Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin

Biological Chemistry

Volumn 382, Issue 3, 2001, Pages 443-448

  Guo, Z Y ^a   Feng, Y M ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Disulfide bond; Folding; Insulin; Secretion; Site directed mutagenesis

Indexed keywords

CYSTEINE; INSULIN; INSULIN RECEPTOR; MUTANT PROTEIN; PROINSULIN; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CIRCULAR DICHROISM; CONTROLLED STUDY; CONVULSION; DISULFIDE BOND; GENE DELETION; HORMONE ACTION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INSULIN RELEASE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECRETION; PROTEIN STRUCTURE; RECEPTOR BINDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS; SWINE;

AMINO ACID SUBSTITUTION; ANIMALS; CIRCULAR DICHROISM; CYSTEINE; DISULFIDES; HUMANS; INSULIN; MICE; MICE, INBRED ICR; MUTAGENESIS, SITE-DIRECTED; PROINSULIN; PROTEIN FOLDING; RECEPTOR, INSULIN; SERINE; SWINE;

ANIMALIA; SACCHAROMYCES CEREVISIAE; SUIDAE; SUS SCROFA;

EID: 0035037739     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.054     Document Type: Article

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