wang, R.Y.5
Katsoyannis, P.G.6
Weiss, M.A.7
-
39
-
-
0029566026
-
Structure of a protein in a kinetic trap
-
Hua, Q. X., Gozani, S. N., Chance, R. E., Hoffmann, J. A., Frank, B. H., and Weiss, M. A. (1995). Structure of a protein in a kinetic trap. Nat Struct Biol 2, 129-138.
-
(1995)
Nat Struct Biol
, vol.2
, pp. 129-138
-
-
Hua, Q.X.1
Gozani, S.N.2
Chance, R.E.3
Hoffmann, J.A.4
Frank, B.H.5
Weiss, M.A.6
-
40
-
-
0030606309
-
Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue
-
Hua, Q. X., Hu, S. Q., Frank, B. H., Jia, W., Chu, Y. C., Wang, S. H., Burke, G. T., Katsoyannis, P. G., and Weiss, M. A. (1996a). Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue. J Mol Biol 264, 390-403.
-
(1996)
J Mol Biol
, vol.264
, pp. 390-403
-
-
Hua, Q.X.1
Hu, S.Q.2
Frank, B.H.3
Jia, W.4
Chu, Y.C.5
Wang, S.H.6
Burke, G.T.7
Katsoyannis, P.G.8
Weiss, M.A.9
-
41
-
-
0037126725
-
A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers
-
Hua, Q. X., Jia, W., Frank, B. H., Phillips, N. F., and Weiss, M. A. (2002b). A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers. Biochemistry 41, 14700-14715.
-
(2002)
Biochemistry
, vol.41
, pp. 14700-14715
-
-
Hua, Q.X.1
Jia, W.2
Frank, B.H.3
Phillips, N.F.4
Weiss, M.A.5
-
42
-
-
0026549524
-
Structure and dynamics of des-pentapeptide-insulin in solution: the moltenglobule hypothesis
-
Hua, Q. X., Kochoyan, M., and Weiss, M. A. (1992a). Structure and dynamics of des-pentapeptide-insulin in solution: the moltenglobule hypothesis. Proc Natl Acad Sci U S A 89, 2379-2383.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 2379-2383
-
-
Hua, Q.X.1
Kochoyan, M.2
Weiss, M.A.3
-
44
-
-
33748785712
-
The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state
-
Hua, Q. X., Mayer, J. P., Jia, W., Zhang, J., and Weiss, M. A. (2006b). The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state. J Biol Chem 281, 28131-28142.
-
(2006)
J Biol Chem
, vol.281
, pp. 28131-28142
-
-
Hua, Q.X.1
Mayer, J.P.2
Jia, W.3
Zhang, J.4
Weiss, M.A.5
-
45
-
-
33747670241
-
Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B-chain
-
Hua, Q. X., Nakagawa, S. H., Hu, S. Q., Jia, W., Wang, S., and Weiss, M. A. (2006c). Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B-chain. J Biol Chem 281, 24900-24909.
-
(2006)
J Biol Chem
, vol.281
, pp. 24900-24909
-
-
Hua, Q.X.1
Nakagawa, S.H.2
Hu, S.Q.3
Jia, W.4
Wang, S.5
Weiss, M.A.6
-
46
-
-
0035899983
-
Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge
-
Hua, Q. X., Nakagawa, S. H., Jia, W., Hu, S. Q., Chu, Y. C., Katsoyannis, P. G., and Weiss, M. A. (2001). Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge. Biochemistry 40, 12299-12311.
-
(2001)
Biochemistry
, vol.40
, pp. 12299-12311
-
-
Hua, Q.X.1
Nakagawa, S.H.2
Jia, W.3
Hu, S.Q.4
Chu, Y.C.5
Katsoyannis, P.G.6
Weiss, M.A.7
-
47
-
-
47249140371
-
Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications
-
Hua, Q. X., Nakagawa, S. H., Jia, W., Huang, K., Phillips, N. B., Hu, S. Q., and Weiss, M. A. (2008). Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. J Biol Chem 283, 14703-14716.
-
(2008)
J Biol Chem
, vol.283
, pp. 14703-14716
-
-
Hua, Q.X.1
Nakagawa, S.H.2
Jia, W.3
Huang, K.4
Phillips, N.B.5
Hu, S.Q.6
Weiss, M.A.7
-
48
-
-
0345073631
-
A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor
-
Hua, Q. X., Nakagawa, S. H., Wilken, J., Ramos, R. R., Jia, W., Bass, J., and Weiss, M. A. (2003). A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor. Genes Dev 17, 826-831.
-
(2003)
Genes Dev
, vol.17
, pp. 826-831
-
-
Hua, Q.X.1
Nakagawa, S.H.2
Wilken, J.3
Ramos, R.R.4
Jia, W.5
Bass, J.6
Weiss, M.A.7
-
49
-
-
0029991679
-
Native and non-native structure in a protein-folding intermediate: spectroscopic studies of partially reduced IGF-I and an engineered alanine model
-
Hua, Q. X., Narhi, L., Jia, W., Arakawa, T., Rosenfeld, R., Hawkins, N., Miller, J. A., and Weiss, M. A. (1996b). Native and non-native structure in a protein-folding intermediate: spectroscopic studies of partially reduced IGF-I and an engineered alanine model. J Mol Biol 259, 297-313.
-
(1996)
J Mol Biol
, vol.259
, pp. 297-313
-
-
Hua, Q.X.1
Narhi, L.2
Jia, W.3
Arakawa, T.4
Rosenfeld, R.5
Hawkins, N.6
Miller, J.A.7
Weiss, M.A.8
-
50
-
-
0025996911
-
Receptor binding redefined by a structural switch in a mutant human insulin
-
Hua, Q. X., Shoelson, S. E., Kochoyan, M., and Weiss, M. A. (1991). Receptor binding redefined by a structural switch in a mutant human insulin. Nature 354, 238-241.
-
(1991)
Nature
, vol.354
, pp. 238-241
-
-
Hua, Q.X.1
Shoelson, S.E.2
Kochoyan, M.3
Weiss, M.A.4
-
51
-
-
0026482979
-
Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24→Gly]insulin with implications for receptor recognition
-
Hua, Q. X., Shoelson, S. E., and Weiss, M. A. (1992b). Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24→Gly]insulin with implications for receptor recognition. Biochemistry 31, 11940-11951.
-
(1992)
Biochemistry
, vol.31
, pp. 11940-11951
-
-
Hua, Q.X.1
Shoelson, S.E.2
Weiss, M.A.3
-
52
-
-
0025778802
-
Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor recognition
-
Hua, Q. X., and Weiss, M. A. (1991). Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor recognition. Biochemistry 30, 5505-5515.
-
(1991)
Biochemistry
, vol.30
, pp. 5505-5515
-
-
Hua, Q.X.1
Weiss, M.A.2
-
53
-
-
2442715309
-
Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate
-
Hua, Q. X., and Weiss, M. A. (2004). Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate. J Biol Chem 279, 21449-21460.
-
(2004)
J Biol Chem
, vol.279
, pp. 21449-21460
-
-
Hua, Q.X.1
Weiss, M.A.2
-
54
-
-
67649811215
-
Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins
-
Hua, Q. X., Xu, B., Huang, K., Hu, S. Q., Nakagawa, S., Jia, W., Wang, S., Whittaker, J., Katsoyannis, P. G., and Weiss, M. A. (2009). Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem 284, 14586-14596.
-
(2009)
J Biol Chem
, vol.284
, pp. 14586-14596
-
-
Hua, Q.X.1
Xu, B.2
Huang, K.3
Hu, S.Q.4
Nakagawa, S.5
Jia, W.6
Wang, S.7
Whittaker, J.8
Katsoyannis, P.G.9
Weiss, M.A.10
-
55
-
-
36849051281
-
The A-chain of insulin contacts the insert domain of the receptor. Photo-cross-linking and nonstandard mutagenesis of the diabetes-related A3 crevice
-
Huang, K., Chan, S. J., Hua, Q. X., Chu, Y. C., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S. H., et al. (2007). The A-chain of insulin contacts the insert domain of the receptor. Photo-cross-linking and nonstandard mutagenesis of the diabetes-related A3 crevice. J Biol Chem 282, 35337-35349.
-
(2007)
J Biol Chem
, vol.282
, pp. 35337-35349
-
-
Huang, K.1
Chan, S.J.2
Hua, Q.X.3
Chu, Y.C.4
Wang, R.5
Klaproth, B.6
Jia, W.7
Whittaker, J.8
de Meyts, P.9
Nakagawa, S.H.10
-
56
-
-
29644434204
-
Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly
-
Huang, K., Dong, J., Phillips, N. B., Carey, P. R., and Weiss, M. A. (2005). Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly. J Biol Chem 280, 42345-42355.
-
(2005)
J Biol Chem
, vol.280
, pp. 42345-42355
-
-
Huang, K.1
Dong, J.2
Phillips, N.B.3
Carey, P.R.4
Weiss, M.A.5
-
57
-
-
33748660053
-
Structure-specific effects of protein topology on cross-beta assembly: studies of insulin fibrillation
-
Huang, K., Maiti, N. C., Phillips, N. B., Carey, P. R., and Weiss, M. A. (2006). Structure-specific effects of protein topology on cross-beta assembly: studies of insulin fibrillation. Biochemistry 45, 10278-10293.
-
(2006)
Biochemistry
, vol.45
, pp. 10278-10293
-
-
Huang, K.1
Maiti, N.C.2
Phillips, N.B.3
Carey, P.R.4
Weiss, M.A.5
-
58
-
-
3342960841
-
How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor
-
Huang, K., Xu, B., Hu, S. Q., Chu, Y. C., Hua, Q. X., Qu, Y., Li, B., Wang, S., Wang, R. Y., Nakagawa, S. H., et al. (2004). How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor. J Mol Biol 341, 529-550.
-
(2004)
J Mol Biol
, vol.341
, pp. 529-550
-
-
Huang, K.1
Xu, B.2
Hu, S.Q.3
Chu, Y.C.4
Hua, Q.X.5
Qu, Y.6
Li, B.7
Wang, S.8
Wang, R.Y.9
Nakagawa, S.H.10
-
59
-
-
84894405346
-
Insulin-like growth factors I and II
-
Humbel, R. E. (1990). Insulin-like growth factors I and II. Eur J Biol 277, 103-118.
-
(1990)
Eur J Biol
, vol.277
, pp. 103-118
-
-
Humbel, R.E.1
-
60
-
-
0037312881
-
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse
-
Izumi, T., Yokota-Hashimoto, H., Zhao, S., Wang, J., Halban, P. A., and Takeuchi, T. (2003). Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes 52, 409-416.
-
(2003)
Diabetes
, vol.52
, pp. 409-416
-
-
Izumi, T.1
Yokota-Hashimoto, H.2
Zhao, S.3
Wang, J.4
Halban, P.A.5
Takeuchi, T.6
-
61
-
-
0142241183
-
Peptide models of four possible insulin folding intermediates with two disulfides
-
Jia, X. Y., Guo, Z. Y., Wang, Y., Xu, Y., Duan, S. S., and Feng, Y. M. (2003). Peptide models of four possible insulin folding intermediates with two disulfides. Protein Sci 12, 2412-2419.
-
(2003)
Protein Sci
, vol.12
, pp. 2412-2419
-
-
Jia, X.Y.1
Guo, Z.Y.2
Wang, Y.3
Xu, Y.4
Duan, S.S.5
Feng, Y.M.6
-
62
-
-
0013914317
-
Insulin synthesis by recombination of A and B-chains: a highly efficient method
-
Katsoyannis, P. G., and Tometsko, A. (1966). Insulin synthesis by recombination of A and B-chains: a highly efficient method. Proc Natl Acad Sci U S A 55, 1554-1561.
-
(1966)
Proc Natl Acad Sci U S A
, vol.55
, pp. 1554-1561
-
-
Katsoyannis, P.G.1
Tometsko, A.2
-
63
-
-
0020410498
-
Supernormal insulin: [D-PheB24]-insulin with increased affinity for insulin receptors
-
Kobayashi, M., Ohgaku, S., Iwasaki, M., Maegawa, H., Shigeta, Y., and Inouye, K. (1982). Supernormal insulin: [D-PheB24]-insulin with increased affinity for insulin receptors. Biochem Biophys Res Commun 107, 329-336.
-
(1982)
Biochem Biophys Res Commun
, vol.107
, pp. 329-336
-
-
Kobayashi, M.1
Ohgaku, S.2
Iwasaki, M.3
Maegawa, H.4
Shigeta, Y.5
Inouye, K.6
-
64
-
-
0031009430
-
Alanine scanning mutagenesis of insulin
-
Kristensen, C., Kjeldsen, T., Wiberg, F. C., Schäffer, L., Hach, M., Havelund, S., Bass, J., Steiner, D. F., and Andersen, A. S. (1997). Alanine scanning mutagenesis of insulin. J Biol Chem 272, 12978-12983.
-
(1997)
J Biol Chem
, vol.272
, pp. 12978-12983
-
-
Kristensen, C.1
Kjeldsen, T.2
Wiberg, F.C.3
Schäffer, L.4
Hach, M.5
Havelund, S.6
Bass, J.7
Steiner, D.F.8
Andersen, A.S.9
-
65
-
-
0030941110
-
Inactive conformation of an insulin despite its wild-type sequence
-
Kurapkat, G., De Wolf, E., Grötzinger, J., and Wollmer, A. (1997). Inactive conformation of an insulin despite its wild-type sequence. Protein Sci 6, 580-587.
-
(1997)
Protein Sci
, vol.6
, pp. 580-587
-
-
Kurapkat, G.1
de Wolf, E.2
Grötzinger, J.3
Wollmer, A.4
-
66
-
-
0027960567
-
Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor
-
Kurose, T., Pashmforoush, M., Yoshimasa, Y., Carroll, R., Schwartz, G. P., Burke, G. T., Katsoyannis, P. G., and Steiner, D. F. (1994). Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor. J Biol Chem 269, 29190-29197.
-
(1994)
J Biol Chem
, vol.269
, pp. 29190-29197
-
-
Kurose, T.1
Pashmforoush, M.2
Yoshimasa, Y.3
Carroll, R.4
Schwartz, G.P.5
Burke, G.T.6
Katsoyannis, P.G.7
Steiner, D.F.8
-
67
-
-
36549015742
-
Insulin receptor structure and its implications for the IGF-1 receptor
-
Lawrence, M. C., McKern, N. M., and Ward, C. W. (2007). Insulin receptor structure and its implications for the IGF-1 receptor. Curr Opin Struct Biol 17, 699-705.
-
(2007)
Curr Opin Struct Biol
, vol.17
, pp. 699-705
-
-
Lawrence, M.C.1
McKern, N.M.2
Ward, C.W.3
-
68
-
-
0035949709
-
Solid-state NMR studies of the secondary structure of a mutant prion protein fragment of 55 residues that induces neurodegeneration
-
Laws, D. D., Bitter, H. M., Liu, K., Ball, H. L., Kaneko, K., Wille, H., Cohen, F. E., Prusiner, S. B., Pines, A., and Wemmer, D. E. (2001). Solid-state NMR studies of the secondary structure of a mutant prion protein fragment of 55 residues that induces neurodegeneration. Proc Natl Acad Sci USA 98, 11686-11690.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11686-11690
-
-
Laws, D.D.1
Bitter, H.M.2
Liu, K.3
Ball, H.L.4
Kaneko, K.5
Wille, H.6
Cohen, F.E.7
Prusiner, S.B.8
Pines, A.9
Wemmer, D.E.10
-
69
-
-
0346565748
-
The possible mechanism of binding interaction of insulin molecule with its receptor
-
Liang, D. C., Chang, W. R., Zhang, J. P., and Wan, Z. L. (1992). The possible mechanism of binding interaction of insulin molecule with its receptor. Sci China B 35, 547-557.
-
(1992)
Sci China B
, vol.35
, pp. 547-557
-
-
Liang, D.C.1
Chang, W.R.2
Zhang, J.P.3
Wan, Z.L.4
-
70
-
-
33747584896
-
The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity
-
Lou, M., Garrett, T. P., McKern, N. M., Hoyne, P. A., Epa, V. C., Bentley, J. D., Lovrecz, G. O., Cosgrove, L. J., Frenkel, M. J., and Ward, C. W. (2006). The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity. Proc Natl Acad Sci U S A 103, 12429-12434.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 12429-12434
-
-
Lou, M.1
Garrett, T.P.2
McKern, N.M.3
Hoyne, P.A.4
Epa, V.C.5
Bentley, J.D.6
Lovrecz, G.O.7
Cosgrove, L.J.8
Frenkel, M.J.9
Ward, C.W.10
-
71
-
-
33748639228
-
Structure of the insulin receptor ectodomain reveals a folded-over conformation
-
McKern, N. M., Lawrence, M. C., Streltsov, V. A., Lou, M. Z., Adams, T. E., Lovrecz, G. O., Elleman, T. C., Richards, K. M., Bentley, J. D., Pilling, P. A., et al. (2006). Structure of the insulin receptor ectodomain reveals a folded-over conformation. Nature 443, 218-221.
-
(2006)
Nature
, vol.443
, pp. 218-221
-
-
McKern, N.M.1
Lawrence, M.C.2
Streltsov, V.A.3
Lou, M.Z.4
Adams, T.E.5
Lovrecz, G.O.6
Elleman, T.C.7
Richards, K.M.8
Bentley, J.D.9
Pilling, P.A.10
-
72
-
-
0027177107
-
Oxidative refolding of insulin-like growth factor 1 yields two products of similar thermodynamic stability: a bifurcating protein-folding pathway
-
Miller, J. A., Narhi, L. O., Hua, Q. X., Rosenfeld, R., Arakawa, T., Rohde, M., Prestrelski, S., Lauren, S., Stoney, K. S., Tsai, L., et al. (1993). Oxidative refolding of insulin-like growth factor 1 yields two products of similar thermodynamic stability: a bifurcating protein-folding pathway. Biochemistry 32, 5203-5213.
-
(1993)
Biochemistry
, vol.32
, pp. 5203-5213
-
-
Miller, J.A.1
Narhi, L.O.2
Hua, Q.X.3
Rosenfeld, R.4
Arakawa, T.5
Rohde, M.6
Prestrelski, S.7
Lauren, S.8
Stoney, K.S.9
Tsai, L.10
-
73
-
-
0033586410
-
Probing the disulfide folding pathway of insulin-like growth factor-I
-
Milner, S. J., Carver, J. A., Ballard, F. J., and Francis, G. L. (1999). Probing the disulfide folding pathway of insulin-like growth factor-I. Biotechnol Bioeng 62, 693-703.
-
(1999)
Biotechnol Bioeng
, vol.62
, pp. 693-703
-
-
Milner, S.J.1
Carver, J.A.2
Ballard, F.J.3
Francis, G.L.4
-
74
-
-
42449127920
-
Mutations in the insulin gene can cause MODY and autoantibodynegative type 1 diabetes
-
the Norwegian Childhood Diabetes Study Group
-
Molven, A., Ringdal, M., Nordbø, A. M., Raeder, H., Støy, J., Lipkind, G. M., Steiner, D. F., Philipson, L. H., Bergmann, I., Aarskog, D., et al., and the Norwegian Childhood Diabetes Study Group. (2008). Mutations in the insulin gene can cause MODY and autoantibodynegative type 1 diabetes. Diabetes 57, 1131-1135.
-
(2008)
Diabetes
, vol.57
, pp. 1131-1135
-
-
Molven, A.1
Ringdal, M.2
Nordbø, A.M.3
Raeder, H.4
Støy, J.5
Lipkind, G.M.6
Steiner, D.F.7
Philipson, L.H.8
Bergmann, I.9
Aarskog, D.10
-
75
-
-
0026859563
-
Structure and evolution of insulins: implications for receptor binding
-
Murray-Rust, J., McLeod, A. N., Blundell, T. L., and Wood, S. P. (1992). Structure and evolution of insulins: implications for receptor binding. Bioessays 14, 325-331.
-
(1992)
Bioessays
, vol.14
, pp. 325-331
-
-
Murray-Rust, J.1
McLeod, A.N.2
Blundell, T.L.3
Wood, S.P.4
-
76
-
-
0028868961
-
Identification of the receptor-recognition surface of bombyxin-II, an insulin-like peptide of the silkmoth Bombyx mori: critical importance of the B-chain central part
-
Nagata, K., Hatanaka, H., Kohda, D., Kataoka, H., Nagasawa, H., Isogai, A., Ishizaki, H., Suzuki, A., and Inagaki, F. (1995a). Identification of the receptor-recognition surface of bombyxin-II, an insulin-like peptide of the silkmoth Bombyx mori: critical importance of the B-chain central part. J Mol Biol 253, 759-770.
-
(1995)
J Mol Biol
, vol.253
, pp. 759-770
-
-
Nagata, K.1
Hatanaka, H.2
Kohda, D.3
Kataoka, H.4
Nagasawa, H.5
Isogai, A.6
Ishizaki, H.7
Suzuki, A.8
Inagaki, F.9
-
77
-
-
0028868960
-
Three-dimensional solution structure of bombyxin-II an insulin-like peptide of the silkmoth Bombyx mori: structural comparison with insulin and relaxin
-
Nagata, K., Hatanaka, H., Kohda, D., Kataoka, H., Nagasawa, H., Isogai, A., Ishizaki, H., Suzuki, A., and Inagaki, F. (1995b). Three-dimensional solution structure of bombyxin-II an insulin-like peptide of the silkmoth Bombyx mori: structural comparison with insulin and relaxin. J Mol Biol 253, 749-758.
-
(1995)
J Mol Biol
, vol.253
, pp. 749-758
-
-
Nagata, K.1
Hatanaka, H.2
Kohda, D.3
Kataoka, H.4
Nagasawa, H.5
Isogai, A.6
Ishizaki, H.7
Suzuki, A.8
Inagaki, F.9
-
78
-
-
0025992754
-
Implications of invariant residue LeuB6 in insulin-receptor interactions
-
Nakagawa, S. H., and Tager, H. S. (1991). Implications of invariant residue LeuB6 in insulin-receptor interactions. J Biol Chem 266, 11502-11509.
-
(1991)
J Biol Chem
, vol.266
, pp. 11502-11509
-
-
Nakagawa, S.H.1
Tager, H.S.2
-
79
-
-
0026634650
-
Importance of aliphatic sidechain structure at positions 2 and 3 of the insulin A chain in insulinreceptor interactions
-
Nakagawa, S. H., and Tager, H. S. (1992). Importance of aliphatic sidechain structure at positions 2 and 3 of the insulin A chain in insulinreceptor interactions. Biochemistry 31, 3204-3214.
-
(1992)
Biochemistry
, vol.31
, pp. 3204-3214
-
-
Nakagawa, S.H.1
Tager, H.S.2
-
80
-
-
16344376210
-
Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B-chain
-
Nakagawa, S. H., Zhao, M., Hua, Q. X., Hu, S. Q., Wan, Z. L., Jia, W., and Weiss, M. A. (2005). Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B-chain. Biochemistry 44, 4984-4999.
-
(2005)
Biochemistry
, vol.44
, pp. 4984-4999
-
-
Nakagawa, S.H.1
Zhao, M.2
Hua, Q.X.3
Hu, S.Q.4
Wan, Z.L.5
Jia, W.6
Weiss, M.A.7
-
81
-
-
0022549577
-
Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin
-
Nanjo, K., Sanke, T., Miyano, M., Okai, K., Sowa, R., Kondo, M., Nishimura, S., Iwo, K., Miyamura, K., Given, B. D., et al. (1986). Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin. J Clin Invest 77, 514-519.
-
(1986)
J Clin Invest
, vol.77
, pp. 514-519
-
-
Nanjo, K.1
Sanke, T.2
Miyano, M.3
Okai, K.4
Sowa, R.5
Kondo, M.6
Nishimura, S.7
Iwo, K.8
Miyamura, K.9
Given, B.D.10
-
82
-
-
0027311222
-
Role of native disulfide bonds in the structure and activity of insulin-like growth factor 1: genetic models of protein-folding intermediates
-
Narhi, L. O., Hua, Q. X., Arakawa, T., Fox, G. M., Tsai, L., Rosenfeld, R., Holst, P., Miller, J. A., and Weiss, M. A. (1993). Role of native disulfide bonds in the structure and activity of insulin-like growth factor 1: genetic models of protein-folding intermediates. Biochemistry 32, 5214-5221.
-
(1993)
Biochemistry
, vol.32
, pp. 5214-5221
-
-
Narhi, L.O.1
Hua, Q.X.2
Arakawa, T.3
Fox, G.M.4
Tsai, L.5
Rosenfeld, R.6
Holst, P.7
Miller, J.A.8
Weiss, M.A.9
-
83
-
-
0035918550
-
Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism
-
Nielsen, L., Khurana, R., Coats, A., Frokjaer, S., Brange, J., Vyas, S., Uversky, V. N., and Fink, A. L. (2001). Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism. Biochemistry 40, 6036-6046.
-
(2001)
Biochemistry
, vol.40
, pp. 6036-6046
-
-
Nielsen, L.1
Khurana, R.2
Coats, A.3
Frokjaer, S.4
Brange, J.5
Vyas, S.6
Uversky, V.N.7
Fink, A.L.8
-
84
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., and Mori, M. (2002). Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109, 525-532.
-
(2002)
J Clin Invest
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
Araki, E.6
Mori, M.7
-
85
-
-
0009718890
-
Insulin's crystal structure at 2.5A resolution
-
Peking, I. R. G. (1971). Insulin's crystal structure at 2. 5A resolution. Peking Rev 40, 11-16.
-
(1971)
Peking Rev
, vol.40
, pp. 11-16
-
-
Peking, I.R.G.1
-
86
-
-
0035868890
-
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
-
Pierce, S. B., Costa, M., Wisotzkey, R., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D. M., Pasquinelli, A. A., et al. (2001). Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev 15, 672-686.
-
(2001)
Genes Dev
, vol.15
, pp. 672-686
-
-
Pierce, S.B.1
Costa, M.2
Wisotzkey, R.3
Devadhar, S.4
Homburger, S.A.5
Buchman, A.R.6
Ferguson, K.C.7
Heller, J.8
Platt, D.M.9
Pasquinelli, A.A.10
-
87
-
-
0017293453
-
Receptor-binding region of insulin
-
Pullen, R. A., Lindsay, D. G., Wood, S. P., Tickle, I. J., Blundell, T. L., Wollmer, A., Krail, G., Brandenburg, D., Zahn, H., Gliemann, J., et al. (1976). Receptor-binding region of insulin. Nature 259, 369-373.
-
(1976)
Nature
, vol.259
, pp. 369-373
-
-
Pullen, R.A.1
Lindsay, D.G.2
Wood, S.P.3
Tickle, I.J.4
Blundell, T.L.5
Wollmer, A.6
Krail, G.7
Brandenburg, D.8
Zahn, H.9
Gliemann, J.10
-
88
-
-
0035814878
-
Putative disulfide-forming pathway of porcine insulin precursor during its refolding in vitro
-
Qiao, Z. S., Guo, Z. Y., and Feng, Y. M. (2001). Putative disulfide-forming pathway of porcine insulin precursor during its refolding in vitro. Biochemistry 40, 2662-2668.
-
(2001)
Biochemistry
, vol.40
, pp. 2662-2668
-
-
Qiao, Z.S.1
Guo, Z.Y.2
Feng, Y.M.3
-
89
-
-
33646429254
-
In vitro folding/unfolding of insulin/single-chain insulin
-
Qiao, Z. S., Guo, Z. Y., and Feng, Y. M. (2006). In vitro folding/unfolding of insulin/single-chain insulin. Protein Pept Lett 13, 423-429.
-
(2006)
Protein Pept Lett
, vol.13
, pp. 423-429
-
-
Qiao, Z.S.1
Guo, Z.Y.2
Feng, Y.M.3
-
90
-
-
0038043253
-
In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process
-
Qiao, Z. S., Min, C. Y., Hua, Q. X., Weiss, M. A., and Feng, Y. M. (2003). In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process. J Biol Chem 278, 17800-17809.
-
(2003)
J Biol Chem
, vol.278
, pp. 17800-17809
-
-
Qiao, Z.S.1
Min, C.Y.2
Hua, Q.X.3
Weiss, M.A.4
Feng, Y.M.5
-
91
-
-
0036175125
-
Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse
-
Ron, D. (2002). Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse. J Clin Invest 109, 443-445.
-
(2002)
J Clin Invest
, vol.109
, pp. 443-445
-
-
Ron, D.1
-
92
-
-
0033781382
-
Three-dimensional solution structure of a disulfide bond isomer of the human insulin-like growth factor-I
-
Sato, A., Koyama, S., Yamada, H., Suzuki, S., Tamura, K., Kobayashi, M., Niwa, M., Yasuda, T., Kyogoku, Y., and Kobayashi, Y. (2000). Three-dimensional solution structure of a disulfide bond isomer of the human insulin-like growth factor-I. J Pept Res 56, 218-230.
-
(2000)
J Pept Res
, vol.56
, pp. 218-230
-
-
Sato, A.1
Koyama, S.2
Yamada, H.3
Suzuki, S.4
Tamura, K.5
Kobayashi, M.6
Niwa, M.7
Yasuda, T.8
Kyogoku, Y.9
Kobayashi, Y.10
-
93
-
-
0027154233
-
Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry
-
Sato, A., Nishimura, S., Ohkubo, T., Kyogoku, Y., Koyama, S., Kobayashi, M., Yasuda, T., and Kobayashi, Y. (1993). Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry. Int J Pept Protein Res 41, 433-440.
-
(1993)
Int J Pept Protein Res
, vol.41
, pp. 433-440
-
-
Sato, A.1
Nishimura, S.2
Ohkubo, T.3
Kyogoku, Y.4
Koyama, S.5
Kobayashi, M.6
Yasuda, T.7
Kobayashi, Y.8
-
94
-
-
0028268592
-
A model for insulin binding to the insulin receptor
-
Schäffer, L. (1994). A model for insulin binding to the insulin receptor. Eur J Biochem 221, 1127-1132.
-
(1994)
Eur J Biochem
, vol.221
, pp. 1127-1132
-
-
Schäffer, L.1
-
95
-
-
0026548864
-
Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions
-
Shoelson, S. E., Lu, Z. X., Parlautan, L., Lynch, C. S., and Weiss, M. A. (1992). Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions. Biochemistry 31, 1757-1767.
-
(1992)
Biochemistry
, vol.31
, pp. 1757-1767
-
-
Shoelson, S.E.1
Lu, Z.X.2
Parlautan, L.3
Lynch, C.S.4
Weiss, M.A.5
-
96
-
-
0018133234
-
Synthesis and biological activity of two disulphide bond isomers of human insulin: [A7-A11, A6-B7-cystine]- and [A6-A7,A11-B7-cystine]insulin (human)
-
Sieber, P. S., Eisler, K., Kamber, B., Riniker, B., Rittel, W., Märki, F., and de Gasparo, M. (1978). Synthesis and biological activity of two disulphide bond isomers of human insulin: [A7-A11, A6-B7-cystine]- and [A6-A7, A11-B7-cystine]insulin (human). Hoppe Seylers Z Physiol Chem 359, 113-123.
-
(1978)
Hoppe Seylers Z Physiol Chem
, vol.359
, pp. 113-123
-
-
Sieber, P.S.1
Eisler, K.2
Kamber, B.3
Riniker, B.4
Rittel, W.5
Märki, F.6
de Gasparo, M.7
-
97
-
-
0014146156
-
Evidence for a precursor in the biosynthesis of insulin
-
Steiner, D. F. (1967). Evidence for a precursor in the biosynthesis of insulin. Trans N Y Acad Sci 30, 60-68.
-
(1967)
Trans N Y Acad Sci
, vol.30
, pp. 60-68
-
-
Steiner, D.F.1
-
98
-
-
0031995477
-
The proprotein convertases
-
Steiner, D. F. (1998). The proprotein convertases. Curr Opin Chem Biol 2, 31-39.
-
(1998)
Curr Opin Chem Biol
, vol.2
, pp. 31-39
-
-
Steiner, D.F.1
-
99
-
-
0025285086
-
Lessons learned from molecular biology of insulin-gene mutations
-
Steiner, D. F., Tager, H. S., Chan, S. J., Nanjo, K., Sanke, T., and Rubenstein, A. H. (1990). Lessons learned from molecular biology of insulin-gene mutations. Diabetes Care 13, 600-609.
-
(1990)
Diabetes Care
, vol.13
, pp. 600-609
-
-
Steiner, D.F.1
Tager, H.S.2
Chan, S.J.3
Nanjo, K.4
Sanke, T.5
Rubenstein, A.H.6
-
100
-
-
35448994352
-
Insulin gene mutations as a cause of permanent neonatal diabetes
-
the Neonatal Diabetes International Collaborative Group
-
Støy, J., Edghill, E. L., Flanagan, S. E., Ye, H., Paz, V. P., Pluzhnikov, A., Below, J. E., Hayes, M. G., Cox, N. J., Lipkind, G. M., et al., and the Neonatal Diabetes International Collaborative Group. (2007). Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A 104, 15040-15044.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 15040-15044
-
-
Støy, J.1
Edghill, E.L.2
Flanagan, S.E.3
Ye, H.4
Paz, V.P.5
Pluzhnikov, A.6
Below, J.E.7
Hayes, M.G.8
Cox, N.J.9
Lipkind, G.M.10
-
101
-
-
0025372089
-
The insulin A and B-chains contain structural information for the formation of the native molecule. Studies with protein disulphide-isomerase
-
Tang, J. G., and Tsou, C. L. (1990). The insulin A and B-chains contain structural information for the formation of the native molecule. Studies with protein disulphide-isomerase. Biochem J 268, 429-435.
-
(1990)
Biochem J
, vol.268
, pp. 429-435
-
-
Tang, J.G.1
Tsou, C.L.2
-
102
-
-
0029059589
-
Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions
-
Torres, A. M., Forbes, B. E., Aplin, S. E., Wallace, J. C., Francis, G. L., and Norton, R. S. (1995). Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions. J Mol Biol 248, 385-401.
-
(1995)
J Mol Biol
, vol.248
, pp. 385-401
-
-
Torres, A.M.1
Forbes, B.E.2
Aplin, S.E.3
Wallace, J.C.4
Francis, G.L.5
Norton, R.S.6
-
103
-
-
0034048940
-
Genetically engineered insulin analogs: diabetes in the new millenium
-
Vajo, Z., and Duckworth, W. C. (2000). Genetically engineered insulin analogs: diabetes in the new millenium. Pharmacol Rev 52, 1-9.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 1-9
-
-
Vajo, Z.1
Duckworth, W.C.2
-
104
-
-
48149093031
-
The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition
-
Wan, Z. L., Huang, K., Hu, S. Q., Whittaker, J., and Weiss, M. A. (2008). The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J Biol Chem 283, 21198-21210.
-
(2008)
J Biol Chem
, vol.283
, pp. 21198-21210
-
-
Wan, Z.L.1
Huang, K.2
Hu, S.Q.3
Whittaker, J.4
Weiss, M.A.5
-
105
-
-
0025777247
-
The insulin A and B-chains contain sufficient structural information to form the native molecule
-
Wang, C. C., and Tsou, C. L. (1991). The insulin A and B-chains contain sufficient structural information to form the native molecule. Trends Biochem Sci 16, 279-281.
-
(1991)
Trends Biochem Sci
, vol.16
, pp. 279-281
-
-
Wang, C.C.1
Tsou, C.L.2
-
106
-
-
76649144177
-
A brief account on the study of the insulin crystal structure
-
Wang, D. C. G., and Gu, X. C. (2010). A brief account on the study of the insulin crystal structure. Sin China Series C 53, 13-15.
-
(2010)
Sin China Series C
, vol.53
, pp. 13-15
-
-
Wang, D.C.G.1
Gu, X.C.2
-
107
-
-
0032918044
-
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse
-
Wang, J., Takeuchi, T., Tanaka, S., Kubo, S. K., Kayo, T., Lu, D., Takata, K., Koizumi, A., and Izumi, T. (1999). A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest 103, 27-37.
-
(1999)
J Clin Invest
, vol.103
, pp. 27-37
-
-
Wang, J.1
Takeuchi, T.2
Tanaka, S.3
Kubo, S.K.4
Kayo, T.5
Lu, D.6
Takata, K.7
Koizumi, A.8
Izumi, T.9
-
108
-
-
37249047933
-
Structural insights into ligand-induced activation of the insulin receptor
-
Ward, C., Lawrence, M. C., Streltsov, V., Garrett, T., McKern, N., Lou, M. Z., Lovrecz, G., and Adams, T. (2008). Structural insights into ligand-induced activation of the insulin receptor. Acta Physiol (Oxf) 192, 3-9.
-
(2008)
Acta Physiol (Oxf)
, vol.192
, pp. 3-9
-
-
Ward, C.1
Lawrence, M.C.2
Streltsov, V.3
Garrett, T.4
McKern, N.5
Lou, M.Z.6
Lovrecz, G.7
Adams, T.8
-
109
-
-
1642468519
-
The properties of protein fibers produced. Reversibly from soluble protein molecules
-
Waugh, D. F. (1941). The properties of protein fibers produced. Reversibly from soluble protein molecules. Am J Physiol 133, 484-P485.
-
(1941)
Am J Physiol
, vol.133
-
-
Waugh, D.F.1
-
110
-
-
0006567078
-
The linkage of corpuscular protein molecules. I. A fibrous modification on insulin
-
Waugh, D. F. (1944). The linkage of corpuscular protein molecules. I. A fibrous modification on insulin. J Am Chem Soc 66, 663.
-
(1944)
J Am Chem Soc
, vol.66
, pp. 663
-
-
Waugh, D.F.1
-
112
-
-
0000335935
-
A fibrous modification of insulin. I. The heat precipitate of insulin
-
Waugh, D. F. (1946b). A fibrous modification of insulin. I. The heat precipitate of insulin. J Am Chem Soc 68, 247-250.
-
(1946)
J Am Chem Soc
, vol.68
, pp. 247-250
-
-
Waugh, D.F.1
-
113
-
-
0034687669
-
Hierarchical protein "un-design": insulin's intrachain disulfide bridge tethers a recognition alpha-helix
-
Weiss, M. A., Hua, Q. X., Jia, W., Chu, Y. C., Wang, R. Y., and Katsoyannis, P. G. (2000). Hierarchical protein "un-design": insulin's intrachain disulfide bridge tethers a recognition alpha-helix. Biochemistry 39, 15429-15440.
-
(2000)
Biochemistry
, vol.39
, pp. 15429-15440
-
-
Weiss, M.A.1
Hua, Q.X.2
Jia, W.3
Chu, Y.C.4
Wang, R.Y.5
Katsoyannis, P.G.6
-
115
-
-
0003919736
-
-
New York, NY: Higher Education Press and Springer-Verlag
-
Wuthrich, K. (1986). NMR of Proteins and Nucleic Acids (New York, NY: Higher Education Press and Springer-Verlag).
-
(1986)
NMR of Proteins and Nucleic Acids
-
-
Wuthrich, K.1
-
116
-
-
3142579218
-
Diabetes-associated mutations in insulin: consecutive residues in the B-chain contact distinct domains of the insulin receptor
-
Xu, B., Hu, S. Q., Chu, Y. C., Huang, K., Nakagawa, S. H., Whittaker, J., Katsoyannis, P. G., and Weiss, M. A. (2004a). Diabetes-associated mutations in insulin: consecutive residues in the B-chain contact distinct domains of the insulin receptor. Biochemistry 43, 8356-8372.
-
(2004)
Biochemistry
, vol.43
, pp. 8356-8372
-
-
Xu, B.1
Hu, S.Q.2
Chu, Y.C.3
Huang, K.4
Nakagawa, S.H.5
Whittaker, J.6
Katsoyannis, P.G.7
Weiss, M.A.8
-
117
-
-
2542626810
-
Diabetes-associated mutations in insulin identify invariant receptor contacts
-
Xu, B., Hu, S. Q., Chu, Y. C., Wang, S., Wang, R. Y., Nakagawa, S. H., Katsoyannis, P. G., and Weiss, M. A. (2004b). Diabetes-associated mutations in insulin identify invariant receptor contacts. Diabetes 53, 1599-1602.
-
(2004)
Diabetes
, vol.53
, pp. 1599-1602
-
-
Xu, B.1
Hu, S.Q.2
Chu, Y.C.3
Wang, S.4
Wang, R.Y.5
Nakagawa, S.H.6
Katsoyannis, P.G.7
Weiss, M.A.8
-
118
-
-
67649827251
-
Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains
-
Xu, B., Huang, K., Chu, Y. C., Hu, S. Q., Nakagawa, S., Wang, S., Wang, R. Y., Whittaker, J., Katsoyannis, P. G., and Weiss, M. A. (2009). Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains. J Biol Chem 284, 14597-14608.
-
(2009)
J Biol Chem
, vol.284
, pp. 14597-14608
-
-
Xu, B.1
Huang, K.2
Chu, Y.C.3
Hu, S.Q.4
Nakagawa, S.5
Wang, S.6
Wang, R.Y.7
Whittaker, J.8
Katsoyannis, P.G.9
Weiss, M.A.10
-
119
-
-
0037377495
-
A peptide model of insulin folding intermediate with one disulfide
-
Yan, H., Guo, Z. Y., Gong, X. W., Xi, D., and Feng, Y. M. (2003). A peptide model of insulin folding intermediate with one disulfide. Protein Sci 12, 768-775.
-
(2003)
Protein Sci
, vol.12
, pp. 768-775
-
-
Yan, H.1
Guo, Z.Y.2
Gong, X.W.3
Xi, D.4
Feng, Y.M.5
-
120
-
-
0030907296
-
A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
-
Yoshioka, M., Kayo, T., Ikeda, T., and Koizumi, A. (1997). A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46, 887-894.
-
(1997)
Diabetes
, vol.46
, pp. 887-894
-
-
Yoshioka, M.1
Kayo, T.2
Ikeda, T.3
Koizumi, A.4
-
121
-
-
0014182530
-
Synthesis of an insulin B-chain disulfide polymer
-
Zahn, H., and Schmidt, G. (1967). Synthesis of an insulin B-chain disulfide polymer. Tetrahedron Lett 50, 5095-5098.
-
(1967)
Tetrahedron Lett
, vol.50
, pp. 5095-5098
-
-
Zahn, H.1
Schmidt, G.2
-
122
-
-
0034660242
-
Conformational correlation and coupled motion between residue A21 and B25 side chain observed in crystal structures of insulin mutants at position A21
-
Zeng, Z. H., Liu, Y. S., Jin, L., Zhang, Y., Havelund, S., Markussen, J., and Wang, D. C. (2000). Conformational correlation and coupled motion between residue A21 and B25 side chain observed in crystal structures of insulin mutants at position A21. Biochim Biophys Acta 1479, 225-236.
-
(2000)
Biochim Biophys Acta
, vol.1479
, pp. 225-236
-
-
Zeng, Z.H.1
Liu, Y.S.2
Jin, L.3
Zhang, Y.4
Havelund, S.5
Markussen, J.6
Wang, D.C.7
-
123
-
-
76649103701
-
The first protein ever synthesized in vitro
-
Zhang, Y. S. (2010). The first protein ever synthesized in vitro. Sin China Series C 53, 16-18.
-
(2010)
Sin China Series C
, vol.53
, pp. 16-18
-
-
Zhang, Y.S.1
|